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I have been doing a little research on a peptide called Klotho derived peptide (KP1). It’s supposed to heal the kidneys. If anyone has any good info let me know. It might be promising for guys with high creatinine levels while cycling to add on their protocols.
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It's been around since 2022 and was first published here: https://www.nature.com/articles/s41467-022-28096-z
The only data at the moment is in mice and there's no data in humans or here on EVO on this peptide currently. It does seem to show some promise in both liver and kidney repair but it's still very new and in my opinion too new to attempt yet in yourself. You'd be an n=1 individual experiment. If you do decide to use it be sure and stay here on EVO and keep us posted. Get a full bloodwork panel done on liver and kidneys beforehand and then report back with bloodwork again after to see if it's helping.
Sorry there isn't more info on this here but that journal article should give you a lot to chew on as to whether to decide to try it out in a human. As for dose and just for your reference the dosing in mice was 0.31 μM/day/kg body weight. The MW of KP1 is 3228g/mol so you'd wanna use the formula to convert μM to μg which equals about 1mg/day/kg body weight.
If you're 100kg this equates to 100mg/day of KP1 peptide. Now, this is what they gave mice so it's likely HIGHLY overdosed and the translation dose from mice to humans has never been trialed yet to my knowledge and I checked for you.
I don't think it's time yet to run KP1 if you can even source it anywhere.
What about using glutathione
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why do you want to heal the kidneys with a peptide, what is your issue? thats my first question @Geochrist70
If creatinine is high on cycle, the smart move is monitoring labs, checking blood pressure, checking creatine intake, and lowering training stress first because heavy training alone can spike creatinine, and adding KP1 without fixing the basics is guessing not solving the problem. Overall, I find injecting a peptide when you can just take a few caps of n2guard and drink water makes no sense to me.
KP1 is interesting on paper because klotho signaling is linked to kidney protection and reduced fibrosis, but right now it is all animal and lab data with 0 real human cycle use to prove it actually lowers creatinine or protects kidneys.
my 2 cents is it could cause kidney stones! (yes stones)
You can check this study but wont tell you much
https://pmc.ncbi.nlm.nih.gov/articles/PMC3227531/
