I need to be just come out say this in the opener sentence, I'm very much against antidepressants and large pharma. Yet they have a place and purpose!
Ok, before I lose you here, please bear with me; Yet at the same time this statement makes me a hypocrite because I have Incorporated them in my life when need be (when needed).. Personally I'm an advocate with exhausting all resources possible before using antidepressants, antidepressants are pushed down people's throats too frivolously, nevertheless at the same time some people do in fact need them, that is the reality, mental health issues are very real and sometimes needs medication..
Cycling and depression: What's the best options to assist with such symptoms?
I personally feel using natural supplements before considering any meds. 5-HTP comes to mind, DHEA, Injection Vitamin B, Gaba and even L-tryptophan. L-trytophent is an amino acid, a protein building block that can be found in many plant and animal proteins. L-tryptophan is called an “essential” amino acid because the body can’t make it. It must be acquired from food.
5-HTP, GABA and L-tryptophan could be used for treating insomnia, sleep apnea, depression, anxiety, facial pain, a severe form of premenstrual syndrome called premenstrual dysphoric disorder (PMDD), smoking cessation, grinding teeth during sleep (bruxism), attention deficit-hyperactivity disorder (ADHD), Tourette's syndrome, and to improve athletic performance. The list goes on.
FYI, I have tourette's/Ticks and this truly has provided comfort and a sense of calm, removing the dreaded anxious feeling that comes along with having ticks.
How does it work?
L-tryptophan is naturally found in animal and plant proteins. L-tryptophan is considered an essential amino acid because our bodies can't make it. It is important for the development and functioning of many organs in the body. After absorbing L-tryptophan from food, our bodies convert it to 5-HTP (5-hyrdoxytryptophan), and then to serotonin. Serotonin is a hormone that transmits signals between nerve cells. It also causes blood vessels to narrow. Changes in the level of serotonin in the brain can alter mood.
I'm not a licensed medical practitioner therefore I can't give any medical advise, although I will give some suggestions based on personal experience.
Ok, now that we've talked about a "few" natural alternatives, let's take a deeper look into meds and how they can be very detrimental with AAS use.
Let's leap frog here real fast, scroll down and read the study in the read title labeled as "SSRI's and Gear" , scan that over and return back here
and we shall continue.
*
*
*
*
*
Welcome back
For myself I have always resorted to Wellbutrin and/or Busparin (Buspar). Just an FYI, buspar can act muck like cabergoline when assisting with delayed ejaculations or inability to have an orgasm. Click here to learn more about buspar and sexual dysfunctions from AAS or medications (https://pubmed.ncbi.nlm.nih.gov/1035003 ... 0in%20men.
Let's get right into it with AAS and how some compounds can in fact be used as antidepressants like drugs during a cycle/blast. And - How some compounds can in
fact be the culprit for depression, tiredness, lethargy and loss of sense of well being.
AAS (androgens) especially Halo because it's extremely aggressive can result in a decrease peak of plasma corticosterone concentrations by way of potentially disabling HSD-11B or 11B-HSD which are hosts of enzymes that catalyze the conversion of cortisone to active cortisol.. Almost inducing a state of adrenal fatigue by other methods of action, basically inducing adrenal fatigue like symptoms..You can experience this while on most AAS "especially" Trenbolone, drol and some pro-hormones (MT1/SD), there can be a slew of rather aggressive sides not only from it's toxicity to the liver but through this other indirect course of action yielding a slew of undesired sides in "some" users....
I suggest adding some DHEA with some sublingual vitamin b12 complex and take it from there.. Try and cut back on caffeine, actually I would suggest extracting it from your daily life for a bit if someone is experiencing adrenal like symptoms.
An other suggestions, you may want to add some low to a moderate dose of GHRP-6 and/or Hexarelin, these peptide both act in a similar mechanisms and have been known to increase the release of ACTH which can improve the serum plasma levels with cortisol, restoring it to a health functional state, hindering any "halotestin or AAS" related sides that may be present by way of adrenal fatigue like symptoms..
AAS, love-hate relationship with many trade-offs!
