CHAPTER 7 - Evolutionary Anabolic Factor Ebook
There are several factors that contribute to the unavailability or unpopularity of the following compounds. Discontinued production is usually the primary reason why these steroids are impossible or rare to find nowadays. Low demand, which can be a consequence of weak bodybuilding properties, high cost, and/or novelty, can also be a significant factor. Most of the information provided below is deemed more relevant for academic purposes than for practical applications since these products are almost impossible to find anywhere.
Danocrine is a trade name of Sanofi Winthrop of the compound danazol, which is a synthetic hormone derived from ethisterone. It is practically insoluble in water, but soluble in chloroform and in acetone. It has a melting point of 225 C. The diluents contained in Danocrine are lactose, maize starch, purified talc, magnesium stearate, titanium dioxide, and gelatin.
Danocrine is technically an anti-gonadotropin and it is therapeutically used to treat hereditary angioedema, gynecomastia, and other hormone-related disorders like pain and infertility associated with endometriosis. It is counterindicated for pregnant women and lactating mothers.
In bodybuilding, Danocrine is used mainly to counter the possible side effects of highly aromatizable compounds. Occurrence of androgenic reactions with this drug is rare and non-permanent. An asset of this compound is the fact that it is not classified as a controlled substance in the United States.
Danocrine comes in 50 mg, 100 mg, and 200 mg capsules and tablets. In the US, the price range for Danazol capsule is from $4.50-$5 per capsule, which is considered to be a high price to pay for a low anabolic effect. Its generic versions are typically at lowered prices. Danocrine is also a c-17aa oral making it stressful to the liver, especially if administered in high dosages and prolonged periods. These Danocrine downsides make this drug rarely seen in bodybuilding therapy.
Estandron (testosterone and estrogen blend)
Estandron is a blend of 3 testosterone esters – propionate (20mg), phenylpropionate (40mg), and isocaproate (40mg). This makes it almost similar to the drug Sustanon 250, which has all of the aforementioned esters plus the decanoate ester.
The more accurate comparison, however, is with Sustanon 250's low-dosed 'sister' Sustanon 100. Estandron, manufactured by the pharmaceutical giant Organon, is very similar to Sustanon 100 on a milligram for milligram consideration. These two drugs also share the same three esters, and the only standout difference between them is that Estandron contains an estrogen blend, namely, estradiol benzoate (1mg) and estradiol phenylpropionate (4mg).
The add-on if estrogen in Estandron is to counter the virilization symptoms of testosterone. It is obvious then that the target clientele for this compound is women. Female users who experiment with Estrandron find it effective to induce muscle growth. Men, who have to contend with estrogen-related side effects even with plain testosterone-based compounds, veer away from Estrandron. To take drugs that contain estrogen, such as Estanron, can exacerbate said concerns.
Women benefit from a weekly dosage of 1 ml of Estandron. For men, a weekly dosage of 2ml to 4ml is required for desirable gains. Male users should also take this drug with anti-estrogen agent to avoid possible estrogenic side effects, such as fat and water accumulation and gynecomastia.
One positive aspect of this drug is that it is not a popular drug choice of counterfeiters; meaning, that should you decide to get this product, you'll get the real thing. This is because of the premise that testosterone with estrogen items are not in great demand amongst athletes.
Megagrisevit-Mono (clostebol acetate)
Megagrisevit-Mono is a testosterone derivative with an added chloro group at the 4-position. This alteration prevents this compound from being 5-alpha reduced to dihydrotestosterone (DHT). DHT is known to cause some of the side effects of steroids use, such as hair loss and water retention. Nevertheless, it is important to remember that DHT also benefits bodybuilders, and thus it should not be considered as a side-effect androgen only. DHT plays a significant role in the overall functioning of the central nervous system (CNS). The CNS and the skeletal muscles, collectively known as the neuromusclular system, fulfill a give-and-take role in muscle building and growth.
Megagrisevit-Mono is considered a mild anabolic compound with minimal androgenic potency. The 4-choloro alteration at the A-ring makes this compound unable to aromatize. As such, gynecomastia and water retention are not often experienced with the use of Megagrisevit-Mono.
This compound is available in both oral and injectable versions. The hydrogen substitution at the A-ring weakens its efficacy. This is the reason why athletes prefer the injectable form, since it is much more effective on a milligram for milligram basis.
