Approved Log My Superdrol, Sustanon, Masteron, Trenbolone, HGH cycle Log

[AE1079]

Primo doesn’t reduce estrogen because it doesn’t interact with the aromatase enzyme or have any direct effect on estrogen levels.

Estrogen is usually produced when testosterone or other aromatising compounds are converted into estrogen by the aromatase enzyme. Since primo doesn’t aromatise (convert into estrogen) and lacks anti-estrogenic properties like an aromatase inhibitor, it neither increases nor decreases estrogen levels. It simply doesn’t influence estrogen metabolism at all.

If you’re running a cycle that includes both primo and an aromatising compound like test or sus, the total amount of aromatising compound is lower in comparison to the overall dosage of all compounds in the cycle. This can make the estrogen-related side effects seem less pronounced, but the actual amount of estrogen being produced remains dependent on the aromatising compound.

Are you sure bro?

 

[AE1079]

Primo doesn’t reduce estrogen because it doesn’t interact with the aromatase enzyme or have any direct effect on estrogen levels.

Estrogen is usually produced when testosterone or other aromatising compounds are converted into estrogen by the aromatase enzyme. Since primo doesn’t aromatise (convert into estrogen) and lacks anti-estrogenic properties like an aromatase inhibitor, it neither increases nor decreases estrogen levels. It simply doesn’t influence estrogen metabolism at all.

If you’re running a cycle that includes both primo and an aromatising compound like test or sus, the total amount of aromatising compound is lower in comparison to the overall dosage of all compounds in the cycle. This can make the estrogen-related side effects seem less pronounced, but the actual amount of estrogen being produced remains dependent on the aromatising compound.

Can you explain the downstream pathway of primobolan metabolised in the body?

 

[hypogaeum]

Are you sure bro?

Fairly certain. I’d have to check my notes, but my memory of primo is that its molecular structure lacks the necessary features to interact with the aromatase enzyme (which is responsible for converting androgens into estrogen). It’s this same inability to convert to estrogen that means that it can’t actively reduce estrogen (like an AI).

 

[hypogaeum]

Apologies @Jason breville for derailing the thread

 

[Jason breville]

Hahaha all good guys good info regardless

 

[Jason breville]

Hi guys, would it be best if I grabbed Arimidex or Aromasin?

 

[LevButlerov]

Hi guys, would it be best if I grabbed Arimidex or Aromasin?

@Jason breville best you get aromasin, its a better Ai safer too
I would always have it with a testosterone based cycle

 

[hypogaeum]

@Jason breville best you get aromasin, its a better Ai safer too

I agree. A bit less agressive than Arimidex.

12.5mg to 25mg EOD should help.

 

[AE1079]

Fairly certain. I’d have to check my notes, but my memory of primo is that its molecular structure lacks the necessary features to interact with the aromatase enzyme (which is responsible for converting androgens into estrogen). It’s this same inability to convert to estrogen that means that it can’t actively reduce estrogen (like an AI).

Aside from the molecular structure, it’s been found that primos metabolites have AI Properties, I can’t remember the name of the particular metabolite, but it also shows in bloodwork when ran with a test base, ran 1:1 you can cut your e2 from anywhere from 20-40%. So the metabolic pathway being 3a reduced, it is strongly inhibited which is a little strange and different from other DHTs - two isoenzymes in particular ARK1C4 being the main one is present largely in the liver and the mammary gland in particular which may explain AI inhibiting effects to some
Degree (expressed in other areas too) which can have a effect on E2 metabolism as well, with skeletal muscle being affected by two other enzymes called AKR1C1 and AKR1C4 which also allows mRNA expression more so with use of test, which also may explain the synergy of Test and Primo.

This is where it gets tricky, because we don’t have a lot of studies on it. From what I explained above, it can give structure to the point of its synergistic effects, and the initial metabolite antagonising the EBR and EAR causing inhibition of aromatase, explaining the anecdote of dry gains, increased free test and SHBG being lowered.. thoughts ?

