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Hey Gents,
Just wanted to share what has helped protect me over the years of using PEDs. More so for the newbies, since the same questions always pop up.
Firstly, I am by no means an expert, nor do I think I am inherently more knowledgeable or experienced than anyone else. I still have much to learn and plenty of people to learn from, so always do your own research too.
I’ll try to keep this straight to the point with a reason behind every compound, supplement, or ancillary. I do have the journal articles to support what I’m saying, so let me know if you want them. For readability, I’ve left them out.
I’m sure most of you already know the basics like staying hydrated to manage haemotocrit and blood pressure, and avoiding processed foods to improve cholesterol. So I’ll skip over lifestyle practices.
To start, I believe there are three things that arguably kill you quicker than anything else. If you control these, the chance of suffering a severe episode or death from gear use becomes much lower than baseline without a protocol:
1. Blood Pressure
2. Cholesterol
3. Haemotocrit
Liver and kidney management are just as important, but if we are talking strictly about abrupt mortality, those three are usually the main culprits.
---
1. Telmisartan
Not the strongest blood pressure medication, but one of the more well-tolerated with a wide array of benefits:
Decreases blood pressure by 8–12 mmHg (20–30% reduction in hypertensive risk).
Improves insulin sensitivity by 10–15% via mild PPAR-γ agonism.
Decreases CRP (C-Reactive Protein) by up to 25%, a key marker of systemic inflammation.
Reduces heart muscle thickening and improves arterial elasticity.
It is fat soluble, so it should be taken with food for maximum absorption.
Timing: Once per day.
---
2. Rosuvastatin & Ezetimibe Together
This is the gold standard combination for aggressive LDL reduction. Honestly, I don’t see the need to move to something more hardcore like a PCSK9 inhibitor unless you’re severely predisposed to cholesterol issues.
Why Rosuvastatin?
It appears to have less effect on crossing the blood–brain barrier compared to older statins, so it avoids many stereotypical statin side effects.
Why take both?
Some people are “hyper-absorbers” of dietary cholesterol. Ezetimibe reduces dietary cholesterol absorption, while rosuvastatin inhibits cholesterol synthesis in the liver. If you only take rosuvastatin, the body can compensate by absorbing more cholesterol. Together, you cover cholesterol from both ends.
Important note: Clinical literature shows that rosuvastatin can decrease CoQ10 levels, but this is easily offset with CoQ10 supplementation. You should be taking this anyway when using statins.
Increases HDL cholesterol by 5–10%.
Decreases triglycerides by 15–20%.
Decreases LDL cholesterol by 55–65% and ApoB by around 50%.
Decreases plaque rupture risk by 20–25% and stabilises arterial walls.
Decreases hsCRP by 30–40%, lowering inflammation.
Solubility: Fat soluble, best taken with food.
Timing: Once per day, usually evening.
---
3. Fish Oil
Decreases triglycerides by 20–30%.
Decreases blood pressure by 4–6 mmHg.
Decreases clotting and platelet aggregation by 15–20%. This partially offsets haemotocrit risk — it does not lower haemotocrit itself, but it reduces the blood thickness danger.
Decreases CRP by 20–25% and IL-6 by 20%.
Improves joint lubrication and brain membrane health.
Solubility: Fat soluble, best taken with meals.
Timing: Two to three doses per day.
---
4. TUDCA, NAC & Milk Thistle
This trio works synergistically, where the combined effect is greater than the sum of its parts.
TUDCA highlights:
Decreases ALT and AST by 20–40% and protects bile flow.
Slows fibrosis progression by about 40% in both animal and human studies.
Reduces jaundice and other liver disease symptoms by ~50%.
Improves insulin sensitivity by 10–20% and decreases fasting glucose by 5–15%.
NAC highlights:
Increases glutathione by 30–40% and decreases oxidative stress.
Increases nitric oxide bioavailability by up to 40%.
Reduces systemic inflammation by 15–30%.
Improves insulin sensitivity by 10–20%.
Decreases triglycerides by 10–15%.
