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Need2Slin commands insulin to do exactly what you want!
Need2Slin works, not like typical muscle gainers, primarily by it's ability to mimic/boost insulin and by increasing cAMP. Real insulin, actually breaks down the enzyme that caused cAMP which is why you can get fat if you don't know how to use insulin. cAMP is classified as a second messenger, meaning that it exerts it's effects by acting as a manner secondary and in response to a first messenger signaling molecule. When a first messenger signaling molecule binds to a cell surface, the second messenger is activated that increases cAMP production. cAMP signals your body how to produce energy to feed muscles, increasing Protein metabolism in the process, so you get a greater metabolic rate, improved glycogen uptake, increased Protein and fat synthesis and increased testosterone levels. So all the calories you eat are used to build muscle and this in combination with your hard training is enough to create an extremely anabolic environment!
The following experiment shows Need2Slin’s powerful insulin mimetic abilities in healthy individuals compared to hand picked supplements (chosen specifically for the purpose of increasing insulin response):
http://needtobuildmuscle.net/forum/f2/need-2-slin-experiment-9015.html
What are the benefits of Need2Slin?
It does a variety of things that every dedicated fitness enthusiast likes!
• Increase lean body mass
• Lower body fat
• Faster metabolism
• Boost thyroid output
• Increase testosterone
• Improve insulin sensitivity in muscle
• Improve glycogen uptake
• Improve Blood Lipids
• Increase natural energy
• Enhance muscular blood flow
• Increase Androgen receptor sensitivity
Direction:
To increase fat loss, take two capsules 30 minutes before each meal containing 40g of carbohydrates or more. To increase mass gains, use three capsules before each meal containing 60-100grams of carbohydrates. Use in conjunction with an appropriate diet and training program. Another popular method of use is to take just 1 capsule morning, noon, and night. This allows for constant steady levels throughout a 24 hour period.
Need2Slin's Ingredient profile:
Gymnema sylvestre (75% gymnemic acid)
Gymnema sylvestre is known as "destroyer of sugar" because Ayurvedic physicians observed that chewing a few leaves of Gymnema sylvestre suppressed the taste of sugar. In experimental and clinical trials, Gymnema sylvestre has been successful in controlling the blood sugar level without reducing it to below the normal blood sugar levels, an effect sometimes seen with the use of insulin or oral hypoglycemic therapy. Gymnema sylvestre can also play a role in treating conditions caused by excessive sugar intakes. Conditions like obesity, hyperglycemia, anemia and osteoporosis. [1-4]
Acetyl-L-Carnitine
Acetyl-L-Carnitine (ALCAR) is an acetylated form of L-Carnitine. It passes through the blood brain barrier better than L-carnitine, because of the acetylation. ALCAR helps shuttle free fatty acids into the mitochondria where they are burned off for energy. This is important because normally it is hard for the fatty acids to enter the mitochondria. This means more fat and less carbohydrates and protein, will be burned for energy in the mitochondria. ALCAR has also been shown to improve insulin response and it has been proven to have significant benefits on mood and overall health like improvements in ADHD, increasing fertility, reducing recovery from exercise, reducing fatigue, curing depression, reversing hyperthyroidism, healing cirrhosis of the liver, sexual enhancement, increased cardiovascular health, removing toxins from the body, and many other conditions. [5]
Na-RALA
Na-RALA is the sodium salt form of R-Lipoic Acid and it is 30% stronger than K-RALA. Na-RALA is a powerful antioxidant and in addition to this it has a potential role in improving blood sugar control. In one study ALA, a 50/50 mixture of S-and R-Lipoic Acid, has significantly increased the insulin sensitivity of diabetic patients. [6-8]
L-Norvaline
L-Norvaline is an analog of the branched chain amino acid Valine. L-Norvaline works by inhibiting the arginase enzyme thus increasing arginine concentrations, which in turn increase circulating levels of Nitric Oxide, or NO2. NO2 is what is responsible for increased blood flow which results in a rapid and dramatic muscle pumps.[9]
