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Introduction
Welcome Evolutionary.org Hardcore 2.0 #190- Retatrutide and how bodybuilders can benefit by Para Pharma. In this episode, the guys go deeper under the hood of the car to discuss Retatrutide. They go over all the new stuff that has been coming out on the drug, and also give their unique perspectives on how you can best use this compound for fat loss success.
Retatrutide background facts
Retatrutide, also called LY-3437943, is considered the most modern GLP-1 drug that is currently available in the bodybuilding scene. It is designed for both diabetes and obesity. Although it isn't FDA-approved yet, it is expected to be approved within the next 1-2 years and has shown amazing progress among those who have been lucky enough to use it so far. Ely Lilly is developing it as an improvement on their widely successful drug called Tirzepatide. The main difference between these drugs is that Retatrutide is a triple-agonist hormone receptor medicine, while Tirzepatide is a dual-agonist hormone receptor medicine. Semaglutide is only a single agonist, which Steve explains is why the drug maker Novo Nordisk is getting their clocks cleaned by Ely Lilly and trying desperately to catch up with a newer version themselves.
Those who have used it have reported some amazing fat loss benefits, while also reporting very low side effects in the process. This makes it a far superior choice over outdated fat loss drugs since you get better results and you get fewer issues. Steve explains how he believes this drug, once approved, will be a huge hit and replace many other diabetes and obesity drugs.
What retatrutide does in the body
Steve digs deep to explain how Retatrutide works so you can understand the benefits. As mentioned already, it does 3 things as a triple agonist in the body to change what is going on.
- It regulates insulin secretion and appetite by acting on the GLP-1 receptor. GLP-1 stands for glucagon-like peptide-1.
- It improves glucose and lipid metabolism by acting on the glucose-dependent insulinotropic polypeptide (GIP) receptor.
- The 3rd thing that it does is change your energy expenditure by acting on the glucagon receptors (GCG-r).
Essentially, using this drug will turn your body more into a fat burner rather than a fat storer.
Mobster then discusses fat loss alternatives and goes over the nasty side effects that people have resorted to over the years. Retatrutide won't give you these issues such as enlarged heart, raised HR, raised body temperature, explosive anal leakage, sweating orange colors, etc.
Steve then gets into the diabetes aspect and how beneficial Retatrutide is for those and explains why.
What the studies show
Steve says that phase 3 studies are coming in 2026, but as of this podcast, we have plenty of solid studies that have previously been done, and more have been hitting the wire.
They have shown improvements in things like HbA1c, fasting glucose, lipid health, blood pressure, and more. There have also been studies showing a reduction in tumor volume for things like pancreatic cancer.
When it comes to fat loss, the studies are something special. Steve talks about a study that showed that, on average, users lost over 40 pounds or 18% of their body weight after just 6 months on the drug. The same study had people go 11 months total and ended up still losing an additional 15 pounds and an additional 7% of their body weight on top.
Another study took a look at results for those on the drug for a year and showed a 24% total weight loss when users used between 8 and 12 mg per week. This beat every other drug tested in the study, and it wasn't even close.
https://www.sciencedirect.com/science/article/pii/S2667368125000063
Another study involved 350 adults, and it was almost an even split between males/females. Those who only ran 1mg for 24 weeks still lost over 7% of their body weight. Those who did 4 mg lost 13%, those who did 8mg lost 17%, and those who did 12mg lost 18%. The placebo group only lost 1%.
https://www.diabetes.co.uk/news/2025/mar/retatrutide-melts-fat-fast-but-at-a-cost-warn-experts.html
Mobster talks about this study, which he said annoyed him because he showed it could cause bone issues or kidney problems. Out of the study, only 2 people had any issues, and they were people who dropped way too much weight, too fast, and were skipping dosages. The other one lost 33% of their body weight quickly and developed kidney stones. Steve says that it likely was caused by dehydration since your body is shedding body fat via the urine.
Mobster then goes over a couple more things he found that he wanted to talk about and rants a bit.
https://www.medscape.com/viewarticle/retatrutide-produces-greatest-weight-loss-2025a100009a
Dosages and sides
The dosages on these drugs have been shown in studies to vary from 1mg to 12 mg. However, for most of you, Steve thinks you should start at 1-2 mg a week, then you can gradually increase the dose to up to 2mg, 3 mg, and a maximum 4mgs. He does not see a point in going higher. You also should allow the drug 3-4 weeks to reach peak levels, as it is designed to be a slow-release drug with a long half-life.
Mobster then debates weekly injections vs. microdosing the product.
The symptoms that are usually reported are things like diarrhea, heartburn, nausea, and stomach upset. Steve says that you can greatly reduce your chances of side effects by simply watching your diet and only eating clean foods.
Another issue is rebound effects when you come off. This is a very real issue that you need to be aware of before you use Retatrutide.
Where to buy?
Para Pharma can be purchased from Ugfreak.to.
Ugfreak.to is an approved source that has been around for 15 years, providing customers with outstanding oral steroids, injectable steroids, ancillaries, PCT products, and more. When you purchase from them, you know you are getting the authentic Para Pharma brand and not fakes.
They provide lightning-quick domestic shipping to American customers, with no need to worry about customs and no need to stress about how long it takes. They ship typically within a few days, and you get your package lightning fast. They also offer international shipping to many other countries.
They have reps on the forums to further assist with setting up cycles and answer questions you may have. If there is ever an issue, they are on call to help with your order and make sure you are taken care of.
Forums
Forums on our forums? read on:
The age old debate about whether you need to be in a surplus to gain muscle. If you’re using anabolics how does this change eating at maintenance? Would you gain more Read More.........
I’ve noticed that certain supplements don’t do anything for me. While some supplements work really good Read More..........
I’m 40 years old and I’ve been cycling steroids for the past 5 years. I took a break before that but I was also using steroids in my early 20s I got blood work Read More..........
My goals are to gain some lean-moderate muscle mass. And also recomp. I’m 5’9’’ and 175 pounds with 12% body fat. 37 Read More..........
I’m looking to do some testosterone boosting to build more muscle right now my physique is pretty lean and skinny and I weigh about 138 pounds Read More..........
References
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- Remote functionalization reactions in steroids: discovery and application
- Steroids and the endometrium
- Steroids-dopamine interactions in the pathophysiology and treatment of CNS disorders
- Evidence for a key role of steroids in the modulation of pain
- Heterocyclic steroids: Efficient routes for annulation of pentacyclic steroidal pyrimidines
