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Aicar???

SimplyScarlet

New member
AICAR was showing up in a search I was running and I just wanted to know your opinions on it. It seems like it would work, but way too expensive. What do you all know about it?
 
Well sorry. I don't even know what u r talking about if you did a search as u said did it not say what it was when u came across it? Cause I have never heard of it.

KRAZIEONE - for all your DIO LABS needs....
 
Well sorry. I don't even know what u r talking about if you did a search as u said did it not say what it was when u came across it? Cause I have never heard of it.

KRAZIEONE - for all your DIO LABS needs....

5-aminoimidazole-4-carboxamide-1-β-D-riboruranoside (AICAR) used as a major fat cutter and reduces the risk of diabetes.

Are we really just going back and forth with each other on two different threads?? Lol
 
AICAR can be effective, and especially effective if you combine it with GW. They actually have a synergistic effect for enhanced fat loss together. There is a lot of info out there on GW and AICAR if you look around a bit. I'd post some links if I had them handy
 
AICAR can be effective, and especially effective if you combine it with GW. They actually have a synergistic effect for enhanced fat loss together. There is a lot of info out there on GW and AICAR if you look around a bit. I'd post some links if I had them handy

Thank you for the info. RickRock. There's nothing more fun then synergistic effects. Lol
 
SimplyScarlet - I know about Aicar but never actually ran it myself. Before I started into building my physique I was a hardcore cyclist and all I wanted to do is get lighter and faster. From everything I read Aicar does that. It should make cardio sessions a breeze and like Rick Rock said adding GW will be amazing. I have ran GW 4 times and love it every time - my endurance goes up and my ability to manage oxygen is just incredible. I have heard that Aicar made some ultra runners expel a lot of water via getting the "runs" for short term periods while under the compound. Endurance people love to be very low BF% so climbing is a walk in the park but I have yet to really hear people raving about it's endurance capabilities. I do know that there were a few pro cyclist who already got popped by WADA this year for using it before races. It must work - if you do try it log this (I think it would be the first log on Evo for Aicar) I woul really like to hear your results.
 
Studies have shown that GW1516, an agonist of peroxisome-proliferator-activated receptor δ (PPAR- δ) and amp-activated protein kinase can mimic some of the beneficial effects of exercise in skeletal muscle without really exerting an effort to exercise (Narkar et al. 2008). Studies reported that the signaling of AMPK and that of PPAR are interacting which then results to many adaptations in skeletal muscle. This has been shown in treadmill running tests in mice where pathway-specific drugs endurance capacities were targeted. The investigators found out that the PPAR-delta agonist and training synergistically increase the oxidative myofibers and running endurance in adult mice (Narkar et al. 2008). This is the same with the arguments of Wade (2008) who reported that mouse was supercharged to 75% increase endurance when coupled with exercise.

This has been supported by another investigation conducted by Oliveret al. (2001) where they reported that GW1516 increased expression of the reverse cholesterol transporter ATP-binding cassette A1 as observed in cells of the intestine, fibroblasts and macrophages. Furthermore, they reported that the agonist hormone the apolipoprotein A1-specific efflux of cholesterol. When they administered the drug to the middle-aged rhesus monkeys which develops spontaneous adult-onset obesity, they found out that the drug increased the serum high-density lipoprotein cholesterol (79%), which is the good cholesterol. The ratio was between HDLC and total cholesterol was also improved among all doses used. The administration of which is dose-dependent accompanied with decrease in the concentration of low-density lipoproteins. Decrease in the fasting triglycerides was also observed with the rate of 56%. This decrease if further complemented with the decrease in VLDL (50% decrease) when plasma of the monkeys were analyzed. The study then has clearly demonstrated that administration of the GW1516 allowed the rhesus monkeys to maintain glucose concentrations in the normal range despite the fact that they are hyperinsulinemic, suggesting potential clinical applications in treating and managing diabetes (Oliver et al. 2001).

Another hormone or synthetically produce peptide, AICAR, has been shown to cause mice to experience the benefits of exercise without actually doing it. In addition, other studies demonstrated that 44% increase in resistance and endurance was observed in stagnant mouse, and could be tripled when coupled with GW1516 (Goodyear, 2008).


Acadesine (5-amino-1-[ß-D-ribofuranosyl]imidazole-4-carboxamide), also known as AICAR, is a protein that is an amp-activated protein kinase activator (Menasche et al. 1995). It is a prototype hormone which belongs to a newly recognized classification of therapeutic compounds/agents called adenosine-regulating agents because they primarily induce the increase in the local availability of adenosine, especially for the adenosine triphosphate depleted regions or tissues (Gruber et al. 1989). Its structural conformation is shown as the following:



Chemical properties:

Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Melting Point: 214-2150C

An important characteristic of Aicar is its ability to elicit inhibition for the production of lipids or lipogenesis through increased phosphorylation of acetyl-coA carboxylase (ACC). This has been shown in mice adipocytes when AICAR was administered and an increased activation of the cellular amp-activated protein kinase was observed (Sullivan et al. 1994). The same effects have been observed in sedentary mice that have been treated with AICAR for 4 weeks. They observed that there still induced metabolic genes and even enhanced running endurance by 44% (Narkar et al. 2009). This suggests that Aicar can be used to target the PPAR receptors to elicit exercise-like effects and benefits.

