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I have been doing a lot of reading on both substances the last few nights and came across this good article. so decided to share it with NTBM family.
please discuss... share your experience, thoughts, knowledge, etc.
and just an FYI... extreme peptide carries both of these substances for your research needs.
Follow Russianstars link:
http://www.extremepeptide.com/Idev//...ate.php?id=103
- StageX
*****************************************************
Clenbuterol vs. albuterol
By Anthony Roberts
One of the first articles I ever wrote which was widely circulated
was about Clenbuterol. I wrote it partially to clear up some
misconceptions about the drug, and partially because I got tired of answering
the same questions over and over. Several years later, that article
has been circulated on almost every anabolic steroid discussion board
on the internet, and those boards who havent actually reposted the
article still regularly discuss one of the concepts pioneered in the
article namely the use of Benadryl with Clenbuterol.
Now, its several years later, and Ive mostly abandoned Clen for my
own personal use, and actually recommend Albuterol (Salbutamol) as a
much better alternative. Albuterol is a (relatively) selective beta-2
adrenoreceptor agonist, just like Clenbuterol. Honestly, I had pretty
much given up on Clen a couple of years ago because for my own
personal reasons (I had experienced much better results with Ephedrine and
Caffeine). Then, a couple of weeks ago, I tried my first bottle of
Albuterol, mostly out of curiosity and wow! I like it much more than
Clenbuterol. I mentioned this fact to my research assistant, and she
told me that a lot of figure competitors also prefer Albuterol over
Clenbuterol. I had no idea about that, but based on the effects I had
with Albuterol I can see why. Clen is simply too harsh on most
people; they get too jittery, too shaky, and too anxious. It's a lot to
go through to burn some fat.
But in my own personal experience, Albuterol produces a much
cleaner type of stimulant effect than Clenbuterol. I don't know how
to really describe this other than to say that the Clen-shakes
just arent as bad with Albuterol in addition, Im able to focus
better on my work when I use Albuterol, while with Clen Im
stimulated but not really focused.
But even though Albuterol produces a much cleaner stimulant-type
feeling in most people, the main question is “How well does it burn
fat? As far as fat-burning stimulants go, how does it stack up to
Clenbuterol? Lets face it, most people are really only concerned with
the end results, right? Well, at least in me and the people I've
worked with, Albuterol seems to produce significantly better results than
Clen in terms of fat burning effects and it produces them just a
bit more quickly too. This makes sense, if you think about it.
Albuterol is often thought of as a shorter acting version of
Clen and, to draw an analogy, when we look at the steroids which are shorter
acting versions (think about comparing something like Testosterone
Propionate vs./ Cypionate, or NPP vs./ Deca)- they typically produce
more dramatic results a bit quicker than their long acting cousins.
I'm finding the same thing to be true with Albuterol. When we take a
look at a medical study!
examining Clenbuterol vs. a beta-2 agonist which has an even longer
half life Salmeterol, we see that Clen out performs it in
terms of anabolic effects (1). So I think it would only be logical to
assume that something that was a shorter acting beta-2 agonist than
Clen would likely outperform it, right?
Let me just restate that, to make sure we're all on the same page,
ok? Clenbuterol outperforms longer acting beta-2 agonists, in terms
of anabolic effects. Albuterol is a beta-2 agonist with a shorter
acting effect than Clenbuterol. Therefore, it's only logical that
Albuterol is going to be more anabolic than Clen, right? Ok, let's move
on.
To understand how Albuterol works, first we need to take a look at
the Beta adrenergic system. This system is comprised of something
called adrenoreceptors, and the most well known (to bodybuilders anyway)
of the adrenoreceptors are the beta receptors. Beta receptors are
embedded in the cell's outer phospholipid membrane, and are stimulated by
all the really popular stimulants ephedrine, Clenbuterol, etc...
These receptors can further be divided into three subtypes: 1, 2, & 3,
(of which we are primarily concerned with type-2, because the type-3
variety seems to primarily be less relevant in humans than in other
animals, and because Albuterol doesn't stimulate the type-1
receptor). There also exists a type of receptor known as an alpha receptor,
which isn't relevant here, but warrants a brief explanation.
