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Thread: creatine enhances steroids? Creatine is a myostatin blocker? Interesting....

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    EVO V.I.P. ~Vision~'s Avatar
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    creatine enhances steroids? Creatine is a myostatin blocker? Interesting....



    Study 1
    HMB Proved More Effective than Leucine in Inhibiting Protein Degradation


    Protein plays a significant role in building muscles. However, protein degradation may occur in skeletal muscle and lead to muscle atrophy and death, which highlights the urgent need to develop more effective therapies to inhibit protein degradation and combat muscle atrophy.
    β-hydroxy-β-methyl- butyrate (HMB) is a key metabolite of leucine. Previous studies have shown that both HMB and leucine can inhibit muscular protein degradation.
    However, questions about which one is more effective, whether insulin contributes to the antiatrophic effects of HMB and leucine, and what the underlying mechanism is still remain unknown.
    Recently, using a starvation model, researchers from China Agricultural University and the Institute of Subtropical Agriculture (ISA) of the Chinese Academy of Sciences compared the effects of leucine (within a range that is physiologically relevant) and HMB on protein degradation in order to examine the underlying mechanisms and assess the contribution of insulin in protein analytic response to HMB and leucine.
    The researchers found that the inhibitory effect of HMB was more potent than that of Leu and KIC, and was significantly abolished in the presence of LY294002 and rapamycin.
    In the presence of insulin, the inhibitory effect of HMB was still more effective than that of Leu and KIC. Interestingly, LY294002 treatment markedly attenuated the effect of HMB, while rapamycin treatment failed to exert the same effect.
    Overall, HMB appears to be more potent than leucine in inhibiting protein degradation in the absence or presence of insulin, and this inhibitory effect may depend on PI3K/Akt signaling pathway regardless of insulin.
    mTOR signaling was only involved in the effect of HMB in the absence of insulin.
    The study entitled "β-Hydroxy-β-methyl Butyrate is more potent than leucine in inhibiting starvation-induced protein degradation in C2C12 myotubes" was published in The chemical sports world waits with baited breath for the arrival of myostatin blockers: new muscle strengthening substances that sabotage the protein myostatin in muscle tissue, and thereby boost muscle build up. According to a human study in Molecular and Cellular Endocrinology, a supplement that works in exactly this way has been available for years. If we're to believe this study, good old creatine is a myostatin blocker.

    The authors of the study are sports scientists at Arak University in Iran. They wanted to know exactly how creatine [chemical structure is shown here] works. Some scientists regard creatine as little more than a battery that provides muscle cells with energy and fluid. That's why you gain a couple of kilos of muscle tissue if you take a course of creatine, these scientists claim. Your strength increases in the gym as well, but the effect is temporary. If you stop taking the creatine then the positive effects disappear. But there's a small group of researchers who say that creatine does much more. They say creatine also stimulates the manufacture of muscle tissues.
    The researchers did a trial with 27 male students. Of these, 8 did nothing Ė the control group.


    The other 19 students trained for 8 weeks using weights. The students went to the gym three times a week, where they did 6 basic exercises that covered all the major muscle groups: bench-press, lat-pulldown, biceps curl, leg press, knee extension and leg curl. The students trained at 60-70 percent of their 1RM, and did three sets of each exercise. The students rested for no longer than 2 minutes between sets.Half of the students who trained took creatine. In the first week they took a daily 0.3 g creatine per kilo bodyweight, and in the remaining weeks they took a daily 0.05 g creatine per kilogram bodyweight. It doesn't take a genius to work out that the test subjects who trained became more muscular and stronger, and that the creatine supplement enhanced the effect.
    The researchers measured the concentration of myostatin in the subjects' blood. Weight training reduced the concentration. And training while using creatine reduced the concentration even further.





    The researchers measured the concentration of the protein growth and differentiation factor-associated serum protein-1 [GASP-1]. This protein neutralises myostatin. There's a patent in which researchers describe how synthetic versions of can cause muscle growth by manipulating GASP-1.
    [United States Patent 7,192,717] Whatever, the production of GASP-1 increased as a result of strength training and it increased even more in the subjects who combined strength training and creatine supplementation.





    The researchers conclude that creatine doesn't just pump up the muscles temporarily. So creatine is a real anabolic, responsible for increased muscle protein production. "Decreasing myostatin and inhibiting its function by GASP-1 may play an important role in increasing muscle strength and mass by resistance training", they write. "Supplementation with creatine resulted in greater increases in muscle mass and strength, and these improvements were accompanied by more decreased myostatin levels."
    Source:
    Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30.

  2. #2
    EVO V.I.P. Eddie Haskell's Avatar
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    HMB and creatine do work not sure how strong in reality but they work. I use both daily.

  3. #3
    Staff Writer LevButlerov's Avatar
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    Creatine enhances everything, kind of a workhorse supplement in our industry.
    Lev Butlerov - Evolutionary.org Staff Author
    Lev Butlerov holds a Masters Degree in Biology, he is NASM Certified, ISSA Certified, The National Council on Strength & Fitness (NCSF) certified and is currently working on his American Council on Exercise (ACE) certificate.

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    Moderator Mobster's Avatar
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    I know some come off it when 'on' but I stay on it
    Last edited by Mobster; 06-04-2021 at 04:50 PM.

  5. #5
    Growing Brother HolderWA's Avatar
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    Creatine is the best out there, I used it daily for the last 10 years.

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    Official Representative (VIP) Vadim Fedorov's Avatar
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    I like Creatine as it enhances everything we take and do

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    Official Representative (VIP) ballin2504's Avatar
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    Iíve always supplemented with creatine definitely has great benefits.

  8. #8
    Moderator India #1 Tiger Salman Khan's Avatar
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    creatine ..increase lean muscle mass ..gain muscle, increase strength
    its the best

  9. #9
    Big Moderator RoySimpson's Avatar
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    Creatine is a great addition!

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    EVO V.I.P. ~Vision~'s Avatar
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    Like many said here, it's truly amazing stuff..

    Don't by into the over priced name brands either, most are all the same.. Cheap and effective.

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