Other studies also demonstrated that the effects of Aicar are enhanced when combined with GW1516. This has been demonstrated in the sedentary mice which produced a transcriptional profile that is unique (189 genes). The interesting thing on this is that, most of the genes (52) out of the 189 genes actually overlapped with many of the genes that have been shown to be regulated by exercise. However, the cultures of muscles from mice have also shown that there is a need for the PPAR-delta for the two hormones (AICAR and GW1516) to take effect (Gough et al. 2008).

The chemical reactivity of acadesine was reported to be silent in normal conditions, meaning when ATP concentrations are in the normal levels, but becomes functional when the said phosphate form is decreased (Mullane 1993). Because of its ability to harvest the positive effects of the protective autocoid without the limiting effects associated with using adenosine as the substrate or a congineer of adenosine, it has been exploited and applied in different medical medications to treat illnesses and abnormalities such ischamia and its sequelae. Acadesine was found to protect the organ from injury during the onset of ischemia (Galinanes et al. 1992). This has been shown in preliminary studies in rats suffering from ischemia, Aicar was applied through perfusion; functional recovery from the illness was immediately observed (2.5 hours). It has also been shown that acadesine reacts immediately and hastily with hypochlorous acid (HOCl) which then provides protection over a number of critical biological targets (Bullough et al. 1993). This has been supported by a number of other studies which also concluded that acadesine indeed offers a cardioprotective effects. Such treatments have also been supplemented to human patients who are suffering from ischemia and/or coronary artery bypass grafting (CABG). Furthermore, acadesine has been proven in clinical studies to prevent aggregation of clotting of blood platelets. Also, it improves contractile functioning of the ventricles in postischemic events, decreases the level of free-radical and oxidant-induced cardiac damages (Matthew et al. 1995); however, it was also demonstrated to have no effect in superoxide anions that were generated by xanthine-xanthine oxidase or hydrogen peroxide induced peroxidation (Bullough et al. 1993). In addition, it also allows adherence of the inhibitneutrophil (PMN) to endothelium and inhibits the accumulation of the PMN in the myocardium experiencing ischemia (Levin et al. 1990).
 
Because there is no miracle drug. Even when using this or any other product you have to eat extremely strict and calorie deficient. Hard work trumps chemicals every time. Otherwise everyone and their mother cud just stick a needle in the their ass and be buff and ripped. Its a misconception of a lot of uneducated people in the world of fitness that u just take products and get results. Results ONLY come from hard work.

KRAZIEONE - for all your DIO LABS needs....
 
Ok, did some more research... People aren't going all gaga for it because it would cost between $400-$800 a day for a therapeutic dosage and they recommend it be run for three to four weeks. Lol on the plus side you only have to take it three times a week.

Anyone feel like donating to a cause? I'm only about $3,200 short. I'll log all results. J/k ;-)
 
its pricey, hard to find since there are so many fake sites out there, and it has high sides.

I wrote an article on aicar and GW together years ago but hence, a virus wiped out everything on my computer and I don't remember where it was published. you can probably google it somehow somewhere.
 
Ok, did some more research... People aren't going all gaga for it because it would cost between $400-$800 a day for a therapeutic dosage and they recommend it be run for three to four weeks. Lol on the plus side you only have to take it three times a week.

Anyone feel like donating to a cause? I'm only about $3,200 short. I'll log all results. J/k ;-)

What are you Calling a Therapeutic Dose, how many MG EOD.
I can't seem to find a Realistic Dosing Protocol.
Some People say that it goes by Weight.
Others are saying 10 to 15 Mg EOD to start.
One Guy is saying 20 mg EOD to Start........................ JP
P.S.
Also found a place selling 50 Mg for about $35, but have no Idea if they're Legit.
 
What are you Calling a Therapeutic Dose, how many MG EOD.
I can't seem to find a Realistic Dosing Protocol.
Some People say that it goes by Weight.
Others are saying 10 to 15 Mg EOD to start.
One Guy is saying 20 mg EOD to Start........................ JP
P.S.
Also found a place selling 50 Mg for about $35, but have no Idea if they're Legit.

What I read was it takes about 3g to be effective. Given that it's mostly sold at 50 mg and 100 mg for around $40. That's going to put some hurt on the the bank account.
 
What I read was it takes about 3g to be effective. Given that it's mostly sold at 50 mg and 100 mg for around $40. That's going to put some hurt on the the bank account.

I didn't see anything Remotely close to that, But I don't doubt it, being that Everyone seems to be Guessing as far as Dosing............. JP
P.S.
Also, you would need to Research the Sellers, as I'm not familiar with any that do Sell it.
P.S.S.
If the one post I read was at All Accurate, 20 mg EOD, wouldn't even get you through 1 Week.
It would be about 5 Vials a Month @ 50 Mg a Vial.
 
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