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As in like for extended periods of time? I would think it would be extremely bad for your heart
phillip oliver
New member
Is 500 just going to be a long ass cycle or are you going to blast every so often if so what would it be 3 grams.
jbranken
Advanced Cyborg Brother
They're also closely monitored by high end doctors and on a ton of meds for their health.
Pros: keeping more mass post cycle
cons: wrecked RBC, HDL, LDL, bp, etc
Ancillaries would be multiple bp meds, multiple cholesterol meds, frequent blood donation, blood thinners, a lot of bloodwork and god knows what else
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meathead96
Advanced Cyborg Brother
LOL right wtf is a cruise to the pro's. They don't slow down at all. 500mg is a joke to them. I've been on well over 500mg of gear for well over a year. There are a lot more people that do it but most lie about it. Not saying its healthy. I am monitored by a doc and on lots of support supps and bp meds.
sourcenyne
New member
sourcenyne
New member
I cruise with 250mg test-e/350mg masteron or proviron per week. My blood work is all within acceptable ranges for cardiovascular indicators. I know it is a lot of androgens though. As long as I am asymptomatic and bloods are clear I don't see a reason to discontinue.
ozcroboy
Buff Brother
Cruising is new to me and I understand why ppl do it. But even cruising at low dosages kills ur natural test so I assume ppl do it that are low on natural t as a trt option?!?! Sum1 fill me in aa I can't understand how being on full tym can be good for u?
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sourcenyne
New member
Basically, our balls haven't worked in years. When you go on TRT you should do so knowing that it is a life long commitment. Doesn't matter if you use hCG during your treatment to stave off primary hypogonadism, you still induce (or likely already have) secondary hypogonadism which becomes irreversible over time.
I had testicular cancer and had my left testicle removed along with all of the nerves and vasculature connected to it, so I had an excuse to jump on without much consideration. However, even if you are a eugonadal male choosing to engage in long-term TRT, you should do so knowing that your HPTA will become compromised beyond repair within the first year, probably less.
There is progress with drugs such as triptorelin and FSH/LH suspensions, but these don't always restore pituitary gonadotropin output. Triptorelin can actually chemically castrate you if used incorrectly. Past a certain point, use of SERMs like nolvadex and clomid is a joke.
I had testicular cancer and had my left testicle removed along with all of the nerves and vasculature connected to it, so I had an excuse to jump on without much consideration. However, even if you are a eugonadal male choosing to engage in long-term TRT, you should do so knowing that your HPTA will become compromised beyond repair within the first year, probably less.
There is progress with drugs such as triptorelin and FSH/LH suspensions, but these don't always restore pituitary gonadotropin output. Triptorelin can actually chemically castrate you if used incorrectly. Past a certain point, use of SERMs like nolvadex and clomid is a joke.
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If you want to eventually have your normal T levels go back to normal than its not something to concider. I mean, the longer you go suppressing your natural T the less likely you will gain back your natty levels. Now.....if you DONT GIVE A SHIT and have low T anyways than IMO its the only way to go. By cruising you will be able to actually RETAIN MOST OF YOUR GAINS. BUt....it makes no sence to me to CRUISE AT BLASTING LEVELS. Why? because unless you have a genetic defect that allows you to be resistant to Myostatin, if you keep on doseing that high your LBM gains will slow WAYYYYYYYYYY down if not flat out cease. BUt.....if you cruise just above normal ranges you can KEEP T LEVELS HIGH allowing you to keep your gains but not TOO HIGH as to allow Myostatin to come down and allow you to BLAST again and gain more muscle.
ozcroboy
Buff Brother
yeah as i assumed. thanks for the clarification guys. im 36 and think i wud only ever consider blast n cruise if i already had my kids n my nat levels were low. prob wudnt consider a blast n cruise till late 40s obv. thats just me. muscles are great but its not the only thing in my life for me to even consider a permanent low test dose. again unless i was low T or similar. it sounds like sum ppl are choosing blast n cruise a lot younger than that even with nat T levels. that sounds nuts to me. no pun intended.