Alpha receptors differ from beta receptors in that they are activated
at significantly lower catecholamine levels than are the beta
receptors. A catecholamine is simply an organic compound that affects the
sympathetic nervous system. For example, dopamine, norepinephrine and
epinephrine are all catecholamines.
We are, as I said previously, mostly concerned with Beta-2 receptors,
because those are what we see stimulated with Albuterol. It should
come as no surprise to anyone who has used Clenbuterol as well as
Albuterol is that when you stimulate your beta receptors, it causes
something called vasodilatation (increased blood flow). Stimulation of
these receptors also stimulates the break down of fatty acids into the
blood stream for use as fuel, which causes a reduction in stored fat.
Of course, this increased blood flow also comes with an increased
heart rate.
This explains how Beta-2 adrenergic stimulation can also increase
your body temperature a bit however this isn't something that's
too noticeable on a thermometer most people will feel a bit hotter,
and some will even break a sweat (I fall into the latter category).
Beta-agonists work to do this by increasing heat production in the
cell's powerhouse, the mitochondria, which will also increase your
basal metabolic rate, and decrease your appetite. Not too many people
feel hungry after a whopping dose of stimulants.
There is also some evidence that Beta-Agonists are anabolic (more
properly, however, this would actually be anti-catabolic). This is
because Beta-agonists also act to initiate a hormonal cascade that
involves the activation of a compound called cAMP (basically:
cyclic-Adenosine Monophosphate). After this, cAMP activates calpistatin that is the
inhibitor of calpain. Calpain works to degrade protein in skeletal
muscle (among other functions). Therefore, we already saw that how
stimulation of beta 2 receptors have the ability to increase energy
expenditure and free up body fat to be used as fuel, and now we have some
understanding of how that stimulation can also have the potential to
be anti-catabolic as well .
Now that we're all on the same page regarding the beta-adregenic
system, and what sorts of effects we can expect when we stimulate it
with beta-2 agonists lets take a more specific look at Albuterol, and
why I think it's such a great compound.
When we take a look at Albuterol's ability to burn fat, it's
clear that it has the ability to aid fat loss in both normal as well as
obese men (2). That's not very different from Clenbuterol, in any
way. However, in my personal experience with it, I think that Albuterol
really outperforms Clen in areas of strength gains as well as for
athletic purposes. lets take a look at my claim and see how Albuterol
performs in humans.
In one study, subjects were given Albuterol and performed 9 weeks of
isokinetic knee extensions (there was also a group who performed the
same exercise routine but were not given Albuterol). The Albuterol
group, predictably, had better strength gains than the non-Albuterol
group (only a therapeutic dose was given) (3). In my own experience,
strength gains with Albuterol are much better and seen more quickly
than I see them with Clen. In fact, while I don't particularly
experience much of a performance enhancing effect from Clen in the gym; on
the other hand I see strength gains and muscular improvements within
the first couple weeks of using Albuterol. Of course, this is likely
a pure anabolic effect and probably not easily explained as a simple
enhanced anti-catabolic effect, and likely can't be explained
away with the Calpain idea you read about earlier. I still think that
I can take a pretty good shot at explaining why Albuterol is
anabolic, though. Strong body of evidence exists to suggest that Albuterol influences the
release of cAMP. As you may know, cAMP also plays an important role in
mediating certain catecholamines secreted by the adrenal medulla have
an inhibitory effect on muscle dependent protein degradation, but in
addition, norepinephrine released from adrenergic terminals may
actually increase the rate of protein synthesis(not just decrease the rate
of their degradation) in oxidative muscles, thereby leading to
increased protein accretion (representing a true anabolic effect). That's
most likely the way that we receive part of the anabolic effect from
Beta-stimulation. Another way is perhaps through the beta-adrenergic
stimulated lowering of Interleukin-6 from fat cells (long story).
