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View Poll Results: Your preference Decanoate or NPP

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Thread: Nandrolone decanoate "long ester" is most efficient for muscle growth over NPP

  1. #1
    EVO V.I.P. ~Vision~'s Avatar
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    Nandrolone decanoate "long ester" is most efficient for muscle growth over NPP

    Nandrolone decanoate "long ester" is most efficient for muscle growth over NPP

    Nandrolone at its most efficient
    Chemical athletes who want to use nandrolone to build up their muscle mass are best off choosing a preparation with a) the longest ester possible, b) the highest concentration possible and c) injecting it in their gluteus muscle instead of in their shoulders. This according to a 1997 study published by andrologists at the University of Sydney in the Journal of Pharmacology and Experimental Therapeutics.




    Study
    The researchers did an experiment with 23 healthy, non-obese men aged between 18 and 40. They divided the men up into 4 groups and injected each group with a different nandrolone preparation. All preparations contained 100 mg nandrolone.
    Then the researchers measured the amount of nandrolone in the men's blood each day for the next 32 days.

    Injection sites
    The first group were given an injection of 100 mg nandrolone phenylpropionate [structural formula shown above] in their buttock. Nandrolone phenyl propionate used to be an ingredient in Organon's Durabolin, and is now found in UG preparations. Phenylpropionate is an ester that does not remain in the blood as long as decanoate. The 100 mg was in an ampoule of 4ml groundnut oil.
    The second group got the same kind of injection, but containing nandrolone decanoate, the steroid in Deca-Durabolin.
    The third group also got an injection containing 100 mg nandrolone decanoate in the buttocks, but this time the nandrolone was concentrated in 1 ml groundnut oil.
    And finally, the fourth group were injected with 100 mg nandrolone decanoate, dissolved in 1 ml groundnut oil, in the shoulder muscle.





    Results
    Nandrolone phenylpropionate gives a rapid peak in the blood, but the peak subsides after 4-5 days. Nandrolone decanoate doesn't cause a peak, but remains present for much longer in the blood.
    More nandrolone enters the blood if you inject it in a more concentrated form: 1 ml instead of 4 ml.
    Injecting into the buttocks results in more nandrolone in the blood than injecting into the shoulders.
    In the table below the shaded part shows the total amount of nandrolone that shows up in the blood after four separate injections.
    Look at the 'area under the curve'.

    Sponsor
    The research was partly financed by "Organon" Australia

    Source:
    J Pharmacol Exp Ther. 1997 Apr; 281 (1): 93-102.

    Pharmacokinetics and Pharmacodynamics of Nandrolone Esters in Oil Vehicle: Effects of Ester, Injection Site and Injection Volume

    Charles F. Minto, Christopher Howe, Susan Wishart, Ann J. Conway and David J. Handelsman

    Journal of Pharmacology and Experimental Therapeutics April 1997, 281 (1) 93-102;
    Abstract
    We studied healthy men who underwent blood sampling for plasma nandrolone, testosterone and inhibin measurements before and for 32 days after a single i.m. injection of 100 mg of nandrolone ester in arachis oil. Twenty-three men were randomized into groups receiving nandrolone phenylpropionate (group 1, n = 7) or nandrolone decanoate (group 2, n = 6) injected into the gluteal muscle in 4 ml of arachis oil vehicle or nandrolone decanoate in 1 ml of arachis oil vehicle injected into either the gluteal (group 3, n = 5) or deltoid (group 4,n = 5) muscles. Plasma nandrolone, testosterone and inhibin concentrations were analyzed by a mixed-effects indirect response model. Plasma nandrolone concentrations were influenced (P < .001) by different esters and injection sites, with higher and earlier peaks with the phenylpropionate ester, compared with the decanoate ester. After nandrolone decanoate injection, the highest bioavailability and peak nandrolone levels were observed with the 1-ml gluteal injection. Plasma testosterone concentrations were also influenced (P < .001) by the ester and injection site, with the most rapid, but briefest, suppression being due to the phenylpropionate ester, whereas the most sustained suppression was achieved with the 1-ml gluteal injection. Plasma inhibin concentrations were also significantly influenced by injection volume and site, with the lowest nadir occurring after the nandrolone decanoate 1-ml gluteal injection. Thus, the bioavailability and physiological effects of a nandrolone ester in an oil vehicle are greatest when the ester is injected in a small (1 ml vs. 4 ml) volume and into the glutealvs. deltoid muscle. We conclude that the side-chain ester and the injection site and volume influence the pharmacokinetics and pharmacodynamics of nandrolone esters in an oil vehicle in men.


