Retatrutide - it’s the real deal

[LevButlerov]

They are going in stages of efficacy and improvements, etc...

I sat in on a multitude of conferences at the A4M this year and some other biohacking conventions and have also had some pretty in depth discussions with some of the best naturopathic doctors in the world and have gotten a ton of insight on GLP-1 Agonists and in depth analysis and understanding of the main three, ozempic, mounjaro and now retatrutide...

in short, mounjaro (tirzepatide) has the added GIP receptor which makes it stronger than ozempic (semaglutide) but then retatrutide goes one step fruther and you get the following three...

• GIP (Gastric Inhibitory Polypeptide) receptor
• GLP-1 (Glucagon-Like Peptide-1) receptor
• GCG (Glucagon) receptor

Heres a recent 48 week trial that was done on people with obesity, or overweight with weight-related conditions—except type 2 diabetes.

Dosage	24-Week Results	48-Week Results
1 mg	7.2%	8.7%
4 mg	12.9%	16.3%
8 mg	17.3%	23.9%
12 mg	17.5%	24.2%
Placebo	1.6%	2.1%

Retatutride vs Tirzepatide vs Semaglutide: A Comparison​

Medication	Weight Loss	Duration	Type of Receptor Agonist	FDA-approval for Weight Loss
Retatrutide	24.2%	48 weeks	Triple	Trials Ongoing
Semaglutide	20%	68 weeks	Single	Yes, under Wegovy
Tirzepatide	26.6%	84 weeks	Dual	Yes, under Zepbound

Here are some ACTUAL study data showing the downside that has been seen with it so far

In clinical trials, retatrutide has shown promising results for weight loss, but like any medication, it comes with potential side effects and considerations. Phase II trial results did include data on adverse events:

• A significant percentage of participants (73% to 94%) reported adverse events while taking retatrutide, particularly in the higher 8-mg and 12-mg groups.
• The most commonly experienced side effects were gastrointestinal issues, including nausea, diarrhea, vomiting, and constipation.
• Digestive side effects mainly occurred during the dose escalation phase and were mostly mild to moderate in severity—lower starting doses seemed to lessen this severity.
• There were slight increases in certain digestive enzyme levels, such as amylase and lipase. But there was only one reported serious case of pancreatitis.
• Participants taking higher doses of retatrutide experienced an increase in heart rate during the first 24 weeks, after which it decreased.
• No serious cases of low blood sugar or significant complications like thyroid cancer were reported among participants.
• Some individuals (7% of those on retatrutide compared to 1% on placebo) experienced skin sensitivity, but these cases were not serious.

There is a firm belief it will eventually get through trials and be on bigger than the others and with the amount of money in this market now, i would venture to guess that to be true.. i will be doing a TON more in terms of discussion and study on it along with all GLP-1's and have been developing a significant amount of knowledge base on them because there are some pretty insane comments and opinions out there amongst media, social media etc. that are just insanely off base and non factual so it can be difficult to sift through the bull shit but im on it!

@dylangemelli I found retatrutide easier to handle for most of my clients. no digestive issues like with semgaltudie. Limited now ith Tirzepatide but for sure Retatrutide is one of the best.
The most sides I saw was from semaglutide, even with micro dosing it has sides, @Pigsy just did micro dosing log with semgalutide, it's up here
https://www.evolutionary.org/forums/threads/semaglutide-ozempic-log.102197/

 

[awm1981]

They are going in stages of efficacy and improvements, etc...

I sat in on a multitude of conferences at the A4M this year and some other biohacking conventions and have also had some pretty in depth discussions with some of the best naturopathic doctors in the world and have gotten a ton of insight on GLP-1 Agonists and in depth analysis and understanding of the main three, ozempic, mounjaro and now retatrutide...

in short, mounjaro (tirzepatide) has the added GIP receptor which makes it stronger than ozempic (semaglutide) but then retatrutide goes one step fruther and you get the following three...

• GIP (Gastric Inhibitory Polypeptide) receptor
• GLP-1 (Glucagon-Like Peptide-1) receptor
• GCG (Glucagon) receptor

Heres a recent 48 week trial that was done on people with obesity, or overweight with weight-related conditions—except type 2 diabetes.