Coleus Forskholii (20% forskolin)
Forskolin is one of the most interesting ingredients in Need2Slin. Scientific studies have found that along with increasing thyroid activity and thermogenesis, forskolin is also a potent anabolic. This occurs primarily through elevation of cAMP and forskolin is one of the best OTC compounds available for triggering dramatic increases in cAMP levels. In one study forskolin has shown to be able to increase cAMP levels 4.82 times more than a placebo. And in another study, forskolin demonstrated that it can raise cAMP levels in fat cells. This shows the ability of the compound to enhance lipolysis, which means that forskolin has powerful fat-burning effects as well as being a potent anabolic agent. Another added benefit of forskolin is that it increases cAMP independently of epinephrine, thus providing stimulant free energy. [10-12]
Synephrine HCL
Synephrine HCL is another powerful cAMP activator. It also activates the beta-3 adrenoreceptors and, therefore, displays a lipolytic and thermogenetic capacity as it boosts norepinephrine levels. Especially the beta-3 receptors, are the key to burning fat and by stimulation of these receptors, more fatty acids will be burned and used for energy.[13-14]
Banaba Leaf (20% corosolic acid)
The blood sugar regulating properties of banaba have been demonstrated in cell culture, animal and human studies. In isolated cells, the active ingredient in banaba extract, corosolic acid, is known to stimulate glucose uptake. In diabetic mice, rats and rabbits, banaba feeding reduces elevated blood sugar and insulin levels to normal. In one study banaba demonstrated to alleviate many of the symptoms of diabetes in genetically obese mice and may offer promise as a therapeutic supplement for the normalization of blood glucose levels in humans with hyperglycemia and have beneficial effects in patients with non-insulin-dependent diabetes mellitus. In humans with type II diabetes, banaba extract, at a daily dosage of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. In another study Researchers concluded that corosolic acid is an effective agent for the control of blood sugar without any side effects. Moreover, it was determined that even a one-time dose of corosolic acid created a "memory effect" in which the blood sugar support effects lasted for several days. Beside these 2 studies numerous clinical studies have continued to validate that corosolic acid can play an instrumental role in the prevention and treatment of hyperglycemia and obesity in type 2 diabetics.[15-16]
[1] Nahas and Moher 55 (6): 591. (2009);
Complementary and alternative medicine for the treatment of type 2 diabetes
[2] Phytother Res. 2010 Sep;24(9):1370-6.
A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro.
[3] J Ethnopharmacol. 1990 Oct;30(3):295-300.
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients.
[4] J Ethnopharmacol. 1990 Oct;30(3):281-94.
Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.
[5] Acetyl-L-carnitine
[6] Am J Med. 2011 Jan;124(1):85.e1-8.
Effects of alpha-lipoic Acid on body weight in obese subjects.
[7] Hormones (Athens). 2006 Oct-Dec;5(4):251-8.
Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid.
[8] Nutr Rev. 2008 November; 66(11): 646–657.
Alpha-lipoic acid supplementation and diabetes
[9] Am J Physiol. 1998 Jan;274(1 Pt 2):H342-8.
Arginase modulates nitric oxide production in activated macrophages.
[10] J Int Soc Sports Nutr. 2005; 2(2): 54–62.
Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women
[11] Obes Res. 2005 Aug;13(8):1335-43.
Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.
[12] http://www.drmajeed.com/articles/2002DiterpeneForskolin.pdf
[13] Gougeon R et al. "Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium." Obes Res. 13, 7:1187-94, 2005.
[14] Preuss HG et al. "Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview." J Med. 33, 1-4:247-64, 2002.
[15] Diabetes Res Clin Pract. 2006 Aug;73(2):174-7. Epub 2006 Mar 23.
Effect of corosolic acid on postchallenge plasma glucose levels.
[16] J Ethnopharmacol. 2003 Jul;87(1):115-7.
Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.
