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Can confirm that the generic BAC was used with other peptides and did not cause any adverse reactions. I can source Hospira if that makes a genuine difference.
Community Research MOTS-C Peptide - Overview, Dosing, and Reviews
- Thread starter HarleyGuy
- Start date
Threads marked with the 'Community Research' prefix involve ongoing research, high-quality logs, or in-depth community discussions backed by experience, data, or expert input.
bros have a separate fridge lol
bros i used to watch that show as a kid too. funny
I'm currently in my second week of SS31 with it and I agree, maybe that's what made the difference.
LevButlerov
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is that a quad injection? @OwEv751
Subq of quad (or I think it was), was trying to grab a different fat part away from the abdomens since there's now a few hard nodules formed from the Mots-c. Probably could move slightly more towards the thighs.
Going to pause on Mots-c to check bloods first before doing any more testing. Thinking my Eos could be too elevated right now.
Can i suggest trying a different dilution ratio, this helped me with MT2 as an example. 10mg/2.5-3ml
LevButlerov
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Never pin your quad period, even IM, its the place with all sorts of issues @OwEv751
and I suggest listening to @G-Merc 80 you should dilute
Thanks, I'll try increase to 10mg/3ml. I'll try another subq shot and if that doesn't work I might need to do IM....
I agree with @LevButlerov and @G-Merc 80 just dilute more and always avoid quads, no need to use quads when site rotation isn't in play with such a small amount of Bac water. Use love handles at the back.
Il add my two cents so far after 3 weeks using mots c in my current protocol. Iv been using it 2mg m/w/f in the am as pre workout about 45 minutes before weight training and 1:45 before cardio. Iv been logging how I feel the days I take it. I find what I’m noticing most and really all I’m noticing is it seems to make cardio much much easier. Almost feels like I’m using half the energy to achieve the same results. 3ml bac to 10mg/20mg bottle and no injection issues. Doing sub q on the abdomen. I get a small red lump that last for about 15 minutes then there is zero sign of an injection.
I’m going to finish my current bottle and stay off it for a few weeks to see if I notice a difference.
I’m going to finish my current bottle and stay off it for a few weeks to see if I notice a difference.
This is great feedback @Scott40 thank you so much for contributing to our community research on MOTS-c
You should put this review in your log with dosing on all that you're taking including a pic of yourself with face blurred. Let's get you up and running you have good input for us. Update here
https://www.evolutionary.org/forums/threads/2026-cycle-log-east-coast-scott.110012/
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what brand of mots-C are you using? @Scott40
One vial from biogenix, the other was from another trusted source.
Attachments
Nice choice going with @biogenix and TD pic too.
Attention all:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Results are here: A case study was done on mixing your MOTS-c with HGH in the same slin pin
Case Study: Can we mix HGH with MOTS-c?Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast @rayray01
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Last edited:
you are the best! nice experimentAttention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Attention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Super cool infused both myself. Please do include me in any such studies brother, I will always be up for it. @HarleyGuy
Time to load up the boat then. Go ahead and slam both of them.Attention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Is that multi dose vial spike ? Were did you source if don’t mind me asking thanks
Done! I added you to the tags and will cut and paste you moving forward always. Thanks for your interest brother I'm not surprised as your an enthusiast like me and a great member of EVO!
It appears so yes! Next up is HGH with Reta. I wanna have case studies on all the most popular peptides to see if we can save our EVO brothers and sisters some time and money.
It appears so!
Bros, hell yeah! Anytime you can save on pins and save on needles, that's a good thing. I'm glad you posted this experiment.Attention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast @rayray01
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Awesome, I use them them, let me ask what is the dosage for the research purpose, what are other controls in place to ensure consistency across all participating eVo family members, when is the start and end date of the study. Any specific protocols thst are being followed. What is the study for in terms of outcome? Or is it as simple as can we use the same syringe and mix the two. I want to make sure I am following all the guidelines for it. Please advise. @HarleyGuy
I deleted my other post about generic bac water because i saw this one. Did you just start mots? You can probably just take anti histamines while your body adapts. With glow i just didnt bother, pinned til my body stopped reacting.
This is an adapter from comfort-in. It’s used for there needle free auto injector. Which is great by the way for anyone who hasn’t seen the product.Is that multi dose vial spike ? Were did you source if don’t mind me asking thanks
This is quite common. The injection site can be irritated/itchy for me for a day or two. Less so if I go shallow IM rather than sub-q
Good question, I wish I had more detailed answer for you but it was a one time deal using myself as the guinea pig. HGH was ceased for 6 days prior to the experiment so any observed spike in IGF1 ought to have come from that morning's HGH IM injection.
It's as simple as that pretty much. We can mix HGH with MOTS-c and HGH with KLOW is what we know if we are going by way of my experiment as an n=1 form of evidence for a conclusion. The experiment was done IM in order to spike IGF about 3 hours after administration of HGH and as shown the IGF went way above high range, meaning the MOTS-c played no role in the efficacy of the HGH and, presumably, the MOTS-c efficacy remained unchanged as well.
You can check out the mixing of HGH with KLOW here as well
Case Study: Mixing HGH with 4 other peptides?
Be super interested in this one brother
Love it! You shall be tagged good sir!Be super interested in this one brother
The easiest constant in all this is GH, which ought to predictably spike IGF after 3 hours if injected IM and is an easy marker to test if it stayed stable in an environment with other peptides. Anything added to the GH we can presume wasn't interfered with if IGF spikes as expected meaning the GH wasn't compromised therefore anything added in with it musn't have been as well. It isn't an exact science but it's not nothing either.
There currently aren't 'every day' blood markers to test for levels of those 3 peptides you mentioned so you'd have to piggyback those one at a time with GH and see if any of them interfered with the GH via IGF1 bloodwork to then 'conclude' that each of those can be mixed with another peptide. It's a good peptide because it has 191 amino acids so if anything was going to mess with another peptide it would be a big beast like GH. MOTS-c for example is only a 16-chain amino acid.
