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Introduction
Welcome Evolutionary.org Hardcore 2.0 #185- Semaglutide new information on GLP-1 Peptides by Ultima. In this episode, the guys go over Semaglutide, its mechanisms of action, how to dose it as a bodybuilder, studies, user experiences, and how to use it as part of your steroid stack.
Semaglutide information
Steve starts the podcast off by talking about the background of Semaglutide. Novo Nordisk markets the drug as Wegovy for weight management and has been used by millions of people to help them manage their weight. It is also sold as Ozempic as an injectable diabetes medication and Rybelsus as an oral medication for diabetes. Steve says that last year there were over 15M prescriptions filled. He also says that in the USA, insurance companies will pay a large portion or all for diabetes prescriptions, but have backed off of covering the cost for weight loss. This has caused the out-of-pocket price of the drug to be $1000 a month in some cases for people seeking help with fat loss.
Semaglutide is used by bodybuilders to help give them an edge. One of the obvious ways is to use it as part of a cutting or recomposition cycle. Another important thing to be aware of is the competition from rival Ely Lilly, which has been working on Retatrutide, and has Tirzepatide already FDA approved.
Mechanisms of action
Steve says that semaglutide is a single agonist, while Tirzepatide is a dual agonist, and Retatrutide is a triple agonist. If you take a look at previous podcasts you can learn more about Reta and Tirz and see how they work as well. But in this one, the guys will explain specifically how Semaglutide works.
Semaglutide is a GLP-1, which stands for glucagon-like peptide-1, receptor agonist. In simple terms, it will mimic the natural GLP-1 hormone. One of the reasons it works so well as a diabetes medication is its ability to control blood sugar by releasing insulin and by manipulating the amount of sugar released from the liver. This helps prevent hypoglycemic issues compared to things like insulin or other diabetes drugs that can cause a sharp drop in blood sugar causing the person to need to consume sugar to get it back up.
When it comes to weight loss it works great in a few different ways and the guys go over each.
- It slows down the emptying of the stomach which forces you to eat small portions and punishes you for overeating
- It increases the feeling of being full during a meal.
- It reduces appetite overall, so you don't feel the urge to eat every 2-3 hours, like most Americans do.
Many users will say they feel disgusted even smelling or looking at food while on Semaglutide when before they used it they would regularly eat those foods daily.
Mobster talks about the bodybuilder mentality of thinking you need 8 meals a day and 500g of protein. It isn't going to happen on Semaglutide, which will kill your appetite, so that you will be lucky to get 2 or 3 meals a day.
Studies
This was an interesting study where diabetics and overweight people ran around 2.5mgs a week for 20 weeks. They ended up losing almost 11% of their total body weight. Those that kept going for 48 weeks lost another 8% on top of that. What makes this study fascinating though is those that who were given a placebo instead for 48 weeks ended up gaining back 7%. This shows that this drug works incredibly well.
This study compared those who took Semaglutide vs. those who got the very risky and dangerous sleeve gastrectomy bariatric surgery. Those who took Semaglutide lost 20% of their body weight over the course of 16 months. The beauty part of it all was that compared to those who had the surgery, Semaglutide won when it came to improving lipid health, glucose, weight loss, BMI, and even things like heart rate.
This is a very cool study that showed over the course of 4 years obese, or those with poor heart health, patients lost 8CM off their waist and 10% of total body weight vs. the placebo group who only lost 1% of total weight. This study was done on over 15,000 people!
Mobster then goes over some news articles that talk about Semaglutide.
Steve talks about a new medication that Novo is working on called CagriSema which is a mix of Semaglutide and cagrilintide. https://www.prnewswire.com/news-releases/cagrisema-2-4-mg--2-4-mg-demonstrated-22-7-mean-weight-reduction-in-adults-with-overweight-or-obesity-in-redefine-1--published-in-nejm-302487770.html It showed a 22.7% mean weight reduction in adults with overweight or obesity.
Forum user experiences
https://www.evolutionary.org/forums/threads/semaglutide-ozempic-log.102197/ Pigsy
He only ran it for only 4 weeks but he microdosed it.
https://www.evolutionary.org/forums/threads/semaglutide-journey.102943/ poopoobum
Mobster talks about his alcoholism and how using Semaglutide has helped him reduce his alcohol consumption and get him on track.
He also talks about Zucchini who follows ketogenic. https://www.evolutionary.org/forums/threads/pre-cycle-log-recommendation-review-on-my-planned-micro-dosing-cycle.102688/
He used Semaglutide and lost 50 pounds in 5 months, which included a vacation.