Milk Thistle highlights:
Provides mild hepatoprotection, decreases liver enzymes by 10–15%.
Reduces fibrosis risk.
Together:
Provide 40–50% protection against steroid-related liver damage.
Strong reductions in oxidative stress (up to 50%).
Meaningful improvements in insulin sensitivity and systemic inflammation.
Solubility and Timing:
TUDCA is water soluble, split into two doses per day with food.
NAC is water soluble, best on an empty stomach, split into two doses. Avoid taking with protein as it can reduce absorption.
Milk Thistle is fat soluble, taken once per day with food.
---
5. Cialis (Tadalafil)
Most of you are already on this one anyway
Decreases blood pressure by 4–6 mmHg.
Improves nitric oxide release by 20–30%.
Decreases pulmonary hypertension by 15–20%.
Improves kidney blood flow and exercise oxygen efficiency.
Solubility: Fat soluble, take with food.
Timing: Once per day.
---
6. Astragalus Extract
Decreases proteinuria by 20–25%.
Improves GFR by 10–15%. (GFR is not the best kidney test — cystatin C is more accurate — but it still shows benefit.)
Strengthens immunity.
Decreases TNF-α and systemic inflammation by 10–15%.
Solubility: Water soluble, can be taken anytime.
Timing: Two to three doses per day.
---
7. Berberine & Alpha Lipoic Acid
This combination is easily as effective as metformin for improving insulin sensitivity. R-Alpha Lipoic Acid can be used instead for better bioavailability.
Berberine decreases HOMA-IR by 25–30%, indicating improved insulin sensitivity.
Berberine decreases LDL cholesterol by 15–20% and triglycerides by 15%.
Alpha Lipoic Acid increases mitochondrial function and improves insulin sensitivity by 15–20%.
Together they reduce liver fat accumulation by about 20%.
Solubility and Timing:
Berberine is fat soluble and should be taken with meals, split into three doses per day.
Alpha Lipoic Acid is water soluble and best on an empty stomach, split into two doses per day.
---
8. Curcumin & Citrus Bergamot
Curcumin decreases CRP by 20–25% and TNF-α (Measurement of Inflammation) by 15%. It also supports joint and cognitive health.
Citrus Bergamot decreases LDL cholesterol by 15–20%, decreases triglycerides by 15%, and increases HDL cholesterol by about 10%.
Both are fat soluble and should be taken with food.
---
9. Magnesium, Taurine & CoQ10
Magnesium decreases blood pressure by 3–4 mmHg and improves glucose control.
Taurine decreases blood pressure by 4–6 mmHg, improves endurance, and stabilises heart rhythm.
CoQ10 decreases systolic blood pressure by 8–10 mmHg, decreases CRP by 20%, and increases mitochondrial ATP production by 20%.
Magnesium and taurine are water soluble. CoQ10 is fat soluble and should be taken with food.
---
Final Notes
For haemotocrit, blood donation is the most effective way to manage elevated levels. If you cannot donate blood, IP6 and nattokinase are good alternatives.
In total I have used up to 35–40 different ancillaries and vitamins at once, but I have listed what I believe to be the essentials.
Other useful additions include (You don't need to take all these. I only did because I was seeing what improved my biomarkers and blood test results):
Vitamin D, probiotics, digestive enzymes, SAMe, nattokinase, vitamin K2, CDP-choline, phosphatidylcholine, glucosamine, pregnenolone, P5P, T4, L-theanine, grape seed extract, L-carnitine (both acetyl and tartrate), alpha GPC, sodium butyrate, butyric acid, oregano oil, L-tyrosine, iodine, selenium, and donepezil.
I have always had a fascination for biology, PEDs, and analysing bloodwork. My philosophy is that people are going to use this stuff anyway, even if we tell them not to, so it makes sense to share safer ways to do it. One day I would love to turn this into a side hustle, but for now I genuinely just enjoy helping others stay safe.
If you guys would like I can go over what I believe is the gold standard blood test you can get from imedical too.