My plan for 2026 is to get to all these using GH as the constant and the other peptides as the variables.
They should be fine. I multi load all my peptides to reduce pokes, though the pin can get dull after 6 vials lol.
The main issue multiloading pins isnt efficacy, is degradation from an unfavourable pH environment.
Degradation is also a time and compound dependent effect where some compounds have a wider stable pH range and some peptides are more fragile than other, degrading faster when out of range.
Mutli loading is fine for immediate injection as the harsh pH environment does not persist in the body. Upon injection, the solution rapidly dilutes.
Time mixed in syringe
<10mins negligible
10-30mins a risk of degradation starting
1hr+ noticable degradation in effect could be possible.
The other issue with multiloading pins is reconstituting for higher concentrations/low injection volumes. At higher concentrations, multi loaded pins are more susceptible to precipitation (peptide falling out of solution) because of the sudden pH shift. These are my recons, and i get precip between some.
Triple GLOW180mg 3ml recon
3mg = 0.05ml
250bpc 500tb 2250ghk
BPC 50mg 3ml recon
1.5mg = 0.09ml
TB500 30mg 3ml recon
750mcg = 0.075ml
HGH 80iu 26.5mg recon with 3.33ml
6iu = 0.25ml
Nad 1000mg recon 10ml
25mg = 0.25ml
Mots-c 40mg recon 2ml
1mg = 0.05ml
Reta 20mg recon with 1.5ml pfizer
1mg = 7.5units or 7.5iu or 0.075ml
As an example, Gh80iu didnt want to fully dissolve at 2.7ml bac, but at 3.33ml it fully dissolved. When introduced to my TB recon, it precipitates on contact and falls out of solution. I added all those except reta. When i add nad last with its extra bac, the glow from the draw redissolves the compounds about 98% clearing up the syringe.
If your not reconning for max concentration, youll be fine for immediate injection. If you are reconning for concentration and get precip, draw some extra bac water to disolve it more.
Peptides are more durable than the fragile glass people take them for. Janoshik has already debunked the non sense of needing to gently swirl your peptides while reconstituting them. He stated he took 2 vials one swirled, one shaken. He tested for degradation at the 30 day mark. The difference was negligible at best.
He also left hgh out it the sun all day and shook the shit out of it. Tested fine. I have personally violentally shook my hgh with hatred, still gives me good sleep.
That's amazing and here i was pinning dozen times with different needles, wasted so many needles over the last year.... lolThey should be fine. I multi load all my peptides to reduce pokes, though the pin can get dull after 6 vials lol.
The main issue multiloading pins isnt efficacy, is degradation from an unfavourable pH environment.
Degradation is also a time and compound dependent effect where some compounds have a wider stable pH range and some peptides are more fragile than other, degrading faster when out of range.
Mutli loading is fine for immediate injection as the harsh pH environment does not persist in the body. Upon injection, the solution rapidly dilutes.
Time mixed in syringe
<10mins negligible
10-30mins a risk of degradation starting
1hr+ noticable degradation in effect could be possible.
The other issue with multiloading pins is reconstituting for higher concentrations/low injection volumes. At higher concentrations, multi loaded pins are more susceptible to precipitation (peptide falling out of solution) because of the sudden pH shift. These are my recons, and i get precip between some.
Triple GLOW180mg 3ml recon
3mg = 0.05ml
250bpc 500tb 2250ghk
BPC 50mg 3ml recon
1.5mg = 0.09ml
TB500 30mg 3ml recon
750mcg = 0.075ml
HGH 80iu 26.5mg recon with 3.33ml
6iu = 0.25ml
Nad 1000mg recon 10ml
25mg = 0.25ml
Mots-c 40mg recon 2ml
1mg = 0.05ml
Reta 20mg recon with 1.5ml pfizer
1mg = 7.5units or 7.5iu or 0.075ml
As an example, Gh80iu didnt want to fully dissolve at 2.7ml bac, but at 3.33ml it fully dissolved. When introduced to my TB recon, it precipitates on contact and falls out of solution. I added all those except reta. When i add nad last with its extra bac, the glow from the draw redissolves the compounds about 98% clearing up the syringe.
If your not reconning for max concentration, youll be fine for immediate injection. If you are reconning for concentration and get precip, draw some extra bac water to disolve it more.
Peptides are more durable than the fragile glass people take them for. Janoshik has already debunked the non sense of needing to gently swirl your peptides while reconstituting them. He stated he took 2 vials one swirled, one shaken. He tested for degradation at the 30 day mark. The difference was negligible at best.
He also left hgh out it the sun all day and shook the shit out of it. Tested fine. I have personally violentally shook my hgh with hatred, still gives me good sleep.
Damn bro lol. I pin like 6 peps in the am, 7 on fridays. And pm is 3. All but reta goes in the am pins cause it just dont fit. Lol
Warning though, some people cant handle pins after drawing from multiple vials cause it gets duller each time. Id rather rather 1 ouchie to wasting another 5 pins any day.
My stack is 6 peptides in tbe am, 3 in the pm plis reta on fridays. Thatd be 64 injections a week if done individually. I currently use 15 slins a week. A 100 count lasts 6.7 weeks. Without multiloading at all, a 100 count would last 1.6 weeks.
$40 a box taxs in amazon
Multiload - 7.8 boxs x $40 = $312
Solo load - 33.8 boxs x $40 = $1331
Absolute insanity
Yea man, I literally go through 100 pack in less than a week.
Hgh
Reta (weekly)
Ss31
Motc
Nad
Boc157/tb500
Dsip
Aod9604
5mq1
Epithalon (20 days every 4 months)
Glutathione
Thymosin Alpha
Ghk-Cu
Kpv
Kisspeptin
Before hgh
It was ipamorelin, cjc1295, Westmoreland.