Dosage	24-Week Results	48-Week Results
1 mg	7.2%	8.7%
4 mg	12.9%	16.3%
8 mg	17.3%	23.9%
12 mg	17.5%	24.2%
Placebo	1.6%	2.1%

Retatutride vs Tirzepatide vs Semaglutide: A Comparison​

Medication	Weight Loss	Duration	Type of Receptor Agonist	FDA-approval for Weight Loss
Retatrutide	24.2%	48 weeks	Triple	Trials Ongoing
Semaglutide	20%	68 weeks	Single	Yes, under Wegovy
Tirzepatide	26.6%	84 weeks	Dual	Yes, under Zepbound

Here are some ACTUAL study data showing the downside that has been seen with it so far

In clinical trials, retatrutide has shown promising results for weight loss, but like any medication, it comes with potential side effects and considerations. Phase II trial results did include data on adverse events:

• A significant percentage of participants (73% to 94%) reported adverse events while taking retatrutide, particularly in the higher 8-mg and 12-mg groups.
• The most commonly experienced side effects were gastrointestinal issues, including nausea, diarrhea, vomiting, and constipation.
• Digestive side effects mainly occurred during the dose escalation phase and were mostly mild to moderate in severity—lower starting doses seemed to lessen this severity.
• There were slight increases in certain digestive enzyme levels, such as amylase and lipase. But there was only one reported serious case of pancreatitis.
• Participants taking higher doses of retatrutide experienced an increase in heart rate during the first 24 weeks, after which it decreased.
• No serious cases of low blood sugar or significant complications like thyroid cancer were reported among participants.
• Some individuals (7% of those on retatrutide compared to 1% on placebo) experienced skin sensitivity, but these cases were not serious.

There is a firm belief it will eventually get through trials and be on bigger than the others and with the amount of money in this market now, i would venture to guess that to be true.. i will be doing a TON more in terms of discussion and study on it along with all GLP-1's and have been developing a significant amount of knowledge base on them because there are some pretty insane comments and opinions out there amongst media, social media etc. that are just insanely off base and non factual so it can be difficult to sift through the bull shit but im on it!

Thanks Dylan as always for the info and appreciate your responses to my questions as well!

Im again gonna be in the 1.5mg/week range with the umbrella labs retatrutide and so far so good!

Will also be running my bloods soon just to see if anything looks out of the ordinary but I feel great so not expecting anything.

 

[dylangemelli]

@dylangemelli I found retatrutide easier to handle for most of my clients. no digestive issues like with semgaltudie. Limited now ith Tirzepatide but for sure Retatrutide is one of the best.
The most sides I saw was from semaglutide, even with micro dosing it has sides, @Pigsy just did micro dosing log with semgalutide, it's up here
https://www.evolutionary.org/forums/threads/semaglutide-ozempic-log.102197/

Yes, so far i have found it quite tolerable for everyone i have monitored on it as well! Good info bro

 

[dylangemelli]

Thanks Dylan as always for the info and appreciate your responses to my questions as well!

Im again gonna be in the 1.5mg/week range with the umbrella labs retatrutide and so far so good!

Will also be running my bloods soon just to see if anything looks out of the ordinary but I feel great so not expecting anything.

awesome bro, let me know how everything goes!

 

[LevButlerov]

Yes, so far i have found it quite tolerable for everyone i have monitored on it as well! Good info bro

@dylangemelli I think retatrutide will be the new "ozempic" hyped glp-1 but one that actually has little sides.

 

[Oracle911]

@dylangemelli I think retatrutide will be the new "ozempic" hyped glp-1 but one that actually has little sides.

just less of an appetite supression at low dose like ozempic, but more overall benefits without the sides for sure

 

[LevButlerov]

just less of an appetite supression at low dose like ozempic, but more overall benefits without the sides for sure

I think the side effects are the real issue with semaglutide. When compared to retatrutide its night and day but I bet thats not for all, depends on the individual to a degree as well. @Oracle911

 

[Oracle911]

I think the side effects are the real issue with semaglutide. When compared to retatrutide its night and day but I bet thats not for all, depends on the individual to a degree as well. @Oracle911

ive been on 1mg for like 4 months and then 1.5mg for another 2 on top and i feel fine in all ways shapes and forms, also body hasnt gotten used to it which is great, granted im doing it more for health purposes but i like not having to up it constantly.

 

[dylangemelli]

@dylangemelli I think retatrutide will be the new "ozempic" hyped glp-1 but one that actually has little sides.

