3,3’-Diindolylmethane

Diindolylmethane is safe to use

Introduction

3,3’-Diindolylmethane is a mouthful of a word, but it is one of the prime compounds found in vegetables that give them their health benefits. Being a natural substance, it is produced when the body breaks down indole-3-carbinol which is another compound found in cruciferous green vegetables like kale and broccoli. Both of these are available in supplement form and compliment each other well taken together. In this article, we will explore 3,3’-Diindolylmethane and tell you why you should make sure to get plenty of it.

3,3’-Diindolylmethane
- Formula Structure

How it works

3,3’-Diindolylmethane works by adjusting estrogen metabolism which can suppress cancers that are fed by excess hormones, for example, breast cancer. But that isn't all, it also contains some incredible antioxidants which will work to detoxify your body against many diseases. So far the research proves it does have a strong effect at suppressing cancer growth via both these mechanisms.

Let's take a closer look at the newest studies and research and find out all the great things 3,3’-Diindolylmethane can do for you.

New breast cancer treatment could help thousands of women - as it 'slashes risk of disease returning by a quarter'https://t.co/6YAd2U57xR

— The Sun (@TheSun) September 21, 2020

Cancer

Every person reading this has had a loved one who has dealt with breast cancer, which is a horrible disease. Treatment can sometimes be surgery, other times it can be chemotherapy, and in severe cases, the entire breast must be removed. Even after suffering from this disease women must then go on anti-estrogen medications for years to make sure there is not a reoccurrence.

Body Producing Hormones

One study which was published in 'Nutrition and Cancer' showed that supplementing with 3,3’-Diindolylmethane led to positive changes in estrogen metabolism of the two dozen females followed post-cancer.

Another study showed that subjects who supplemented with 3,3’-Diindolylmethane had additional protection from several types of additional cancers of the prostate, colon, and ovarian.

The building block of all steroids, testosterone is a naturally-produced hormone in the body. It is secreted by the testes and is responsible for the balanced growth and maintenance of primary and secondary sexual characteristics in males - deepening of the voice, broadness of shoulders and narrowing of the pelvis, rapid hair growth (especially on the face, legs and pubis), and the production of semen for sexual reproduction. Read More..

Prostate

When men age their bodies will metabolize something called DHT (dihydrotestosterone) from testosterone. This male hormone is what gives men penises in the first place, and is a key sex hormone. The problem is this DHT also has negative side effects like the frying of head hair follicles and an enlarged prostate. The bad news is 10% of men reading this will have prostate cancer in their lifetime and 80% of men older than 80 years old have cancer cells already present in their prostate! So this is something very serious to think about.

(1/5) Proud to share our (updated) latest work on prostate cancer metastasis: https://t.co/7lu21l7XfR

We use #3Dculture to understand how collections of cells switch from growth to invasion. This is a key event to understand how cancer cells become metastatic. pic.twitter.com/QXaFKSC3gh

— David Bryant 🏳️‍🌈 (he/him) (@DavidBryantLab) September 22, 2020

Compounding this problem is many bodybuilders naturally have high hormones, and they also may use testosterone boosters or anabolic steroids to give them a performance edge. This further increases the chances of prostate problems.

Some of the early warnings of prostate cancer are urinary issues, but you can also have no symptoms at all. An enlarged prostate can also affect your urinary stream, cause infections, and hurt your kidney health.

Human growth hormone (also known as hgh, somatropin, nutrobal, nutropin) is a peptide hormone which stimulates growth on the cellular level. It is a protein which has endocrine functions in living animals and is synthesized in cells from amino acids. Growth hormones stimulate cell reproduction and cell regeneration in humans and animals. In the fitness world, it is used across the spectrum as a performance enhancing drug, and in the non-fitness world it's used as an anti-aging compound. Read More..

The problem here is doctor’s first instinct is to block your body from producing hormones. The side effects of doing this are lower libido, erectile dysfunction, and less muscle/strength.

A better way is to get plenty of 3,3’-Diindolylmethane daily starting as soon as possible! It has been shown in research to help calm the prostate and help it fight off prostate cancer.

Antioxidant

3,3’-Diindolylmethane works incredibly well, especially when stacked with other vitamins and minerals as being a potent antioxidant. The secret to how it works is it will defend the good cells in your body from free radicals, allowing them to sweep away diseases across the board; otherwise, these bad guys will cause oxidative stress in the body. This is why people tend to have a domino effect of cancer, diabetes, heart disease, etc. all coming on as they age.

Vitamins and minerals - potent antioxidant

Side effects

3,3’-Diindolylmethane is safe to use at proper levels. People who overdose on it may have issues with rash, vision, or other allergic reactions. Certain medications that treat estrogen could interact too much with it as well, but this is only an issue if you are on too many drugs at one time.

Dosage

It is recommended you supplement with 250-350mgs a day of 3,3’-Diindolylmethane along with a proper diet rich in vitamins and minerals. Luckily, it can be found at many online supplement stores and is not expensive to purchase a month's worth.

Indole-3-carbinol is a substance that is produced by the breakdown of glucosinolate glucobrassicin, which is found in liberal amounts in cruciferous vegetables; such as broccoli, cabbage, and collard greens. It is also produced in labs for use in supplements, and it has amazing health benefits. Ongoing research with Indole has shown it to have anti-carcinogenic, antioxidant, and anti-atherogenic effects. Indole is part of the reason why green vegetables are so healthy and why those that consume them generally have less health issues than those who do not. Read More..

Best foods

Your best bet for getting ample 3,3’-Diindolylmethane is eating foods rich in indole-3-carbinol since it is formed after that is digested. These foods include the following:

• • Broccoli
  • Cabbage
  • Cauliflower
  • Kale
  • Mustard Greens
  • Brussel sprouts

Make sure you cook these vegetables lightly in a steamer or boil for no more than a few minutes. This will ensure you cook away the chemicals that tend to upset the stomach, while also not killing off the nutrition. It is also very important that you buy organic produce, as conventional have been treated with pesticide and herbicide killing off the nutrition.

Stacking supplements for best results

Supplement Stack

We are big believers in stacking supplements for best results. In this case, it makes a lot of sense to stack 3,3’-Diindolylmethane with other compounds like vitamins, minerals, Indole-3-carbinol, and others to give you maximum health benefits. Instead of spending hundreds of dollars buying all of these things separately, our solution is finding a quality all in 1 product like Ostazol M1-MK instead. M1-MK contains 307mgs of 3,3’-Diindolylmethane per serving, along with two dozen additional ingredients to give you the absolute best results. You can learn about all these products at evolutionary.org and elitefitness.com.

M1-MK - Quality all in 1 product

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References

• Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol
• 3,3'-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy
• 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice
• Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies
• 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells
• 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5