Individuals with a predisposition towards male pattern hair loss, acne, or hirsutism opt for Megagrisevit-Mono, for this drug exhibits low androgenic activity. Women particularly favor this drug because they can avoid virilization symptoms commonly associated with compounds that display strong androgenic actions.
This steroid is usually used in conjunction with other drugs because of its low anabolic effect. The common practice is to take this drug with other non-aromatizing anabolics during contest preparation. At this stage, the effective daily intake is 20mg (2vials) of Megagrisevit-Mono with an average dose of another anabolic (about 20mg-30mg). This stack protocol results to lean muscle gain minus water retention, which is an ideal combination during contest preps. Women are advised to administer lower dosages with an intake of not more than 10mg per day.
If the user is not prone to the common side effects, he/she can stack this drug with strong non-aromatizing steroids like Halotestin or Proviron. This results to leaner and harder looking physique.
Nowadays, this steroid is impossible to find in the black market or anywhere else, for that matter. This is because Megagrisevit-Mono has been discontinued for quite a while now. On the Italian market, products containing the clostebol compound are Alfa-Trofodermin and Trofodermin. These are transdermal versions of this steroid. Nontheless, since the transdermal route is never a reliable means for effective steroid administration, these products are never in high demand.
The rarity of this compound is primarily due to its discontinuance. This means that if you're getting Miotolan these days, it is likely to be a counterfeited version. However, it is important to know at this point that this synthetic steroid was hard to find outside of Japan (where it was originally manufactured) even in its heydays. There is, however, some news that one underground manufacturer is allegedly currently producing legitimate generic furazabol. This claim though is yet to be determined.
Miotolan is a DHT derivative; thus, users need not worry about the estrogen-related side effects like fat and water retention and gynecomastia. It is considered as a mild anabolic and androgenic compound. The alteration in the A-ring prevents Miotolan from aromatizing, and instead, allows it to bind with receptors at the muscle tissues to exert its anabolic effects.
Both natural and synthetic steroid hormones are characterized by a molecular structure of 17 carbons arranged in four rings. The ring carbons are thus numbered 1 to 17, and the 4 rings are labeled A-D. Side chain carbons, meanwhile, are numbered 18 upwards. The biological behavior of the different steroids depends on the nature of the substituents attached to the basic molecular structure.
Although this drug only slightly affects the endogenous testosterone level, it can bring about androgen-related reactions. Acne, excessive body or facial hair growth, and alopecia can be experienced by sensitive individuals.
Miotolan is preferred during cutting cycle before a competition, when athletes are after harder and more defined muscles. It is usually stacked with mild anabolics like Equipoise and Deca-Durabolin. Daily dosage is recommended at 10mg to 20mg (10 to 20 tablets). Miotolan is a c-17aa oral; thus, users should avoid high dosages and prolonged use.
Currently, there is a non-methylated derivative of furazabol, which is marketed under the trade name Furagano. However, there is dearth of information and anecdotal data on Furagano since it has only been recently commercially introduced.
Orabolin is a trade name for the oral anabolic steroid ethylestrenol, manufactured by the drug firm Organon. In the United States, it was once available as Maxibolin (not to be confused with the Mexican vitamin supplement Maxibol). Currently, Orabolin is rarely seen in the US since it is only manufactured in few countries.
Orabolin is similar to nandrolone (19-nortestosterone) in structure. The only difference between these two is that Orabolin is an oral version. This explains why this drug is so-named because it has been originally endorsed as an oral alternative to the injectable Deca Durabolin, a nandrolone-based compound.
Orabolin is an anabolic steroid with mild androgenic properties. Estrogen-related side effects are unlikely since this compound only slightly aromatizes. Just like Estandron, Orabolin primarily targets female users, as it is designed to cause relatively lesser virilizing side effects. Most female users find Orabolin a reliable drug for maintaining ideal blood hormone levels. Such levels are generally easier to control with oral steroids than with injectable forms.
Both female and male users, nonetheless, should be aware of dosage administration of this drug since it is a c-17aa oral. Prolonged use and excessive dosage can cause both reversible and irreversible damage to the liver. Thus, the advice is to limit the dosage to not more than 8 weeks. The commonly practiced intake for men is 20 to 40 mg (10-20 tabs). For women, it is 12 to 16 mg daily. To heighten the effects of mild anabolics like Orabolin, the advice is to stack them with another steroid and not to ramp up the dosage beyond what is recommended. An increased dosage can result to an increased likelihood of users experiencing estrogenic side effects. Overdosing with Orabolin, or any c-17aa compounds, puts the liver under undue stress.