Another guy is Roidrage69 who likes to cycle Semaglutide off and on. https://www.evolutionary.org/forums/threads/roidrage69-training-log-sponsored-by-purity-source-labs.103669/
He is a huge guy who routinely is around 250 pounds and says that Semaglutide prevents him from eating more than 1750 calories.
He has lost a total of 55 pounds and his wife has lost 50 pounds too. His main complaint was he said he lost some strength and muscle. He also says that high-fat foods make him gassy so he has to be careful what he eats. His overall diet stayed the same, but he was eating less on Semaglutide and it was giving him crazy good weight loss.
Steve says that getting gas from high-fat foods has to do with slow gastric emptying. He also says that Roidrage69 has said that the rebound effect when you come off can be an advantage because you can build back a lot of strength and quality mass during that weight gain.
How to dose it and side effects
Steve goes over the scenarios on how to dose it. In the bodybuilding world, it will vary from those who are extremely obese.
Steve recommends most of you start at a low dose of .25mg for the first 2 weeks. Then you can increase to .5mgs for the next 2 weeks after that. From there you can keep the dose there or gradually increase it week by week at your leisure. Look for increased sides as an indication of if you need to keep it there or lower the dose. A max dosage for most would be 1.5-2.5mgs.
The product comes in peptide form so needs to be properly stored and reconstituted.
The oral version dosing can vary from 2-14mgs a day but Steve doesn't recommend wasting your time with it. Stick with the injectable which only needs to be taken weekly.
The side effects can be rough for some people especially when you first start using it.
One of the biggest complaints is things like diarrhea, heartburn, nausea, and other stomach issues. Most people report the sides the first month then the sides get better. Some potentially serious sides are very rare including effects on the pancreas, kidney issues, and things like tumors in the thyroid.
Good Ultima cycles to use it with
Mobster says it's more about what NOT to use. He says to avoid bulking steroids like Deca, dbol, and high doses of Testosterone. He likes low-dose Anavar of 30-50mg a day for men. For females, you can run 2.5mgs a day. Steve says females can go up to 5 or 10mgs.
Mobster also likes Turinabol and it's great for endurance and won't mess with your cardio.
Steve loves the Primobolan idea. It has very low sides and doesn't bother your stomach like other steroids might. The same goes for Equipoise which is also a great option. A dose of 500mgs a week is plenty and you can run it for 12 weeks.
Why the guys love Ultima
Ultima has high-quality products across the board and they are a 1 stop shop for everything the guys have talked about on this podcast.
They have great shipping, service, and prices. This is why they are used by professionals and gym rats.
Where to buy?
Ultima can be purchased from Osgear.se.
Osgear.se is an approved source that has been around for 15 years, providing customers with outstanding oral steroids, injectable steroids, ancillaries, PCT products, and more. When you purchase from them, you know you are getting the authentic Ultima brand and not fakes.
They provide lightning-quick domestic shipping to American customers, with no need to worry about customs and no need to stress about how long it takes. They ship typically within a few days and you get your package lightning fast. They also offer international shipping as well to many other countries.
They have reps on the forums to further assist with setting up cycles and answer questions you may have. If there is ever an issue, they are on call to help with your order and make sure you are taken care of.
Forums
Forums on our forums? read on:
what’s up everyone I’m about to start my first oral cycle ever and it’s going to be 6 weeks of anavar and tbol together! I was wondering what kind of supplements you recommend Read More............
Hi all, Wondering if anyone has a source for oral semaglutide in Canada (west)? Can only seem to find an injectable source so Read More..........
I’m looking to kickstart my first testosterone cycle it’s gonna be 600 mg a week and I’m 25 years old and I’m 5’10” 230 lbs. Looking to do a Read More.........
This will be my first real cycle I’m 28 years old and I’m around 5’8” and 85 kg I’m looking to use testosterone between 300 and 400 mg a week Read More.........
26 years old and 6’1’’ 184 pounds. I train hard 1 hour per session 4-6x per week. first cycle I did some pro hormones and I will say that the side effects weren’t Read More...........
References
- Comparison Of Efficacy Of Steroids Alone And Combination Of Steroids With Hyaluronidase On Mouth Opening In Oral Submucous Fibrosis Patients
- Steroids and the endometrium
- Effect of Preoperative Oral Steroids in Comparison to Anti-inflammatory on Anesthetic Success of Inferior Alveolar Nerve Block in Mandibular Molars with Symptomatic Irreversible Pulpitis-A Double-blinded Randomized Clinical Trial
- Treatment of oral mucosal manifestations of chronic graft-versus-host disease: dexamethasone vs. budesonide
- A potential side effect of oral topical steroids: Central serous chorioretinopathy
