Heart Growth from test?

[ascendandforget]

Hey Guys I was wondering if anyone would know if there are real possibilities of heart issues/growth from using a relatively low dose of test (250-350mg) ?
A family member has a condition which really messes with their heart and there is a low possibility of me having it so was wondering if anyone would know what the potential risk increase might be.
(dilated cardiomyopathy caused by lamin ac)

 

[LevButlerov]

Hey Guys

welcome again to the EVO family @ascendandforget I saw you trying to buy meds on India mart (bad idea) just the other day
https://www.evolutionary.org/forums/threads/anyone-ordered-from-india-mart.111232/post-2091332

Ordered some prescription medications, the seller did an awful job of trying to hide them and got siezed right away. Almost impossible to get through nz customs with any sort of medication, especially from india mart

I was wondering if anyone would know if there are real possibilities of heart issues/growth from using a relatively low dose of test (250-350mg) ?
A family member has a condition which really messes with their heart and there is a low possibility of me having it so was wondering if anyone would know what the potential risk increase might be.
(dilated cardiomyopathy caused by lamin ac)

There was a big study on this that didnt show higher major heart attack stroke or cardiac death risk, you can call this more objective info.
https://www.nejm.org/doi/full/10.1056/NEJMoa2215025
Quote from actual study:

testosterone-replacement therapy was noninferior to placebo with respect to the incidence of major adverse cardiac events

But with a family history of cardiomyopathy you cannot just guess on 250mgs test! you need to get a full log going now with bloodwork, blood pressure, resting hr, food, training, cardio, weight, and weekly updates so the EVO family can help you safely. self TRT can be safe when it is monitored, but without a log noone here can tell you risk, so start the log before cycling fully. 15min of your time to change your life!

HOW-TO LOG?

Why is a Log Journal important?

• Doing a log will actually help you way more than just dropping random updates. When you lay it all out week by week you start to see patterns in your body that you won’t catch otherwise.
• Other guys here run logs all the time and there’s no privacy issue, nobody is asking for your name or anything personal, it is just training, diet, and how the compound feels.
• The feedback you get is also way better because people can follow along and spot things you might miss. It also helps the next guy who is thinking about running the same compound so you are giving back while you learn.
• Even if you think you might not stick with it, just starting the log makes it easier to come back and add quick notes. That way you get more out of what you are running instead of keeping it all in your head.

To really guide you we need more info from you:

• Please share your diet, training, cardio, sleep, supplements etc log with us in a NEW thread, full log journal so our guidance is based on facts you provide.
• It will take 15-20 minutes max.
• We have 100s of years of experience between us, so you need to post a LOG Journal with your stats (weight,height,age, years training, cycle history) diet, training, cardio, supplement, sleep details. If you don't log what you eat or train now, open NOTES on phone and start recording it there and paste here. Very easy.
• Please post a Log Journal asap for us

Please click the anabolic forum
https://www.evolutionary.org/forums/forums/anabolic-steroids-and-peds.2/
top RIGHT, you see: +POST THREAD
click that

in Title: write your cycle name, like> My _____ Cycle Log
___ = the name of your log
example: My testosterone cycle Log
in body: write your planned cycle or cycle you doing now, your diet, training and we will help you along on your cycle

here are examples of LOG Journals
https://www.evolutionary.org/forums/threads/first-testosterone-cycle-log.104133/
https://www.evolutionary.org/forums/threads/sustanon-trenomast-deca-dbol-cycle-journal.105881/
https://www.evolutionary.org/forums/threads/s-gentz-2025-26-growth-phase-log-with-psl.106514/
https://www.evolutionary.org/forums...var-bpc157-beligas-pharmaqo-cycle-log.104843/
https://www.evolutionary.org/forums...g-log-sponsored-by-purity-source-labs.103669/
https://www.evolutionary.org/forums...erone-cycle-and-beginner-training-log.106310/
https://www.evolutionary.org/forums/threads/average-trt-back-to-savage-cycle-journal.106252
https://www.evolutionary.org/forums...-testosterone-masteron-primobolan-deca.105348
https://www.evolutionary.org/forums...odybuilding-log-masters-55-competitor.102611/
https://www.evolutionary.org/forums...ron-npp-tren-anadrol-log-to-stage-2025.102590