So yea that stuff adds up.quick heck to.keep a stock of all those constantly throughout the years is expensive but less expensive to bulk buy them, so i just get 10vials at a time for each. Atleast will save a little bit on needles side of things not to mention number of pins.
Thank you so much @Shakey for sharing that. Life saver!!
Hgh
Reta (weekly)
Ss31
Motc
Nad
Boc157/tb500
Dsip
Aod9604
5mq1
Epithalon (20 days every 4 months)
Glutathione
Thymosin Alpha
Ghk-Cu
Kpv
Kisspeptin
Before hgh
It was ipamorelin, cjc1295, Westmoreland.
So yea that stuff adds up.quick heck to.keep a stock of all those constantly throughout the years is expensive but less expensive to bulk buy them, so i just get 10vials at a time for each. Atleast will save a little bit on needles side of things not to mention number of pins.
Thank you so much @Shakey for sharing that. Life saver!!
Oh, nice idea! I like this combo, but it has to be wisely chosen — both of these compounds strongly affect metabolism. But with the right doses and properly chosen carbs, it will give great power.
Once you start something, please tag it in the post — thanks!
No problem. Id look into buyin slins factory direct as well, cut the costs even more. Alibaba. All the pins on amazon are all chinese anyways.
Heck all the pins and i would say 95% off all the peptides are all Chinese, just branded and repackaged under different brands, whether capsules or vials, they did a test of top 20 peptides brands and all of them passed and scored less than 0.25% apart in purity, which led them to conclude that seems like the source is the same just branded differently.
Well said. What is always worth checking, and has a huge impact on the stability of the product after reconstitution, is whether the vial has a vacuum — then you know the environment inside is free of oxygen, which affects a longer usability period.They should be fine. I multi load all my peptides to reduce pokes, though the pin can get dull after 6 vials lol.
The main issue multiloading pins isnt efficacy, is degradation from an unfavourable pH environment.
Degradation is also a time and compound dependent effect where some compounds have a wider stable pH range and some peptides are more fragile than other, degrading faster when out of range.
Mutli loading is fine for immediate injection as the harsh pH environment does not persist in the body. Upon injection, the solution rapidly dilutes.
Time mixed in syringe
<10mins negligible
10-30mins a risk of degradation starting
1hr+ noticable degradation in effect could be possible.
The other issue with multiloading pins is reconstituting for higher concentrations/low injection volumes. At higher concentrations, multi loaded pins are more susceptible to precipitation (peptide falling out of solution) because of the sudden pH shift. These are my recons, and i get precip between some.
Triple GLOW180mg 3ml recon
3mg = 0.05ml
250bpc 500tb 2250ghk
BPC 50mg 3ml recon
1.5mg = 0.09ml
TB500 30mg 3ml recon
750mcg = 0.075ml
HGH 80iu 26.5mg recon with 3.33ml
6iu = 0.25ml
Nad 1000mg recon 10ml
25mg = 0.25ml
Mots-c 40mg recon 2ml
1mg = 0.05ml
Reta 20mg recon with 1.5ml pfizer
1mg = 7.5units or 7.5iu or 0.075ml
As an example, Gh80iu didnt want to fully dissolve at 2.7ml bac, but at 3.33ml it fully dissolved. When introduced to my TB recon, it precipitates on contact and falls out of solution. I added all those except reta. When i add nad last with its extra bac, the glow from the draw redissolves the compounds about 98% clearing up the syringe.
If your not reconning for max concentration, youll be fine for immediate injection. If you are reconning for concentration and get precip, draw some extra bac water to disolve it more.
Peptides are more durable than the fragile glass people take them for. Janoshik has already debunked the non sense of needing to gently swirl your peptides while reconstituting them. He stated he took 2 vials one swirled, one shaken. He tested for degradation at the 30 day mark. The difference was negligible at best.
He also left hgh out it the sun all day and shook the shit out of it. Tested fine. I have personally violentally shook my hgh with hatred, still gives me good sleep.
But production also plays a key role here — the lyophilization process, temperature, and excipients like mannitol. With substances like GH, also glycine and disodium hydrogen phosphate.
It’s not that simple
”
100%
They do produce 75% lol and i think india was 15%?
Agreed. I forgot to add buffer interactions as a reason for precipitation as wellWell said. What is always worth checking, and has a huge impact on the stability of the product after reconstitution, is whether the vial has a vacuum — then you know the environment inside is free of oxygen, which affects a longer usability period.
But production also plays a key role here — the lyophilization process, temperature, and excipients like mannitol. With substances like GH, also glycine and disodium hydrogen phosphate.
It’s not that simple
That makes things easierAttention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast @rayray01
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Yer i usually do mot c in the morning gh at night anyway
Pigsy
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Im the same all peptides other than gh morning. Gh evening. Mots c affects my sleep. Gh a night alone helps
-------------------------------------------------------------------------
One of my loggers posted this on his log promoting the use of MOTS-C. Felt like I needed to share
Yea, my source is from India, where I have personally visited the manufacturing facility and seen it with my own two eyes. Direct from the manufacturer, that is only way I can maintain 20 different kinds with 20-30 vials stock for each. Next business trip to China is will sort out a Chinese manufacturer as well. @Shakey
LevButlerov
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Domestic-Supply.com
I'll check it nowAttention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast @rayray01
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
looks promising actually @HarleyGuy
Thats awesome. Im switching to factory direct pins, 1 order, year supply. Will save me $750cad. And i multi load, so already pin frugal. Lol
Amen to that bro.
I've always said that you can certainly mix them. I mean after all, they are going to the same place.Attention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast @rayray01
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
Those are some good findings.
