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oliverrxx
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this article outlines why t4 is a must, the process of conversion from t4 to t3 is necessary.
we want types 1 and 2 deiodinase there is a 3rd way which is responsible for 20 percent of the conversion of t4 into the "active" t3 but we want types 1 and 2 of the enzyme . to reiterate this enzyme is created during the conversion process and allows the gh receptors to up regulate
gh is highly synergistic with t3 but we need the conversion process take place to create the enzyme
t3 will increase igf levels while on exogenous hgh however taking straight t3 will limit anabolic effect of hgh
the active thyroid hormone and igf/insulin have a direct link for example if there is neither igf or insulin the active thyroid hormone will have no physiological effect from t3
somatostatin (SS) increases when exogenous hgh is released the thyroid also contains SS producing cells, higher levels of SS can inhibit thyroid stimulating hormone (hormone responsible for release of t4 and subsequently t3)
so when you add GH into your body from an outside source, you are triggering the body into releasing SS, because your body no longer needs to produce its own supply of GH…and unfortunately, the release of SS can also inhibit TSH, and therefore limit the amount of T4 your body produces.
WHICH LIMITS THE CONVERSION OF T4 TO T3 WHICH INHIBITS THE AMOUNT OF THE DEIDINASE ENYMES TYPES 1 AND 2 WHICH HELP WITH THE TRANSFER OF GENE TRANSCRIPTION OF HGH AND UPREGULATING HGH RECEPTORS INCLUDING SATELLITE CELLS OF IGF
As noted before, T3 enhances many effects of GH by several mechanisms, including (but not limited to): increasing IGF-1 levels, IGF-1 mRNA levels
HOWEVER If we use T3 + GH, we get a decrease in the anabolic effect of GH.
the enzyme that would regulate some of T3’s ability to stimulate protein synthesis, while they are simultaneously signaling the body to produce an inhibitory enzyme (D3) we want to introduce t4 to get enzymes D1 and D2
D3 enzyme to inhibit the T3/GH synergy that is necessary.
ADDING T3 SHUTS DOWNT THE PATHWAYS OF HGH GENE TRANSCRIPTION WHILE T4 STIMULATES THESE PATHWAYS
to some it up So we want elevated T3 levels when we take GH, or we won’t be getting ANYWHERE NEAR the full anabolic effect of our injectable GH without enough T3. And now we know that not only do we need the additional T3, but we actually want the CONVERSION process of T4 into T3 to take place, because it’s the presence of those mediator enzymes that will allow the T3 to be synergistic with GH, instead of being inhibitory as is seen when T3 is simply added to a GH cycle. And remember, we don’t only want T3 levels high, but we want types 1 and 2 deiodinase to get us there- and when we take supplemental T3, that just doesn’t happen…all that happens is the type 3 deiodinase enzyme shows up and negates the beneficial effects of the T3 when we combine it with GH.
https://******************/articles/thyroid-hormone-growth-hormone/
we want types 1 and 2 deiodinase there is a 3rd way which is responsible for 20 percent of the conversion of t4 into the "active" t3 but we want types 1 and 2 of the enzyme . to reiterate this enzyme is created during the conversion process and allows the gh receptors to up regulate
gh is highly synergistic with t3 but we need the conversion process take place to create the enzyme
t3 will increase igf levels while on exogenous hgh however taking straight t3 will limit anabolic effect of hgh
the active thyroid hormone and igf/insulin have a direct link for example if there is neither igf or insulin the active thyroid hormone will have no physiological effect from t3
somatostatin (SS) increases when exogenous hgh is released the thyroid also contains SS producing cells, higher levels of SS can inhibit thyroid stimulating hormone (hormone responsible for release of t4 and subsequently t3)
so when you add GH into your body from an outside source, you are triggering the body into releasing SS, because your body no longer needs to produce its own supply of GH…and unfortunately, the release of SS can also inhibit TSH, and therefore limit the amount of T4 your body produces.
WHICH LIMITS THE CONVERSION OF T4 TO T3 WHICH INHIBITS THE AMOUNT OF THE DEIDINASE ENYMES TYPES 1 AND 2 WHICH HELP WITH THE TRANSFER OF GENE TRANSCRIPTION OF HGH AND UPREGULATING HGH RECEPTORS INCLUDING SATELLITE CELLS OF IGF
As noted before, T3 enhances many effects of GH by several mechanisms, including (but not limited to): increasing IGF-1 levels, IGF-1 mRNA levels
HOWEVER If we use T3 + GH, we get a decrease in the anabolic effect of GH.
the enzyme that would regulate some of T3’s ability to stimulate protein synthesis, while they are simultaneously signaling the body to produce an inhibitory enzyme (D3) we want to introduce t4 to get enzymes D1 and D2
D3 enzyme to inhibit the T3/GH synergy that is necessary.
ADDING T3 SHUTS DOWNT THE PATHWAYS OF HGH GENE TRANSCRIPTION WHILE T4 STIMULATES THESE PATHWAYS
to some it up So we want elevated T3 levels when we take GH, or we won’t be getting ANYWHERE NEAR the full anabolic effect of our injectable GH without enough T3. And now we know that not only do we need the additional T3, but we actually want the CONVERSION process of T4 into T3 to take place, because it’s the presence of those mediator enzymes that will allow the T3 to be synergistic with GH, instead of being inhibitory as is seen when T3 is simply added to a GH cycle. And remember, we don’t only want T3 levels high, but we want types 1 and 2 deiodinase to get us there- and when we take supplemental T3, that just doesn’t happen…all that happens is the type 3 deiodinase enzyme shows up and negates the beneficial effects of the T3 when we combine it with GH.
https://******************/articles/thyroid-hormone-growth-hormone/
