Does Berberine inhibit the muscle growth?

[ftfaaa]

Recently I am studying the effective ingredient of Glucose Disposal Agent(GDA). There is one thing called Berberine.

I read the wiki of Berberine https://en.wikipedia.org/wiki/Berberine , there is a saying
"It decreases of ATP production, and subsequent activation of AMPK, which leads to suppression of mTOR signaling."

I remember we need to activate mTOR to build muscle. So although Berberine in GDA want to keep stable insulin, the saying means Berberine will also inhibit the muscle growth. Right?

I also find a literature https://www.ncbi.nlm.nih.gov/pubmed/...t=AbstractPlus

"CONCLUSIONS:
Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy."

[stevesmi]

nah you will be fine

[muskate]

Berberin should actually help muscle growth if anything since it increases muscle insulin sensitivity.

The better your muscle insulin sensitivity - the more food that gets shuttled into muscle cells.

[Mobster]

The key word is 'decreases' and even then it'd depend on other aspects not necessarily addressed. So 1) it doesn't stop or block anything - just lowers it and 2) it ignores your training, diet and any other supps you'd be using.

[Masonic Bodybuilder]

It is a lot more complex when it comes to building muscle than that. There are tons of things going on that either help or hurt muscle growth day to day.