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Arimistane (Androsta-3,5-diene-7,17-dione) is a metabolite of 7-Keto DHEA, which does not convert into testosterone or estrogen.  In fact, just like the drug Aromasin, arimistane is actually a suicide aromatase inhibitor (AI), so it will permanently bind to the aromatase enzyme and prevent any estrogen rebound.  Furthermore, it has also been shown to reduce cortisol, raise LH (luteinizing hormone), and increase testosterone levels.

arimistane chemical structure

Fig 1. Arimistane chemical structure

Table of Contents

What is cortisol?

Cortisol is produced in the adrenal glands, and it's a nasty steroid hormone that spikes when a person is stressed (physically and mentally), or when blood glucose drops.   When cortisol rises it will do many negative things, including suppressing the body's immune system, eating away at muscle, and storing fat.  What's more, it can cause fluctuations in allergies and inflammation in the body.

Unfortunately, athletes will experience a rise in cortisol during and after their workouts, which can negate potential benefits they are trying to achieve.  For this reason, inhibiting cortisol can make your workouts more efficient, allowing you to work out harder and get greater returns on your investment.  Therefore, arimistane will be extremely useful for an athlete, as it will help keep your cortisol levels in check.

estrogen chemical structure

Fig 2. Estrogen chemical structure

What is estrogen?

Estrogen is known as a female hormone, and when a person runs an anabolic steroid that aromatizes into estrogen (such as testosterone, dianabol, deca durabolin, etc) it will cause a rise of estrogen in the body.  As we all know, high estrogen levels will cause many problems in the individual.  For instance, water retention, bloating, high blood pressure, insomnia, are some of the most widespread problems caused by the domino effect triggered by estrogen.  Hence, people should run an aromatase inhibitor (AI) while using those compounds in order to keep estrogen in check.  However, arimistane not only inhibits estrogen – it also prevents this hormone from rebounding after cycle.  As a matter of fact, this is why we call it a suicide aromatase inhibitor.

On the flip side, not having enough estrogen can cause problems as well.  Sometimes, using too much of the wrong aromatase inhibitor can backfire on a person, since low estrogen can cause problems like low libido, joint issues, and mood swings.  Nevertheless, arimistane is a mild compound that won't slam down your estrogen, like letrozole would.

cortisol chemical structure

Fig 3. Cortisol chemical structure

User results

  • Those who take arimistane report several benefits from this compound:
  • Increase in testosterone levels
  • Improved recovery
  • Drying out/hardening and more vascularity
  • Increased libido
  • Reduced fat storage
  • Lowering of cortisol and estrogen levels

How to Use

Arimistane is strong enough to use on cycle, and also gentle enough to use during post cycle therapy (PCT), or solo as well.

Dosages on cycle are dependent on what compounds you are stacking it with, but generally users will run it at around 100 milligrams (mg) per day.  Meanwhile, during PCT it can serve as an AI at 50mgs per day (ED) or every other day (EOD).  Finally, as solo you can take 100-200mgs of arimistane, for 4 weeks on, and off.

Side Effects

Due to arimistane's mild nature, users can enjoy its benefits with little concerns about side effects.  However, if abused or used incorrectly, the individual can experience low estrogen side effects such as joint pain, mood swings, and a drop in libido.

Where to find

Arimistane is still legally sold online as part of certain supplements.  On such supplement is DSpark, as it contains arimistane and is sold at n2bm.com.  All in all, when looking for arimistane make sure you only use a trusted supplement company.


Want to read about Arimistane on our forums? check out these threads:


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Steve Smi (Also known as Steve Smith), has over 12 years of experience in the bodybuilding and fitness industry. He's the co-Host of the popular Evolutionary Radio Podcast - over 500,000 listens! He has been a personal trainer and writer for the last 10 years with over 1000 articles written. He's been a moderator on forums for over 10 years. Steve holds the following certifications and records: NASM Personal Trainer NASM Fitness Nutrition Specialist Florida Local Powerlifting champion Top writer for 2019 Fitness rated

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