Just wanted to share what has helped protect me over the years of using PEDs. More so for the newbies, since the same questions always pop up.
Firstly, I am by no means an expert, nor do I think I am inherently more knowledgeable or experienced than anyone else. I still have much to learn and plenty of people to learn from, so always do your own research too.
I’ll try to keep this straight to the point with a reason behind every compound, supplement, or ancillary. I do have the journal articles to support what I’m saying, so let me know if you want them. For readability, I’ve left them out.
I’m sure most of you already know the basics like staying hydrated to manage haemotocrit and blood pressure, and avoiding processed foods to improve cholesterol. So I’ll skip over lifestyle practices.
To start, I believe there are three things that arguably kill you quicker than anything else. If you control these, the chance of suffering a severe episode or death from gear use becomes much lower than baseline without a protocol:
1. Blood Pressure
2. Cholesterol
3. Haemotocrit
Liver and kidney management are just as important, but if we are talking strictly about abrupt mortality, those three are usually the main culprits.
---
1. Telmisartan
Not the strongest blood pressure medication, but one of the more well-tolerated with a wide array of benefits:
Decreases blood pressure by 8–12 mmHg (20–30% reduction in hypertensive risk).
Improves insulin sensitivity by 10–15% via mild PPAR-γ agonism.
Decreases CRP (C-Reactive Protein) by up to 25%, a key marker of systemic inflammation.
Reduces heart muscle thickening and improves arterial elasticity.
It is fat soluble, so it should be taken with food for maximum absorption.
Timing: Once per day.
---
2. Rosuvastatin & Ezetimibe Together
This is the gold standard combination for aggressive LDL reduction. Honestly, I don’t see the need to move to something more hardcore like a PCSK9 inhibitor unless you’re severely predisposed to cholesterol issues.
Why Rosuvastatin?
It appears to have less effect on crossing the blood–brain barrier compared to older statins, so it avoids many stereotypical statin side effects.
Why take both?
Some people are “hyper-absorbers” of dietary cholesterol. Ezetimibe reduces dietary cholesterol absorption, while rosuvastatin inhibits cholesterol synthesis in the liver. If you only take rosuvastatin, the body can compensate by absorbing more cholesterol. Together, you cover cholesterol from both ends.
Important note: Clinical literature shows that rosuvastatin can decrease CoQ10 levels, but this is easily offset with CoQ10 supplementation. You should be taking this anyway when using statins.
Increases HDL cholesterol by 5–10%.
Decreases triglycerides by 15–20%.
Decreases LDL cholesterol by 55–65% and ApoB by around 50%.
Decreases plaque rupture risk by 20–25% and stabilises arterial walls.
Decreases hsCRP by 30–40%, lowering inflammation.
Solubility: Fat soluble, best taken with food.
Timing: Once per day, usually evening.
---
3. Fish Oil
Decreases triglycerides by 20–30%.
Decreases blood pressure by 4–6 mmHg.
Decreases clotting and platelet aggregation by 15–20%. This partially offsets haemotocrit risk — it does not lower haemotocrit itself, but it reduces the blood thickness danger.
Decreases CRP by 20–25% and IL-6 by 20%.
Improves joint lubrication and brain membrane health.
Solubility: Fat soluble, best taken with meals.
Timing: Two to three doses per day.
---
4. TUDCA, NAC & Milk Thistle
This trio works synergistically, where the combined effect is greater than the sum of its parts.
TUDCA highlights:
Decreases ALT and AST by 20–40% and protects bile flow.
Slows fibrosis progression by about 40% in both animal and human studies.
Reduces jaundice and other liver disease symptoms by ~50%.
Improves insulin sensitivity by 10–20% and decreases fasting glucose by 5–15%.
NAC highlights:
Increases glutathione by 30–40% and decreases oxidative stress.
Increases nitric oxide bioavailability by up to 40%.
Reduces systemic inflammation by 15–30%.
Improves insulin sensitivity by 10–20%.
Decreases triglycerides by 10–15%.