Need2Slin works, not like typical muscle gainers, primarily by it's ability to mimic/boost insulin and by increasing cAMP. Real insulin, actually breaks down the enzyme that caused cAMP which is why you can get fat if you don't know how to use insulin. cAMP is classified as a second messenger, meaning that it exerts it's effects by acting as a manner secondary and in response to a first messenger signaling molecule. When a first messenger signaling molecule binds to a cell surface, the second messenger is activated that increases cAMP production. cAMP signals your body how to produce energy to feed muscles, increasing Protein metabolism in the process, so you get a greater metabolic rate, improved glycogen uptake, increased Protein and fat synthesis and increased testosterone levels. So all the calories you eat are used to build muscle and this in combination with your hard training is enough to create an extremely anabolic environment!
The following experiment shows Need2Slin’s powerful insulin mimetic abilities in healthy individuals compared to hand picked supplements (chosen specifically for the purpose of increasing insulin response):
http://needtobuildmuscle.net/forum/f2/need-2-slin-experiment-9015.html
What are the benefits of Need2Slin?
It does a variety of things that every dedicated fitness enthusiast likes!
• Increase lean body mass
• Lower body fat
• Faster metabolism
• Boost thyroid output
• Increase testosterone
• Improve insulin sensitivity in muscle
• Improve glycogen uptake
• Improve Blood Lipids
• Increase natural energy
• Enhance muscular blood flow
• Increase Androgen receptor sensitivity
Direction:
To increase fat loss, take two capsules 30 minutes before each meal containing 40g of carbohydrates or more. To increase mass gains, use three capsules before each meal containing 60-100grams of carbohydrates. Use in conjunction with an appropriate diet and training program. Another popular method of use is to take just 1 capsule morning, noon, and night. This allows for constant steady levels throughout a 24 hour period.
Need2Slin's Ingredient profile:
Gymnema sylvestre (75% gymnemic acid)
Gymnema sylvestre is known as "destroyer of sugar" because Ayurvedic physicians observed that chewing a few leaves of Gymnema sylvestre suppressed the taste of sugar. In experimental and clinical trials, Gymnema sylvestre has been successful in controlling the blood sugar level without reducing it to below the normal blood sugar levels, an effect sometimes seen with the use of insulin or oral hypoglycemic therapy. Gymnema sylvestre can also play a role in treating conditions caused by excessive sugar intakes. Conditions like obesity, hyperglycemia, anemia and osteoporosis. [1-4]
Acetyl-L-Carnitine
Acetyl-L-Carnitine (ALCAR) is an acetylated form of L-Carnitine. It passes through the blood brain barrier better than L-carnitine, because of the acetylation. ALCAR helps shuttle free fatty acids into the mitochondria where they are burned off for energy. This is important because normally it is hard for the fatty acids to enter the mitochondria. This means more fat and less carbohydrates and protein, will be burned for energy in the mitochondria. ALCAR has also been shown to improve insulin response and it has been proven to have significant benefits on mood and overall health like improvements in ADHD, increasing fertility, reducing recovery from exercise, reducing fatigue, curing depression, reversing hyperthyroidism, healing cirrhosis of the liver, sexual enhancement, increased cardiovascular health, removing toxins from the body, and many other conditions. [5]
Na-RALA
Na-RALA is the sodium salt form of R-Lipoic Acid and it is 30% stronger than K-RALA. Na-RALA is a powerful antioxidant and in addition to this it has a potential role in improving blood sugar control. In one study ALA, a 50/50 mixture of S-and R-Lipoic Acid, has significantly increased the insulin sensitivity of diabetic patients. [6-8]
L-Norvaline
L-Norvaline is an analog of the branched chain amino acid Valine. L-Norvaline works by inhibiting the arginase enzyme thus increasing arginine concentrations, which in turn increase circulating levels of Nitric Oxide, or NO2. NO2 is what is responsible for increased blood flow which results in a rapid and dramatic muscle pumps.[9]