The reason why Orabolin remains an obscure steroid in bodybuilding is because the gains are much less significant than those delivered by other more popular compounds. As with other uncommon compounds, Orabolin is rarely counterfeited. The reason (again) is there is no high demand for this drug.
Prostanozol (demethylstanozolol tetrahydropyranyl)
Prostanozol is so named because it is marketed as an alternative to Winstrol (stanozolol). It is an oral anabolic steroid recently marketed in the US as a supplement product. It was introduced in 2005, and this is why Prostanazol is not (yet) considered as a controlled substance since it was still an unknown drug during the enactment of the 1991 and 2004 anabolic steroid laws.
Although this drug is often compared to Winstrol, Prostanazol is structurally different from the more popular Winstrol, particularly in the removal of the c-17aa group. The removal of this group makes Prostanozol liver-friendly; however, this makes it also less orally bioavailable. This means that it is easily metabolized by the liver before it can exert any effect on the body.
To slightly improve its oral bioavailability, an ether group is added. We said 'slightly improve' because although this increases its oil solubility there is still the absence of an oil carrier to contend with. The lack of an oil carrier results to lowered lymphatic delivery. In such case, the dosage intake is increased. This is the main drawback of Prostanozol. Because of poor oral bioavailability, male users have to take 100-150mg of this drug to come up with satisfactory lean gains. For female users, a significantly lower dosage of 25mg capsule per day is advised, which can be ramped up to a maximum of 2 capsules per day.
Because it is new to the market, there is little available data on this drug, except for its rudimentary chemical properties. Important basic information on this drug for bodybuilders is that Prostanozol does not convert to estrogen. Thus, it is categorized as a cutting drug or a lean mass agent.
Old School Juice I
Before the arrival of the so-called next-generation drugs, there was the old school juice group. This group of drugs does not require neither high-tech process to make them, nor highfalutin' words to describe them (recombitant seems to be the favorite word of many of these next-gen drugs). These are classic steroids that deliver the stuff straight to the point (or glutes, for that matter), with rarely a segue.
Although some will say old school compounds are passe, they cannot deny the popularity of these steroids from their introduction in the world of bodybuilding and up to now. The following are the classic muscle builders that your forefathers have relied on during their bodybuilding heydays.
Dianabol (methandienone, methandrostenolone)
Dianabol or D-bol is considered as the grandfather of all anabolic steroids. The majority of bodybuilders who have used and are using steroids got their baptism of fire with Dianabol. This compound was formulated through the collaboration of Dr. John Ziegler and the pharmaceutical company Ciba in the late 1950's.
Dianabol was developed in that era to counter Soviet Union's dominance in the weightlifting arena. The Soviet team, by many accounts, had been using testosterone injections as performance and physique boosters. Since its synthesis, Dianabol has become the main staple of many bodybuilders' stack, which is why many consider it as the most popular steroid ever created. Arnold Z., for one, has admitted using D-bol as a mainstay in his cycles during his stellar bodybuilding career.
Many say that its fame has led D-bol to its downfall. Ciba discontinued the production of the original Dianabol when FDA announced that D-bol's primary use as a therapeutic drug has been overshadowed by its popularity as a bodybuilding agent. The discontinuance, however, has not stopped many from acquiring and manufacturing this compound. Generic methandrostenolone continues to be produced to meet the never-ending demand.
Dianabol maximizes muscle hypertrophy through protein synthesis and glycogenolysis; these are two of the most important processes in bodybuilding. Protein synthesis is a complicated multi-stage process. To offer its most basic explanation, protein synthesis is the utilization of amino acids and proteins to create muscle tissues. Protein sources can come from diets and from the breakdown of muscles within the body.
When you engage in a physical exercise such as bodybuilding, you break down muscle fibers rapidly and continuously. Dianabol works by inhibiting that breakdown process, thereby keeping your muscle gains intact.