P.S. are you listening to our podcast? if not, you should; this podcast is about steroids, sarms, peptides, and bodybuilding:
https://www.evolutionary.org/podcasts/
https://podcasts.apple.com/us/podcast/evolutionary-bodybuilding-radio/id1798623410
https://open.spotify.com/show/53q1RFTgG4h6TQHsJ4xY6Z

@HarleyGuy @Allupfromhere @Pigsy @waggat @Trenhead3cc @Kopite67
@Grumpy @LH5515 @Yuri @Doctakay @catdadironman @bss @Shakey @Ohdamn

 

[ascendandforget]

welcome again to the EVO family @ascendandforget I saw you trying to buy meds on India mart (bad idea) just the other day
https://www.evolutionary.org/forums/threads/anyone-ordered-from-india-mart.111232/post-2091332



There was a big study on this that didnt show higher major heart attack stroke or cardiac death risk, you can call this more objective info.
https://www.nejm.org/doi/full/10.1056/NEJMoa2215025
Quote from actual study:

But with a family history of cardiomyopathy you cannot just guess on 250mgs test! you need to get a full log going now with bloodwork, blood pressure, resting hr, food, training, cardio, weight, and weekly updates so the EVO family can help you safely. self TRT can be safe when it is monitored, but without a log noone here can tell you risk, so start the log before cycling fully. 15min of your time to change your life!

HOW-TO LOG?

Why is a Log Journal important?

• Doing a log will actually help you way more than just dropping random updates. When you lay it all out week by week you start to see patterns in your body that you won’t catch otherwise.
• Other guys here run logs all the time and there’s no privacy issue, nobody is asking for your name or anything personal, it is just training, diet, and how the compound feels.
• The feedback you get is also way better because people can follow along and spot things you might miss. It also helps the next guy who is thinking about running the same compound so you are giving back while you learn.
• Even if you think you might not stick with it, just starting the log makes it easier to come back and add quick notes. That way you get more out of what you are running instead of keeping it all in your head.

To really guide you we need more info from you:

• Please share your diet, training, cardio, sleep, supplements etc log with us in a NEW thread, full log journal so our guidance is based on facts you provide.
• It will take 15-20 minutes max.
• We have 100s of years of experience between us, so you need to post a LOG Journal with your stats (weight,height,age, years training, cycle history) diet, training, cardio, supplement, sleep details. If you don't log what you eat or train now, open NOTES on phone and start recording it there and paste here. Very easy.
• Please post a Log Journal asap for us

Please click the anabolic forum
https://www.evolutionary.org/forums/forums/anabolic-steroids-and-peds.2/
top RIGHT, you see: +POST THREAD
click that

in Title: write your cycle name, like> My _____ Cycle Log
___ = the name of your log
example: My testosterone cycle Log
in body: write your planned cycle or cycle you doing now, your diet, training and we will help you along on your cycle

here are examples of LOG Journals
https://www.evolutionary.org/forums/threads/first-testosterone-cycle-log.104133/
https://www.evolutionary.org/forums/threads/sustanon-trenomast-deca-dbol-cycle-journal.105881/
https://www.evolutionary.org/forums/threads/s-gentz-2025-26-growth-phase-log-with-psl.106514/
https://www.evolutionary.org/forums...var-bpc157-beligas-pharmaqo-cycle-log.104843/
https://www.evolutionary.org/forums...g-log-sponsored-by-purity-source-labs.103669/
https://www.evolutionary.org/forums...erone-cycle-and-beginner-training-log.106310/
https://www.evolutionary.org/forums/threads/average-trt-back-to-savage-cycle-journal.106252
https://www.evolutionary.org/forums...-testosterone-masteron-primobolan-deca.105348
https://www.evolutionary.org/forums...odybuilding-log-masters-55-competitor.102611/
https://www.evolutionary.org/forums...ron-npp-tren-anadrol-log-to-stage-2025.102590

P.S. are you listening to our podcast? if not, you should; this podcast is about steroids, sarms, peptides, and bodybuilding:
https://www.evolutionary.org/podcasts/
https://podcasts.apple.com/us/podcast/evolutionary-bodybuilding-radio/id1798623410
https://open.spotify.com/show/53q1RFTgG4h6TQHsJ4xY6Z