Ok, now i have been down 10mg mots am and pm for about 4 days. What i have noticed and it may be just in my head but i feel my energy levels are consistant throughout the day. Usually if ive trained in the morning i get a tired part around 2pm. This hasnt happened for a few days. Unsure if its due to better sleep or the mots. Waiting to have bloods done in the next few days and i will share results as my liver functions were a bit high last time. I have ra so it throws random figures every now and then.
Yessir will do! Thanks for hopping on the research thread @US-pharmacies!
Despite this case study I still do too
Nice share @War Born Peptides! That's a pretty funny to way to put. @War Born Peptides MOTS-c win!!View attachment 209259
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One of my loggers posted this on his log promoting the use of MOTS-C. Felt like I needed to share
Look us eh boys? To think of where we've come from and now we're "pin frugal" health freaks!
I love it!!
Awesome update @fingers86 thanks for continuing to share your feedback on the research threads! This is great feedback for the double digit MOTS-c club. I'm currently at 2mg ED.
If you could post bloods here we can take a look (and log too obviously).
How much liquid is too much for subq 1 injection though?Look us eh boys? To think of where we've come from and now we're "pin frugal" health freaks!
I've done 0.6ml (60iu) subQ and I know @Shakey has done a full 1.0ml (100iu) I'm pretty sure, but he can pipe in and clarify.
I used to be given a medication (multiple ml's) that literally the purpose was for it to create a big ball/lump subQ for it to disperse over a month's time so as long as you can put up with a little lump I don't think there's 'too much' per se except that it might affect the absorption rate.
Ive done a full ml sub q, well 0.95ml i think it was. Was a multi-load of 6 or 7 peptides i think.
1ml is considered the max single site in common typical situations. Exceptions include 2-3ml in high bodyfat areas for medications to absorb over long times as @HarleyGuy had. Theres also situations were 5mls are done with a slow infusion over time. (E.g. high dose immunoglobin)
IM general max varies a fair amount by muscle group. Generally 3ml is considered max.
Delt 1-2ml
Ventrogluteal 3-4ml
Vastus latetalis 4-5ml
Dorsogluteal 4-5ml
All hail OCD
Interestingly I tried mixing my gh and mots c this morning as I fell asleep last night and missed my gh shotAttention all:Results are here:
A case study was done on mixing your MOTS-c with HGH in the same slin pin
Punchline: MOTS-c can be mixed in the same slin pin as your HGH with no apparent drop in efficacy presumably by MOTS-c and provably by HGH.
Uses:
- Save on slin pins
- Save on time
- Less injections
TAGS:
MOTS-c users:
@Allupfromhere @Darth_Vader @jwright1275 @G-Merc 80 @Dreamer @RogueCherry @Freakfitness @Eveflorence @Doctakay @jenkemj @willipede @Made_Man @TheOne1 @madcap71 @Flash_is_Fast @fatboy999
@Demon_throne powered by @Unitedau
@Shakey powered by @biogenix
@HarleyGuy MOTS-c powered by @biogenix
@San Andreas powered by @War Born Peptides
@jenkemj powered by @Prymal
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast @rayray01
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Pigsy @s.gentz @toddthelineman @Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules @G-Merc 80
When mixing in the slin pin it turned milky and thickened i did still pin it seems fine but they definitely reacted when mixed not sure ill be doing that again
Nice write up bro. Heaps of useful info!!MOTS-c PEPTIDE (a.k.a.: "MOTS")
A readable layman's overview
View attachment 205576
View attachment 205575
References:
https://pubmed.ncbi.nlm.nih.gov/31293078/
https://www.nature.com/articles/s41467-020-20790-0
https://doi.org/10.1016/j.cmet.2015.02.009
Journal of Alzheimer's Drug Discovery Foundation
Human Trial 1b of MOTS-c Analogue Results
EVO - Members' Dosing and Anecdotal Reports
What Is MOTS-c Peptide? (And Why We Are Paying Attention)
MOTS-c is a 16 amino acid peptide that is coded by the mitochondrial genome. The mitochondria are the “power generators” in cells that convert chemical energy from food into a form that cells can use. MOTS-c is a mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA and involved in regulating metabolism and energy balance. It plays a key role in helping the body adapt to metabolic stress, such as exercise and caloric restriction. MOTS-c has shown to protect against insulin resistance and obesity in older test subjects, muscle catabolism in the aging, and even supports memory function in aging subjects.
Unlike most peptides, MOTS-c can travel to the nucleus and influence gene expression related to metabolism and cellular function.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome
- MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway
- MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis
- MOTS-c protects against age- and diet-dependent insulin resistance and obesity even in the environment of a high fat diet
- MOTS-c efficacy may only be clinically significant in older human subjects where it is observed to be in decline as subjects age
Important Reality Check!
- MOTS-c is not approved by regulatory agencies like Health Canada or the FDA
- Most evidence is preclinical (animal-based)
- Long-term safety and optimal dosing in humans are unknown (EVO members' anecdotal experiences and dosing seen below)
- MOTS-c has had clinically significant results in aging animal-based and human subjects and may not be efficacious to younger subjects
- Not everyone may need this and this is not a promotion for you to use MOTS-c, however clinical data in rodents (and minimal human studies) shows it is very promising!
Why MOTS-C Matters For Us?
MOTS-c activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy often referred to as the body’s “metabolic master switch.”
This pathway is also activated by:
- Exercise
- Fasting
- Caloric restriction in general
Our Potential Fitness Benefits of MOTS-C
1. Increased Fat Burning & Improved Metabolism
MOTS-c has been shown to improve metabolic flexibility and prevent fat accumulation even under high-fat diet conditions in animal models.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Demonstrated reduced weight gain and improved glucose metabolism in mice
2. Improved Endurance & Physical Performance
Study Evidence (see references):
- Research shows MOTS-c can enhance physical performance and mimic some adaptations typically seen with exercise.
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
- Improved running capacity and muscle function in older mice
3. Better Muscle Energy Utilization
MOTS-c improves how skeletal muscle uses glucose, making workouts more efficient at the cellular level.