Anecdotally, Clenbuterol and ephedrine have both shown themselves
capable of temporarily increasing strength, and I would bet most
beta-agonists have this effect, but I don't think has been shown as
conclusively in the medical literature as it has been with Albuterol.
Albuterol has been shown to increase muscle size (3-6) as well as strength
and endurance (3) while people have anecdotally reported that Clen
seems to lower their aerobic capacity. Clenbuterol has a disadvantage
when compared with Albuterol in the area of strength gains, probably
due to the act that it use-dependently inhibits action potential
firing in skeletal muscle fibers, which is not directly caused by
inherent Beta-2 stimulant activities (7) . I think that's the best
quasi-scientific explanation I Again, my own personal experience and that
of my research assistant(s) would also seem to strongly support this
claim all of us have gotten leaner, bigger and stronger with the use
of Albuterol, while with Clen, we got more ripped but not really stronger (and certainly
not much bigger). Anecdotally, we've seen Clenbuterol fall a bit
flat when people use it for anabolic effects, although in animals it
would appear to be highly anabolic, though human studies are a bit
shaky (ha!) in this area.
One of the things I really like about Albuterol is that it has the
potential to actually be used on my cycle to make it safer by improving
my lipid profile (cholesterol) or during PCT to help get my
cholesterol levels back in check. This is because Albuterol shows
significant benefits to cholesterol as it works to lower total cholesterol,
specifically LDL (the bad stuff) while at the same time elevating HDL
(the good stuff).(8)
In my own particular case, cholesterol never seems to be an issue,
but now that I'm working with Oasis for HRT, it's certainly in my
best interests to show up every three months with nice looking blood
work.
So now is the part you've been waiting for (or the part you
skipped to, ignoring the rest of the article whatever). How much of
this should you take, and how often? Well, I can tell you that I have
found the best results by working my way up from 4mgs taken once a
day, up to 4-8mgs taken 3x a day. I know that some people will think
that 24ms a day of this stuff is going to be too much (it is, after all,
a stimulant). But I can tell you that I have a pretty good tolerance
for stimulants (I've taken up to 200mcg/day of Clenbuterol, and
some other pretty hefty stimulants that I probably shouldn't mention
in polite company). Most people are going to find their sweet spot at
about 4mgs of Albuterol 3x a day or so women will probably take
about half that dose, and be fine with it.
I think that Albuterol is about to become very popular, very
soon and I, for one, am looking forward to seeing less of my old Clen
article around the net, and more of this one.
References:
1. Anabolic effects of the beta 2-adrenoceptor agonist salmeterol are
dependent on route of administration
N. G. Moore, G. G. Pegg, and M. N. Sillence
Am J Physiol Endocrinol Metab, Sep 1994; 267: E475 - E484.
2.Schiffelers SL, Saris WH, Boomsma F, and van Baak MA. beta(1)- and
beta(2)-Adrenoceptor-mediated thermogenesis and lipid utilization in
obese and lean men. J Clin Endocrinol Metab 86: 2191–2199, 2001
3. Effect of salbutamol on muscle strength and endurance performance
in nonasthmatic men. Med Sci Sports Exerc. 2000 Jul;32(7):1300-6.
4. J Strength Cond Res. 2005 Feb;19(1):102-7. Oral Albuterol dosing
during the latter stages of a resistance exercise program
5. The effects of Albuterol and isokinetic exercise on the
quadriceps muscle group.Med Sci Sports Exerc. 1995 Nov;27(11):1471-6
6. Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal
muscle strength in young men.Martineau L, Horan MA, Rothwell NJ, Little
RA
7. Different Ability of Clenbuterol and Salbutamol to Block Sodium
Channels Predicts Their Therapeutic Use in Muscle Excitability
Disorders
Jean-François Desaphy, Sabata Pierno, Annamaria De Luca, Paola
Didonna, and Diana Conte Camerino
Mol. Pharmacol., Mar 2003; 63: 659
8. Metabolism. 1996 Jun;45(6):712-7 Effects of oral albuterol on
serum lipids and carbohydrate metabolism in healthy men. Maki KC,
Skorodin MS, Jessen JH, Laghi F
***********************************************************
please discuss... share your experience, thoughts, knowledge, etc.
and just an FYI... extreme peptide carries both of these substances for your research needs.
