Before the infamous prohormone ban, there were many very effective products legally available for purchase, such as the most popular 1-AD (1-Androstenediol) and 4-AD (4-Androstenediol). However, in spite of the ban, there have been a number of different new “modern” prohormones to hit the market after the prohibition took place.
All in all, these products are very popular, but are they effective? Are they worth the money, or these are just the next product mainstream that supplement companies are marketing to young and naive gym rats? In this article, we will take a look at the first 5 of the top 10 most popular modern prohormones, and break down what they can actually do for you.
1-Andro (also known as Androsterone – 3b-hydroxy-androst-1-ene-17-one) is an endogenous steroid hormone and a weak androgen with approximately 1/7th of testosterone’s potency. Once introduced in the body, it converts to 1-Testosterone. Since this compound does not convert to estrogen or DHT, there cannot be any estrogenic side effects, such as gynecomastia or water retention. Additionally, 1-Andro is non-methylated, so there should be little or no liver toxicity at all, making liver supporting supplements unnecessary. Nonetheless, it is possible for blood work results to show liver enzymes slightly elevated.
This prohormone can be used for either a cutting or a bulking cycle. A good dose of 1-Andro would be 330 milligrams (mg) per day for 6-8 weeks. After finishing the cycle, a good mini PCT would be required, which should include clomid at 25mg per day, nolvadex at 20mg per day, and a good natural testosterone booster for 4 weeks.
4-Andro (also known as 4-Androsterone – 3b-hydroxy-androst-4-ene-17-one) is a precursor to 4-Androstenediol and 1-Androstenedione, which is a precursor to testosterone. This means that through a two-step conversion process, 4-Andro will convert into testosterone within the body. Just like 1-Andro, this prohormone is non-methylated and thus not toxic to the liver. However, it does aromatize to estrogen, so the use of an aromatase inhibitor (AI) is necessary when cycling this compound.
4-Andro is typically used as a bulking prohormone because it produces more muscle fullness, strength gains and size gains when compared to 1-Andro. In fact, 4-Andro is often stacked with 1-Andro as parts of a “bulking” cycle.
A good dose of 4-Andro would be 300-750mgs per day depending on individual experience with performance enhancing drugs (PEDs). Regarding the recommended cycle duration, the user would run it for 6-8 weeks. As mentioned above, you should use an aromatase inhibitor to block estrogen during the cycle, as well as something to keep blood pressure at normal levels. After using 4-Andro, a mini-PCT would be required. This should include clomid at 25mg per day, nolvadex at 20mg per day, and a good natural testosterone booster for 4 weeks.
This particular prohormone is unique because it is not even on the market yet. As its name suggests, 1,4-DHEA (also known as: 1,4-DHEA – 3b-hydroxy-androsta-1,4-diene-17-one) is the new DHEA version of the old Boldione prohormone that was banned in 2012. Two of the expected benefits of this product are appetite stimulation and joint repair.
5-DHEA (chemical name: 5-DHEA – 3b-hydroxy-androst-5-ene-17-one) is a hormone that is naturally made by the adrenal glands in the human body (specifically near the kidneys, liver, and by the testes in men). As you may already know, DHEA serves as a precursor to the male and female sex hormones (androgens and estrogens), and it works by converting to Androstenedione, which is then converted into testosterone.
Interestingly, after the age of 30, DHEA levels in the body begin to decrease. Therefore, 5-DHEA is a great compound for men who are just hoping to get into shape. Moreover, it will modulate cortisol levels, boost testosterone and lessen the side effects while on a cycle. As a result, when it is combined with an anti-estrogen, 5-DHEA can further boost testosterone and yield great results.
Interestingly, DHEA is also taken for systemic lupus erythematosus (SLE), Sjögren's syndrome (an immune condition characterized by dry mouth and dry eyes), weak bones (osteoporosis), a form of muscular dystrophy called myotonic dystrophy, fibromyalgia, multiple sclerosis (MS), low levels of steroid hormones (Addison's disease), depression, schizophrenia, chronic fatigue syndrome (CFS), muscle damage from exercise, inflammatory bowel disease, to slow the progression of Parkinson's disease, for withdrawal symptoms, and for a condition called atrichia pubis.
Epi-Andro (also known as: 3b-hydroxy-androstane-17-one) is naturally produced in the body by the 5a-reductase enzyme. This enzyme is less prevalent in some people, so natural production will vary from person to person. When taken orally, Epi-Andro converts to dihydrotestosterone (DHT), which is 5 times as androgenic as testosterone, making this compound efficient in increasing lean muscle mass, muscle hardness, strength, and aggression. As a matter of fact, some users have even experienced an increase in fat loss while using this prohormone. Since this compound is “dry” (no estrogen conversion), it is typically used when looking to gain strength and lean mass without experiencing any water retention.
A good cycle of Epi-Andro would be 300-400mg per day for 6-8 weeks, and you will definitely want to run an on cycle support supplement, since Epi-Andro can cause prostate swelling and increased blood pressure. As for the PCT, a mini PCT would be required, and it should include clomid at 25mg per day, nolvadex at 20mg per day, and a good natural testosterone booster for 4 weeks.
CLICK to READ Part 2 of my Top 10 Modern prohormone series....
- Effects of prohormone supplementation in humans: a review
- Synthetic Androgens as Designer Supplements
- Analysis of the nutritional supplement 1AD, its metabolites, and related endogenous hormones in biological matrices using liquid chromatography-tandem mass spectrometry
- Dietary Reference Intakes for Calcium and Vitamin D.
- Performance-Enhancing Drugs
- Insights into Supplements with Tribulus Terrestris used by Athletes
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