I did a Cruise on Test C, early last year at 500 mg a Week, and 50 mg Proviron a Day.
I really would have to get my Journal, but I seem to remember doing that for only 20 Weeks.
I really didn't start out with a Cruise in mind, but I was really getting a lot out of the Test C.
Before I knew it, 20 Weeks was Gone, and I started a Cutting Cycle..................................................JP
P.S.
I do remember that I did an Elaborate PCT, because I didn't want any Problems.
Elaborate for me, since my PCT is usually only 4 to 6 Weeks, I did 8 Weeks, Clomid and Nolva, and before I started, I did HCG up until the Start.
Everything went Remarkable Well, but I don't see another Cruise in my Immediate Future.
I really would have to get my Journal, but I seem to remember doing that for only 20 Weeks.
I really didn't start out with a Cruise in mind, but I was really getting a lot out of the Test C.
Before I knew it, 20 Weeks was Gone, and I started a Cutting Cycle..................................................JP
P.S.
I do remember that I did an Elaborate PCT, because I didn't want any Problems.
Elaborate for me, since my PCT is usually only 4 to 6 Weeks, I did 8 Weeks, Clomid and Nolva, and before I started, I did HCG up until the Start.
Everything went Remarkable Well, but I don't see another Cruise in my Immediate Future.
sourcenyne
New member
I don't have the option of coming off, so if I ever really have to normalize liver values or other things like hematocrit (never a problem, blood donor) or whatever, I just have to go to 150mg per week I guess. But I haven't had to so far.
This is a good post. Very good.
meathead96
Advanced Cyborg Brother
Ok smart guy, do you think the pro's maintain they're weight and size on 200mg of test? How do they continue to gain size and weight? More gear and mostly lots of insulin and GH. Once you hit a certain point you will not maintain everything on a cruise dose of 200mg or less of test. Trust me I have been there done that. I'm not saying that this is a good or healthy idea by any means but your bro-science doesn't fly. If Phil Heath dropped to 200mg of test he would wither away and it would take a very long time for him to get back where he started.
sourcenyne
New member
I'm going to go ahead and agree with meathead. Mateo, do us a favor and post the study which says that myostatin downregulates in response to administration of supraphysiological doses of androgens?
I doubt you will find it because there are ethical dilemmas which prevent real studies from being conducted on the effects of bodybuilding doses of steroids. So.... You're just speculating bud.
Pro's continue to make consistent gains over years and years of blasting doses. Even the downregulation of intracellular AR concentrations has never been proved due to the same reason I cited above. Anecdotally, it doesn't appear to be the case anyway.
I doubt you will find it because there are ethical dilemmas which prevent real studies from being conducted on the effects of bodybuilding doses of steroids. So.... You're just speculating bud.
Pro's continue to make consistent gains over years and years of blasting doses. Even the downregulation of intracellular AR concentrations has never been proved due to the same reason I cited above. Anecdotally, it doesn't appear to be the case anyway.
Flip Digler
Advanced Cyborg Brother
^^^^ I love you little deer , is that gmo pop corn you have their ?
Caaannn Uuuu Diigg It ?
Caaannn Uuuu Diigg It ?
sourcenyne
New member
Lol. How can u feed that cute little guy MonsantoPop!
If you need that much Test to maintain go ahead. I know I sure as hell dont. If the pros need it(which they do) it sucks to be them. THE MORE YOU ABUSE DRUGS, THE MORE YOUR BODY NEEDS PERIOD. ITS A FACT (NOT BROSCIENCE). If you take one pain pill for pain, sooner or later you will need two pain pills and than 3. IN OTHER WORDS THE DRUG STOPS WORKING. If you keep CRUISING AT HIGH LEVELS OF TEST....you will not only need to keep cruising at that level, YOU WILL EVENTUALLY NEED TO UP THE TEST!
