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Human Chorionic Gonadotropin (HCG)


human chorionic gonadotropinHuman chorionic gonadotropin, known as HCG, is a drug commonly used by athletes at the end of after the end of a steroid cycle. This is not just because it has the potential of dramatically improving the level of naturally-occurring testosterone, but also due to the fact that it is extremely potent to treat undescended testicles in young males.

The synthetic form of this hormone is admired worldwide for its efficacy and dramatic weight loss results. It is considered by many athletes as one of the best products to lose fat, on the internet and at traditional supplement stores. Human chorionic gonadotropin also plays a role in cellular differentiation/proliferation and may activate apoptosis. It even helps athletes using steroids to avoid the ‘crash’ associated with the decreased or eliminated use of anabolic androgenic steroids.

Human chorionic gonadotropin (HCG) is best used during a steroid cycle to maintain testicular function so that testes are responsive to luteinizing hormone as soon as its production is restored. The significance of HCG in a steroid cycle is greater when the steroid stack is completely non-aromatizing in nature and dosed high enough to be fully inhibitory of natural testosterone production.

HCG is available in different forms like total hCG, C-terminal peptide total hCG, intact hCG, free β-subunit hCG, β-core fragment hCG, hyperglycosylated hCG, nicked hCG, alpha hCG, and pituitary hCG. It is a glycoprotein composed of 237 amino acids with a molecular mass of 25.7 kDa and is heterodimeric, with an α (alpha) subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and β (beta) subunit that is unique to hCG.

Human Chorionic Gonadrotropin acts in the body like luteinizing hormone (LH) to stimulate the testes for producing testosterone, the male primary sex hormone, when natural luteinizing hormone is not present or insufficient. HCG is extensively used parenterally as an ovulation inducer in lieu of luteinizing hormone and ovulation can be triggered by its administration, in the presence of one or more mature ovarian follicles. This hormone may be administered for enhancing the production of progesterone or to stimulate the Leydig cells for the synthesis of testosterone. HCG is also a popular drug to enhance the level of muscle gain without putting up weight and is usually offered as a glycoprotein powder to be diluted with water and taken by injection, either intramuscularly or subcutaneously.

A low calorie diet with 500 calories per day and HCG can do wonders to burn body fat and not muscles for fuel. Dosages of 100 IU daily, 200 IU EOD, or 250 IU three times per week for general use are effective while a dose of 500 IU EOD or 250 IU daily may be good enough for those into bodybuilding and amateur or professional sports.

HCG can lead to an increase in the levels of estrogens caused by the natural testosterone that may cause gynecomastia in some cases. High doses of this hormone may be associated with sodium and water retention and using HCG in doses above 500 IU may cause an increase in epitestosterone levels. It is highly recommended that the use of Human chorionic gonadotropin (hCG) should always be complemented with an ancillary drug like Nolvadex. The use of HCG should be stopped at least two weeks before stopping the use of Nolvadex else it may suppress the production of natural testosterone by itself.

HCG is not advised to girls and women, especially those who may get pregnant while using it or already pregnant or lactating. It is also not advised to children or those diagnosed with hypertension, high blood pressure, and prostate or breast cancer or liver damage, kidney damage, stroke, high blood pressure, and respiratory problems. Abuse or overdosing of HCG can lead to side effects like abnormal sperm production, a rise of estrogen in men (resulting in enlarged breasts), hair loss, or loss of sex drive.


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Written by
Albert Wolfgang is a professional medical writer with over 20 years of experience. He hold multiple personal training certifications, including the coveted NASM and AFAA certificates. He graduated with honors with a B.S. and M.S. in biochemistry with a minor in physical studies. Albert and his team have trained over 100 IFBB professional bodybuilders, including Hollywood stars and many up and coming fitness stars.

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