 

[hypogaeum]

Aside from the molecular structure, it’s been found that primos metabolites have AI Properties, I can’t remember the name of the particular metabolite, but it also shows in bloodwork when ran with a test base, ran 1:1 you can cut your e2 from anywhere from 20-40%. So the metabolic pathway being 3a reduced, it is strongly inhibited which is a little strange and different from other DHTs - two isoenzymes in particular ARK1C4 being the main one is present largely in the liver and the mammary gland in particular which may explain AI inhibiting effects to some
Degree (expressed in other areas too) which can have a effect on E2 metabolism as well, with skeletal muscle being affected by two other enzymes called AKR1C1 and AKR1C4 which also allows mRNA expression more so with use of test, which also may explain the synergy of Test and Primo.

This is where it gets tricky, because we don’t have a lot of studies on it. From what I explained above, it can give structure to the point of its synergistic effects, and the initial metabolite antagonising the EBR and EAR causing inhibition of aromatase, explaining the anecdote of dry gains, increased free test and SHBG being lowered.. thoughts ?

Interesting. I can see the line of thinking you’re on and I don’t mind it. There are studies on other DHT derivatives like Mast that have hinted at similar effects through inhibition of aromatase or modulation of estrogen receptors, so it’s not unreasonable to expect similar from primo.

I’d love to see a study that could tell us how much primo use impacts aromatase activity versus simply altering estrogen receptor interaction or metabolism.

 

[AE1079]

Interesting. I can see the line of thinking you’re on and I don’t mind it. There are studies on other DHT derivatives like Mast that have hinted at similar effects through inhibition of aromatase or modulation of estrogen receptors, so it’s not unreasonable to expect similar from primo.

I’d love to see a study that could tell us how much primo use impacts aromatase activity versus simply altering estrogen receptor interaction or metabolism.

Sorry bro, I’m not questioning you but do you understand these terms in pharmacology and how it affects how biology in humans? I just want to know if you understand as I can go off tangents if not all good.

Mast works more like a SERM, acting on E2BR and E2AR binder as a negative agonist , hence the word “mast” meaning mast cell, working as an anti prolific agent in breast tissue.

Primo was made for different reasons as an anabolic agent for babies and women with muscle wasting disease, they found testosterone virillised in children and women and needed something more towards non- aromatisation and something they can use in infants, so they removed BA from it as well so it can be tolerated (hence why pharma primo has massive PIP) also has shown its use originally in anaemia patients which is interesting,

I’ll be doing a write up soon of primo vs mast from a clinical point of view and it’s Pharmacology and chemistry, and use in bodybuilding anecdotally and what they both do at a cellular level. Hopefully it clear the confusion up for the two, problem is bro, there aren’t enough studies in Anabolics. If they are, they get quickly pulled by pharma companies.

 

[AE1079]

Interesting. I can see the line of thinking you’re on and I don’t mind it. There are studies on other DHT derivatives like Mast that have hinted at similar effects through inhibition of aromatase or modulation of estrogen receptors, so it’s not unreasonable to expect similar from primo.

I’d love to see a study that could tell us how much primo use impacts aromatase activity versus simply altering estrogen receptor interaction or metabolism.

I wish we could alter ERs but we can only antagonise and agonise receptors to create different transcription at the nucleus, it would be good though L!

 

[hypogaeum]

Sorry bro, I’m not questioning you but do you understand these terms in pharmacology and how it affects how biology in humans? I just want to know if you understand as I can go off tangents if not all good.

Mast works more like a SERM, acting on E2BR and E2AR binder as a negative agonist , hence the word “mast” meaning mast cell, working as an anti prolific agent in breast tissue.

Primo was made for different reasons as an anabolic agent for babies and women with muscle wasting disease, they found testosterone virillised in children and women and needed something more towards non- aromatisation and something they can use in infants, so they removed BA from it as well so it can be tolerated (hence why pharma primo has massive PIP) also has shown its use originally in anaemia patients which is interesting,

I’ll be doing a write up soon of primo vs mast from a clinical point of view and it’s Pharmacology and chemistry, and use in bodybuilding anecdotally and what they both do at a cellular level. Hopefully it clear the confusion up for the two, problem is bro, there aren’t enough studies in Anabolics. If they are, they get quickly pulled by pharma companies.

