Myostatin Rebilding Cycle

[Slose]

So I've come across a few sources that are using this technique recently. I know it is based off the study that baiscally states that when test is introduced, mystatin levels increase. They peak around day 56 (week 8) and then start to decline to base levels. It acts as a catylist to muscle growth. But they can also limit muscle growth.
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration. - PubMed - NCBI
You can use any AAS you like I'm just using test. It goes something like this:

Weeks 1-6 Test 500mg
Weeks 5-6 Test 500mg (Long ester is used)
Weeks 7-10 Stop the AAS and no pct this is where you are in theory, lowering your myostatin levels. By using a longer ester this helps you through the 4 weeks by keeping test levels elevated.
Weeks 11-16 test 500mg short or long ester
After this you run your usua

All you are doing differently is just splitting your cycle into 2 by taking a 4 week break in the middle with a long ester. I do agree that you get more gains in weeks 1-6 then 7-12 of a 12 weeks cycle. This could be due to myostatin. It's hard to say. I believe we are still in the stone age when it comes to cycle length (pretty much no studies on this) So I'm not saying anyone should try this or that this works. I just want to see what others think.

 

[jp4355]

The #1 Problem that you seem to have Ignored.

Is what is known as "Steady State".
This is achieved when Peak Blood Plasma Levels are attained.
It will usually take between 4 to 5 Half-Lives of whatever Hormone you are using.

So you have just reached Steady State by around Week 4 to 5 with Long Ester Test.
Then that 4 Week Break will put your Hormone Levels back down to almost Natty.

Then you have to Reestablish Steady State, all over again for Weeks 11 to 16.

So you would make more Gains if you just stayed on your Cycle, instead of Interrupting it...................... JP
P.S.
Steady State ~ is where Hormone Levels rise and fall within a 2-Fold Window.

You can go to this Link and put in the #'s, then you'll see what I'm talking about.

http://steroidcalc.com/

 

[muskate]

Keep it simple stupid. KISS.

I am in academia. I am the one actually doing these studies. What looks great on paper often doesn't translate into real world results.

Here's the problem with your plan. When you stop the test at week 6, the esters have already built up in your blood stream and will still be released for 2 months after your last injection. Weeks 7-10 you are not off even though you are not doing injections.

The only way your plan could work is if you used testosterone without an ester. I.e. test suspension.

 

[Slose]

You both agree that you get more gains in weeks 1-6 then 7-12? You can front load to get to steady state by week 2.5 (90%) Or you can use a faster ester. Easy problem to fix. I was saying to use a long ester cause you will need some test for those 4 weeks and will have very little by week 8 which is where you want to stop cause according to the study 56 days (8 weeks) is where the myostatin peaks and really slows progress down. So you want your levels high for the first half of the break. Maybe NPP then deca for the last week (1-6) then tren ace to end (11-17) and in theory get lot more out of the gear with a lot less gear in your body.

 

[stevesmi]

I like that you come up with a lot of theories on steroids.. your other one is that sides are caused by low estrogen. you remind me a lot of my first year or two studying steroids and experiencing them.

having said that the whole myostatin thing is absurd. your body never wants to keep mass on it for a reason. this is why i laugh when noobs claim that they gain 20 or 30 pounds in 10 weeks. ummm.. no you didn't. rich piana has a video out that he gained 70 pounds in a year of muscle.. ummmm.. no he didn't. these are wild claims that are scientifically impossible. you can gain a lot of weight fast, but it damn well sure won't be all muscle.. if such a thing was true then why isn't every person who uses steroids 600 pounds of muscle?

 

[Slose]

For having 30k posts you seem more new to this then me. You told me to use a AI when I had low estrogen. I said I had every symptom. I thought you were fucking with me but you were srs. Then you now say there aren't any sides to low estrogen?! Dum dum dum

So myostatin does exist. I'm not making this up. It's just hard to say how much effects are cycles. You got a study to disprove my claims? Or you just spewing off bs? I gained 65lbs in 60 days. More then a pound a day. For 2 months. Most of it being muscle I went went from 140lbs 12% bf to 205lbs 16% bf while I was in prision. Skinny pill head to a sober pretty strong natty. Then progress slowed wayyyyy down. So I decided to eat even more and only gained fat after that. The muscle stayed close to the same. You probably won't believe that. But myostatin is def real and is more relevant when you reach your potential and tells your system when enough is enough. Myostatin inhibitors are more then likely going to play a huge role in the future of BB.