Anavar, Masteron, Proviron, Testosterone..
The paradox with 3 of the 4 hormones mentioned (test,mast and proviron) they are essentially the most favored when it concerns that "feel good effect" that we look for when running compounds.Let's look at your supra-physiological dosages of Testosterone (which has 3 mechanisms of action,1-testosterone, 2-conversion to estro, 3-conversion to DHT) and your other compounds like mast/proviron..Basically, your reaction with these compounds/hormones by way of exogenous sources along with their aggressiveness as a potent hormone (DHT) and interplay's with E2 (by was of test conversion) all these can significantly decrease the corticosterone and ACTH response through its pathways, by initiating a response via the hypothalamus..
(Anavar is known to be outstanding for blocking cortisol levels from having excessive dumps).
I'll include a study that explains more on how Dihydrotestosterone and it's derivative can potentially display some cross-reactivity that will disrupted corticolsteroids which may possess blocking properties of cortisol..In a nut shell, DHT's could possibly act somewhat as a cortisol "blocker" in sensitive users..End result, adrenal fatigue like symptoms!
Just my take, I'm no specialist..I'm just looking at things from a different approach, it may not be the most popular belief.
(study)
J Neurosci. 2006 Feb 1;26(5):1448-56.
The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.
Lund TD1, Hinds LR, Handa RJ.
Author information
Abstract
Estrogen receptor beta (ERbeta) and androgen receptor (AR) are found in high levels within populations of neurons in the hypothalamus. To determine whether AR or ERbeta plays a role in regulating hypothalamo-pituitary-adrenal (HPA) axis function by direct action on these neurons, we examined the effects of central implants of 17beta-estradiol (E2), 5alpha-dihydrotestosterone (DHT), the DHT metabolite 5alpha-androstan-3beta, 17beta-diol (3beta-diol), and several ER subtype-selective agonists on the corticosterone and adrenocorticotropin (ACTH) response to immobilization stress. In addition, activation of neurons in the paraventricular nucleus (PVN) was monitored by examining c-fos mRNA expression. Pellets containing these compounds were stereotaxically implanted near the PVN of gonadectomized male rats. Seven days later, animals were killed directly from their home cage (nonstressed) or were restrained for 30 min (stressed) before they were killed. Compared with controls, E2 and the ERalpha-selective agonists moxestrol and propyl-pyrazole-triol significantly increased the stress induced release of corticosterone and ACTH. In contrast, central administration of DHT, 3beta-diol, and the ERbeta-selective compound diarylpropionitrile significantly decreased the corticosterone and ACTH response to immobilization. Cotreatment with the ER antagonist tamoxifen completely blocked the effects of 3beta-diol and partially blocked the effect of DHT, whereas the AR antagonist flutamide had no effect. Moreover, DHT, 3beta-diol, and diarylpropionitrile treatment significantly decreased restraint-induced c-fos mRNA expression in the PVN. Together, these studies indicate that the inhibitory effects of DHT on HPA axis activity may be in part mediated via its conversion to 3beta-diol and subsequent binding to ERbeta.
"SSRI's and Gear"
Introduction
Today’s world can be painstakingly stressful,People are in a rush to compete or get somewhere,
with a self appointed deadline.. With this being said ,many people are turning to medication,
as large phrama tends to peddle medication and dispense it down our throats (It seems that everyone now suffers from some sort of mental aliment)..
There was a study performed in 2005 as it showed that 27 million Americans were taking antidepressants (This is just America alone), almost double by 2010, and steadily increased up until 2015 this represents roughly 25% of the population at this time, and this number has certainly expected to rise as studies show antidepressant usage has been on a continual increase. Unfortunately enough its been proven that usage continues to rise significantly among young/adult men.
Let’s begin the discussion and what this article pertains to,and about is users taking antidepressants and how they affect anabolic steroid, post cycle therapy, testosterone levels and in general building muscle.
This discussion has taken place on are numerous internet panels, thousands of questions/concerns regarding antidepressant usage and anabolic steroid cycles..
To keep on point and avoid going off topic on the details about how these antidepressants effect depression and anxiety,we will merely only discuss how they affect bodybuilding and steroid usage.
