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Letrozone vs. Winstrol

Letrozone as a standalone cutting cycle, is it as powerful as winstrol?

Letrozone (LZ) is a very powerful transdermal agent for lowering estrogen and increasing lean mass.  It is mostly used to keep estrogen low during your steroid cycle, but it is still strong enough to be used by itself. It combines the power of formestane, arimistane, 11-oxo, 7, 8 benzoflavone and I3 Carbonyl in one topical formula.   Letrozone uses a groundbreaking transdermal matrix to carry these ingredient through your skin into your bloodstream and to their destination, deep in the androgen receptors of your muscle cells.  Not just activating androgen receptors but lowering estrogen by grabbing on to the aromatase enzyme and keeping it from doing its job.  All ingredients considered, the use of Letrozone will create a prime environment for gaining muscle mass and losing bodyfat.

letrozone AI

Fig 1. Letrozone Bottle

One of the main anabolic ingredient in Letrozone is called formestane, and it was originally developed as a suicidal aromatase inhibitor, but was banned because it was deemed “too anabolic.” What “suicide aromatase inhibitor” basically means is that the aromatase enzyme will attach to formestane like it would with testosterone and basically try to convert it into an estrogen.  This is the job of the aromatase enzyme, it hangs out in male breast tissue area and will convert steroids that are passing through into estrogen hormones.  Formestane has the type of structure that the aromatase enzyme targets, but when the aromatase enzyme tries to turn formestane into an estrogen, it finds itself trapped in a type of bond that it can’t break away from.  The two structures, formestane and aromatase, are locked together and  will not effect the body in any way,  they end up being neutralized and discarded.  This where the “suicide aromatase inhibitor” part comes in; essentially, formastane causes the aromatase enzyme to commit suicide.

formestane vs exemestane

Fig 2. Formestane vs Exemestane (Suicidal Aromatase Inhibitors)

When you use formestane and arimistane to keep the aromatase enzyme in check, you are also allowing for more free-flowing testosterone and steroids to do their job.  However, not all of the formestane you apply on the skin will get locked into a suicide bond with an aromatase enzyme unit.  When taking Letrozone, you are applying so much more formestane, that you will have a lot of leftover formestane hanging out in your system.  This formestane will not remain as itself for long.  Another very different enzymatic conversion will turn much of that formestane into the very potent anabolic steroid known as 4-hydroxyTestosterone.  Some experts have even compared the anabolic to androgenic ration of 4-hydroxyTestosterone to that of the steroid Primobolan Depot.  Therefore, it should not only build lean mass, but it should do so even while on a caloric deficit.

During a cutting diet, the catabolic hormone known as cortisol may rise pretty high.  Cortisol is the hormone mainly responsible for signaling the muscle cells to released their stored energy into the body, so that it can be used by the now starving systems (diets cause this reaction).  The use of the prohormone 11-oxo in Letrozone ensures that LZ works as a very effective cortisol reducer.  As a result of keeping this stress hormone from getting too high, you reduce unwanted muscle loss and accumulation of fat around the mid section.  Yes, it is the stress hormone cortisol that will work to put a lot of fat around your belly and mid section.  Some of the most stressed out people you know may have love handles that were a result of high cortisol.  11-oxo in Letrozone will keep this stress hormone to a minimum no matter how strict your diet is.

The use of Letrozone creates a combination of lowered estrogen, increased free testosterone, lowered cortisol and high levels of the steroid 4-hydroxyTestosterone.  This combination is sure to put on lean mass even on the most experienced bodybuilder. Besides helping you easily put on mass, LZ will melt the body fat right off the chest and belly area, which suffer most from estrogen and cortisol fatty deposits.

To use as a standalone cutting cycle, apply 4ml of Letrozone to your chest and oblique area every 8hrs.


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Written by
Albert Wolfgang is a professional medical writer with over 20 years of experience. He hold multiple personal training certifications, including the coveted NASM and AFAA certificates. He graduated with honors with a B.S. and M.S. in biochemistry with a minor in physical studies. Albert and his team have trained over 100 IFBB professional bodybuilders, including Hollywood stars and many up and coming fitness stars.


  1. As anyone logged a cycle with Letrozone? If you use 12 ml/day, how many bottles do you need? Do you need PCT after a cycle?

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