    - - - Updated - - -

    Bonus read -

    How one same "ester" effects users differently

    Recently I've noticed the topic about the usage of 1 particular ester yielding different results in users..
    Or, others claiming one ester to be Superior to the next.. This is all individual based on ones static system of checks/loops, no two individuals are the same..
    This is why people argue that cypionate is much more potent than enanthate,
    as this is a fragile argument at best and makes little sense,
    as your muscles/receptors are only recognizing free bi0hormone no matter what the ester that was utilized to deploy the parenting hormone!

    These are great questions & a worthwhile topic, as there's some real truth behind this

    Let's begin with the expression of a single hormones yielding an opposite effect - rather than a positive "smooth" response to the hormone as some individuals claim/experience..
    An appropriate example to begin with would be that of an alcoholic...

    Why? Because of Genetics, I'll explain!


    Everyone posses different gene expression, with enzymes, protein bonds, and so on..
    (Enzymes are known to catalyze more then 5k biochemical types)..
    Yet our bodies posses inhibitors and activator molecules that can greatly effect the activity,
    by increasing or decreasing hormonal actives..
    Now, that of an alcoholic, it's a genetic predisposition (same applies for particular endocrines with sensitive users concerning AAS) in which one posses a group of particular enzymes that metabolize alcohol much differently compared to other individuals,
    thus the effects will be much greater, and more detrimental in some individuals over the next..(Different metabolization)

    Now, let's compare this to the hormones!

    (Example) Testosterone can have 3 roles
    1) Being testosterone as it's primary function..
    2) Converting into DHT (dihydrotestosterone: a more potent metabolite/androgen)..
    3)Converting into estrogen


    Here you see this effect differs greatly by individual instances, as genetics, age or even ethnicity (in some cases),
    or even sex may be a factor, whether one has a greater presence of aromatase enzymes, or even a deficiency..
    Hormones/esters have various biosynthetic pathways occurring in the endocrine,
    some either or before reaching their target tissue(to control plasma levels or active compounds),
    or at times after termination of their actions (inactivation and elimination)..
    However many of hormones and esters are metabolized within their target tissue,
    in which a complex interplay between activation and inactivation mechanisms serve to regulate the specificity and the amplitude of the hormonal response..

    This is why "singular ester" hormone treatment is NOT designed as a one size fits all therapy...
    Just an FYI: There's two main types of enzymes that act in the cleaving process of the ester in which activate the hormone...
    These 2 particular "Enzymes" are esterases & hydrolysate.. These come along and cleave pieces of the ester off the hormone,
    thereby releasing the active chemical (parenting steroid hormone) and allowing it to do its job (ultimately muscle building/tissue via protein synthesis, positive nitrogen balance and so on )...
    Now in the bloodstream which testosterone and blood born nutrients and substances circulate is recognized as the "medium".
    These enzymes circulate in the medium and directly affect the release of "active" hormone in the bloodstream by ester cleavage, thus exerting different expression per individuals, trigger a chute of cellular interaction at receptor sites that will differ from one to the next..

    People need to remember that hormones are "chemical messengers" that rely messages to cells that display specific receptors for each hormone and respond to the signaling.. Depending on the ester and the individuals metabolization ratio the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events..

    This is why the "same/singular hormone ester" effects people differently, because there's numerous ways a hormone can yield different effects.. So, depending on which transcription factors are present different genes will be transcribed in response...Thereby the reason some individuals tend to bloat and others do NOT, as some can run 250mgs of Test and begin to see signs of fluid retention or edema exert in the circular system, or particular regions of the body.. Yet, there's individuals that can utilize 1000mgs of Test and remain dry.. Of course diet permitting.. (but this article's about biosynthesis, and not diet)

    PSL,
    Vision

  2. #2
    EVO V.I.P. Eddie Haskell's Avatar
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    I voted for deca durabolin but I like both NPP and DECA. I find deca easier to manage ironically than NPP.

  3. #3
    EVO Veteran RickRock's Avatar
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    Great post. I agree completely. In my experience Deca has been far better for results over NPP

  4. #4
    Official Representative (VIP) Vadim Fedorov's Avatar
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    I am in agreement and great post

  5. #5
    Moderator Mobster's Avatar
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    I'd go with Deca. I know it worked for me

  6. #6
    Big Moderator RoySimpson's Avatar
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    I prefer deca everytime!

  7. #7
    Moderator India #1 Tiger Salman Khan's Avatar
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    Deca ...always gives me desired results...

  8. #8
    Cyborg Humanoid Brother ElevenBravo77's Avatar
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    Great post bro! My next blast will be Test and Deca. It will be my first time using Nandrolone.

  9. #9
    Proficient Brother aussieBEAST's Avatar
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    I like both NPP and deca, over here hard to get npp but deca easier. I even saw norma hella deca durabolin 2ml amps the other week.

  10. #10
    EVO V.I.P. Tazz's Avatar
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    great post here !

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