Follow Russianstars link:
http://www.extremepeptide.com/Idev//...ate.php?id=103
- StageX
*****************************************************
Clenbuterol vs. albuterol
By Anthony Roberts
One of the first articles I ever wrote which was widely circulated
was about Clenbuterol. I wrote it partially to clear up some
misconceptions about the drug, and partially because I got tired of answering
the same questions over and over. Several years later, that article
has been circulated on almost every anabolic steroid discussion board
on the internet, and those boards who havent actually reposted the
article still regularly discuss one of the concepts pioneered in the
article namely the use of Benadryl with Clenbuterol.
Now, its several years later, and Ive mostly abandoned Clen for my
own personal use, and actually recommend Albuterol (Salbutamol) as a
much better alternative. Albuterol is a (relatively) selective beta-2
adrenoreceptor agonist, just like Clenbuterol. Honestly, I had pretty
much given up on Clen a couple of years ago because for my own
personal reasons (I had experienced much better results with Ephedrine and
Caffeine). Then, a couple of weeks ago, I tried my first bottle of
Albuterol, mostly out of curiosity and wow! I like it much more than
Clenbuterol. I mentioned this fact to my research assistant, and she
told me that a lot of figure competitors also prefer Albuterol over
Clenbuterol. I had no idea about that, but based on the effects I had
with Albuterol I can see why. Clen is simply too harsh on most
people; they get too jittery, too shaky, and too anxious. It's a lot to
go through to burn some fat.
But in my own personal experience, Albuterol produces a much
cleaner type of stimulant effect than Clenbuterol. I don't know how
to really describe this other than to say that the Clen-shakes
just arent as bad with Albuterol in addition, Im able to focus
better on my work when I use Albuterol, while with Clen Im
stimulated but not really focused.
But even though Albuterol produces a much cleaner stimulant-type
feeling in most people, the main question is “How well does it burn
fat? As far as fat-burning stimulants go, how does it stack up to
Clenbuterol? Lets face it, most people are really only concerned with
the end results, right? Well, at least in me and the people I've
worked with, Albuterol seems to produce significantly better results than
Clen in terms of fat burning effects and it produces them just a
bit more quickly too. This makes sense, if you think about it.
Albuterol is often thought of as a shorter acting version of
Clen and, to draw an analogy, when we look at the steroids which are shorter
acting versions (think about comparing something like Testosterone
Propionate vs./ Cypionate, or NPP vs./ Deca)- they typically produce
more dramatic results a bit quicker than their long acting cousins.
I'm finding the same thing to be true with Albuterol. When we take a
look at a medical study!
examining Clenbuterol vs. a beta-2 agonist which has an even longer
half life Salmeterol, we see that Clen out performs it in
terms of anabolic effects (1). So I think it would only be logical to
assume that something that was a shorter acting beta-2 agonist than
Clen would likely outperform it, right?
Let me just restate that, to make sure we're all on the same page,
ok? Clenbuterol outperforms longer acting beta-2 agonists, in terms
of anabolic effects. Albuterol is a beta-2 agonist with a shorter
acting effect than Clenbuterol. Therefore, it's only logical that
Albuterol is going to be more anabolic than Clen, right? Ok, let's move
on.
To understand how Albuterol works, first we need to take a look at
the Beta adrenergic system. This system is comprised of something
called adrenoreceptors, and the most well known (to bodybuilders anyway)
of the adrenoreceptors are the beta receptors. Beta receptors are
embedded in the cell's outer phospholipid membrane, and are stimulated by
all the really popular stimulants ephedrine, Clenbuterol, etc...
These receptors can further be divided into three subtypes: 1, 2, & 3,
(of which we are primarily concerned with type-2, because the type-3
variety seems to primarily be less relevant in humans than in other
animals, and because Albuterol doesn't stimulate the type-1
receptor). There also exists a type of receptor known as an alpha receptor,
which isn't relevant here, but warrants a brief explanation.
