Nutrobal (Mk-677) is an orally administrated growth hormone secretagogue originally developed by Reverse Pharmacology. A secretagogue is the term for a substance that chemically signals for the pituitary gland to secrete growth hormone. In other words, Nutrobal could be compared to peptides like GHRP-6 or Ipamorelin, only it doesn't require any injections nor does it have any side effects like GHRP-6. This GHS (Growth Hormone Secretagogue) was developed in an aim to combat such conditions as muscle wasting, obesity and osteoporosis. It was also targeted towards treatment of elderly hip fracture patients, so there are a myriad of studies done on safety.
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How it Works
Growth hormone pulse intensity can be increased through 4 possible mechanisms:
- Increasing GHRH (growth hormone releasing hormone) release.
- Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
- Reducing somatostatin release (somatostatin turns off GH release).
- Inhibiting of somatostatin receptor signaling.
Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting. After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
Trials testing the effects of this GHS on fighting obesity showed an increase in lean body mass, but neither total, nor visceral adipose tissue was effected. This study gave subjects 25mgs of Nutrobal per day for 8 weeks. The subjects showed an increase in basal metabolic rate after 2 weeks, and an increase in serum levels of GH, IGF-1 and IGF-1 binding protein-3. Increase in lean body mass was hypothesized to be caused by an increase in calorie deposition into the muscle and appetite decrease as opposed to reducing fat storage directly.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.
How can it help you?
Elevated growth hormone has literally endless list of benefits to the human body, why do you think everyone tries to get their hands on HGH? That's why Nutrobal (Mk-677) is so effective, it increases Growth Hormone and IGF-1 levels.
As the studies show, Nutrobal can be used for a number of reasons from growing muscle mass, to getting shredded. It does not compete with the levels of growth hormone one can get from exogenously administered HGH, so you can use it with hgh cycles. In fact, by using nutrobal, you can easily get amazing increases of your own natural growth hormone pulses without having to deal with annoying and painful daily HGH injections. It's like using HGH without having to inject daily.
In a multitude of studies, Nutrobal (Mk-677) increased IGF-1 levels by between 39-89%. To give you an idea of what IGF-1 does, here are some IGF-1 benefits:
- Increased Fat Oxidation (fat loss).
- Increased Muscle gains (lean mass).
- Tightening up loose skin.
- Healing old injuries.
- Healing Bones, Tendons and Ligaments.
In fact, many users report growing up to 6 lbs of lean muscle mass in 8 weeks of IGF-1 only cycles. That's an amazing result, but injecting IGF-1 daily is painful, costly and frustrating. Now, there is an oral-only alternative.
|NOTE: Only ramp up andarine if you have the dosing schedule and side effects schedule properly planned. Otherwise, stick to a lower dose. See this andarine (s4) dosing schedule.Glossary:|
ED = every day
mgs = milligrams
tabs = tablets
caps = capsules
This is an amazing cutting stack with Cardarine and Andarine, which will help melt off the stubborn fat and increase your muscle mass.
Results have been shown from doses between 5-25mgs a day, dose dependent results should be expected. Higher doses, over 50mgs, have been reported by some, but I don't see the need to overdo it.
Some of the usual side effects that go with elevated GH levels such as numb hands, some lethargy, as well as slight increased appetite have been reported with the use of Mk-677.
Interestingly, during prolonged administration both IGF-1 and GH were increased with no increase in cortisol.
Some anecdotal evidence suggested there was a temporary small increase in prolactin when beginning administration, so individuals who are very prone to prolactin side effect may want to incorporate a short schedule of HCGenerate ES to prevent problems. I want to stress, this is only an issue for guys who are extremely prone to prolactin sides, which is usually 1% of users. How do you know if you're prone to prolactin sides? If you get gynecomastia from taking trenbolone, you're prone to prolactin sides.
Nutrobal (Mk-677) was found to be very safe and, in fact, showed to reduce tumors in mice, which was hypothesized to be from an increased immune system response.
Want to read about SARMS on our forums? check out these threads:
- MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial
- The Safety and Efficacy of Growth Hormone Secretagogues
- Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial
- Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man
- Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats
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