 

[stevesmi]

For having 30k posts you seem more new to this then me.

lol that is a funny one.

You told me to use a AI when I had low estrogen.
no i didn't

I said I had every symptom. I thought you were fucking with me but you were srs. Then you now say there aren't any sides to low estrogen?! Dum dum dum
no i didn't again. estrogen should be balanced. you seem to think every symptom is linked to estrogen problems, and i am saying that isn't always the case, only bloodwork will show that.. I am actually a believer on a cycle to keep estrogen levels near high levels within range so you are wrong on that theory and haven't read enough of my posts obviously



So myostatin does exist. I'm not making this up. It's just hard to say how much effects are cycles. You got a study to disprove my claims? Or you just spewing off bs?

you seem to be looking for trouble and you are wasting my time with this sort of nonsense

I gained 65lbs in 60 days. More then a pound a day. For 2 months. Most of it being muscle I went went from 140lbs 12% bf to 205lbs 16% bf while I was in prision.

you didn't gain that much muscle in 60 days and with your attitude I am not surprised you were in prison, you sound like someone with a temper issue

Skinny pill head to a sober pretty strong natty. Then progress slowed wayyyyy down. So I decided to eat even more and only gained fat after that. The muscle stayed close to the same. You probably won't believe that. But myostatin is def real and is more relevant when you reach your potential and tells your system when enough is enough. Myostatin inhibitors are more then likely going to play a huge role in the future of BB.

i do not have time to dumb down my posts, i have a lot of people on here to help but let me try really quick. our bodies are not meant to gain a lot of mass quickly, and not meant to gain size indefinetly. I don't believe in fast gains and I don't believe in blowing up to massive size, that isn't healthy (see dallas mccarver).. myostatin thing is silly simply because anything that blocks it could mean anything grows, that includes organs, that includes your ass, that includes your stomach,
anything. plus they are a complete waste of money and even if you had legit myostatin blockers, it would cost so much money upfront but fuck you up long term anyway.

and yes i have a study to dispute your claims. read the one about the women put on myostatin blockers who blew up their thighs crazy big. there was also another one done on rats too which showed organ growth to dangerous levels.. google them

in bold.... bottom line is obsessing about 'getting big' fast is something skinny dudes do, but it isn't the way i preach it.. long and steady gains rule the roost. focus on gaining 1-2 pounds a year over the long term and you will be a beast at 40. that is exactly what marc lobliner told me on our podcast he did.

i agree with what musky said above, keep it SIMPLE. when we overcomplicate shit it only becomes more counter productive and more of a mind fuck..

 

[Mobster]

The whole mysostatin thing is, for now, a pipe dream. I'll lay it out for you.

Let's say there ARE guys following the protocol you suggest. Did they, in essence, unlock the key? Did they go from a fairly normal 160-180lbs to 300+ Is any of them (lets be nice and say a couple added the kind of weight (water and tissue) that you did) still growing? That they added the 60lbs you mentioned and kept adding. So one of them is 330...350 or even 400.

I'll answer it. No. It's not happened because someone will have done hat cycle at some point in the last 60+ years we've been using gear to get bigger. Only Kreg Kovacs and Trevor Smith have been 400lbs and muscular. I know a bunch of regional, national and international class strongmen all of which are between 300 and 440lbs. The REALLY BIG ones are as tall as I am (6'3) or taller.

But lets pretend it IS possible. It's a bad idea. Switching off the inhibtors isn't a good idea. Even if it was as simple as 'take a' and grow and take b and stop the growth there would be, like the synthol and other oil jabbing morons we can see om the net, some idiot who'd take it too far. I'm biggish framed but how about the prospect for unlimited muscle growth on a small frame = injury. I can carry on.

 

[Masonic Bodybuilder]

I completely disagree that the best gains are week 1-6. I use long esters almost every cycle and blood hormone levels don't peak until around week 5. I see the best gains from week 5-6 on to the end.