Cardarine is a non-hormonal compound, so it will not lead to suppression. But you can still use HCGenerate ES with it for additional test boosting benefits - it will not hurt at all. As for the possible time to run Cardarine - you can safely run it for quite a long time, but it is best to run it in 12 week cycles with a little break in between. It's not like Cardarine will hurt you, but it is more effective to use it this way.