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Thread: Does Berberine inhibit the muscle growth?

  1. #1
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    Does Berberine inhibit the muscle growth?

    Recently I am studying the effective ingredient of Glucose Disposal Agent(GDA). There is one thing called Berberine.

    I read the wiki of Berberine https://en.wikipedia.org/wiki/Berberine , there is a saying
    "It decreases of ATP production, and subsequent activation of AMPK, which leads to suppression of mTOR signaling."

    I remember we need to activate mTOR to build muscle. So although Berberine in GDA want to keep stable insulin, the saying means Berberine will also inhibit the muscle growth. Right?

    I also find a literature https://www.ncbi.nlm.nih.gov/pubmed/...t=AbstractPlus

    "CONCLUSIONS:
    Berberine impairs muscle metabolism by two novel mechanisms. It impairs mitochonidrial function stimulating the expression of atrogin-1 without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulated protein degradation but also suppressed protein synthesis, causing muscle atrophy."

  2. #2
    Moderator stevesmi's Avatar
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    nah you will be fine
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  3. #3
    V.I.P. muskate's Avatar
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    Berberin should actually help muscle growth if anything since it increases muscle insulin sensitivity.

    The better your muscle insulin sensitivity - the more food that gets shuttled into muscle cells.

  4. #4
    Moderator Mobster's Avatar
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    The key word is 'decreases' and even then it'd depend on other aspects not necessarily addressed. So 1) it doesn't stop or block anything - just lowers it and 2) it ignores your training, diet and any other supps you'd be using.

  5. #5
    Growing Moderator Masonic Bodybuilder's Avatar
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    It is a lot more complex when it comes to building muscle than that. There are tons of things going on that either help or hurt muscle growth day to day.



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