NOW!! PROS....who are in a TOTALLY DIFFERENT LEAGUE(no pun intended) have two things working against them. Test resistance like I mentioned AND SUCH A HIGH UNNATURAL AMOUNT OF MUSCLE MASS that your right PROS, not the average Joe Blow bodybuilder, need MORE TEST JUST TO MAINTAIN.
he all natty like dat popcorn
sourcenyne
New member
Sorry dude but you're wrong again. You cannot compare a hormone to an opioid. The pharmacokinetics and behavior are entirely different. Opioid receptors proliferate to accommodate higher amounts of circulating drugs. Androgens and hormones are mediated by many more factors than the receptor alone, including binding proteins and globulins, enzymatic metabolism and conversion to other substances etc. AR proliferates too of course, but it isn't the only factor.
I mean, aside from the fact that the comparison you are making between hormones and other drugs isn't valid, it doesn't even appear to be the case anecdotally. Anyone who has run gear with all other factors in check, including sleep, diet and training and basically eats at maintenance can tell you that gains are more or less commensurate to the amount of drugs used, at that point. But being on 500mg of test will put on size and muscle to the point that 500mgs of test can allow for and sustain. This does not, however, mean that one day you'll just start shrinking and be like "shit my 500mg of test is only equivalent to 150mg now because of my tolerance!"
You don't build tolerance to hormones in the classical sense typically associated with street drugs. If anything, it is based on weight and the ability of X amount of androgens to sustain X amount of lean mass, which will be a relatively constant factor. If the athlete wants to gain more weight, then yes he may need to use more androgens. But it doesn't just STOP WORKING. You are fundamentally misunderstanding the way hormones work.
There is no such thing as testosterone resistance as it applies to bodybuilders and normal steroid users. There are very rare medical conditions like androgen intolerance, but this doesn't apply to any of us. Please find me a study on "testosterone resistance secondary to anabolic steroid use" and I will buy you your next cycle.
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Tell me the advantages of cruising at higher than needed amount of Test. Cruising meaning.....I am done BLASTING, I am letting my body chemistry come back to normal, giving my lipids, liver and other organs a break. What would be the advantage of Cruising at a HIGHER THAN NEEDED AMOUNT?
sourcenyne
New member
Definitely no advantages aside from maintains higher amounts of lean mass. I think it is a bad idea personally. But that isn't what we are talking about anymore. You made "factual" statements about hormones which simply weren't true. You do not become intolerant to testosterone, period. Ever. You only use more because you have reach a weight which requires a higher amount of androgens to sustain.
That is what I said.
Maybe, Phil Heath and the rest of the pros have mutations in the MSTN gene. I would speculate, that the majority of the pros have a mutation in at least one copy of the MSTN gene. This gives you something to consider.
sourcenyne
New member
Don't make me quote you dude. Either way, I agree with you that exceeding 250mg of test per week during a cruise is excessive, even though I spice up my cruises all the time with proviron, masteron, primo, etc. I just had beef with your interpretation of how it all works. No hard feelings.
Are you saying Myostatin does not thwart LBM gains after a while????
sourcenyne
New member
Of course it does, but obviously not to a degree that would require a professional bodybuilder to drop to HRT levels in order to return to homeostasis so that gains could once again be effected. Given the level of development we see and the known year-round blasts/"cruises" of pros, it cannot possibly be the case.
Well, the pros are whole other animal. They never get off, and they have rare genetics.
sourcenyne
New member
I agree. A lot of people downplay their genetics and chock it all up to drugs and timing, but I think there is something to be said for genetics here. The thing is that even if they has a defect in myostatin receptors or an actual MTSN gene mutation, the gene would have to either be codominant or they would have to have a homozygous mutation (in both copies) which would have been evident from basically birth. I would like to know if the gene is codominant, because if it isn't and the defect is only in one copy then the functional copy would be dominantly expressed, which would make them normal.
I have read testicular cancer is common (vs. other cancers) in 15-35 year olds.. how old were you when you got it and did you catch it early? I know if caught early its an easy fix today. but if you let it go you can definitely die if it spreads
this is scary to young men on here and something to keep an eye on.
