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Top 10 Modern Prohormones – Part 2

If you have not read part 1 of my Top 10 Prohormone series, please read it before you go on.

In Part 2 of the Top 10 Modern Prohormones we will discuss the remaining 5 compounds. Some of them are very unique in how they work, while some are simple conversions. After finishing this article you will have a good idea of what these products can do for you, and you'll be able to decide whether they are worth a try or not.


5aOHP (chemical name: 17beta-{1-Ketoethyl}-androstane-3-one, 17a-ol) is an anabolic progestin that converts to stanolone, which is better known as dihydrotestosterone or DHT for short. This causes 5aOHP to act like Winstrol because it helps achieve a lean look and adds mass without aggression. However, there is one major difference between winstrol and 5aOHP – the latter one will not cause any hair loss that is commonly associated with the use of winstrol.


Fig 1. 5aOHP Chemical Structure

A good dosage would be 100-200 milligrams (mg) per day split into two separate doses. Unlike the case of many other prohormones, a very mild PCT after a cycle of 5aOHP should be enough. Typically a strong natural testosterone booster will do the job, although some users will also incorporate a SERM into their PCT protocol as an additional reassurance of proper recovery.


1,4-OHP (chemical name: 17beta-{1-Ketoethyl}-androsta-1, 4-diene-3-one, 17a-ol) is a precursor to boldenone, so just like equipoise this particular prohorome will increase appetite and will enhance recovery. Due to the appetite increase, 1,4-OHP is often used in a bulking stack, where it will help build lean mass without adding significant water quickly when compared to something like 4-Andro. All in all, this prohormone is highly anabolic and mildly androgenic, which will contribute to a nice increase in vascularity. Besides, it is also very easy on the joints.


This prohormone is very unique because it works on a completely new and different pathway. It is not an anabolic, progestin, or an estrogen, but 6-Keto still yields muscle growth and mass gains. Due to this, 6-Keto is the perfect prohormone to stack with virtually any other prohormone. Nonetheless, there is still a lot unknown about the specifics of this particular prohormone.


Fig 2. 6-Keto-Progesterone


7-Keto (also known as 7-Hydroxy-DHEA) is a derivative of DHEA, so this hormone does not actually build muscle in the traditional way we think of. Instead, it works by reducing cortisol, thus helping build muscle by stopping it from breaking down. This is the reason 7-Keto was used in many cortisol control products.


Fig 3. 7-Keto-DHEA

Interestingly, when studied on rats, 7-Keto demonstrated thermogenic activity. There was also a study done in 2007 on overweight human adults. In this study, it was determined that when 7-Keto was given in conjunction with a calorie restricted diet the result was a reversal of the decline in resting metabolic rate (RMR) that is normally associated with dieting. There was also a proven ability for 7-Keto to increase RMR by 1.4% above baseline levels, and give an increase of 5.4% when administered with a calorie restricted diet. The great thing about this particular hormone is that it produces these effects without impacting the cardiovascular or central nervous system (CNS), which is often the case with stimulant based thermogenic products. Therefore, it is not surprising that 7-Keto is added in many fat burning products.


This particular compound (chemical name: Androst 3 5-dien-7 17-dione) is a metabolite of 7-Keto, and it is a very strong suicide aromatase inhibitor (AI). In fact, it is often referred to as “Arimistane” or “Erase.” Although this hormone does not directly contribute to muscle building, it is a very beneficial compound, since many of the prohormones on the market today convert to estrogen, so the use of an aromatase inhibitor is necessary while using them. You would definitely want to use arimistane when running something like 4-Andro, or other very “wet” compounds.

arimistane chemical structure

Fig 4. Arimistane chemical structure


Every time there is a “crack down” on supplements and prohormones, companies rush to come out with the next best legal alternative to what was previously on the market. The 10 prohormones that were described in this series of articles are some of the most popular among those who use this class of compounds today, and, as time goes on, we will continue to see more and more of these products popping up at supplement stores. I hope you were able learn a lot about these prohormones and form your own opinion in regards to their value in bodybuilding.


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Matt Ashlar is a full time dad and an amazing bodybuilder. He has over 10 years of experience in bodybuilding, fitness, TRT and sarms. He's been at the forefront of supplement design and industry leaders. He has trained many bros in the community and helped guys iron out their cycles. He's a true PhD in our industry. He has the knowledge and the looks.

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