People disregard primo alot, but id argue its super popular for a reason because one it works and 2 its overall safety profile, i have bloodwork on 300mg test and 300mg primo and my markers looked amazing, its does work, ive experienced it first hand, 300-400mg is what i typically run it at, keeps my estrogen at 16 which is perfectly in range, id start low run blood work after 4-6 weeks and adjust if u feel u can tolerate more.