@HarleyGuy @Allupfromhere @Pigsy @waggat @Trenhead3cc @Kopite67
@Grumpy @LH5515 @Yuri @Doctakay @catdadironman @bss @Shakey @Ohdamn

Haha yea was only buying accutane but wasnt expecting it to arrive. I haven't hoped on yet, still doing research n what not and if i do decide to ill definitely get a log up and running. Thanks for the study ive have a browse

 

[Doctakay]

Hey Guys I was wondering if anyone would know if there are real possibilities of heart issues/growth from using a relatively low dose of test (250-350mg) ?
A family member has a condition which really messes with their heart and there is a low possibility of me having it so was wondering if anyone would know what the potential risk increase might be.
(dilated cardiomyopathy caused by lamin ac)

As @LevButlerov suggested, have a squiz through that paper and I would absolutely start a log. Plenty of great minds here to help.

I have seen potential issues with Nandralone but nothing major with bioidentical testosterone, but I havent personally delved into this area tbf.

Is there any testing procedure you can do to estimate your potential to risk? Gene testing or something the likes of an Echo?

 

[ascendandforget]

As @LevButlerov suggested, have a squiz through that paper and I would absolutely start a log. Plenty of great minds here to help.

I have seen potential issues with Nandralone but nothing major with bioidentical testosterone, but I havent personally delved into this area tbf.

Is there any testing procedure you can do to estimate your potential to risk? Gene testing or something the likes of an Echo?

Yea im on a waiting list for gene testing but that shit is going to take so long since where I live they are incredibly slow with testing unless you are like abt to die

 

[Sheshredz]

people normally take Nebivolol as it prevent left ventricular hypertrophy.

Also Telmisartan lowers blood pressure and that helps keep your heart healthy.

 

[ascendandforget]

people normally take Nebivolol as it prevent left ventricular hypertrophy.

Also Telmisartan lowers blood pressure and that helps keep your heart healthy.

thanks ive have a look into them

 

[Sheshredz]

thanks ive have a look into them

No problem

 

[Shakey]

Hey Guys I was wondering if anyone would know if there are real possibilities of heart issues/growth from using a relatively low dose of test (250-350mg) ?
A family member has a condition which really messes with their heart and there is a low possibility of me having it so was wondering if anyone would know what the potential risk increase might be.
(dilated cardiomyopathy caused by lamin ac)

Youve caught my interest with this. Let me see what i can find for peer reviewed studies on both trt level and supraphysiological aas levels and ill link em here.

I second @LevButlerov , full monitoring on a log and any testing that can be done like an echo etc. Not sure what country your in but is your doctor easy to talk to about heart health while on cycle?

 

[Mobster]

Directly just by using test. No. You don't hear of those being treated with steroids for medical issues having enlarged hearts as such.

But LOTS of athletes have enlarged hearts due to the indirect issue (heart is a muscle and GH can make it happen). The issue is thus:

You train (so run, lift weights etc) so the heart works harder. Steroids enable you to do more. So the heart works more.

 

[Mobster]

Yea im on a waiting list for gene testing but that shit is going to take so long since where I live they are incredibly slow with testing unless you are like abt to die

So pony up the cash. That you had ready to buy test with lol

 

[toddthelineman]

Taking steroids is a cardiac risk. If you were responsible person, you should always be watching out for your heart. If you know you have a heart problem you should probably not use steroids if you care about your health and your life if you don’t have an existing heart problem, and you introduce a cardiac risk, such as steroids than the responsible thing to do is to keep a close eye on your heart. So if you take 350 mg of test for like a year, your heart probably will be bigger. So whatever your risk tolerance is, that’s how you need to answer your question.

 

[ascendandforget]

Youve caught my interest with this. Let me see what i can find for peer reviewed studies on both trt level and supraphysiological aas levels and ill link em here.

I second @LevButlerov , full monitoring on a log and any testing that can be done like an echo etc. Not sure what country your in but is your doctor easy to talk to about heart health while on cycle?

havent really tried talking to doctor about being on cycle whatsoever tbh I dont think he would be too impressed

 

[Shakey]

havent really tried talking to doctor about being on cycle whatsoever tbh I dont think he would be too impressed

Most wouldnt. Online doctors seem to not care as much towards the stuff atleast here in canada it seems.

