CJC 1295 without DAC is a 30 amino acid peptide hormone, better known in the community as a GHRH (growth hormone releasing hormone). Essentially, what this means is this peptide will release a series of pulses over a long period of time which usually equates to fewer injections. Even though CJC 1295’s main function upon creation was found to boost protein synthesis, increased growth of muscle tissue and many other benefits come with it as well. CJC 1295 also helps injury recovery times, reduce body fat, boost immune system and bone density and cellular repair (skin and organs). To clear up many misconceptions, let’s get the semantics out of the way from the beginning. CJC 1295 without DAC is not CJC-1295, but is misnamed Mod GRF. When a peptide doesn’t include DAC it’s really not CJC 1295 but commonly called so. Confusing right? Here is a visual of MOD GRF (CJC 1295 no DAC):
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GHRH’s are paired specifically with GHRP’s in order to create a synergy between the peptides that will unlock the body’s own stores of growth hormone. Even though many peptides work in some capacity by themselves, it is most beneficial to run your GHRH alongside a GHRP. This is why CJC 1295 is highly desirable, and it's one of the most widely used in the bodybuilding community. Right now, it has been debated which CJC 1295 is best to use. While MOD GRF (CJC 1295 no DAC) is commonly used with GHRP’s to increase pituitary GH pulse, more frequent injections will need to be administered. The CJC 1295 with DAC will result in a series of smaller pulses; therefore, injections will be less frequent - often two to three times a week.
DAC or no DAC?
As I have just stated above, when a person sees the term CJC 1295 without DAC this is really means that they are looking at MOD GRF 1-29. This tetrasubstitued peptide is a modified version of the original GRF 1-29 peptide better known as Semorelin. Due to the extreme short half life of the original GRF 1-29, chemists were able to modify the peptide to offer a longer biological activity that reduced the metabolic clearance. Although with MOD GRF 1-29 its modification had resulted in a greater peptide bond, the average user will still likely need to inject two to three times a day with a GHRP to get the maximum effectiveness for releasing endogenous growth hormone. Now when the drug affinity complex (DAC) was added to CJC 1295, it allowed for an even greater possibility to utilize smaller GH pulses (what was once thought of as a bleed) that, when combined with a GHRP, will activate growth hormone stores to release throughout the day and night. When the DAC component was added, this allowed the peptide half-life to be extended to about one week and also provided for steadier blood levels after injection. Now that we understand how important the DAC factor is, this becomes a much more viable and cost effective way to utilize CJC 1295 with DAC along with a GHRP. The DAC, when added, is able to bind to albumin that circulates the body, literally being able to last for days as it looks for receptors to bind to. So, in short, if you prefer to use shorter spikes of GH release then the use of the MOD GRF 1-29 (CJC 1295 without DAC) is going to be optimal. However, if your prefer fewer injections and still want to unleash your growth hormone stores, then 2-3 times a week injections of CJC 1295 with DAC along with your daily injection of GHRP would be the way to proceed for maximizing growth hormone release.
Dosage and Usage
The naming might have thrown you for a loop, but don’t let that stop you from understanding the reason why you should utilize one of the best GHRH’s out there. CJC 1295 is probably the best and most widely use GHRH along with your chosen GHRP. Like all of the other peptides you are dealing with, it is a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. As already stated before, to mimic the natural release of growth hormone through the natural spikes you would achieve through the day MOD GRF 1-29 (CJC 1295 without DAC) should be injected 1-3 times per day at 100mcg-200mcg doses along with your GHRP of choice. Now, the most cost effective and in my opinion better way to utilize CJC 1295 is to go with the CJC 1295 with DAC. This will allow the bodybuilder or athlete to inject 2mg of CJC 1295 with DAC twice weekly along with their daily injection of GHRP. This will offer smaller but more frequent growth hormone pulses that would ideally get a user closer to exogenous HGH doses.
Water retention, tingling, numbness and decreased insulin can be associated with use of CJC 1295. Also noted is tiredness, feeling of lethargy, head rush or euphoria, itching. Positive side effects can be increased lean body mass, increased protein synthesis, faster recover, reduced body fat, promotion of bone density, and cellular stimulation for internal organs and skin cells.
In conclusion, CJC 1295 with DAC is a powerful growth hormone releasing hormone that can be effectively used with a GHRP in order to maximize the greatest endogenous growth hormone release bodybuilders and athletes are looking for. Even though CJC 1295 with DAC may be a bit more expensive than MOD GRF 1-29 (CJC 1295 without DAC), it is still the preferred and more powerful GHRH component in your peptide protocol.
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog
- Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects
- A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS
- Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation
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Hello. Thanks for this great piece on info.
I’m undecided between DAC or without DAC. I see you recommend DAC, but what’s your opinion about keeping constant high GH levels with it as opposed to some pulses through the day? I’ve read that it goes against our body nature and it can be dangerous in the long term (acromegaly as side effect for example)? What is your opinion about it? That’s the only thing why i’m hesitating on using DAC.
Really hope you can read this because i’m really interested in your opinion.
If you use cjc1295, you need to experiment with DAC and without DAC, because everyone responds differently. However, this article is about 2 years old.
What is not mentioned is that since the time of this article, the peptide industry has been taken over by chinese gangsters. The peptides are 99% fake and many times contain harmful heavy metals you will be injecting. I highly suggest using nutrobal mk677 instead of any of the hgh releasing peptides, read this: