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Thread: Inhibitor of HPTA negative feedback loop and applications...

  1. #1
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    Lightbulb Inhibitor of HPTA negative feedback loop and applications...

    Hi everyone, new to the forum as a poster but been using this site among a few others as reference for many years now. \

    I wanted to see if anyone has had experience or any knowledge about blocking the inhibition (negative feedback loop) that exogenous administration of AAS has on our Hypothalamus Pituitary Gonadal/Test axis. Here is an extremely promising study, from 1985 () about opioid antagonists playing a role in HPTA negative feedback loop inhibition.

    https://www.ncbi.nlm.nih.gov/pubmed/374068

    I have only encountered one or two sparse threads on this subject in all my time and am curious to see if anyone out there has further insight into this subject, as it would quite honestly be the most optimal cycle if we could block suppression (shut down of natural test) for the duration of the cycle. PCT would be drastically revolutionized...

    As a molecular biologist and human performance enthusiast I'm always looking to learn more about how we can improve our cycling of AAS and alleviate the stress these compounds cause, hoping there are more of us out there on evolutionary...

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    Sorry this is the correct link to the study I am referencing : https://www.ncbi.nlm.nih.gov/pubmed/3842024

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    Moderator stevesmi's Avatar
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    there is no such thing. when you put exogenous hormones in your body it signals your pituitary glands to stop producing LH and FSH

    it is our bodies way of regulating itself..

    now you can bypass the pituitary glands and mimic LH by using hcg. but that will only stimulate leydig cells which will plump up your balls
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    Moderator Mobster's Avatar
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    Study references work well if there are several. One doesn't. If anyone had found a way round it we'd be on gear year round and have no side issues.

    Multiple record holder. British and European Grip Champion. Magazine writer. Strength Training Coach. Former supplement company owner.

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    Moderator Mobster's Avatar
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    It's a unicorn idea.

    Multiple record holder. British and European Grip Champion. Magazine writer. Strength Training Coach. Former supplement company owner.

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    V.I.P. muskate's Avatar
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    Quote Originally Posted by stevesmi View Post
    there is no such thing. when you put exogenous hormones in your body it signals your pituitary glands to stop producing LH and FSH

    it is our bodies way of regulating itself..

    now you can bypass the pituitary glands and mimic LH by using hcg. but that will only stimulate leydig cells which will plump up your balls
    Exactly.

    When you put artificial anabolic hormones in your body your body basically goes
    "Wow, we got all these anabolic hormones floating around, we no longer need to produce our own"

    Nothing will change that

  7. #7
    Growing Moderator Masonic Bodybuilder's Avatar
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    I agree. It is not possible. Using exogenous hormones means suppression.

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    Moderator dylangemelli's Avatar
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    sorry to tell you brother but thats just not possible... its a great thought and we all wish it was true but its just not

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