 

[mcstabby]

Most GP's have no fucking clue what being on cycle is. I had low and i mean next to zero testosterone after a number of cancer surgeries and treatments due to infections and various other complications. Felt like absolute dirt for a few years in fact. Spoke to a clinical psychologist and she asked if i had ever had a full blood panel done. Asked me to get a refereal and see and endo. She did a full hormone blood panel. I did some reasearch and started on test 125mg. 8 weeks later, I was a new man. Never looked back. Fuck GP's

 

[stevesmi]

Dallas McCarver's heart was 3x normal.

i can tell you that even running test at slightly above real trt amounts can cause thickening blood and cholesterol levels being off

nobody on here is a cardiologist (as far as I know) so this would be a conversation to have with them or at worst working with them to ensure you are doing it the safe way

 

[stevesmi]

Most GP's have no fucking clue what being on cycle is. I had low and i mean next to zero testosterone after a number of cancer surgeries and treatments due to infections and various other complications. Felt like absolute dirt for a few years in fact. Spoke to a clinical psychologist and she asked if i had ever had a full blood panel done. Asked me to get a refereal and see and endo. She did a full hormone blood panel. I did some reasearch and started on test 125mg. 8 weeks later, I was a new man. Never looked back. Fuck GP's

this is correct.

reminds me of my conversation on the phone 2 days ago with my brokerage firm and being connected to the 'general department' and talking to a guy who just pretended to be doing something and who had no clue how to solve a thing, who then swiftly transferred me to another person. that is essentially what GP's are. just people who went to med school who don't have any sort of special skill but have the power to give you a referral or write a script

 

[Shakey]

Most GP's have no fucking clue what being on cycle is. I had low and i mean next to zero testosterone after a number of cancer surgeries and treatments due to infections and various other complications. Felt like absolute dirt for a few years in fact. Spoke to a clinical psychologist and she asked if i had ever had a full blood panel done. Asked me to get a refereal and see and endo. She did a full hormone blood panel. I did some reasearch and started on test 125mg. 8 weeks later, I was a new man. Never looked back. Fuck GP's

Agreed. My gp screamed at me for bringin up cbd for my seizures. Yelled it was a gateway drug. Lol

 

[Shakey]

havent really tried talking to doctor about being on cycle whatsoever tbh I dont think he would be too impressed

Okay so ive browsed a bit and found some reading for you. Id say along with good monitoring on your bloods and bp etc on your log, trt+ or 250 would be preferable til you know your results from gene testing.

@LevButlerov @HarleyGuy You guys might enjoy these for some light reading. The first one though admits the study cohort is small and some findings were from individual cases but interesting non the less.

Anabolic–Androgenic Steroids Induced Cardiomyopathy: A Narrative Review of the Literature
"Chronic supraphysiologic AAS use promotes cardiac injury and adverse cardiac remodeling via oxidative stress, androgen receptor overactivation, RAAS dysregulation, and pro-apoptotic signaling. These changes could lead to hypertension, dyslipidemia and atherosclerosis, myocardial fibrosis and hypertrophy, arrhythmias, heart failure, and kidney injury. Vascular dysfunction, increased arterial stiffness, and a prothrombotic state further compound the cardiovascular risks."
"Although cessation of AAS use may lead to partial or complete reversal of cardiac dysfunction in some individuals, others may experience irreversible myocardial damage. The reversibility appears to depend on dosage, duration of exposure, and early intervention."
https://pmc.ncbi.nlm.nih.gov/articles/PMC12467473

Testosterone replacement therapy in heart failure: A systematic review of randomized controlled trials - couldnt get the free text, apparently springer studies are harder to get
"Our search yielded 653 records, of which 12 studies met the inclusion criteria. Key findings include significant improvements in muscle strength and aerobic capacity as well as increases in lean muscle mass and decreases in fat mass in certain trials. Additionally, improvements in insulin sensitivity and shortening of the QT interval were reported. TRT did not consistently affect blood pressure, lipid profiles, or heart rate, nor did it lead to any serious adverse effects."
https://link.springer.com/article/10.1007/s42000-025-00658-y

Anabolic androgenic steroids and cardiomyopathy: an update
This one mentions that Testosterone Replacement therapy for Assessment of long-term Vascular Events and efficacy ResponSE (TRAVERSE) study @LevButlerov mentioned.

