Why do we use TUDCA rather than UDCA(or ursodiol) with oral steroids?

[ftfaaa]

I find the liver toxic of oral steroids is due to Cholestasis. So even though we use Milk Thistle or ALA, they are only anti-oxidant and they can't solve the problem from the root. However UDCA(or ursodiol) is the prescribed drug to cure Cholestasis. TUDCA is the taurine conjugate form of ursodeoxycholic acid (UDCA) and it a OTC supplements. I don't know how effective is this OTC supplement.

So why don't we directly use UDCA along with oral steroids? Because UDCA is a drug which is proven effective by science. We can get steroids from some black markets so I think it's not hard to get prescribed drug also. I'm just curious about why we don't use UDCA if it truly solve the problem.

 

[muskate]

UDCA is only available with a prescription. Getting a doctor to write you a prescription isn’t as easy as you would think.

Adding a taurine molecule to the compound will only benefit you since taurine has a host of positive benefits in itself.

 

[ftfaaa]

UDCA is only available with a prescription. Getting a doctor to write you a prescription isn’t as easy as you would think.

Adding a taurine molecule to the compound will only benefit you since taurine has a host of positive benefits in itself.

Thanks man.

I think UDCA can also be bought in black market like exemestane, cloimd etc. And in wiki, I don't find any saying talking about TUDCA with Cholestasis.

 

[macedog24]

https://www.ncbi.nlm.nih.gov/m/pubmed/7615206/

Here is one study hope this helps, i will post more info when i get up.

 

[stevesmi]

n2guard contains TUDCA and dozens of additional ingredients.. it is a wonderful support supplement and will do the job.

 

[Mobster]

I find the liver toxic of oral steroids is due to Cholestasis. So even though we use Milk Thistle or ALA, they are only anti-oxidant and they can't solve the problem from the root. However UDCA(or ursodiol) is the prescribed drug to cure Cholestasis. TUDCA is the taurine conjugate form of ursodeoxycholic acid (UDCA) and it a OTC supplements. I don't know how effective is this OTC supplement.

So why don't we directly use UDCA along with oral steroids? Because UDCA is a drug which is proven effective by science. We can get steroids from some black markets so I think it's not hard to get prescribed drug also. I'm just curious about why we don't use UDCA if it truly solve the problem.

So it's not easy.