Ok this is a very lamen breakdown of your igf levels. Insulin is key here...
When insulin is high (fed state) your livers production of gh to igf1 is also high.
At this time it is also telling your pituitary gland to produce less gh secretion.
When insulin is low (fasted state) gh secretion is high because the negative feedback loop is weakened and gh becomes more essential for providing energy primarily through the breakdown of fat stores (lypolisis). This is you body trying to regain homeostasis.
Now the liver needs insulin fo it to be responsive to gh.
When insulin is high, the liver is more sensitive to gh, leading to increased production of igf1. Low insulin reduces the liver's sensitivity to gh, which can lead to lower igf1 levels.
When the liver produces more igf1, it tells the pituitary gland to release less gh. Conversely, when igf levels are low, mostly due to low insulin, the feedback is reduced, and gh levels can rise.
The interaction between insulin and gh is a tricky balance that changes depending on your nutritional state. When your fed, high insulin allows gh to promote growth without causing excessive fat breakdown. When fasted, low insulin allows gh to increase, mobilizing fat stores to be used as fuel.
It is so much more to break this down properly but i dont have the knowledge to pass this on to you bro.
@LevButlerov is the man for this but he is also very busy hahaha.
e2 plays a big influence on your livers ability to convert gh to igf1 also. There was a solid article another coach on here had created for gh ill find it for you brother.