Coleus Forskholii (20% forskolin)
Forskolin is one of the most interesting ingredients in Need2Slin. Scientific studies have found that along with increasing thyroid activity and thermogenesis, forskolin is also a potent anabolic. This occurs primarily through elevation of cAMP and forskolin is one of the best OTC compounds available for triggering dramatic increases in cAMP levels. In one study forskolin has shown to be able to increase cAMP levels 4.82 times more than a placebo. And in another study, forskolin demonstrated that it can raise cAMP levels in fat cells. This shows the ability of the compound to enhance lipolysis, which means that forskolin has powerful fat-burning effects as well as being a potent anabolic agent. Another added benefit of forskolin is that it increases cAMP independently of epinephrine, thus providing stimulant free energy. [10-12]
Synephrine HCL
Synephrine HCL is another powerful cAMP activator. It also activates the beta-3 adrenoreceptors and, therefore, displays a lipolytic and thermogenetic capacity as it boosts norepinephrine levels. Especially the beta-3 receptors, are the key to burning fat and by stimulation of these receptors, more fatty acids will be burned and used for energy.[13-14]
Banaba Leaf (20% corosolic acid)
The blood sugar regulating properties of banaba have been demonstrated in cell culture, animal and human studies. In isolated cells, the active ingredient in banaba extract, corosolic acid, is known to stimulate glucose uptake. In diabetic mice, rats and rabbits, banaba feeding reduces elevated blood sugar and insulin levels to normal. In one study banaba demonstrated to alleviate many of the symptoms of diabetes in genetically obese mice and may offer promise as a therapeutic supplement for the normalization of blood glucose levels in humans with hyperglycemia and have beneficial effects in patients with non-insulin-dependent diabetes mellitus. In humans with type II diabetes, banaba extract, at a daily dosage of 32 and 48mg for 2 weeks showed a significant reduction in the blood glucose levels. In another study Researchers concluded that corosolic acid is an effective agent for the control of blood sugar without any side effects. Moreover, it was determined that even a one-time dose of corosolic acid created a "memory effect" in which the blood sugar support effects lasted for several days. Beside these 2 studies numerous clinical studies have continued to validate that corosolic acid can play an instrumental role in the prevention and treatment of hyperglycemia and obesity in type 2 diabetics.[15-16]
[1] Nahas and Moher 55 (6): 591. (2009);
Complementary and alternative medicine for the treatment of type 2 diabetes
[2] Phytother Res. 2010 Sep;24(9):1370-6.
A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro.
[3] J Ethnopharmacol. 1990 Oct;30(3):295-300.
Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients.
[4] J Ethnopharmacol. 1990 Oct;30(3):281-94.
Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.
[5] Acetyl-L-carnitine
[6] Am J Med. 2011 Jan;124(1):85.e1-8.
Effects of alpha-lipoic Acid on body weight in obese subjects.
[7] Hormones (Athens). 2006 Oct-Dec;5(4):251-8.
Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid.
[8] Nutr Rev. 2008 November; 66(11): 646–657.
Alpha-lipoic acid supplementation and diabetes
[9] Am J Physiol. 1998 Jan;274(1 Pt 2):H342-8.
Arginase modulates nitric oxide production in activated macrophages.
[10] J Int Soc Sports Nutr. 2005; 2(2): 54–62.
Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women
[11] Obes Res. 2005 Aug;13(8):1335-43.
Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.
[12] http://www.drmajeed.com/articles/2002DiterpeneForskolin.pdf
[13] Gougeon R et al. "Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium." Obes Res. 13, 7:1187-94, 2005.
[14] Preuss HG et al. "Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview." J Med. 33, 1-4:247-64, 2002.
[15] Diabetes Res Clin Pract. 2006 Aug;73(2):174-7. Epub 2006 Mar 23.
Effect of corosolic acid on postchallenge plasma glucose levels.
[16] J Ethnopharmacol. 2003 Jul;87(1):115-7.
Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study.