You dont believe that some people are born with a genetic defect that allows them to be resistant to Myostatin?
that is a deer? what kind? I always wondered what kind of animal that was .. I want to snuggle it whatever it is
sourcenyne
New member
Yeah I caught it early. I was 24. Stage 1 pure seminoma. I felt something erupt through the surface of my testicle within 15 minutes of shooting 4iu riptropin. Immediately ceased GH and consulted a urologist. I was in surgery the next day and they removed the teste and spermatic cord. I have been clear for over a year now and I actually talked to my doctor about GH. He is 95% sure surgery was curative and I haven't had any symptoms whatsoever.
You dont believe that certain people are born with a genetic defect that allows them to be resistant to Myostain?
sourcenyne
New member
I didn't say that. People have definitely been born with such defects or MTSN mutations, but the incidence is so rare that there are far too many pros for them all to have this defect.
Also read what I response to ledhead. The mutation itself may be more common than we know, but unless the gene is codominantly expressed, then only a homozygous mutation (rare) would have any effect and that kind of thing would be extremely obvious from childhood.
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do you think the GH caused the cancer to occur? maybe you were destined to get it at some point through bad luck/genetics/etc. but I have to wonder if the GH caused it to speed up the process
I am curious because I had a growth down there come up out of nowhere as well and I was sure it was testicular cancer and at best a popped blood vessell, after going to the urologist it ended up being an ingrown hair lol! but from the reading I did i'm amazed at how many people have gotten this
genetics are very real.. you should get a good feel of how good your genetics are after years training.
some dudes are destined to be powerlifters, some bodybuilding, some gym rats. some just don't have any of the above. once trained with a dude the entire summer. almost the same diet, training, hours in the gym. he barely improved while I improved very quickly. I don't have great genetics but I have good ones I think. enough to get me by in this game
some dudes are destined to be powerlifters, some bodybuilding, some gym rats. some just don't have any of the above. once trained with a dude the entire summer. almost the same diet, training, hours in the gym. he barely improved while I improved very quickly. I don't have great genetics but I have good ones I think. enough to get me by in this game
sourcenyne
New member
Definitely man. I never thought I would join the Lance Armstrong club but it happened to me. Here's the thing, I do think I was destined to get it and already had it for a while before GH.
I had a horse riding incident in South America were my left teste (may he rest in peace) went up and came down a couple of hours later. It was never full size again. That happened at 22 years old. It always ached after that and was about half the size of the normal right one. Sure enough, turned cancerous.
Any time your body is dealing with a chronic issue which requires repair via mitosis, you are rolling the dyce for cancer. The p53 gene at the G1 checkpoint of cell division may experience a mutation at any time and allow for tumorogenesis. Even if the chance is 1/100,000, when you are dividing at a rate of 10 to the n'th power to heal and injury or inflammation, those odds start to add up.
What is your take on clogged receptors?
I think GH is risky for young people.. want to hold off on it till later in life. same thing with insulin.
sourcenyne
New member
The androgen receptor up regulates to accommodate higher amounts of circulating gear. In this way, cell signaling and gene transcription can continue to occur at a rate that is commensurate with the amount of gear binding to the receptors.
Your receptors don't really clog, but they may reach a temporarily threshold. You may temporarily hepatically process and excrete large and sudden increases in androgens but eventually your body will accommodate the amount of gear you give it, allowing it to undergo the full effect of the dose. When you cruise again, receptors downregulate due to the absence of high androgen levels. Receptors are highly adaptive when it comes to androgens. The AR that is. For opioids, for example, on the other hand, the proliferation that occurs in response to opioid abuse never returns to normal. You always have an elevated tolerance.
You know. I really hate Rich Piana. He talks about clogged receptors and testosterone tolerance all the time, but he's just guessing and trying to seem like he knows what he's talking about. He needs to take some anatomy and physiology.