Milk Thistle highlights:
Provides mild hepatoprotection, decreases liver enzymes by 10–15%.
Reduces fibrosis risk.
Together:
Provide 40–50% protection against steroid-related liver damage.
Strong reductions in oxidative stress (up to 50%).
Meaningful improvements in insulin sensitivity and systemic inflammation.
Solubility and Timing:
TUDCA is water soluble, split into two doses per day with food.
NAC is water soluble, best on an empty stomach, split into two doses. Avoid taking with protein as it can reduce absorption.
Milk Thistle is fat soluble, taken once per day with food.
---
5. Cialis (Tadalafil)
Most of you are already on this one anyway
Decreases blood pressure by 4–6 mmHg.
Improves nitric oxide release by 20–30%.
Decreases pulmonary hypertension by 15–20%.
Improves kidney blood flow and exercise oxygen efficiency.
Solubility: Fat soluble, take with food.
Timing: Once per day.
---
6. Astragalus Extract
Decreases proteinuria by 20–25%.
Improves GFR by 10–15%. (GFR is not the best kidney test — cystatin C is more accurate — but it still shows benefit.)
Strengthens immunity.
Decreases TNF-α and systemic inflammation by 10–15%.
Solubility: Water soluble, can be taken anytime.
Timing: Two to three doses per day.
---
7. Berberine & Alpha Lipoic Acid
This combination is easily as effective as metformin for improving insulin sensitivity. R-Alpha Lipoic Acid can be used instead for better bioavailability.
Berberine decreases HOMA-IR by 25–30%, indicating improved insulin sensitivity.
Berberine decreases LDL cholesterol by 15–20% and triglycerides by 15%.
Alpha Lipoic Acid increases mitochondrial function and improves insulin sensitivity by 15–20%.
Together they reduce liver fat accumulation by about 20%.
Solubility and Timing:
Berberine is fat soluble and should be taken with meals, split into three doses per day.
Alpha Lipoic Acid is water soluble and best on an empty stomach, split into two doses per day.
---
8. Curcumin & Citrus Bergamot
Curcumin decreases CRP by 20–25% and TNF-α (Measurement of Inflammation) by 15%. It also supports joint and cognitive health.
Citrus Bergamot decreases LDL cholesterol by 15–20%, decreases triglycerides by 15%, and increases HDL cholesterol by about 10%.
Both are fat soluble and should be taken with food.
---
9. Magnesium, Taurine & CoQ10
Magnesium decreases blood pressure by 3–4 mmHg and improves glucose control.
Taurine decreases blood pressure by 4–6 mmHg, improves endurance, and stabilises heart rhythm.
CoQ10 decreases systolic blood pressure by 8–10 mmHg, decreases CRP by 20%, and increases mitochondrial ATP production by 20%.
Magnesium and taurine are water soluble. CoQ10 is fat soluble and should be taken with food.
---
Final Notes
For haemotocrit, blood donation is the most effective way to manage elevated levels. If you cannot donate blood, IP6 and nattokinase are good alternatives.
In total I have used up to 35–40 different ancillaries and vitamins at once, but I have listed what I believe to be the essentials.
Other useful additions include (You don't need to take all these. I only did because I was seeing what improved my biomarkers and blood test results):
Vitamin D, probiotics, digestive enzymes, SAMe, nattokinase, vitamin K2, CDP-choline, phosphatidylcholine, glucosamine, pregnenolone, P5P, T4, L-theanine, grape seed extract, L-carnitine (both acetyl and tartrate), alpha GPC, sodium butyrate, butyric acid, oregano oil, L-tyrosine, iodine, selenium, and donepezil.
I have always had a fascination for biology, PEDs, and analysing bloodwork. My philosophy is that people are going to use this stuff anyway, even if we tell them not to, so it makes sense to share safer ways to do it. One day I would love to turn this into a side hustle, but for now I genuinely just enjoy helping others stay safe.
If you guys would like I can go over what I believe is the gold standard blood test you can get from imedical too.
.
