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What is Epistane?

epistane chemical structure

Fig 1. Epistane Chemical Structure

Chemical Structure:  2a,3a-epithio-17a-methyl-5a-androstan-17b-ol.

Epistane has been mistaken as an anti-E at times, although it does not cause Estrogen related side effects and has been reported by users to lower Estrogen, it should not be confused as a pure AI (Aromatase Inhibitor) compound.  For the Bodybuilder and trained Athlete, Epistane works as a Anabolic agent that delivers dry, lean muscle gains, and works great for cutting as well.   Epistane is much more Anabolic than most people realize and is often under estimated because it is an analogue of an anti-estrogen drug used in Japan.  This has caused some people to mistakenly think Epistane has the same properties, yet that is not the case.

It is true that Epistane should never convert to the illegal Pheraplex.  The only reason this ProHormone got a bad reputation for converting to a banned substance while sitting in storage for too long, is because some of the “cloned” Epistane products were using  17alpha-methyl 2beta,3beta-epithio 5alpha-androstane, instead of the real true compound: 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol., which should never convert to Pheraplex .

Epistane is not just a Pro-hormone, it is already a very powerful active compound that attaches to and activates Androgen Receptor sites.

Epistane is a designer hormone, designed to give you the very best Anabolic effects with limited side-effects from Androgens.

Why is Epistane know as a mild compound?

Epistane causes muscle growth, without being too harsh of an Androgen, thus avoiding side-effects like hairloss and bad acne.  Epistane's mild Androgenic effects, with heavy anabolic effects can be explained by taking a   closer look at it's “Myotropic Ratio”, which is a more technical term used to explain the different in how each hormone acts in the body.  When it comes to Epistane, it's “Mytotropic Ratio” is in range of other hormones like Oxandrolone(Anavar) in that it is way more Anabolic than Androgenic when attaching to receptor sites in the muscle cells and other places.

In more technical terms, when compared to other popular prosteroids on paper, Epistane is 15 times more myotrophic than Helladrol and a whopping 20 times more myotrophic than Pro-Magnon.   It  has a vastly superior "myotrophic ratio" of 12 whereas  H-drol has a myotrophic ratio of 2.6 and Pro-Magnon has a myotrophic ratio of only 1.1.  In layman's terms,  on a milligram-per-milligram basis, Epistane  is far less likely (4.62x less like than  H-drol and 10.91x less likely than Pro-Magnon) to induce undesirable, androgenic mediated type side effects such as acne and hair loss.

Keep in mind that the above statement is dose related as Epistane is a very strong prosteroid.  If you ran a cycle of Epistane with H-drol(more than 75mg) doses, you would experience serious and undesirable side-effects.  Epistane is already very strong and doses of 30-40mg a day are all that's needed to induce very desirable results. For more experienced users some may go as high as 60mg.

How does Epistane increase Mass?

Epistane binds to androgen receptors in skeletal muscle cells and muscle stem cells. When it binds to the receptor site it creates a signal to the cell, telling it to increase protein synthesis and nitrogen retention, thus growth of the cell is certain... Epistane also has an effects on muscle stem cells, which is a very important part of it's actions since those Muscle Stem cells will actually change and fuse with your active adult skeletal muscles, thus increasing the muscles potential for growth and repair and importantly the most desired effect to those using Epistane:  an increase in muscle mass.

Epistane has been used as a solid mass builder, but it has a great place in any cutting cycle as well..  In the presence of Androgens the stem cells ability to form new fat cells are greatly hindered. Since this occurs, you now have increased stem cell conversion to muscle cells and a decrease in the conversion of stem cells to fat cells, giving you a more positive effect of nutrition and training, This is perhaps the main reason why Epistane is so effective, even on bulking cycle, because the fat gain is very minimal.

As with most methylated steroids, the half life requires split dosing, and to increase its bioavailability I suggest taking it with foods containing fat.

What to watch out for.

Epistane will have a negative impact on good cholesterol, blood lipids, blood pressure and the liver, but at lower dosages of 30mg to 50mg and short cycles of 3-4 weeks, you should worry very little in the way of negative sides.

Epistane being largely anabolic is very likely to cause some lethargy but it does not convert to estrogen.

There have been some mistaken reports though lots of forums where users report bloat on Epistane. This is likely because they are using the inferior cloned product, containing the earlier mentioned compound written in italics further up this page  17alpha-methyl 2beta,3beta-epithio 5alpha-androstane.   This compound is the one that is used to convert to the now banned Pheraplex, which is a very wet Steroid.  Real Epistane should not convert to this compound and should always be a very dry, lean muscle gainer.

As mentioned earlier, it is not and anti-e but it can noticeably dry you out.  This occurs partly because of the shift in the testosterone/ estrogen ratio.

Epistane can’t convert to estrogen or DHT, so its affects will be largely anabolic which is great for recovery and nutrient repartitioning (like in a Recomp Cycle), and  considerable amounts of fat loss are often reported by users after only a 2 weeks of use. Muscle mass gains of 6-10LBS are an average gain on a 4-6 week cycle.


On it's own,  Epistane will create very dramatic results,  mainly for the Bodybuilder new to the world of anabolics, where his body is not yet holding an unnatural amount of musculature.   Epistane alone will not only maintain but grow even further mass on the new user.  The experienced Bodybuilder with 3 to 4 cycles already completed, would see more dramatic gains by stacking Epistane along with other compounds for bigger gains in lean mass, and more dramatic fat loss.

Epistane stacks well in any cycle and with any anabolic steroids.  It generally does not have negative interactions with other compounds.  Testosterone, Deca Durabolin, Trenbolone, Trenavar or even Dianabol can all be stacked with Epistane.

When cutting, it provides help in burning fat and the assurance that muscle mass will be spared at times of dieting.  This ensures that only fat will be burned to make up for the caloric deficit. Epistane is very potent anti-catabolic agent during cutting, and can be found in this cycle:  OxandroVar  the one-bottle stack of Prohormones, Prosteroids and Analouges for the perfect cutting cycle.

For body re-composition, or “Recomp Cycles”, Epistane's ability to help decrease fat gains and increase muscle mass make it a really key ingredient to help shift body composition towards a lower boy-fat% while still keeping or gaining body-weight in the form of solid mass.  Stacked together with Trenavar and Methyl-diaz in the PrimobolDx formulation, it creates the perfect environment to run a body re-composition program where fat storage can be mobilized for energy, while muscle cells increase protein synthesis and nitrogen retention.


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Russian Star is an industry leader in peptide design and development. He is a fitness mentor with a Masters degree in molecular chemistry, he's working on his PhD in biochemistry.

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