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AnalogMan
Banned
Climb on board and follow me on this journey.
The success of SERMS has raised interest in producing drugs that do the same thing for other pathways, including the androgen pathway and how it affects bone. Certain osteoanabolic agents called SARMs do slow osteoporosis.
Androgens protect the bone, but using them for osteoporosis and osteopenia has been problematic because of their side effects and because it is difficult to get them in the bloodstream from a pill. Testosterone can be injected into the bloodstream, but that is not an optimal solution. Androgen administration brings acne, enlarged prostate, and negative effects on cholesterol and triglyceride levels in the blood. Indeed, hypogonadism is considered the only condition where the benefits of testosterone exceed the downsides.
Enter SAMRS (selective androgen receptor modulators), that leaves behind the androgenic (bad) side effects of steroids while keeping the anabolic (good) effects. The goal was to find a compound that has anabolic effects without androgenic effects. The anabolic effects would ideally include osteoanabolic (bone building) ones. When we think about what we want in an osteoporosis or osteopenia medicine, that's what we want. People concerned about other conditions such as wasting syndrome and sarcopenia want a compound that has myoanabolic effects (muscle building) without negative effects on the prostate and other organs. SARMS folks...
Bone cells have androgen receptors that respond to hormones (both the body's own and external supplements). Unlike bisphosphonates, which inhibit osteoclast activity, androgens and SARMS increase the rate of formatipon of periosteal bone. It is this osteoanabolic activity that is valuable. In the body's normal functioning, the enzyme aromatase converts testosterone to estradiol but "SARMS" are not subject to this reaction. With me yet?
There is plenty of use of SARMS in hypogonadism, muscle wasting, and prostate diseases. There are a lot of different compounds that act as agonists to androgen receptors. That's exactly how SARMS works on a biochemical level. "Good" stuff people....
Are these SARMs part of the class of chemical compounds called steroids? Some maybe and some maybe not. But buy using non-steroidal ligands for AR receptors these drugs will be more targeted for producing growth.... So people, it's the future, and I think we are worth it. I'm on board, how about you?
Something to think about........................AnalogMan
The success of SERMS has raised interest in producing drugs that do the same thing for other pathways, including the androgen pathway and how it affects bone. Certain osteoanabolic agents called SARMs do slow osteoporosis.
Androgens protect the bone, but using them for osteoporosis and osteopenia has been problematic because of their side effects and because it is difficult to get them in the bloodstream from a pill. Testosterone can be injected into the bloodstream, but that is not an optimal solution. Androgen administration brings acne, enlarged prostate, and negative effects on cholesterol and triglyceride levels in the blood. Indeed, hypogonadism is considered the only condition where the benefits of testosterone exceed the downsides.
Enter SAMRS (selective androgen receptor modulators), that leaves behind the androgenic (bad) side effects of steroids while keeping the anabolic (good) effects. The goal was to find a compound that has anabolic effects without androgenic effects. The anabolic effects would ideally include osteoanabolic (bone building) ones. When we think about what we want in an osteoporosis or osteopenia medicine, that's what we want. People concerned about other conditions such as wasting syndrome and sarcopenia want a compound that has myoanabolic effects (muscle building) without negative effects on the prostate and other organs. SARMS folks...
Bone cells have androgen receptors that respond to hormones (both the body's own and external supplements). Unlike bisphosphonates, which inhibit osteoclast activity, androgens and SARMS increase the rate of formatipon of periosteal bone. It is this osteoanabolic activity that is valuable. In the body's normal functioning, the enzyme aromatase converts testosterone to estradiol but "SARMS" are not subject to this reaction. With me yet?
There is plenty of use of SARMS in hypogonadism, muscle wasting, and prostate diseases. There are a lot of different compounds that act as agonists to androgen receptors. That's exactly how SARMS works on a biochemical level. "Good" stuff people....
Are these SARMs part of the class of chemical compounds called steroids? Some maybe and some maybe not. But buy using non-steroidal ligands for AR receptors these drugs will be more targeted for producing growth.... So people, it's the future, and I think we are worth it. I'm on board, how about you?
Something to think about........................AnalogMan