Ok, before I lose you here, please bear with me; Yet at the same time this statement makes me a hypocrite because I have Incorporated them in my life when need be (when needed).. Personally I'm an advocate with exhausting all resources possible before using antidepressants, antidepressants are pushed down people's throats too frivolously, nevertheless at the same time some people do in fact need them, that is the reality, mental health issues are very real and sometimes needs medication..
Cycling and depression: What's the best options to assist with such symptoms?
I personally feel using natural supplements before considering any meds. 5-HTP comes to mind, DHEA, Injection Vitamin B, Gaba and even L-tryptophan. L-trytophent is an amino acid, a protein building block that can be found in many plant and animal proteins. L-tryptophan is called an “essential” amino acid because the body can’t make it. It must be acquired from food.
5-HTP, GABA and L-tryptophan could be used for treating insomnia, sleep apnea, depression, anxiety, facial pain, a severe form of premenstrual syndrome called premenstrual dysphoric disorder (PMDD), smoking cessation, grinding teeth during sleep (bruxism), attention deficit-hyperactivity disorder (ADHD), Tourette's syndrome, and to improve athletic performance. The list goes on.
FYI, I have tourette's/Ticks and this truly has provided comfort and a sense of calm, removing the dreaded anxious feeling that comes along with having ticks.
How does it work?
L-tryptophan is naturally found in animal and plant proteins. L-tryptophan is considered an essential amino acid because our bodies can't make it. It is important for the development and functioning of many organs in the body. After absorbing L-tryptophan from food, our bodies convert it to 5-HTP (5-hyrdoxytryptophan), and then to serotonin. Serotonin is a hormone that transmits signals between nerve cells. It also causes blood vessels to narrow. Changes in the level of serotonin in the brain can alter mood.
I'm not a licensed medical practitioner therefore I can't give any medical advise, although I will give some suggestions based on personal experience.
Ok, now that we've talked about a "few" natural alternatives, let's take a deeper look into meds and how they can be very detrimental with AAS use.
Let's leap frog here real fast, scroll down and read the study in the read title labeled as "SSRI's and Gear" , scan that over and return back here
*
*
*
*
*
Welcome back
For myself I have always resorted to Wellbutrin and/or Busparin (Buspar). Just an FYI, buspar can act muck like cabergoline when assisting with delayed ejaculations or inability to have an orgasm. Click here to learn more about buspar and sexual dysfunctions from AAS or medications (https://pubmed.ncbi.nlm.nih.gov/1035003 ... 0in%20men.
Let's get right into it with AAS and how some compounds can in fact be used as antidepressants like drugs during a cycle/blast. And - How some compounds can in
fact be the culprit for depression, tiredness, lethargy and loss of sense of well being.
AAS (androgens) especially Halo because it's extremely aggressive can result in a decrease peak of plasma corticosterone concentrations by way of potentially disabling HSD-11B or 11B-HSD which are hosts of enzymes that catalyze the conversion of cortisone to active cortisol.. Almost inducing a state of adrenal fatigue by other methods of action, basically inducing adrenal fatigue like symptoms..You can experience this while on most AAS "especially" Trenbolone, drol and some pro-hormones (MT1/SD), there can be a slew of rather aggressive sides not only from it's toxicity to the liver but through this other indirect course of action yielding a slew of undesired sides in "some" users....
I suggest adding some DHEA with some sublingual vitamin b12 complex and take it from there.. Try and cut back on caffeine, actually I would suggest extracting it from your daily life for a bit if someone is experiencing adrenal like symptoms.
An other suggestions, you may want to add some low to a moderate dose of GHRP-6 and/or Hexarelin, these peptide both act in a similar mechanisms and have been known to increase the release of ACTH which can improve the serum plasma levels with cortisol, restoring it to a health functional state, hindering any "halotestin or AAS" related sides that may be present by way of adrenal fatigue like symptoms..
AAS, love-hate relationship with many trade-offs!
Anavar, Masteron, Proviron, Testosterone..