Glycogenolysis, on the other hand, is the chemical process whose fundamental goal is to conserve energy. Glycogen is the body's main source of energy and it is primarily stored in the liver and muscle cells. As you work out, glycogen gets depleted leading to fatigue and decreased endurance. What Dianabol does is to elevate glycogenolysis by restoring glycogen to maintain and/or enhance your performance level.
Androgenic sides can occur with D-bol, especially in sensitive individuals. Thus, females must take caution when trying out this drug since virilizing symptoms can occur. If there's really a need to use Dianabol, women must restrict themselves to small dosages. A dose of 5mg easily gives female users significant muscle growth with minimal risks.
The usual dosage for men is 25-50 mg/day, preferably in divided doses (four or five doses is the usual practice). It can be taken orally or intramuscularly. Cycle must be limited to 6 weeks and with an equal period for time off.
Dianabol exhibits moderate estrogenic activity; thus, users must not exceed the recommended dosage to avoid estrogen-related concerns, such as water/fat retention and gynecomastia. To counter these possible side effects, users are advised to combine anti-estrogen drugs like Nolvadex in their regimen.
Deca-Durabolin (nandrolone decanoate)
Nandrolone decanoate is also referred to as ND or by its popular trade name Deca Durabolin. Deca was originally manufactured by the pharmaceutical company Organon and was commercially introduced in 1962 as a prescription drug.
Structurally, the generic compound nandrolone shares similarities with the hormone testosterone. The only distinct difference between these two hormones is that nandrolone lacks a carbon atom at the 19th position; thus, it is also known as 19-nortestosterone. Nandrolone displays a low tendency to estrogen conversion, which makes it very popular among bodybuilders. Because of this property, fat/water retention and growth of breast tissues are rarely experienced by its users.
Due to its decanoate ester, Deca is a long-acting steroid whose activity is said to extend from 3 to 4 weeks. Its pharmacodynamics and mild anabolic effects make it more apt for longer cycles than most steroids. Eight-to-12 week-cycle exhibits slow, but quality muscle gains.
The dosage practice with Deca is to inject it once a week. Male users administer 200-600mg of Deca to achieve ideal blood plasma levels. Females can have favorable results with just 50mg per week. This is a versatile drug; it can be stacked with other steroids depending on desired results.
Deca is one of the most counterfeited steroid compounds around; therefore, users must be aware of identifying dubious versions. Another drawback of Deca is that its metabolites can be detected in drug testing for as long as 18 months after discontinuance. This is usually an issue with esterified compounds since their metabolites tend to be stored in fat tissues, particularly in cases of higher dosage and prolonged use.
The problem becomes more pronounced when users are cutting as a part of contest preparation. During the dieting/fasting phase, the tissues release stored fat to compensate for loss of proteins. It is believed that this simultaneously frees steroids into circulation to be eventually excreted from the system with the urine. Take note, however, that this is not a problem unique to Deca. Other esterified injectable compounds, particularly steroids with long-acting esters, can have this disadvantage.
There are some who say that Deca's popularity may be partly due to its 'detectability'. Examples of the most publicized cases of Deca use are Roger Clemens, who was allegedly been injected with this drug by Major League Baseball strength coach Brian McNamee during the 2000 baseball season. TNA wrestler Kurt Angle, UFC's Sean Sherk, and NFL's Shawn Merriman have also tested positive for this drug.
Primobolan (methenolone enanthate, acetate)
Primobolan, or Primo, is reportedly one of the two official Arnold cycle drugs. The other one is, of course, Dianabol. Primobolan comes in both injectable (enanthate) and oral (acetate) forms. Both basically have the same effects, but they differ (obviously) in their routes of administration. The injectable Primobolan is more efficient in delivering the goods, so to speak. It is of no wonder then that this has been quite popular with European athletes before it was discontinued by its original manufacturer Schering AG.
Methenolone, irregardless of the ester attached to it, is generally viewed as a mild steroid. Overall side effects from the drug are minimal; thus, many refer to Primo as the 'gentlest and cleanest' anabolic steroid around. Users usually compare it with Masteron (drostonolone); however, anecdotal evidence concludes that Primo is a stronger mass builder than Masteron.
Primo is a reliable anabolic and anti-catabolic agent. Many bodybuilders report making solid and long-lasting muscle gains while cutting down on calories when they are using this steroid. Remember, that this is not an agent for bulking purposes because it tends to harden and tone muscle rather than build them. When using Primo, expect to gain and maintain pure lean tissue - not quantitative muscle gains. During bulking cycle, the advice is to use Primo in conjunction with other drugs. Testosterone injectables, such as Omnadren and Sustanon, are generally suggested.