Yeah, I get what you’re saying, and you’re spot on about Mast working more like a SERM by binding to estrogen receptors negatively, which explains its anti-proliferative effects. Primo was definitely designed with a different goal in mind, and the whole non-aromatising aspect makes sense for treating muscle-wasting in women and kids without causing vitalisation.

Looking forward to your write-up- there’s so much grey area in how these compounds work at a cellular level, so it’ll be cool to see how you break it all down.

 

[Jason breville]

Morning guys,

Updated cycle below:
Will be pinning every 3 days.
125mg Sus
100mg Primo
100mg Mast P

Also will be Aromasin daily, and 3iu HGH.

Training today below:
Incline bech press (Barbell)
70kg x 13
70kg x 11
70kg x 9
80kg x 4

Cable crossover
12.5kg x 17
12.5kg x 12
12.5kg x 14

Pec deck
28kg x 15
29kg x 15
29kg x 12

Single arm bench (plate loaded)
30kg x 12
30kg x 10
30kg x 10

Tricep push dawon (straight bar)
32.5kg x 18
33.75kg x 15
33.75kg x 13

Skullcrusher
25kg x 14
25kg x 14
25kg x 14

Dip machine plate loaded
80kg x 15
80kg x 13
70kg x 15

 

[AE1079]

Morning guys,

Updated cycle below:
Will be pinning every 3 days.
125mg Sus
100mg Primo
100mg Mast P

Also will be Aromasin daily, and 3iu HGH.

Training today below:
Incline bech press (Barbell)
70kg x 13
70kg x 11
70kg x 9
80kg x 4

Cable crossover
12.5kg x 17
12.5kg x 12
12.5kg x 14

Pec deck
28kg x 15
29kg x 15
29kg x 12

Single arm bench (plate loaded)
30kg x 12
30kg x 10
30kg x 10

Tricep push dawon (straight bar)
32.5kg x 18
33.75kg x 15
33.75kg x 13

Skullcrusher
25kg x 14
25kg x 14
25kg x 14

Dip machine plate loaded
80kg x 15
80kg x 13
70kg x 15

Hey bro out of curiosity, reason for adding aromasin?

 

[LevButlerov]

Morning guys,

Updated cycle below:
Will be pinning every 3 days.
125mg Sus
100mg Primo
100mg Mast P

Also will be Aromasin daily, and 3iu HGH.

Training today below:
Incline bech press (Barbell)
70kg x 13
70kg x 11
70kg x 9
80kg x 4

Cable crossover
12.5kg x 17
12.5kg x 12
12.5kg x 14

Pec deck
28kg x 15
29kg x 15
29kg x 12

Single arm bench (plate loaded)
30kg x 12
30kg x 10
30kg x 10

Tricep push dawon (straight bar)
32.5kg x 18
33.75kg x 15
33.75kg x 13

Skullcrusher
25kg x 14
25kg x 14
25kg x 14

Dip machine plate loaded
80kg x 15
80kg x 13
70kg x 15

@Jason breville your testosterone/sustanon intake is very low, you dont need an Ai imo especially with primo/mast there

training is legit high volume

 

[Jason breville]

Hi guys,

Reason I’m adding in the AI is as per the above due to the results from my blood test. I was going to start at 12.5mg per day

 

[AE1079]

Hi guys,

Reason I’m adding in the AI is as per the above due to the results from my blood test. I was going to start at 12.5mg per day

I’m not going to get involved in this one haha see how you go

 

[LevButlerov]

Hi guys,

Reason I’m adding in the AI is as per the above due to the results from my blood test. I was going to start at 12.5mg per day

remind me please, your estrogen levels were high while you were using primobolan and masteron? @Jason breville

 

[Jason breville]

Hi @LevButlerov , i was using sus, tren and mast, not primo yet. I was going to introdcue primo and remove the tren as suggested above