"Supraphysiological doses of AAS have been shown to induce cardiomyopathy via biventricular dysfunction"
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1214374

 

[HarleyGuy]

Okay so ive browsed a bit and found some reading for you. Id say along with good monitoring on your bloods and bp etc on your log, trt+ or 250 would be preferable til you know your results from gene testing.

@LevButlerov @HarleyGuy You guys might enjoy these for some light reading. The first one though admits the study cohort is small and some findings were from individual cases but interesting non the less.

Anabolic–Androgenic Steroids Induced Cardiomyopathy: A Narrative Review of the Literature
"Chronic supraphysiologic AAS use promotes cardiac injury and adverse cardiac remodeling via oxidative stress, androgen receptor overactivation, RAAS dysregulation, and pro-apoptotic signaling. These changes could lead to hypertension, dyslipidemia and atherosclerosis, myocardial fibrosis and hypertrophy, arrhythmias, heart failure, and kidney injury. Vascular dysfunction, increased arterial stiffness, and a prothrombotic state further compound the cardiovascular risks."
"Although cessation of AAS use may lead to partial or complete reversal of cardiac dysfunction in some individuals, others may experience irreversible myocardial damage. The reversibility appears to depend on dosage, duration of exposure, and early intervention."
https://pmc.ncbi.nlm.nih.gov/articles/PMC12467473

Testosterone replacement therapy in heart failure: A systematic review of randomized controlled trials - couldnt get the free text, apparently springer studies are harder to get
"Our search yielded 653 records, of which 12 studies met the inclusion criteria. Key findings include significant improvements in muscle strength and aerobic capacity as well as increases in lean muscle mass and decreases in fat mass in certain trials. Additionally, improvements in insulin sensitivity and shortening of the QT interval were reported. TRT did not consistently affect blood pressure, lipid profiles, or heart rate, nor did it lead to any serious adverse effects."
https://link.springer.com/article/10.1007/s42000-025-00658-y

Anabolic androgenic steroids and cardiomyopathy: an update
This one mentions that Testosterone Replacement therapy for Assessment of long-term Vascular Events and efficacy ResponSE (TRAVERSE) study @LevButlerov mentioned.
View attachment 243589
"Supraphysiological doses of AAS have been shown to induce cardiomyopathy via biventricular dysfunction"
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2023.1214374

Very well written and great studies you chose! I loved reading this it's actually accessible to most layman readers out there too. Great post brother! I see the OCD is firing on all cylinders this fine evening

couldnt get the free text, apparently springer studies are harder to get

They are ya. I considered paying to have full access but meh, there's so many out there why bother.

 

[Shakey]

Very well written and great studies you chose! I loved reading this it's actually accessible to most layman readers out there too. Great post brother! I see the OCD is firing on all cylinders this fine evening


They are ya. I considered paying to have full access but meh, there's so many out there why bother.

That it was. My interest was caught. I had the studies open all day but i didnt have time to read them until my midnight workout.

You can search the doi for an article/study on sci-hub to get the full text free if they have it. Most authors will also email you a pdf if you email them as well.

 

[HarleyGuy]

Most authors will also email you a pdf if you email them as well.

Very cool I didn't know that.

 

[HarleyGuy]

There was a big study on this that didnt show higher major heart attack stroke or cardiac death risk, you can call this more objective info.
https://www.nejm.org/doi/full/10.1056/NEJMoa2215025

Good study @LevButlerov I hadn't seen this one before.

@ascendandforget Why don't you start up a log for us and we'll help you along with your concerns and your goals as well.

 

[Shakey]

Very cool I didn't know that.

Yup. Their emails are always listed for correspondence and its not gauranteed of course but i hear theyll often send you a copy if you ask nicely. Lol

 

[Mobster]

Directly just by using test. No. You don't hear of those being treated with steroids for medical issues having enlarged hearts as such.

But LOTS of athletes have enlarged hearts due to the indirect issue (heart is a muscle and GH can make it happen). The issue is thus:

You train (so run, lift weights etc) so the heart works harder. Steroids enable you to do more. So the heart works more.

I'll add to this based on info above. The thickened blood does affect BP (hence why, just for myself, I use baby aspirin and Beet juice) and the effects of cholesterol