Since Primobolan is very structurally similar to DHT, it is a very potent fat burner. It binds quite well to the androgen receptor (AR); in fact, it binds with AR with more affinity than testosterone. Such quality has positive effects on lipolysis (breakdown of fats or lipids in fat cells). Because of this quality, Primo users acquire lean muscle gains.
With Primo, the gains are slow but permanent. Further, the drug does not suppress natural testosterone levels when taken in dosages less than 300 mg per week for cycles running less than 10 weeks. This makes this drug ideal for novices who want to try out injectable steroids for the first time. Another asset of this drug is that it rarely negatively impacts the body's cholesterol levels. If it does, the effects are reportedly minimal. Liver damage and cardiovascular disorders can also be easily averted.
Primobolan is available in both oral and injectable forms; not many steroid compounds are available in these two forms. Dianabol and Winstrol also come in both oral and injectable versions; nonetheless, they are not as unique as Primo. Primo has esters for both the oral (acetate) and the injectable (enanthate). And since it is not a c17-alpha-alkylated steroid, Primo is regarded as a liver-friendly compound. But this can also be considered as a drawback as far as this drug's potency is concerned.
Primobolan oral relies heavily on the acetate ester's ability to make it survive digestion. Still, absorption is not at its optimum; thus, daily administration is required. As such, the oral version of Primobolan has fallen out of favor and most bodybuilders now seek the injectable version exclusively. Consequently, production of its oral version is now discontinued by the original manufacturer.
The injectable version has an enanthate ester add-on. Once injected, Primo is gradually released from the site of administration. Esterification makes the drug molecule more fat-soluble, creating a compound that is hydrophobic, resulting in a slow release into the bloodstream. The chemical modification does not affect the potency or efficacy of a certain drug; all it does is to alter the rate of release of the drug.
Women usually opt for Primo, since virilization symptoms rarely occur. Hirsutism, deepened voice, clitoral enlargement, and irregular or stoppage of menstrual cycles are just some of the negative effects women can experience from steroid use. Women become particularly vulnerable to these side effects when they exceed the recommended dosage. Primo male users' main concern is hair loss. Individuals prone to this side effect can use anti hair-loss products, such as Finasteride, to minimize or avoid this problem.
Winstrol, also known as Winstrol V or Winny, is one of the most popular anabolic steroids currently available. A number of high-profile positive drug tests have involved this compound, a testament of its popularity among top-rank athletes. One of the controversial cases is that of Ben Johnson, the Canadian sprinter who set a world record for the 100-meter event in the 1988 Summer Olympics. He was later disqualified for the record and the Olympic Gold due to Winstrol use. Same thing happened during IFBB's 1990 Arnold Classic, when Shawn Ray, the announced winner, and Nimrod King, the Canadian pro, tested positive for this steroid.
Winstrol has a long history as it was first patented in the United States by the Sterling Drug Company (now with Bayer) back in 1962. It is classified as an anabolic steroid; and an anabolic steroid tends to display greater anabolic activity (muscle building) than androgenic effects.
It is derived from dihydrotestosterone (DHT), and this translates to one important thing – Winny does not convert to estrogen. As such, athletes using this compound are unlikely to experience estrogenic side effects, which are generally feminization symptoms, like development of mammary tissues, water retention, and fat accumulation. Therefore, anti-estrogens may not be required when on Winny.
What you get from Winstrol is lean, clean physique. Most anabolic steroids give rise to the problem of subcutaneous fat and water retention, and most of the weight gain during and after protocol may be attributed to both. Not so with Winstrol. The muscle and weight gains are not substantial but they are sustainable and qualitative. This means that even post cycle, you can keep what you have gained.
Users gain lean yet powerful build without a corresponding weight gain. This makes Winstrol ideal for athletes who compete in weight divisions and those who are into sports which require strength and speed like swimming and track-and-field.
Another noteworthy characteristic of oral Winstrol is its high affinity with the SHBG. What makes this characteristic desirable is the fact that this helps out other administered drugs to do their job. SHBG inhibits steroid hormones from binding to receptor sites and exerting their activity. Since Winstrol 'takes over' this hormone, it allows a greater amount of steroid hormones to be in a free state. In essence, Winstrol heightens the efficacy of other synthetically introduced steroids. This is called the synergistic effect of drugs.
