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Thread: Albuterol shows fat loss muscle gain when combined with caffeine

  1. #1
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    Albuterol shows fat loss muscle gain when combined with caffeine

    Background: Albuterol is a beta-2 agonist that has been demonstrated to increase muscle strength in studies in animals and humans. Based on a pilot study of extended-release albuterol Repetabs in children with dystrophinopathies, the authors conducted a randomized, double-blind, placebo-controlled study with a crossover design.

    Methods: Fourteen boys with Duchenne or Becker muscular dystrophy, 6 to 11 years old, completed two treatment periods (albuterol and placebo), 12 weeks each, separated by a 12-week washout period. As the albuterol Repetab formulation was no longer available, an alternate extended release albuterol was used (Volmax, 12 mg per day). Outcome measurements included 1) lean body mass, 2) fat mass, 3) isometric knee extensor and flexor moments, 4) manual muscle testing, and 5) timed functional tests.

    Results: Lean body mass was significantly higher for subjects following albuterol treatment compared to placebo treatment, while fat mass was significantly lower. No differences were found in isometric knee moments or manual muscle tests. Time to run/walk 30 feet was improved following albuterol.

    Conclusions: Short-term treatment with extended release albuterol may increase lean body mass, decrease fat mass, and improve functional measures in patients with dystrophinopathies. However, the significant change in strength of specific muscle groups found in the pilot study was not observed in the present study. These findings may be attributed to differences in the drug release and kinetics between Repetab and Volmax formulations as they affect the concentration of available beta-2 receptors on the muscle cell surface differently.

    Our data indicate that the combination of caffeine and albuterol can increase lean mass and decrease fat mass during growth and weight gain.

    Previous studies done at Pennington Biomedical have demonstrated that the equivalent of oral albuterol 4mg three times a day (tid) with oral caffeine 100mg tid reduces body fat and increases lean tissue in rodents more than the addition of the effect of the two components separately. The combination of albuterol with caffeine changed body composition without changing food intake. An adult male taking albuterol 4 mg orally tid plus caffeine 100mg orally tid increased lean mass by 1.25% and decreased fat mass by 1.2% over a two month period. These effects are expected to be even greater in a growing adolescent. This pilot project will take the first step towards trying to understanding the safety and potential efficacy of this drug combination. The prospect of using inexpensive medications already approved in the pediatric population for the treatment of asthma as a novel treatment for adolescent obesity addresses a medical need that is presently unmet.
    Food restriction in adolescence is not only difficult to accomplish, but it also raises concerns about growth and development. A medication approved for the treatment of obesity in the adolescent age group that improves body composition by reducing body fat and increasing lean tissue without needing to restrict food intake would be a useful tool for physicians who address the treatment of obesity in adolescents. Albuterol is a medication, approved for ages 6 and older, used for the treatment of asthma and has also been shown to increase muscle strength and lean body mass in children with spinal muscular atrophy and in healthy young men during an exercise training program. A drug approved for the treatment of adolescent obesity that increases lean tissue, decreases fat tissue and can be given in conjunction with lifestyle modifications would be welcomed by both pediatricians who treat these adolescents and by adolescents who are stigmatized by their obesity.
    A provisional patent has been submitted by Pennington Biomedical Research Center to protect the combination of caffeine and albuterol in a 1:25 ratio for synergistically increasing muscle mass and decreasing fat mass as a potential treatment for obesity in adolescents.
    This study will be a double-blinded, randomized, placebo-controlled, pilot study in which subjects will be randomized to receive either placebo or a combination of Albuterol 4 mg and Caffeine 100mg three times per day orally for a total of 8 weeks. Each subject will continue on the study intervention for the entire duration of treatment

  2. #2
    NPC Champion Npcclassicphysique champ's Avatar
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    Albuterol or Clenbuterol if you stack with caffeine = fat loss same with ECA.

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    EVO V.I.P. MONSTRO's Avatar
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    Salbutemos vs clenbuterol? anyone here that used both ? can albuterol burn fat as clenbuterol ?

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    Moderator stevesmi's Avatar
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    again the problem is the sides of albuterol and considering people in fitness use it at a much higher dosage then the study to get the results. when you run it that dosages we run it at then you start getting into trouble with heart health, endurance, and heartburn issues. i have ran it before and it was awful. no rason to use it when we have access to cardarine
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    Right now I use 4mg and 200mg caffeine purely for the strength benefit it works I do this 5 days per week pre workout will update with my results 8mg was little strong and again Iím only looking purely for a strength boost if it provides muscle great too lol.

    Albuterol has less effect on heart damage pretty much none at all unlike clenbuterol in all studies which is good it also improves cholesterol levels

    For fat loss clenbuterol is best however.

  6. #6
    Moderator stevesmi's Avatar
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    Quote Originally Posted by DarrenW29 View Post
    Right now I use 4mg and 200mg caffeine purely for the strength benefit it works I do this 5 days per week pre workout will update with my results 8mg was little strong and again Iím only looking purely for a strength boost if it provides muscle great too lol.

    Albuterol has less effect on heart damage pretty much none at all unlike clenbuterol in all studies which is good it also improves cholesterol levels

    For fat loss clenbuterol is best however.
    when i ran albuterol and hiked the dosage up to bodybuilder type dosages I had the same exact side effects as clen and so have others. those studies you are referencing are NOT bodybuilder dosages. they are therapeutic dosages. and the problem with clen and albuterol is if you use them at those dosages you won't get the benefits, you have to jack up the doses.
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  7. #7
    Staff Writer LevButlerov's Avatar
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    Quote Originally Posted by MONSTRO View Post
    Salbutemos vs clenbuterol? anyone here that used both ? can albuterol burn fat as clenbuterol ?
    I've used clenbuterol and albuterol stacked didn't see much of a difference vs using them solo.

    ECA stack with clenbuterol gave me a good lean look.
    Lev Butlerov - Evolutionary.org Staff Author
    Lev Butlerov holds a Masters Degree in Biology, he is NASM Certified, ISSA Certified, The National Council on Strength & Fitness (NCSF) certified and is currently working on his American Council on Exercise (ACE) certificate.

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    EVO V.I.P. BodyMonster34's Avatar
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    bro i don't like clen or albuterol, make me sick . GW better

  9. #9
    Moderator Mobster's Avatar
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    I know a lot of people who hate the way they feel on clen

  10. #10
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    Quote Originally Posted by stevesmi View Post
    when i ran albuterol and hiked the dosage up to bodybuilder type dosages I had the same exact side effects as clen and so have others. those studies you are referencing are NOT bodybuilder dosages. they are therapeutic dosages. and the problem with clen and albuterol is if you use them at those dosages you won't get the benefits, you have to jack up the doses.
    What dosages did you use mate did you get the strength gains

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