Study Evidence (see references):
- MOTS-c enhances insulin sensitivity in skeletal muscle
4. Improved Insulin Sensitivity
One of the strongest areas of evidence: MOTS-c enhances insulin sensitivity and glucose uptake.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Showed improved insulin response and reduced insulin resistance
5. Longevity & Recovery Potential
MOTS-c levels decline with age, and supplementation in animal models has been linked to improved physical function and metabolic health in older subjects.
Study Evidence (see references):
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Human Research (Early but Emerging)
While most data comes from animal studies, early human research suggests MOTS-c is relevant to fitness and metabolic health. A MOTS-c analogue was shown to significantly decrease glucose levels, body weight, and ALT/AST levels at a dose of 25mg ED subQ over 4 weeks.
Human Study (ref: MOTS-c Human Study Extrapolation):
- Found correlations between MOTS-c levels and insulin sensitivity in humans
- "MOTS-c is hypothesized to be involved in the longevity of the Japanese" (ref: MOTS-c Human Study Extrapolation)
- "The findings supported a role for MOTS-c as an endocrine-like peptide influencing insulin signaling pathways. The authors proposed that mitochondrial-derived peptides could serve as metabolic regulators and potential therapeutic targets for conditions such as obesity, insulin resistance, and type 2 diabetes. This study helped establish MOTS-c’s relevance in human metabolic physiology and inspired further investigations into its mechanisms and clinical applications."
- "In the older cohort, higher MOTS-c levels were associated with improved muscle quality, based on maximal leg-press load relative to thigh cross-sectional area."
- "The Phase 1b study was a randomized, double-blind, placebo-controlled evaluation of a 25 mg dose of CB4211 (MOTS-c analogue) given once daily by subcutaneous injection for four weeks in 20 obese subjects with nonalcoholic fatty liver disease (NAFLD)." (ref: Human Trial 1b of MOTS-c analogue results)
- "Evaluation of the exploratory pharmacodynamic endpoints from the Phase 1b stage of the study comparing CB4211 to placebo demonstrated robust and significant reductions in key biomarkers of liver damage, ALT and AST, a significant decrease in glucose levels, and a trend towards lower body weight after four weeks of treatment." (ref: Human Trial 1b of MOTS-c analogue results)
Bottom Line for Fitness (Backed by Science)
MOTS-c is one of the most promising emerging peptides for:
- Fat loss support
- Endurance and performance
- Metabolic efficiency
- Healthy aging
- Liver and organ support
- Alzheimer's treatment
But right now, the science while exciting, is still early-stage and human clinical validation is limited. (ref: MOTS-c Human Study Extrapolation)
EVO members MOTS-c doses, anecdotal feedback and further research requests:
- Quick cruise around EVO led me to these members and their doses with some anecdotal feedback
- Please provide any reviews you wish to contribute include timing and reconstitution method that works best (ie: 2ml in 40mg vial, etc)
- Please update your current dose of MOTS-c including your own quote on your thoughts about this peptide
- MOTS-c is a bit of a niche peptide and those that run it usually know another member that does; I'd ask that you please tag as many EVO brothers or sisters you know that are running MOTS-c so that they can contribute to this research
- If you have or are currently running MOTS-c and were not tagged below please add yourself to this community research thread by replying and I will add you to the list
- Please add any additional research on MOTS-c to add to this research article including anecdotal experieces
@Allupfromhere 2mg ED “Mots c is one of my favs” "Mots c is like and endless fuel tank, i couldnt believe the stability in energy it has given me. Top 3 in my ranks for sure" You can follow his log here
@San Andreas 2mg ED You can follow his log here
@Darth_Vader 5mg e3d You can follow his log here
@Demon_throne 14mg weekly (ie: 2mg ED) "The bread and butter of my mito stack." You can follow his log here
@jwright1275 4mg e3d You can follow his log here
@G-Merc 80 1mg ED “I love MOTS-C and have found that SS31 pairs perfectly with it, just clean feelilng energy boost.” You can follow his log here
@Shakey 1mg ED You can follow his log here
@HarleyGuy 1mg ED You can follow his log here
@Dreamer 5mg Pre-Bed “I have shared around the place how I use MOTS C, I take mine in the evening with my large intake of carbs, I have seen a massive improvement in fasting BGL in the morning and in turn insulin sensititivty by doing this.
I think peptides can be used in numerous different ways and applications once you understand what they do to YOUR body because they do seem to be highly individual, play around with them and monitor with data, they are incredibly useful for alot of things” You can follow his log here
@RogueCherry 1mg ED You can follow her log here
@Freakfitness 1mg ED You can follow his log here
@Eveflorence 2mg ED “Found this worked amazingly well. Noticeable increases in energy, motivation, endurance and overall feeling of well-being. I want to have another run of it soon.” You can follow his log here
@Doctakay 1mg pwo You can follow his log here
@jenkemj 2mg ED You can follow his log here
@willipede 1mg ED You can follow his log here
@Made_Man 2mg ED You can follow his log here
@TheOne1 10mg ED “So far my experience has been positive and i like the extra efficiency it has brought into my workouts. Also I have noticed a bit extra pump too. I'm looking forward to week 2 on this and seeing what else it can unlock as I use it more.” You can follow his log here
@madcap71 2mg pwo You can follow his log here
@Flash_is_Fast 1mg pwo You can follow his log here
@fatboy999 1mg ED You can follow his log here
Thanks for reading,
HarleyGuy
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell@LevButlerov@Mobster@Noah Wixx @Npcclassicphysique champ@Pigsy@s.gentz@toddthelineman@Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules
This could be a different kind of bac water used from one peptide to the other. I'll defer this to @Shakey who stays up until 05:00 reading up on this stuff.
