Hexarelin – an underrated GHRP

Hexarelin is another hexapeptide like GHRP-6.  Unlink the other GHRP’s out there, Hexarelin is the dark horse, the black sheep, the underdog not usually mentioned and often over looked for certain qualities.  This grossly underestimated peptide shouldn’t be pushed to the side, but rather examined to understand its benefits and usability for bodybuilders and athletes alike.

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For starters Hexarelin is not your average GHRP.  The structure of the amino acid is that of a hexapeptide known to help promote the release of growth hormone (GH).  The mechanism of action is not yet fully understood by scientists.  However, what we know is that hexarelin has the ability to act both on the pituitary gland and the hypothalamus.  It is known to give the largest release of GH than any other GHRP.

pituitary gland

Fig 1. Pituitary gland

Like other peptides, hexarelin has the ability to help promote more production of natural growth hormone, and it will not shut down the production of the body’s ability to produce GH.  Hexarelin has been shown in studies to increase bone mineral density, mitosis and meiosis, fat loss, connective tissue strengthening, and improved skin elasticity.


What were the benefits of Hexarelin?

  • The strongest pulse from a GHRP.
  • Increase LBM (lean body mass).
  • Help with fat reduction.
  • Increase bone density.
  • Anti aging properties heals skin.
  • Heart protective properties shown to heal heart tissue.

What are the side effects?

  • Increased  cortisol levels.
  • Increased prolactin levels.
  • Lower libido.
  • Hard to maintain during relations due to increased prolactin.
  • Possible gynecomastia.


Interestingly, the most amazing finding with hexarelin was its ability to act on cardiac receptors separate from the GH releasing properties. The peptide can directly aid in cardio protective left ventricular pressure issues, as well as, help healing scar tissue on the heart.  Studies on lean and obese lab rats concluded that while lean rats were able to take advantage of the GH plasma increase better than the obese rats (the healthier the rat the more hexarelin effectively produced and utilized GH), obese rats did not see the same advantage.  Separate from the studies that monitored GH, both lean and obese rats both received all of the cardio protective properties of hexarelin.


Fig 2. Hexarelin Chemical Structure

How does it Work?

When Hexarelin is given as a subcutaneous injection, it activates the pituitary via a pulse, just like GHRP-6, and helps circulate growth hormone in the body.  Unlike GHRP-6, it does not induce any hunger side effects.  Hexarelin has the ability to not only raise the level of GH in the body but to also suppress somatostatin, which is the main culprit that inhibits GH from being released.  This means that there will be more GH in abundance.  In addition, hexarelin is the strongest GHRP available, so users should notice that desensitization can come much quicker than other GHRP’s.   This makes it less ideal for long term use, but with hexarelin’s ability to raise healthy levels of IGF-1 and GH it can work perfect as a PCT tool for those coming off a synthetic GH/IGF-1 cycle.   The potency of this peptide should not be underestimated and it comes with an increase in cortisol production as well as prolactin.  Nothing close to what might be seen in elevated levels from steroid use, but compared to other GHRP’s it has the strongest affinity to raise cortisol/prolactin.

Dosage and Usage

Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should be done in a cool dry place until reconstituted and placed in a refrigerator.  Bacteriostatic water is used to reconstitute the powder and an insulin syringe is the preferred method for administering subcutaneous injections of hexarelin.  Users will notice 200mcgs is the saturation dose for hexarelin and over a few weeks of use total desensitization may begin to take place.  Also, the occasional flare up of the pituitary has been noted when dosing far beyond saturation doses.  Desensitization can be cleared easily by taking a break from hexerlin usage for a few days to a few weeks.  This GHRP is the strongest, and because of the desensitization factor, I believe the optimal way to use this peptide would be to blend it at low doses with other GHRP’s like GHRP2, GHRP6 or iPamorelin.  By combining a low dose of hexearelin with another GHRP, you are going to increase your ability to put out a greater pulse of growth hormone.  Combine this with GHRH’s and you have a synergistic blend that will release GH more effectively.  In fact, for synthetic HGH users, this may be a viable way to save money on using less exogenous GH by combining it with hexarelin in a GHRP+GHRH cycle.  As a result, utilizing hexarelin in this protocol would establish the maximum GH release in the body.


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