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This is all in good taste I btw
I am enjoying this. Anyways, so would it be safe to say that WHEN YOURE RECPTORS HAVE REACHED A TEMPORARY THRESHOLD they are not untilizing the hormone to its FULLEST CAPCITY?sourcenyne
New member
This is all in good taste I btw
Oh I know man. Discussing and working stuff out is all good learning.
Yes that would be correct. It's important to note that this is a transient effect tho. Just a lag between the sudden introduction of elevated hormones levels and the upregulation of associated receptors. I don't know the actual time frame but given the adaptability of intracellular hormone receptors I would say that lasts maybe a week (speculating, should probably look it up).
It would explain why you don't start to feel immediate BOOM gains and vascularity and whatever from Tren ace on day 1, but rather it takes a week. This also has to do with the time it takes for the entire process of hormone triggering cell signaling cascade triggering transcription triggering protein synthesis and so on, but the AR is a big bottleneck in the process for a minute there.
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Not necessarily, a person can develop gene mutations throughout their life. Less than 1% of people have these mutations, and less than 1% of bodybuildings are pros. I do have literature on these studies at home. The majority of studies on myostatin have been conducted on animals, so the evidence is vague. The studies I have read, showed that over developed muscles are not always expressed at birth. But were/are expressed in a progressive manner. Nevertheless, you are making valid points.
sourcenyne
New member
Wow that is really interesting. I hadn't considered that the mutations could develop over time, which makes perfect sense and happens all the time as in the case of cancer, for example. In that case, yeah I suppose a higher percentage of pro bodybuilders could be expressing myostatin inhibiting genetics than I previously thought. Good shit.
Right....but to clarify.....what you are saying....if taking Myostain out of the equation (which really is not fair becaue Myoatain is a factor) THAT WE COULD CONTINUE TO BLAST AND NOT HAVE ANY RESISTANCE TO THE DRUG
sourcenyne
New member
Yes I believe this to be the case. Resistance would not develop like it does with meth or heroin. Myostatin being a factor, however, periodized regimens of relatively low doses and relatively high doses are likely more effective. We cant know for sure, because there aren't any studies. At least that I know of.
THATS NOT TRUE....maybe not like narcotics but LIKE NARCOTICS resistant non the less. Slice it however you want.
sourcenyne
New member
What is your evidence? Your statement isn't consistent with the medical body of knowledge concerning hormone behavior. I'm a researcher at a well-known university conducting studies on muscular dystrophy. Knowing this stuff is part of my job. Please, present any evidence at all supporting your claim.
sourcenyne
New member
You have given me a project
Deal. Peer reviewed please.
True. Also, people fail to realize that inserting more compounds during the cycle (instead all at the beginning) will make new receptors. That's why I always recommend that people insert Tren (the most anabolic compound) when Myostatin kicks in, that will indeed extend LBM gains for a couple more weeks. Imo, Tren is best as a finisher... The key to success is trying to outsmart the body, which is no easy task.
sourcenyne
New member
I love this approach. If I'm doing a 20 week run, I'll start with my test and primo, gradually increase the primo, throw in the Tren and mast 12 weeks from finish. The winstrol 4 weeks from finish. I don't know the timing at which myostatin accumulates but it just makes sense to increase doses in a graded way.
Do you know the timing?
Day 56 Myostatin kicks in. Here is the thread I made about it. "Why it is better to do 8 weeks cycles or just stay on full cycle full time." There is a study I posted in there too. [/B]
I am going to add in some A-bombs in my current cycle and the beauty part its going to be the first time I have run it so lets see what happens
sourcenyne
New member
Peer reviewed journals or studies are generally the only kind of work that is academically acceptable. It means that the study has been examined by other qualified researchers and has been deemed suitable for publication.
You can find these on places like pubmed, which is widely used in medicine. Also every university will have private databases of peer reviewed literature, but there are public databases too. I believe EBSCOhost is public.