Could be
So even after diluting to 10mg/3mL, I'm still getting mast cell activation. The attached pic was yesterday's 0.167mg shot (5IU) SubQ at the love handles.
Note that this flared up HOURS after my shot. I timed Zyrtec (Cetirizine) to this shot as well.
New Mots-c combat plan:
-No Mots-c injection for 2 weeks
-Add Quercetin 500mg a day
-Add Vit-C 1.5mg split 3x a day
-Keep Fish Oil as is at 3mg a day
-Ketotifen 1mg nightly
-Increase TA-1 from original 2mg to 5mg a week for 2 weeks only. Still pulse at 2x shot a week.
Also getting bloods tomorrow. Will be interesting to see what my eosinophils levels are right now.
Sorry I probably should follow up properly
-Vit C is 1.5g total
-Fish Oil is at 3g
-Photo attached actually
Attachments
Thanks very much for all this feedback and the photo @OwEv751! You're definitely having a reaction for sure. Does any other peptide ever cause this at all?
I love this plan as part of this community research to help others who may get this same reaction, please keep us posted!
If you're comfortable with it can you please post your bloods here (along with in your log but here too) so we can take a look at what's going on? You can black out your personal info.
Thats precipitation, looks like a smoky white haze or almost like it gels and thickens on contact, feels hard to push through syringe? The peptides fell out of solution do to the pH swing most likely. Whats your reconstitution stats?
This is a multi-load with high concentration. Hgh 3iu 0.125ml, TB500 750mcg 0.075ml, BPC 1.5mg 0.09ml, GLOW 3mg 0.05ml. syringe resistance is from undissolved solution. If you get this you can just draw in so extra bac but its technically fine to inject though absorption will be delayed. You can end up with little lumps that take long to absorp, ive got a couple. Took some massage to help along
Some peptides can handle more concentrations and stay in solution during pH swings. Above, note GLOW has stayed seperated mostly and its reconstituted at 180mg x 3ml bac, ive never had GLOW fall out of solution, as to HGH which precipitates with both BPC and TB seperately and together.
Ill start checking tomorrow, but my most unstable recon is 80iu of gh with 3.33ml, at 2.7ml it wont full dissolve. High concentrations can be kicked out of solution easier.
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Not at all. I would think NAD+ would also trigger but nope!
Thanks! I'll share bloods once it's available and keep updated!
I've had the most PIP from NAD+ out of anything, moreso than GHK-Cu even. It also never draws as smoothly as the other peptides and I've made sure the pressure is equalized too. Weird.
Be careful now @Shakey you don't want everyone to know how smart you are do you? Is that why you holdin' out on us with the deadspace article you sly cat?
NAD+ and GLOW multi load IM was fun stuff. I do it once in a while just to feel something. Lol
Nah, just been lazy at this point. The OCD has wandered while i was bedridden. Ill get around to it. Lol
Looked exactly like your picture
Hgh 10iu reconstituted with 1ml bac water
Mots c is 40mg reconstituted with 3mls bac water
I find gh can precip easy. Probably because its 191 amino long but i could be wrong. Multi load your others and keep seperate, or blast like i do and give er a rub after. Lol
The vampiric "I'm dead inside" peptide pin to wake up
Oh I know you will, it's all good bro.
I always load GH separate, it's the big dog 191aa it gets it's own slin pin and it's expensive ASF too. The pins should be gold tipped.
Your hyping everyone up too much. There exoecting a university level paper.The vampiric "I'm dead inside" peptide pin to wake up
Oh I know you will, it's all good bro.
China pins would be lead. Lol
Awesome write up very informative!MOTS-c PEPTIDE (a.k.a.: "MOTS")
A readable layman's overview
View attachment 205576
View attachment 205575
References:
https://pubmed.ncbi.nlm.nih.gov/31293078/
https://www.nature.com/articles/s41467-020-20790-0
https://doi.org/10.1016/j.cmet.2015.02.009
Journal of Alzheimer's Drug Discovery Foundation
Human Trial 1b of MOTS-c Analogue Results
EVO - Members' Dosing and Anecdotal Reports
What Is MOTS-c Peptide? (And Why We Are Paying Attention)
MOTS-c is a 16 amino acid peptide that is coded by the mitochondrial genome. The mitochondria are the “power generators” in cells that convert chemical energy from food into a form that cells can use. MOTS-c is a mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA and involved in regulating metabolism and energy balance. It plays a key role in helping the body adapt to metabolic stress, such as exercise and caloric restriction. MOTS-c has shown to protect against insulin resistance and obesity in older test subjects, muscle catabolism in the aging, and even supports memory function in aging subjects.
Unlike most peptides, MOTS-c can travel to the nucleus and influence gene expression related to metabolism and cellular function.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome
- MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway
- MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis
- MOTS-c protects against age- and diet-dependent insulin resistance and obesity even in the environment of a high fat diet
- MOTS-c efficacy may only be clinically significant in older human subjects where it is observed to be in decline as subjects age
Important Reality Check!
- MOTS-c is not approved by regulatory agencies like Health Canada or the FDA
- Most evidence is preclinical (animal-based)
- Long-term safety and optimal dosing in humans are unknown (EVO members' anecdotal experiences and dosing seen below)
- MOTS-c has had clinically significant results in aging animal-based and human subjects and may not be efficacious to younger subjects
- Not everyone may need this and this is not a promotion for you to use MOTS-c, however clinical data in rodents (and minimal human studies) shows it is very promising!
Why MOTS-C Matters For Us?
MOTS-c activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy often referred to as the body’s “metabolic master switch.”
This pathway is also activated by:
- Exercise
- Fasting
- Caloric restriction in general
Our Potential Fitness Benefits of MOTS-C
MOTS-c has been shown to improve metabolic flexibility and prevent fat accumulation even under high-fat diet conditions in animal models.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Demonstrated reduced weight gain and improved glucose metabolism in mice
Study Evidence (see references):
- Research shows MOTS-c can enhance physical performance and mimic some adaptations typically seen with exercise.
