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Ostarine (MK-2866) during PCT

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MK-2866 Ostarine bottleThe first question we need to ask: Is Ostarine suppressive? Since I first suggested the use of Ostarine in PCT over 3 years ago, not much has changed. Ostarine is suppressive at certain doses but at the right dose it isn't. It doesn't allow for full recovery at any dose and it means PCT must be carried on with a PCT stack (think clomid/nolvadex etc) not Ostarine alone.

So why use it?

When a steroid cycle is finished the body is extremely catabolic, with increased cortisol and lowered IGF eating away at your new muscle. Ostarine (MK-2866) can prevent the immediate catabolism and allow for enough recovery to prevent this initial muscle loss.

Ostarine information.

These were my first experiences with this compound back in 2009.

First, some of you may have heard of one of the first sarms available, S-4 (Andarine), it's the most androgenic SARM. S-4 is 1/3 as strong as testosterone on androgen receptors in the muscles.

On the other hand, Ostarine SARM is much better at promoting lean body mass, its more potent, has a longer half life and displays no androgenic effects, its entirely anabolic.

The dose you may see in studies that showed good lean mass increases was about 3mg-5mg per person; well, before I recently started my myo-t12 log, I ran MK-2866 for 40 days. I dosed it at 10mg every day for 3 weeks 15mg for 1 week and 25mg for 1 weeks, and these are the results:

Weeks 1-3 (10mg): mass increases +3lbs, round full muscles, and increased strength, not as hard looking as you get with s-4, but very good quality, no bloat, no sides. This weight gain was mainly glycogen retention.

Week 4 (15mg): + 2 lbs in 1 week so 5 lbs overall by this stage, no sides, and no increase or decrease in libido like I had with s-4. Ostarine showed no effects on the testis in studies, and I would say its not just hype.

Week 5 + (25mg): +2 lbs, nice lean gains, and some fat loss, though I didn’t measure my BMI which is a shame. I compared s4 with winstrol in the past. Ostarine, I'd say that this is very similar to boldelone, but without any androgen activity, so probably more like primobolan.

The metabolite M1 which seems to cause toxicity in S-4 doesn’t seem to be in Ostarine. As I saw sides were only seen when using it at a much higher dose. In fact, at this point, it's my favorite SARM, as there is no need for multiple daily doses with the 24 hour half life. As a side note, one other thing I noticed was high dosages over 25mgs didn't lean to more gains, but clearly hit me with more side effects.

3 Months after this cycle, the blood work is showing slight suppression and an increase in oestrogen. Overall, I held on to about 5lbs, but I had a better v taper which showed me that fat loss had been profound; sadly, I hadn't done a BMI check before or after.

ostarine (mk-2866) chemical structure

Fig 1. Ostarine (MK-2866) Chemical Structure

My conclusions here

25mg/day is the correct amount for PCT, more than that will cause suppression. This dosage is enough to allow good recovery and help you keep your gains.


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Russian Star is an industry leader in peptide design and development. He is a fitness mentor with a Masters degree in molecular chemistry, he's working on his PhD in biochemistry.

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