Its just going in stages... i would look at it in comparison to say

viagara
cialis
levitra

as they came out, they just got better and had added benefits, less sides etc... here they are just making improvements each time while actually enhancing the efficacy and results

 

[LevButlerov]

Its just going in stages... i would look at it in comparison to say

viagara
cialis
levitra

as they came out, they just got better and had added benefits, less sides etc... here they are just making improvements each time while actually enhancing the efficacy and results

@dylangemelli I actually found tadalafil (cialis) much better than viagra or the later released levitra, interesting enough. Since we are on the topic, your thoughts on levitra? you test it vs cialis?

 

[dylangemelli]

@dylangemelli I actually found tadalafil (cialis) much better than viagra or the later released levitra, interesting enough. Since we are on the topic, your thoughts on levitra? you test it vs cialis?

People tend to respond differently.. one of the draws to cialis was the longer half life to it, which for some is certainly ideal but for others, it can be quite problematic.. .levitra does take about an hour to really kick in so you need to keep that in mind but it is very strong, essentially a stronger version of viagara... so scaling, viagara would technically be the "weakest" yet still strong, then levitra and then cialis however cialis is NOT for everyone based on upon the long half life and chances of issues with too long of an erection etc... ive tried them all in the past, and to be honest, just personally, i always liked viagara myself... but the best was the old superman stack when you got all three LOL

 

[RoidRage69]

I had viagra and Cialis on my anniversary night. I can vouch it's way more effective to stack them.

 

[Npcclassicphysique champ]

I had viagra and Cialis on my anniversary night. I can vouch it's way more effective to stack them.

Cialis viagra anniversary stack bro, KILLED IT @RoidRage69

 

[Npcclassicphysique champ]

People tend to respond differently.. one of the draws to cialis was the longer half life to it, which for some is certainly ideal but for others, it can be quite problematic.. .levitra does take about an hour to really kick in so you need to keep that in mind but it is very strong, essentially a stronger version of viagara... so scaling, viagara would technically be the "weakest" yet still strong, then levitra and then cialis however cialis is NOT for everyone based on upon the long half life and chances of issues with too long of an erection etc... ive tried them all in the past, and to be honest, just personally, i always liked viagara myself... but the best was the old superman stack when you got all three LOL

i find viagra gives me headaches like a mofo bro but cialis is fine no problem, levitra didnt use it much just 1-2 times i think didnt feel jack shit
we should find a member who stacked all 3 @dylangemelli
we have @RoidRage69 with dual stack but I did that too, havent added levitra for a triple stack haha

I had viagra and Cialis on my anniversary night. I can vouch it's way more effective to stack them.

 

[Titties]

i find viagra gives me headaches like a mofo bro but cialis is fine no problem, levitra didnt use it much just 1-2 times i think didnt feel jack shit
we should find a member who stacked all 3 @dylangemelli
we have @RoidRage69 with dual stack but I did that too, havent added levitra for a triple stack haha

@Sydneycitysupplements cock boom (viagra and Cialis) half a tablet works great for me. To be honest first time hearing of a 3rd supp.

 

[RoidRage69]

Now that I think of it I had a bad headache with the viagra. I don't get that with Cialis.

 

[LevButlerov]

Now that I think of it I had a bad headache with the viagra. I don't get that with Cialis.

100% with viagra always headaches but nothing with cialis @RoidRage69

 

[Npcclassicphysique champ]

good Retatrutide log by @Titties
https://www.evolutionary.org/forums/threads/first-ever-log-on-trt-and-retatrutide.102926

 

[Oracle911]

can check my log too if you want, have been using it throughout my growth phase, been on 2mg up from 1.5mg up from 1mg, have been running it for about 6 months non stock now, all that has happened is visceral fat has gotten less and less over time and i stay leaner, am on 2mg now and at my highest calories growing leaner than ive everbeen,

TD 4300
NTD 3000
feel free to check it out, very much recommend reta though very multipurpose, think lantus with the shuttling without the sides

 

[LevButlerov]

can check my log too if you want, have been using it throughout my growth phase, been on 2mg up from 1.5mg up from 1mg, have been running it for about 6 months non stock now, all that has happened is visceral fat has gotten less and less over time and i stay leaner, am on 2mg now and at my highest calories growing leaner than ive everbeen,

TD 4300
NTD 3000
feel free to check it out, very much recommend reta though very multipurpose, think lantus with the shuttling without the sides

For new readers just starting this thread, @Oracle911 has a log with ratatrutide in the stack
https://www.evolutionary.org/forums...eq-hgh-retatrutide-slupp332-cycle-log.103518/