Alpha receptors differ from beta receptors in that they are activated
at significantly lower catecholamine levels than are the beta
receptors. A catecholamine is simply an organic compound that affects the
sympathetic nervous system. For example, dopamine, norepinephrine and
epinephrine are all catecholamines.
We are, as I said previously, mostly concerned with Beta-2 receptors,
because those are what we see stimulated with Albuterol. It should
come as no surprise to anyone who has used Clenbuterol as well as
Albuterol is that when you stimulate your beta receptors, it causes
something called vasodilatation (increased blood flow). Stimulation of
these receptors also stimulates the break down of fatty acids into the
blood stream for use as fuel, which causes a reduction in stored fat.
Of course, this increased blood flow also comes with an increased
heart rate.
This explains how Beta-2 adrenergic stimulation can also increase
your body temperature a bit however this isn't something that's
too noticeable on a thermometer most people will feel a bit hotter,
and some will even break a sweat (I fall into the latter category).
Beta-agonists work to do this by increasing heat production in the
cell's powerhouse, the mitochondria, which will also increase your
basal metabolic rate, and decrease your appetite. Not too many people
feel hungry after a whopping dose of stimulants.
There is also some evidence that Beta-Agonists are anabolic (more
properly, however, this would actually be anti-catabolic). This is
because Beta-agonists also act to initiate a hormonal cascade that
involves the activation of a compound called cAMP (basically:
cyclic-Adenosine Monophosphate). After this, cAMP activates calpistatin that is the
inhibitor of calpain. Calpain works to degrade protein in skeletal
muscle (among other functions). Therefore, we already saw that how
stimulation of beta 2 receptors have the ability to increase energy
expenditure and free up body fat to be used as fuel, and now we have some
understanding of how that stimulation can also have the potential to
be anti-catabolic as well .
Now that we're all on the same page regarding the beta-adregenic
system, and what sorts of effects we can expect when we stimulate it
with beta-2 agonists lets take a more specific look at Albuterol, and
why I think it's such a great compound.
When we take a look at Albuterol's ability to burn fat, it's
clear that it has the ability to aid fat loss in both normal as well as
obese men (2). That's not very different from Clenbuterol, in any
way. However, in my personal experience with it, I think that Albuterol
really outperforms Clen in areas of strength gains as well as for
athletic purposes. lets take a look at my claim and see how Albuterol
performs in humans.
In one study, subjects were given Albuterol and performed 9 weeks of
isokinetic knee extensions (there was also a group who performed the
same exercise routine but were not given Albuterol). The Albuterol
group, predictably, had better strength gains than the non-Albuterol
group (only a therapeutic dose was given) (3). In my own experience,
strength gains with Albuterol are much better and seen more quickly
than I see them with Clen. In fact, while I don't particularly
experience much of a performance enhancing effect from Clen in the gym; on
the other hand I see strength gains and muscular improvements within
the first couple weeks of using Albuterol. Of course, this is likely
a pure anabolic effect and probably not easily explained as a simple
enhanced anti-catabolic effect, and likely can't be explained
away with the Calpain idea you read about earlier. I still think that
I can take a pretty good shot at explaining why Albuterol is
anabolic, though. Strong body of evidence exists to suggest that Albuterol influences the
release of cAMP. As you may know, cAMP also plays an important role in
mediating certain catecholamines secreted by the adrenal medulla have
an inhibitory effect on muscle dependent protein degradation, but in
addition, norepinephrine released from adrenergic terminals may
actually increase the rate of protein synthesis(not just decrease the rate
of their degradation) in oxidative muscles, thereby leading to
increased protein accretion (representing a true anabolic effect). That's
most likely the way that we receive part of the anabolic effect from
Beta-stimulation. Another way is perhaps through the beta-adrenergic
stimulated lowering of Interleukin-6 from fat cells (long story).
Anecdotally, Clenbuterol and ephedrine have both shown themselves
capable of temporarily increasing strength, and I would bet most
beta-agonists have this effect, but I don't think has been shown as
conclusively in the medical literature as it has been with Albuterol.