OK....hey I wanted to pick your brain on something while I have you
I am doing the same run you outlined finishing with Tren and winstrol. I am in a cutting phase. Really trying to lean down. HOwever, I have a question about my strategy. My thoughts are its OK for me to be in a 500 calorie deficit in order to maxmise fat loss. However, being Tren do you believe more calories (especially carbs) are needed? I guess my biggest FEAR is I DONT WANT TO LOOSE MUSCLE. I dont want to get all flat.Yeah, that ought to be fun. I bet your strength increases by twofold...
sourcenyne
New member
OK....hey I wanted to pick your brain on something while I have you
Here is the thing about Tren. Depending on how much you run, your tolerance to carbohydrate intake will be increases significantly. You should look at the animal studies done on Tren, but basically, a process called de novo lipogenesis is effectively blocked regardless of carb consumption. Your deficit is totally fine, the key is to avoid the consumption of dietary fat. Keeping fats at 35-40 grams per day will keep you VERY lean and losing fat. You can still be in a deficit without sacrificing carbs this way, and still maximize fat loss. If you are using primo as well, I've noticed that primobolan allows me to maintain fullness and muscle even at deficits significantly more than 500.
Just make sure to take your 5-6 grams fish oil because reduced fat on Tren may be good for body composition but unsaturated fats are cardio protective. I know people who shred the hell up dropping to 25g fat per day on Tren, but it isn't safe for extended periods of time.
meathead96
Advanced Cyborg Brother
LOL well this thread blew up....Mateo, refer to this thread from two months ago when you were asking questions about the whole myostatin thing. http://www.evolutionary.org/forums/anabolic-steroids-peds/myostatin-cruising-3491.html , now all of the sudden you are an expert on this? Show me some research to back this up? Whether you want to believe it or not, any of the guys that you all look up to that are pro's or have a body that you desire probably are blasting year-round. Did I say its healthy? No. That's not the point of this conversation. If you actually looked halfway decent you probably would have a picture of yourself and not another man in your avatar. BTW...i guarantee you John Cena blasts year-round.
I really dont understand the animosity Meathead. Please let me know how I offended you? Sorry if I did in any way.
meathead96
Advanced Cyborg Brother
I'm sorry your right, I didn't mean to be an ass I'm just trying to get my point across.
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Flip Digler
Advanced Cyborg Brother
This is great stuff , so I'm all about using Steriods the safest possible way , year round , what is it ?
Caaannn Uuuu Diigg It ?
Caaannn Uuuu Diigg It ?
sourcenyne
New member
The safest way? TRT monitored by your physician.
Other than that, you blood work will never tell you that your left ventricle is growing and your arteries are narrowing, no matter how stellar your values are. It may not be fatal, and someone who blasts year around May live to a ripe old age. Or they might not. They might end up like that WWF hall of famer guy recently did.
The point is we all pay to play, one way or another, and in varying degree depending on our ability to tolerate steroid induced pathologies, and of course depending on the measures we take to mitigate them.
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meathead96
Advanced Cyborg Brother
Agreed, cycling really is not healthy in general but blasting year-round or blasting and cruising comes at a price. You choose your path in life. There's no telling for sure whether or not it will catch up to you in the long-run even if bloodwork is good.
I agree. Nevertheless, imo, there is no safe way to use roids. Hmm, I'm on my 22nd year at this game and I been lucky enough to remain unscathed thus far. I don't care what anyone says, when I person takes more than two compounds at the same time for more than 8 week intervals they enter into the realm of Dr. Mengele and turn themselves into a test monkey. All the people I knew from back in the day, who abused steroids, all have some kind of health problems today.
sourcenyne
New member
Mainly heart problems I'm guessing. I have a friend who has been blasting for literally 20 years straight and had what he thought was a heart attack the other day. This guy will take handfuls of orals for 8-10 months at a time with no TUDCA, NAC, Silymarin nothing. Reckless to say the least. BUT, a spotless liver. You just never know what will or will not affect you.
Flip Digler
Advanced Cyborg Brother
For fuck sake all that can happen without , people who don't smoke end up with lung cancer , healthy people drop dead all the time , thought they were doing the right thing . We might be taking more risk . I don't know where I'm going with this , I just want to do it right .
