I’ve used up to 2mg at once and other than feeling nauseous it never stopped my appetite… it did bloat me like crazy however.I literally couldn’t eat more than 1500 cals per day on semaglutide. My fasting blood sugars also dropped 30 points and my liver numbers were all on the low end of normal which is amazing. My doctor was shocked how well it worked for me. I would never think about DNP again. Used it once and that was enough. Turning the heater off and opening the windows during winter was not worth it.