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
- Improved running capacity and muscle function in older mice
MOTS-c improves how skeletal muscle uses glucose, making workouts more efficient at the cellular level.
Study Evidence (see references):
- MOTS-c enhances insulin sensitivity in skeletal muscle
One of the strongest areas of evidence: MOTS-c enhances insulin sensitivity and glucose uptake.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Showed improved insulin response and reduced insulin resistance
MOTS-c levels decline with age, and supplementation in animal models has been linked to improved physical function and metabolic health in older subjects.
Study Evidence (see references):
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Human Research (Early but Emerging)
While most data comes from animal studies, early human research suggests MOTS-c is relevant to fitness and metabolic health. A MOTS-c analogue was shown to significantly decrease glucose levels, body weight, and ALT/AST levels at a dose of 25mg ED subQ over 4 weeks.
Human Study (ref: MOTS-c Human Study Extrapolation):
- Found correlations between MOTS-c levels and insulin sensitivity in humans
- "MOTS-c is hypothesized to be involved in the longevity of the Japanese" (ref: MOTS-c Human Study Extrapolation)
- "The findings supported a role for MOTS-c as an endocrine-like peptide influencing insulin signaling pathways. The authors proposed that mitochondrial-derived peptides could serve as metabolic regulators and potential therapeutic targets for conditions such as obesity, insulin resistance, and type 2 diabetes. This study helped establish MOTS-c’s relevance in human metabolic physiology and inspired further investigations into its mechanisms and clinical applications."
- "In the older cohort, higher MOTS-c levels were associated with improved muscle quality, based on maximal leg-press load relative to thigh cross-sectional area."
- "The Phase 1b study was a randomized, double-blind, placebo-controlled evaluation of a 25 mg dose of CB4211 (MOTS-c analogue) given once daily by subcutaneous injection for four weeks in 20 obese subjects with nonalcoholic fatty liver disease (NAFLD)." (ref: Human Trial 1b of MOTS-c analogue results)
- "Evaluation of the exploratory pharmacodynamic endpoints from the Phase 1b stage of the study comparing CB4211 to placebo demonstrated robust and significant reductions in key biomarkers of liver damage, ALT and AST, a significant decrease in glucose levels, and a trend towards lower body weight after four weeks of treatment." (ref: Human Trial 1b of MOTS-c analogue results)
Bottom Line for Fitness (Backed by Science)
MOTS-c is one of the most promising emerging peptides for:
- Fat loss support
- Endurance and performance
- Metabolic efficiency
- Healthy aging
- Liver and organ support
- Alzheimer's treatment
But right now, the science while exciting, is still early-stage and human clinical validation is limited. (ref: MOTS-c Human Study Extrapolation)
EVO members MOTS-c doses, anecdotal feedback and further research requests:
- Quick cruise around EVO led me to these members and their doses with some anecdotal feedback
- Please provide any reviews you wish to contribute include timing and reconstitution method that works best (ie: 2ml in 40mg vial, etc)
- Please update your current dose of MOTS-c including your own quote on your thoughts about this peptide
- MOTS-c is a bit of a niche peptide and those that run it usually know another member that does; I'd ask that you please tag as many EVO brothers or sisters you know that are running MOTS-c so that they can contribute to this research
- If you have or are currently running MOTS-c and were not tagged below please add yourself to this community research thread by replying and I will add you to the list
- Please add any additional research on MOTS-c to add to this research article including anecdotal experieces
@Allupfromhere 2mg ED “Mots c is one of my favs” "Mots c is like and endless fuel tank, i couldnt believe the stability in energy it has given me. Top 3 in my ranks for sure" You can follow his log here
@San Andreas 2mg ED You can follow his log here
@Darth_Vader 5mg e3d You can follow his log here
@Demon_throne 14mg weekly (ie: 2mg ED) "The bread and butter of my mito stack." You can follow his log here
@jwright1275 4mg e3d You can follow his log here
@G-Merc 80 1mg ED “I love MOTS-C and have found that SS31 pairs perfectly with it, just clean feelilng energy boost.” You can follow his log here
@Shakey 1mg ED You can follow his log here
@HarleyGuy 1mg ED You can follow his log here
@Dreamer 5mg Pre-Bed “I have shared around the place how I use MOTS C, I take mine in the evening with my large intake of carbs, I have seen a massive improvement in fasting BGL in the morning and in turn insulin sensititivty by doing this.
