The 17-α-alkylation is done with most oral steroids to allow them to survive the first pass through the liver. This is also a reason it is hepatoxic. With some steroids, there can be other factors that contribute to hepatoxicity as well.
The 17-α-alkylation is done with most oral steroids to allow them to survive the first pass through the liver. This is also a reason it is hepatoxic. With some steroids, there can be other factors that contribute to hepatoxicity as well.