Since Winstrol is a water-based steroid it necessitates frequent administration. It needs to be injected daily or every other day (every 12-36 hours). This is what makes Winny one of the most expensive steroids to use. Bear in mind that Winstrol is a good steroid for strength gains, bot not for mass. Since it lacks the 3-keto group, it does not bind well to the androgen receptors, limiting the amount of mass you are going to gain on a cycle.
The oral and injectable versions are both c-17 alpha-alkylated chemicals, which makes them both stressful to the liver. This c-17aa alteration is shared by most AAS orals as this gives them improved oral bioavailability. To be on the safe side, users are advised to not exceed the recommended dosage and cycle.
Winstrol is a compound that offers versatile results. For bulking purposes, Dianabol or Anadrol 50 or testosterone is typically stacked with Winstrol.
Old School Juice II
If Dianabol, Deca-Durabolin, Primobolan, and Winstrol are considered as time-tested steroids, the following group is of the time-obscured type. These are AAS that have not enjoyed permanent patronage from bodybuilding circles for several reasons – weak bodybuilding properties, strong competition, unavailability, among others.
Esiclene was originally developed to treat children who have growth disorders. In the 1980's, it became popular with bodybuilders. It is available in various forms, but the injectable version is what is commonly used in bodybuilding. Esiclene is available in 4mg/2ml ampules, 1 mg drops, and 5 mg tablets.
This compound is particularly of interest to bodybuilders who are after bulk. Formebolone displays distinctive anabolic properties, increasing muscle diameter and size within a short period. During contest preparation, Esiclene helps bodybuilders to stimulate a lagging body part.
This is clearly demonstrated with the injectable version. When administered, local inflammation results. Actually, the inflammation (enlargement or swelling) is the accumulation of tissue fluid from the lymph system. Take note that fluid accumulation occurs in the muscle itself and not on the skin. This can cause an awkward-looking muscle, as other muscle group can look slightly bigger or smaller than others. This 'uneven look' and the pain at the point of injection are the major drawbacks of Esiclene.
Anecdotal reports are not favorable with this drug; it tends to work only on small muscle groups, such as the biceps and calves. When administered into larger muscle groups like the chest and back areas, it results to sporadic lumps and bumps.
Esiclene is water-soluble; thus, it has a relatively shorter life span. The common dosage is a daily injection with this substance. Users usually ramp up the dosage; starting from – 1ml on the initial injection to 2 ml (equivalent to an ampule per muscle group) on subsequent days. To minimize the pain factor (inflammation may cause pain in some users), formebolone compounds usually contain 20 mg of lidocaine, a mild pain killer.
In general, users of Esiclene administer it 7 to 14 days prior to a contest to stimulate less-developed muscle groups. As such, it is injected on 2 to 3 muscle groups at the same time. It has been displaced by Synthol, a drug that exerts the same mode of action but with more permanent increase in muscle size. Esiclene is one of the most difficult to find in the black market and elsewhere since all forms of this compound have been discontinued by its original manufacturer.
Nilevar was originally a registered trademark if Searle Laboratories in the United States prior to its discontinuance. Nilevar has the distinction of being the first orally-active androgenic-anabolic steroid to be synthesized and approved in 1956. Its active ingredient norethandrolone is a derivative of nandrolone (19 nortestosterone). It is a c-17aa oral; thus, it is orally bioavailable but stressful to the liver.
Nilevar is the predecessor of Anavar (oxandrolone), which was commercially introduced almost a decade after Nilevar's intro in the US drug market. Put side by side, Anavar is considered to be the better option; and this is why Nilevar has been displaced by its progeny.
Nilevar is a mild to moderate anabolic with androgenic and estrogenic activity. Sensitive users may experience oily skin, acne, and body and facial hair growth. If you're predisposed to male pattern baldness, Nilevar may not be a good choice since it is known to induce this particular side effect. Drugs like Proscar may be futile to combat such adverse reaction. Proscar and other finasteride-based medications are anti-androgens that inhibit the 5-alpha reductase enzyme for converting testosterone to dihydrotestosterone (DHT). DHT is involved in the development of benign prostatic hyperplasia (BPH) and hair loss.
