Along with YK-11, S23 is one of the SARMS that has attained a mythical status of sorts.
So much so, that a lot of bodybuilders these days, who would have originally thought of adding an oral steroid like Anavar or Winstrol to their injectable cycle, are now considering adding S23 instead.
Instead of Dianabol + Test + Var or Deca + Test + Winny, we have Test + S23 producing nearly the same results.
Of course, Dianabol will blow you up a lot more, so will Deca. But you can produce results that are pretty close to what you can achieve with that stack, with S23 added to the mix.
Despite never making it past the pre-clinical stage, YK-11 has become one of the most popular SARMS amongst bodybuilders, thanks to its ability to build muscles almost on par with some anabolic steroids. Read More..
S23 has all the classic traits of an oral steroid. Some people call it a jacked up version of Winstrol. Others call it a high dose of Masteron, whereas there are a few who compare it with Andarine/ S4.
Yet, it is considered to be a SARM that you must use with extreme caution.
Else, it can leave you permanently shut down, or even worse, it can cause infertility. (Temporary though)
Did that get your attention?
Here’s five things that you must absolutely know before running an S23 or Shot 23 cycle.
1 – It is the strongest SARM in the world
S23 was developed from a SARM that was called C-6.
While C-6 was pretty effective at selectively modifying androgen receptors, it was marred by poor oral bioavailability. Also, its binding affinity to androgen receptors was not as good as RAD-140.
Testolone (RAD140) is the newest compound in the family of selective androgen receptor modulators, or as they are better known – SARMS. Therefore, its major advantage over anabolic steroids is that it offers similar positive results, with barely any side effects at all. Indeed, this is quite a unique compound, even when it is compared to other SARMS, and in this article we shall review the most interesting aspects of RAD140. Read More..
So, researchers picked up C6 and made a couple of modifications to the chemical structure. Bingo!
S23 was born. Not only did the bioavailability jump up from 72 to a whopping 96%, but the binding affinity to androgen receptors also increased manifold as well.
This means, that upon oral consumption, you get 96% serum plasma concentration without taxing your liver. Something that was only available with injectable steroids.
To put this into perspective, one of the SARMS that is considered to be extremely strong by most athletes who use it, is RAD-140.
RAD-140 has one of the strongest affinity towards androgen receptors, which makes it very potent at building lean muscle. In comparison, Shot23’s affinity towards androgen receptors is four times that of RAD-140.
How’s that for a strong anabolic compound?
2 - It increases lean body muscle dramatically
S23 is the most powerful muscle-building SARM in the world.
This stuff will blow you up. But it’s not the watery glycogen-filled gains of LGD. It’s not the minimal, lean muscle gain of RAD either.
LGD-4033 is rapidly increasing in popularity, as it has shown to be the strongest and most anabolic-like SARM in existence up to this point. SARMS are quite different from steroids in terms of their makeup, lack of side effects and recovery time. Read more ...
Think explosive muscle gains, almost on par with what you can get with low dose Trenbolone. That’s not a comparison that we make easily.
Most first-timers who use Shot 23 as a standalone SARM and combine it with a diet that has a calorie surplus, and a good workout program that uses progressive overload, will end up gaining at least 15-16 lbs. of quality muscle mass.
Again, some people prefer gaining a shitload of water weight and calling it muscle. Others prefer staying lean, ripped while still gaining a shitload of muscle. If you are one of the latter, S23 will get you there.
Also, this is a terrific compound to add to a cutting cycle. It helps mitigate catabolism and will definitely prevent muscle loss. Why it might even allow you to gain muscle even during extreme cuts.
3 – It burns fat
S23 will burn fat in a dose-dependent manner. This means, the higher the dose, more the fat loss that you experience.
The caveat is that the muscle-building effects do not dose-dependent. So, you’ll have to find an upper tolerable limit where the results are better than the side effects and stick to it.
This compound will allow you to do a complete body recomposition, without the need for any other compound.
If you are lean, to begin with, then it will make you hard and feathered, the kind of look that you’d get from Winstrol or a high dose of Anavar.
If you are holding some amount of fat and water on the belly, this stuff will torch it.
Researchers believe that its fat-burning properties are indirect by means of increasing the basal metabolism. But being a very strong androgenic compound, Shot 23 can burn fat directly as well.
4 – It is the most suppressive SARM
It can possibly shut you down. The most dreaded S23 side effect is that it will suppress you greatly.
All SARMS are suppressive. The moment the body detects an exogenous substance that’s competing with testosterone to bind to androgen receptors, the pituitary reduces the production of LH and in turn, your endogenous testosterone levels plummet.
But unlike most other SARMS, which result in a reduced LH production ranging from 20-30%, Shot 23 results in a 50% reduction in LH production in a span of just two weeks.
It’s difficult to put a number to how much that will suppress your testosterone levels. But a rough estimate says that the suppression can be close to 75%.
There are some users who have experienced a complete shut down while using S23.
This means that you can produce way better results if you run this with TRT or just a mild testosterone cycle.
There are some users who run a SERM along with this to offset some of the symptoms of low T.
Irrespective of how you choose to run S23, it’s a given that you will need to do a PCT to regain normal hormonal function after you complete the cycle. Your body might recover without the PCT as well, depending on your current health. But if you are looking to retain the gains and to keep your physiological functioning normal after stopping the cycle, then a PCT is a must.
5 – It can trigger androgenic side effects
Unlike other compounds like MK-2866 which are partial agonists of androgen receptors and are tissue-selective in their action, Shot23 is a full agonist and a very powerful androgen.
This means that there is every possibility that you might experience mild to severe androgenic side effects.
If this is the first time you are using S23, get ready for roid-rage like aggression and anger.
When we are faced with an event that we have no control over, our reaction can usually be anger! But does anger solve problems? No, it increases the problems and has medical side effects, including… https://t.co/40qp7L48MC
— Mental Health Matters (@MHmattersSOS) June 5, 2020
Most people are taken aback by how severe pronounced the aggression is, considering that you are using a SARM. Not an AAS.
Forums on our forums? read on:
- Preclinical Characterization of a (S)-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-3-(3-Fluoro, 4-Chlorophenoxy)-2-Hydroxy-2-Methyl-Propanamide: A Selective Androgen Receptor Modulator for Hormonal Male Contraception
- Selective Androgen Receptor Modulators (SARMs) - Current Knowledge and Clinical Applications
- Identification of S23 causing both interspecific hybrid male sterility and environment-conditioned male sterility in rice
- Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation
- Selective androgen receptor modulators: the future of androgen therapy?
- Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies
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