Caaannn Uuuu Diigg It ?
Caaannn Uuuu Diigg It ?
sourcenyne
New member
I'm a scientist, but it's general business smarts to minimize risk where possible. I think the same applies to anabolic steroid use. We want the rewards, so it's just about minimizing our risk. Finding a balance of gear, ancillaries and support supplements in conjunction with smart diet, training and rest.
From the little I've read of meathead96's posts and others, there's a lot of people here taking some smart steps to prevent problems. Maybe we should start a thread about support sups.
Yep. Enlarged hearts and Hypertension in the lungs, which both put a person out-of-commission. The handful of orals is all too familiar. One of those guys stayed on for 8 straight years.
I think this is and will continue to be the issue with steroid use. The body is in a constant state of anabolism (new muscle) and having to build blood vessels to that. You are increasing the pipelines (vessels) thus more blood has to be pumped to more areas (cross surface) thus the need for increased blood pressure and demand on the left ventricle. This of course leads to a demand on the pulmonary system, pushing it to produce more O2 for anabolism, but forcing it to a state of hypoxia which leads to vessel constriction and a bigger demand on the right ventricle leading to possible Cor pulmonale.
I would think someone who has been cycling for many yrs should get an EKG and Echo yearly.
Me too! I agree minimize risk, max benefits all start with basic knowledge of the drugs, diet, training and for me most of all rest.
LMAO I posted about Gluconeogenesis the other day (opposite of novo lipo) and I don't think it was understood.
Flip Digler
Advanced Cyborg Brother
Gluconeogem a what ! Lol you guys are the shiznit !
Caaannn Uuuu Diigg It ?
Caaannn Uuuu Diigg It ?
That's where triametidizine comes in, it protects the heart from pretty much all damage from AAS, though its likely not something you want to be running for lengthy periods of time
sourcenyne
New member
See, this is the kind of info I need. Can you elaborate on this drug? I'll do my own research, but if you don't mins sharing your knowledge on it that would be great.
sourcenyne
New member
haha...yes, beta. I'm preparing a talk on cell receptors for an enterovirus, wasn't giving my full attention. Not as familiar with nebivolol as I am propranolol...except I believe it can cause vasodialation through nitric oxide release....again not sure.
meathead96
Advanced Cyborg Brother
Also, through my studies, antibodies might be able to block myostatin. And finding a way to cap myostatin's docking location, preventing it from attaching to it. How great would it be if we found something to temporarily block myostatin? People don't know that the absence of myostatin also interferes with fat deposition, which would lead to slabs of lean muscle...
here is the thing though. if this was possible wouldn't that be dangerous in terms of getting injured? that would mean you would be able to improve very quickly without taking a step back destroying your soft tissues in the process. to me its like taking cortico's before a workout. yeah they will prevent you from feeling any pain during your workout but you will pay the price long term.
Probably not. A 20 to 40 percent increase of muscle mass at a rapid rate, which would be over a couple months time, which would provide ample time for skeletal elements time to grow and meet their new demands.
Wolff's law?!?!?! I agree with you Led that a mass increase of that amount could be handled by the body but I believe what Steve maybe asking is can the body handle the heavier load (from lifting more squat, dead, press) that you need to perform to get such a muscle mas increase. In that case I agree with steve that I think injury would be highly probable, b/c you would have such an accelerated skeletal muscle mass increase beyond what the soft fascia (muscle, tendon, bone, etc..) could handle leading to injury...but i'm guessing here.
sourcenyne
New member
You're exactly right. Connective tissue undergoes adaptions to mechanical load FAR slower than muscle and you would be open to severe injury. It happens all the time to 18-20 year old clueless kids running a superdrol cycle and gaining 20 lbs in 30 days. They go for a 315 bench and tear a pec or delt.
Edit: I didn't catch the timeline. A couple of months, maybe. Still seems quick to me.
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