Those who have predisposed conditions such as the above, generally opt for Deca-Durabolin, an injectable nandrolone compound. Again, comparatively speaking, Nilevar loses out to Deca in terms of estrogenic side effects. This is because Nilevar converts to 17alpha-ethyl estradiol instead of regular estrogen found in Deca. The 17alpha-ethyl estradiol is a more biologically active form of estradio and is, therefore, more potent in exerting side effects. Therefore, water retention and gynecomastia have a relatively high probability of occurring. To prevent these from arising, Nilevar users are advised to take anti-estrogen products, such as Proviron or Nolvadex, right at the beginning of the cycle.
Another drawback of Nilevar is that it exhibits progestational activity, leading to a more pronounced suppression of endogenous testosterone production. This is similarly observed with Deca Durabolin and other 19-norandrogens; however, Nilevar seems more prone to cause subcutaneous fat accumulation and gynecomastia. Remember that these two side effects are typically induced by estrogen and progestin is known to aggravate these concerns.
To prevent these negative reactions – hormonal imbalance, estrogen – and progestin-related effects – HCG and Clomid/Nolvadex are required after Nilevar cycle.
The usual daily intake of Nilevar is 30-40 mg (3-4 tablets) for adequate anabolic effect. The ideal practice is to divide the intake into several and even doses throughout the day. Cycles should run for 6 to 8 weeks, then take a time off. Keep in mind that Nilevar is c17-aa oral, and the ethyl substitution (instead of the methyl group, which is generally used to improve the oral bioavailability of most oral compounds) does not make Nilevar less stressful to the liver. Thus, exceeding the recommended dosage and cycle maybe cause health concerns.
Genabol is a unique steroid item. Unique in a way that it can be classified as a quasi-old school and quasi-designer substance. To understand better what this means, here's a bit of historical info on Genabol.
Genabol was designed by Wyeth Laboratories in 1964 in Philadelphia, PA. This makes Genabol one of the oldest steroids and it is unfortunate that it was never manufactured after its design. For about 30 years, Genabol has figured in many clinical trials, and was reported to yield favorable feedback when tested on children. However, it was never commercially released as a prescription medication and has remained in hiatus for decades, or make that supposed hiatus.
Since it was never commercially manufactured, there was never a test designed to detect this substance. This is the reason why Genabol is considered to be the 'first modern reappearance of old designer steroid phenomenon'. Designer drugs are non-commercial steroids that 'escape' detection because they are unknown compounds at the time of testing. This has been the case with the The Clear, which is actually the anabolic steroid tetrahydrogestrinone or THG. Prior to its identification, it was classified as a designer drug.
Genabol re-emerged with its unknown metabolites during the 2000 Summer Olympics when the International Olympic Committee conducted blood and urine assays on athletes. In mid-2002, the UCLA Analytical Laboratories, headed by Dr. Don Catlin, had found out that athletes were taking this substance and were able to escape detection. Subsequently, Catlin developed a method to detect norbothelone metabolites in the urine. Tammy Thomas, who has been recently tried and convicted for perjury stemming from doping scandal, is just one of popular athletes who has been tested positive for this compound.
The reigning suspicion is that this supposedly obscure drug was being used for quite a long time, even by athletes who were involved in drug-tested competitions. Of course, since this compound has been identified and the fact that it is now being actively screened in competitive sports, the number of Genabol cultists has trimmed down.
Genabol's active ingredient is norbolethone, which is a derivateiv of nanrolone (19-nortestosterone). Thus, Genabol aromatizes at a moderate degree. Likewise, it also exhibits moderate progestational activity, Progestin activity is known to intensify certain side effects, foremost of which are fat and water retention as well as gynecomastia. These side effects are typically induced by estrogen activity.
As such, Genabol is not for lean mass gains as it can cause water and fat accumulation. This is similarly seen in Deca Durabolin, which is a popular trade name for the generic compound nandrolone.
Effective daily dosage for male bodybuilders is 10-15 mg. For women, a 2.5-5mg can give favorable results minus the virilizing side effects. Side effects include oily skin and acne (face, neck and back areas). Since Genabol is a c-17aa oral, users must observe recommended dosage and cycle period. Prolonged use and overdosing can cause damage to the liver.