The paradox with 3 of the 4 hormones mentioned (test,mast and proviron) they are essentially the most favored when it concerns that "feel good effect" that we look for when running compounds.Let's look at your supra-physiological dosages of Testosterone (which has 3 mechanisms of action,1-testosterone, 2-conversion to estro, 3-conversion to DHT) and your other compounds like mast/proviron..Basically, your reaction with these compounds/hormones by way of exogenous sources along with their aggressiveness as a potent hormone (DHT) and interplay's with E2 (by was of test conversion) all these can significantly decrease the corticosterone and ACTH response through its pathways, by initiating a response via the hypothalamus..
(Anavar is known to be outstanding for blocking cortisol levels from having excessive dumps).
I'll include a study that explains more on how Dihydrotestosterone and it's derivative can potentially display some cross-reactivity that will disrupted corticolsteroids which may possess blocking properties of cortisol..In a nut shell, DHT's could possibly act somewhat as a cortisol "blocker" in sensitive users..End result, adrenal fatigue like symptoms!
Just my take, I'm no specialist..I'm just looking at things from a different approach, it may not be the most popular belief.
(study)
J Neurosci. 2006 Feb 1;26(5):1448-56.
The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus.
Lund TD1, Hinds LR, Handa RJ.
Author information
Abstract
Estrogen receptor beta (ERbeta) and androgen receptor (AR) are found in high levels within populations of neurons in the hypothalamus. To determine whether AR or ERbeta plays a role in regulating hypothalamo-pituitary-adrenal (HPA) axis function by direct action on these neurons, we examined the effects of central implants of 17beta-estradiol (E2), 5alpha-dihydrotestosterone (DHT), the DHT metabolite 5alpha-androstan-3beta, 17beta-diol (3beta-diol), and several ER subtype-selective agonists on the corticosterone and adrenocorticotropin (ACTH) response to immobilization stress. In addition, activation of neurons in the paraventricular nucleus (PVN) was monitored by examining c-fos mRNA expression. Pellets containing these compounds were stereotaxically implanted near the PVN of gonadectomized male rats. Seven days later, animals were killed directly from their home cage (nonstressed) or were restrained for 30 min (stressed) before they were killed. Compared with controls, E2 and the ERalpha-selective agonists moxestrol and propyl-pyrazole-triol significantly increased the stress induced release of corticosterone and ACTH. In contrast, central administration of DHT, 3beta-diol, and the ERbeta-selective compound diarylpropionitrile significantly decreased the corticosterone and ACTH response to immobilization. Cotreatment with the ER antagonist tamoxifen completely blocked the effects of 3beta-diol and partially blocked the effect of DHT, whereas the AR antagonist flutamide had no effect. Moreover, DHT, 3beta-diol, and diarylpropionitrile treatment significantly decreased restraint-induced c-fos mRNA expression in the PVN. Together, these studies indicate that the inhibitory effects of DHT on HPA axis activity may be in part mediated via its conversion to 3beta-diol and subsequent binding to ERbeta.
"SSRI's and Gear"
Introduction
Today’s world can be painstakingly stressful,People are in a rush to compete or get somewhere,
with a self appointed deadline.. With this being said ,many people are turning to medication,
as large phrama tends to peddle medication and dispense it down our throats (It seems that everyone now suffers from some sort of mental aliment)..
There was a study performed in 2005 as it showed that 27 million Americans were taking antidepressants (This is just America alone), almost double by 2010, and steadily increased up until 2015 this represents roughly 25% of the population at this time, and this number has certainly expected to rise as studies show antidepressant usage has been on a continual increase. Unfortunately enough its been proven that usage continues to rise significantly among young/adult men.
Let’s begin the discussion and what this article pertains to,and about is users taking antidepressants and how they affect anabolic steroid, post cycle therapy, testosterone levels and in general building muscle.
This discussion has taken place on are numerous internet panels, thousands of questions/concerns regarding antidepressant usage and anabolic steroid cycles..
To keep on point and avoid going off topic on the details about how these antidepressants effect depression and anxiety,we will merely only discuss how they affect bodybuilding and steroid usage.