iPamorelin is one of the cleanest, most versatile and safest GHRP’s out there. The pentapeptide Ipamorelin is somewhat like Hexarelin, but it's cleaner. In some ways, it acts like GHRP-6 or GHRP – 2 without the sloppy sides of elevated hunger issues.
When it comes to peptides, you are going to want a slow and steady release for a strong, clean pulse that mimics natural GH release times. This is going to be better for gains and keeping unwanted side effects down. Ipamorelin acts like a ghrelin mimetic, but, unlike GHRP-6, it has shown to be more stable in suppressing somatostatin and stimulating GH release.
Summary of iPamorelin benefits
- No spikes in cortisol or prolactin at lower dosages.
- Increases LBM.
- Lowers body fat.
- Anti aging properties (faster recovery).
- Improves sleep and mood.
Table of Contents
In my last article on Hexarelin, we went over a list that described the strongest to mildest GHRP’s available. Hexarein came in at the top spot as the most potent GHRP, but it also touted high side effects and quick desensitization. The other end of the spectrum is Ipamorelin – the mildest GHRP. But don’t let its mild characteristics fool you, this pentapeptide can be used to spur a very large GH pulse that produces the least amount of side effects. Ipamorelin can easily be ran at 1200mcgs a day without breaching desensitization levels. Studies have shown that large saturation doses of Ipamorelin had almost no effect on the body’s natural GH production. This is ideal for athletes or bodybuilders concerned with shutting down their body’s natural GH production.
Looking at Ipamorelin’s functions, it can be said that it is similar to GHRP-6 in the way of increasing ghrelin and gastric motility, as well as, targeting a selective GH pulse. Though, the hunger sides on Ipamorelin are virtually zero. This makes it a much more versatile peptide for before-bed time dosing. Unlike GHRP-6 and GHRP-2, Ipamorelin was shown at high doses to have almost no direct impact on cortisol or prolactin production. This means users can dose higher and with greater frequency without having to be worried about cortisol and acetylcholine blood plasma levels being elevated. In short, it may be the mildest GHRP, but it is in no way the weakest. In fact, as a GHRP, it has shown to be one of longest lasting, and, at higher doses, the most potent. Ipamorelin’s function is a slow building one that is much more like the body’s natural growth hormone (GH) release. This makes it the healthiest choice in the bunch!
How does it Work?
After an athlete administers Ipamorelin, a selective pulse is sent that stimulates the hypothalamus/pituitary to release GH. This pulse can endure for approximately three hours after injection. Once the GH pulse is sent, the cells go directly to the muscle to support development while staying clear of any possible bone or cartilage growth. This is good for Ipamorelin users, as long term usage will effect lean body muscle growth without the possibility of experiencing any bone or cartilage deformities. The same cannot be said for synthetic HGH users, who experience pronounced side effect in swelling joints and even in some cases Carpel Tunnel. Ipamorelin will increase cell synthesis, elevate secretion levels of insulin from pancreatic tissue, and increase ghrelin in the stomach – which helps release GH and control hunger. All of these functions work to promote fat loss, shuttling of nutrients, and building clean muscle mass.
Even though Ipamorelin is the mildest and safest on sides out of the entire GHRP family, it still comes with side effects. Ipamorelin targets GH release like GHRP-6, but you won’t find Ipamorelin effecting FSH, PRL, TSH or LH blood serum plasma levels like GHRP-6 or GHRP-2. That being said, theoretically, at high doses Ipamorelin could cause an increase of cortisol or acetylcholine. In practice, when Ipamorelin is the sole GHRP in a cycle, there is hardly any increase in cortisol and acetylcholine blood plasma levels. This is even true if the injections are much higher compared to the effective dose for comparable growth hormone release. So, what are the side effects that can be expected with Ipamorelin? Most users will find the common side effect of a head rush-like feeling and slight headaches. It is suggested that users start supplementation at a lower dose and work their way up. In addition, it is best to inject Ipamorelin 30-45 minutes before working out so that the user is getting the double benefit of both growth hormones working together to maximize results.
Dosage and Usage
Ipamorelin, like other peptides, comes as a freeze dried powder that is very delicate. You can store it in the refrigerator or at room temperature before reconstituting. Once reconstituted with bacteriostatic water, the vials must be stored in a cool dry place like your refrigerator. Insulin syringes are the best way to administer it, usually via subcutaneous injection.
Of course, using iPamorelin with a GHRH like CJC w/out DAC will give the user the biggest increase in GH and IGF-1 as GHRP’s and GHRH’s work together synergetically. The average dosing for Ipamorelin is 200-300mcg two to three times daily. Twelve week cycles are quite normal and PCT would be very minimal – mini-pct is fine. If prolactin issues ever arise, there are products that help reduce prolactin and estrogen-like symptoms. These include aromatase inhibitors (Aromasin, Arimidex, Letrozole), and anti-prolactin aids like Dostinex (Cabergoline).
- Ipamorelin, the first selective growth hormone secretagogue
- Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats
- Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
- Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers
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