Albuterol has been shown to increase muscle size (3-6) as well as strength
and endurance (3) while people have anecdotally reported that Clen
seems to lower their aerobic capacity. Clenbuterol has a disadvantage
when compared with Albuterol in the area of strength gains, probably
due to the act that it use-dependently inhibits action potential
firing in skeletal muscle fibers, which is not directly caused by
inherent Beta-2 stimulant activities (7) . I think that's the best
quasi-scientific explanation I Again, my own personal experience and that
of my research assistant(s) would also seem to strongly support this
claim all of us have gotten leaner, bigger and stronger with the use
of Albuterol, while with Clen, we got more ripped but not really stronger (and certainly
not much bigger). Anecdotally, we've seen Clenbuterol fall a bit
flat when people use it for anabolic effects, although in animals it
would appear to be highly anabolic, though human studies are a bit
shaky (ha!) in this area.
One of the things I really like about Albuterol is that it has the
potential to actually be used on my cycle to make it safer by improving
my lipid profile (cholesterol) or during PCT to help get my
cholesterol levels back in check. This is because Albuterol shows
significant benefits to cholesterol as it works to lower total cholesterol,
specifically LDL (the bad stuff) while at the same time elevating HDL
(the good stuff).(8)
In my own particular case, cholesterol never seems to be an issue,
but now that I'm working with Oasis for HRT, it's certainly in my
best interests to show up every three months with nice looking blood
work.
So now is the part you've been waiting for (or the part you
skipped to, ignoring the rest of the article whatever). How much of
this should you take, and how often? Well, I can tell you that I have
found the best results by working my way up from 4mgs taken once a
day, up to 4-8mgs taken 3x a day. I know that some people will think
that 24ms a day of this stuff is going to be too much (it is, after all,
a stimulant). But I can tell you that I have a pretty good tolerance
for stimulants (I've taken up to 200mcg/day of Clenbuterol, and
some other pretty hefty stimulants that I probably shouldn't mention
in polite company). Most people are going to find their sweet spot at
about 4mgs of Albuterol 3x a day or so women will probably take
about half that dose, and be fine with it.
I think that Albuterol is about to become very popular, very
soon and I, for one, am looking forward to seeing less of my old Clen
article around the net, and more of this one.
References:
1. Anabolic effects of the beta 2-adrenoceptor agonist salmeterol are
dependent on route of administration
N. G. Moore, G. G. Pegg, and M. N. Sillence
Am J Physiol Endocrinol Metab, Sep 1994; 267: E475 - E484.
2.Schiffelers SL, Saris WH, Boomsma F, and van Baak MA. beta(1)- and
beta(2)-Adrenoceptor-mediated thermogenesis and lipid utilization in
obese and lean men. J Clin Endocrinol Metab 86: 2191–2199, 2001
3. Effect of salbutamol on muscle strength and endurance performance
in nonasthmatic men. Med Sci Sports Exerc. 2000 Jul;32(7):1300-6.
4. J Strength Cond Res. 2005 Feb;19(1):102-7. Oral Albuterol dosing
during the latter stages of a resistance exercise program
5. The effects of Albuterol and isokinetic exercise on the
quadriceps muscle group.Med Sci Sports Exerc. 1995 Nov;27(11):1471-6
6. Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal
muscle strength in young men.Martineau L, Horan MA, Rothwell NJ, Little
RA
7. Different Ability of Clenbuterol and Salbutamol to Block Sodium
Channels Predicts Their Therapeutic Use in Muscle Excitability
Disorders
Jean-François Desaphy, Sabata Pierno, Annamaria De Luca, Paola
Didonna, and Diana Conte Camerino
Mol. Pharmacol., Mar 2003; 63: 659
8. Metabolism. 1996 Jun;45(6):712-7 Effects of oral albuterol on
serum lipids and carbohydrate metabolism in healthy men. Maki KC,
Skorodin MS, Jessen JH, Laghi F
***********************************************************
