Gynecomastia, better known as manboobs, gyno and 'bitch tits,' is extremely embarrassing and can lead to psychological insecurities. While it occurs in many men, there is one drug that can treat this condition – letrozole. In this article, we will explain why letrozole is the best drug to fight gynecomastia, and we'll discuss the pro's and con's of using this drug.
Fig 1. Types of Gynecomastia
Table of Contents
What is gynecomastia?
Gynecomastia is the development of abnormal mammary glands in males due to high estrogen or prolactin levels (female hormones). For instance, you may notice that your girlfriend's breasts grow larger when she is near her period because her estrogen levels rise during this time, and the same thing will happen in pregnant women as a consequence of a rise in prolactin.
How men get gynecomastia?
I can remember in middle school there were several boys during P/E who refused to play sports shirtless because of gyno. As a result, even in adulthood they still do not want to take their shirt off at the beach, or in front of the opposite sex. This type of gyno is pubertal or adolescent, and it is caused by an imbalance in hormones during puberty years. Luckily, in some cases it will go away on its own, but in other cases it can linger into adulthood – or for life.
Nevertheless, this is not the only reason gyno can appear. Anabolic steroid use is another common cause of gyno. Unfortunately, certain anabolic steroids aromatize into estrogen, while others can lead to an increase in prolactin levels. Therefore, improper steroid use makes gynecomastia flare up rather quickly.
Steroids that can cause gynecomastia
Examples of steroids that aromatize into estrogen (and can cause estrogen based gyno) are deca durabolin, testosterone, dianabol, equipoise, and many pro-hormones. To complicate matters even more, anadrol is a DHT (dihydrotestosterone) derivative, so it does not convert to estrogen, but it does attach to estrogen receptors, which can cause gyno. Additionally, trenbolone can convert into prolactin, giving the user prolactin based gyno, which is extremely nasty. The good news is that you would typically need to run trenbolone for an abusively long period of time to have to deal with this problem.
Symptoms of gynecomastia
An early indication of gyno flaring up in those who use steroids is sensitive nipples and sore breasts (tenderness). Additionally, in serious cases there may be nipple discharge, which requires immediate action. Unfortunately, enlargement of the male breasts can sometimes be tricky to see because it can be confused with fat. Nonetheless, once it develops, it can be very embarrassing and will need immediate attention.
How letrozole solves gynecomastia?
Letrozole (femara) is the strongest oral aromatase inhibitor (AI) available, and studies have shown that it will drop estrogen levels in men by 65% and 98% in women. Hence, this makes letro more powerful than the popular AI's aromasin and arimidex (anastrozole). Part of the reason it is so strong is because it acts on competitive/reversible binding to the protein enzyme. Therefore, if a person finds themselves in trouble with high estrogen levels, letrozole can be used in a pinch to quickly halt gyno in its tracks before it gets worse.
Letrozole vs. Anastrozole Study
"Our data reveals that letrozole (2.5 mg o.d.) is more effective compared with anastrozole (1.0 mg o.d.) with respect to tissue as well as plasma estrogen suppression in patients with postmenopausal breast cancer."
Source: Clin Cancer Res. 2008 Oct 1;14(19):6330-5. doi: 10.1158/1078-0432.CCR-07-5221.
Interestingly, a study on rodents showed that letrozole actually destroyed breast tissue tumors. So it is not surprising that this drug is medically used to treat hormonally responsive breast cancer after surgery in post menopausal women. What's more, those who use anabolic steroids have discovered that it is a very potent drug to help them slam down estrogen very quickly and efficiently.
In spite of the need to drastically reduce estrogen levels, dropping this hormone quickly does have its drawbacks. It is important to remember that even though estrogen is a 'female hormone,' it still is important for males to have it. Therefore, the potency of letrozole comes with disadvantages; as a result, side effects include mood swings, depression, loss of libido, dry joints, immune system weakness, and a loss in muscle mass. Unfortunately, if gyno is present, the user will have to sacrifice in order to get the desired results of destroying gyno.
The dosages are individual dependent and can range from 0.25 to 1.00 mg (milligram) every day, or every other day.
Even though running letrozole solo can yield positive results, the anti-gyno protocol v3 calls for letrozole to be used as part of a stack, making it a much more aggressive means of fighting gynecomastia, but this stack is mostly recommended for those who have advanced gyno. Please see this link for a detailed explanation of this protocol.
Due to its potent attributes, letrozole should be your first option when wanting to stop or destroy gynecomastia.
Want to read about Letrozole and Gyno on our forums? check out these threads:
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