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Thread: Myostatin: Why You Can't Keep Growing

  1. #1
    Advanced Cyborg Brother jbranken's Avatar
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    Myostatin: Why You Can't Keep Growing

    There was a knowledgable bro on EF (LedHed) a while back who expounded on the subject of myostatin and it rocked my world. Say hello to a bodybuilder's worst nightmare. I hadn't even heard about it until he wrote about it. I've put together a compilation of random facts/studies/definitions on myostatin and exactly what it is for those who haven't heard much about it. It's important to know what it is and what function it serves in your bodybuilding lives. You can plan cycles around it this way.

    Myostatin: A growth factor that regulates the size of muscles beginning in early embryonic development and continuing throughout life. Myostatin acts by inhibiting the growth of muscles, It prevents them from growing too large. Myostatin is also known as growth and differentiation factor 8 (GDF-8). It is a protein made up of two identical subunits. Each subunit contains 110 amino acids. The gene encoding myostatin is termed MSTN (or GDF8) and is on chromosome 2 in band 2q32.1.

    Myostatin is a protein that in humans is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family that inhibits muscle differentiation and growth in the process known as myogenesis. Myostatin is produced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue, by binding a cell-bound receptor called the activin type II receptor.

    What is myostatin-related muscle hypertrophy?
    Myostatin-related muscle hypertrophy is a rare condition characterized by reduced body fat and increased muscle size. Affected individuals have up to twice the usual amount of muscle mass in their bodies. They also tend to have increased muscle strength. Myostatin-related muscle hypertrophy is not known to cause any medical problems, and affected individuals are intellectually normal.

    http://en.m.wikipedia.org/wiki/Myostatin

    http://www.medicinenet.com/script/ma...y=33546&page=1

    http://ghr.nlm.nih.gov/condition/myo...le-hypertrophy



    So there it is folks. There are studies suggesting that after about 56 days or around the 8 week mark of a cycle, your myostatin levels are so ridiculously high that is it nearly impossible to make LBM gains after the fact unless you introduce a more anabolic compound at this point. There is also evidence that after cycling for 20 weeks, myostatin levels eventually return to baseline and won't elevate gain. At this point, LedHed proposed a great way to take advantage of this. This would be for advanced users only.

    Let's say your cycle is:
    Test E 1-20
    Dbol 1-4
    NPP 1-8
    EQ 1-20

    Myostatin will inhibit gains by week 8, correct? Now we introduce tren ace at week 7 for about 6 weeks. Myostatin will still be high but we can get some more LBM this way since tren is such a powerful androgen. Cycle continues..

    Test E 7-13
    Tren ace 7-13
    EQ 7-13

    At this point, there's nothing we can do for additional LBM except wait for myostatin to return to baseline. Now, we drop test and eq to a cruising dose (test 200mg, eq 200-250mg)

    Test E 14-20
    EQ 14-20

    At week 20, myostatin has retuned to baseline. In theory, we can now blast again without myostatin becoming a hindering factor.

    Test E 20-?
    Tren E 20-?
    EQ 20-?
    Mast E 20-?
    Primo 20-?

    I don't buy into this completely because of the fact that if myostatin wasn't a hindering factor after week 20, we would be able to continually build muscle without anything to hold us back. There are studies supporting it though. Either way, as bodybuilders, myostatin is our worst enemy and it is very real. There are even companies selling myostatin inhibitors but to what extent they work, I haven't a clue.
    Last edited by jbranken; 02-14-2014 at 08:43 PM.
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  2. #2
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    Nice inf my good brother very interesting for brothers that always ask why I stop grown or gain more size

  3. #3
    Homo Sapien Bodybuilder
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    Great info! I remember when I brought this up on my spanish forum in Mexico, and was pretty much ridiculed! Bunch of guys pushing product and have no interest in knowledge.

  4. #4
    Advanced Cyborg Brother jbranken's Avatar
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    Quote Originally Posted by paja View Post
    Nice inf my good brother very interesting for brothers that always ask why I stop grown or gain more size
    Yep, we can delay the inevitable as long as we want but maybe shorter cycles are just the best way to go.

    I like running 12 week cycles anyway. Even if my gains stop at week 8-10, I like to keep anabolic activity high in my body to allow the muscle more time to mature
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  5. #5
    Growing Brother Image0r's Avatar
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    great info bro!

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    Senior Moderator
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    I was looking into this Topic back in 2006 to 2007.

    Wyeth Pharmaceuticals had just Published a Clinical Phase I Human study, and had started Phase II.

    The product was called Myo-029.

    It was not put into production because the testing was for Muscular Dystrophy, and no Study Results were ever posted.

    Supposedly, one of Doctors from this very study is the one who developed

    Myo-X myostatin inhibitor for Maximum Human Performance, AKA - mhp............................................... .JP

    P.S.
    I have noticed some Research Companies selling Supposed Myo-029. I doubt if it's Real

    Myostatin Inhibition is the "Holy Grail" of Muscle building, one day hopefully.

  7. #7
    Advanced Cyborg Brother jbranken's Avatar
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    It would be a game changer for sure if there were a legit myostatin inhibitor...
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  8. #8
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    Hey I'm missing some body here king of kings Analogman lol


    Sent from my iPhone using Tapatalk

  9. #9
    V.I.P. ceo's Avatar
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    Quote Originally Posted by jp4355 View Post
    I was looking into this Topic back in 2006 to 2007.

    Wyeth Pharmaceuticals had just Published a Clinical Phase I Human study, and had started Phase II.

    The product was called Myo-029.

    It was not put into production because the testing was for Muscular Dystrophy, and no Study Results were ever posted.

    Supposedly, one of Doctors from this very study is the one who developed

    Myo-X myostatin inhibitor for Maximum Human Performance, AKA - mhp............................................... .JP

    P.S.
    I have noticed some Research Companies selling Supposed Myo-029. I doubt if it's Real

    Myostatin Inhibition is the "Holy Grail" of Muscle building, one day hopefully.
    Same here. I remember reading all about this back around 2007 or so.

    And I agree about the myostatin inhibitors being sold as well. I can't imagine it being inexpensive stuff at all.

  10. #10
    EVO Veteran RickRock's Avatar
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    I've been researching this topic a lot over the last few months myself, and have had some lengthy discussions and PMs with Ledhead on the subject. Myostatin is very real at the way it stops growth after a certain point in a cycle. I have entertained some possible ideas for future cycles as an expiriment to see what I can do to continue growth. Increasing dose at the 7-8 week mark is one way obviously, but another one I have is very similar to your example...which I will be doing next winter. I will run test and NPP for the first 8 weeks, and will be introducing Tren in at around the 7 week mark which will also technically be the start of contest prep for me. The higher anabolic properties of Tren should help add another couple lbs hopefully.

    Great info brother

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