I think peptides can be used in numerous different ways and applications once you understand what they do to YOUR body because they do seem to be highly individual, play around with them and monitor with data, they are incredibly useful for alot of things” You can follow his log here
@RogueCherry 1mg ED You can follow her log here
@Freakfitness 1mg ED You can follow his log here
@Eveflorence 2mg ED “Found this worked amazingly well. Noticeable increases in energy, motivation, endurance and overall feeling of well-being. I want to have another run of it soon.” You can follow his log here
@Doctakay 1mg pwo You can follow his log here
@jenkemj 2mg ED You can follow his log here
@willipede 1mg ED You can follow his log here
@Made_Man 2mg ED You can follow his log here
@TheOne1 10mg ED “So far my experience has been positive and i like the extra efficiency it has brought into my workouts. Also I have noticed a bit extra pump too. I'm looking forward to week 2 on this and seeing what else it can unlock as I use it more.” You can follow his log here
@madcap71 2mg pwo You can follow his log here
@Flash_is_Fast 1mg pwo You can follow his log here
@fatboy999 1mg ED You can follow his log here
@OwEv751 2mg EOD You can follow his log here
@gar71 1mg ED You can follow his log here
Thanks for reading,
HarleyGuy
SLU-PP-332 Research Participants:
@LevButlerov @trenAMP @Nood @RawCutlery @liftedlivingwithlegacy @BigVelvetG @MarkNV @eazy_ @Neuro @US-pharmacies
@liftedlivingwithlegacy @LH5515 @justapotato @Allupfromhere @roguepineapple @fingers86 @Grumpy @Demon_throne @R.AP @rizzlekdizzle @Pigsy @Wookie @AusMade @BeMe @Shakey @kcates @toddthelineman @ROIDDERS @2Thick @Ulter @ballin2504 @Mobster @stevesmi @kcates @Eddie Haskell @eazy_ @CladHQ @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV @rizzlekdizzle @Freki @RawCutlery @Flash_is_Fast
Canadian EVO Loggers:
@BeMe @haldencapital @VerticallyChallenged @XxDennxX @Farmboy @Shakey @Lonewolf112 @frackz @WolfOfRoidStreet @nattybydesign @moreReps21 @JuiceyBrucey007 @zucchini @leaperfr @MTB @Kevdawg @IronCrusader33 @BritishCanadian @teddy_vio @Kevdawg @wye @stevedude19 @SomebodyDope @EL blueberry
MODS, et al: @BeMe @Eddie Haskell @LevButlerov @Mobster @Noah Wixx @Npcclassicphysique champ @Pigsy @s.gentz @stevesmi @toddthelineman @Allupfromhere @ROIDDERS @ceo @2Thick @Ulter
Podcast VIP's: @BeMe @Farmboy @Eddie Haskell@LevButlerov@Mobster@Noah Wixx @Npcclassicphysique champ@Pigsy@s.gentz@toddthelineman@Allupfromhere @Dreamer @Freki @waggat @Yuri @rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @R.AP @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell @satxbber @BIGRED_ @rayray01 @fatboy999 @Lipster @Tankie @kamsikazee @Trenhead3cc @Robules
I was using Mots-C in my current stack at a dose of 1mg on training day's.
I'm off cycle now with it & taking a break of 2-4 weeks before beginning it again.
I'm a 50 year old competitive bodybuilder who has been training for 35 years & with 30 odd years of which I have been on a continuous cycle for the entire time using moderately high doses of various Aas without ever cycling off or dropping to Trt doses.
Most recently over the past 3 or 4 years I have dropped to Trt.
My current cycle is a push in which I'm hoping to regain most of my lost size & conditioning from dropping to Trt, having been diagnosed with a chronic ckd disease condition with which I may have been misdiagnosed & given unnecessary medical treatments for which have impacted my physical, mental & financial abilities which I will I am currently fighting for a proper diagnosis with which is looking promising for me on my side of my concerns.
I am also hoping to jump back onto the stage & compete again.
My most recent bloods came back immaculate.
I'm not certain how much of this was related to Mots-C though I'm thinking that it has contributed to this alongside with the addition of SS31, Telemesartan & Dapigloflozin all of which I have never used in any of my previous 30 year odd cycle before.
This was an excellent review and contribution to this community research @Thoranosaurus_flex! Thank you so much for contributing. With everything you're going through I'm really glad to read that your bloodwork came back like it did. It's very compelling that MOTS-c was involved in helping get your bloodwork healthier.
Please keep us posted when you start this up again and I hope your bloodwork continues to be positive, keep up posted on that too!
You'll notice you have been added to the original post and to the list of EVO brothers who have or are running MOTS-c. Welcome to our little MOTS-c corner of EVO!
I was thinking about the ph being different and how the degrading would come in to play mixing. I was just watching a video about this concerning motsc , Nad, and ss31.They should be fine. I multi load all my peptides to reduce pokes, though the pin can get dull after 6 vials lol.
The main issue multiloading pins isnt efficacy, is degradation from an unfavourable pH environment.
Degradation is also a time and compound dependent effect where some compounds have a wider stable pH range and some peptides are more fragile than other, degrading faster when out of range.
Mutli loading is fine for immediate injection as the harsh pH environment does not persist in the body. Upon injection, the solution rapidly dilutes.
Time mixed in syringe
<10mins negligible
10-30mins a risk of degradation starting
1hr+ noticable degradation in effect could be possible.
The other issue with multiloading pins is reconstituting for higher concentrations/low injection volumes. At higher concentrations, multi loaded pins are more susceptible to precipitation (peptide falling out of solution) because of the sudden pH shift. These are my recons, and i get precip between some.
Triple GLOW180mg 3ml recon
3mg = 0.05ml
250bpc 500tb 2250ghk
BPC 50mg 3ml recon
1.5mg = 0.09ml
TB500 30mg 3ml recon
750mcg = 0.075ml
HGH 80iu 26.5mg recon with 3.33ml
6iu = 0.25ml
Nad 1000mg recon 10ml
25mg = 0.25ml
Mots-c 40mg recon 2ml
1mg = 0.05ml
Reta 20mg recon with 1.5ml pfizer
1mg = 7.5units or 7.5iu or 0.075ml
As an example, Gh80iu didnt want to fully dissolve at 2.7ml bac, but at 3.33ml it fully dissolved. When introduced to my TB recon, it precipitates on contact and falls out of solution. I added all those except reta. When i add nad last with its extra bac, the glow from the draw redissolves the compounds about 98% clearing up the syringe.
If your not reconning for max concentration, youll be fine for immediate injection. If you are reconning for concentration and get precip, draw some extra bac water to disolve it more.
Peptides are more durable than the fragile glass people take them for. Janoshik has already debunked the non sense of needing to gently swirl your peptides while reconstituting them. He stated he took 2 vials one swirled, one shaken. He tested for degradation at the 30 day mark. The difference was negligible at best.
He also left hgh out it the sun all day and shook the shit out of it. Tested fine. I have personally violentally shook my hgh with hatred, still gives me good sleep.
Yea, peptides are more durable than people think. Degradation is a process that take time, and for peptides, its a window long enough for us to abuse. And abuse it we should. Lol
Actually the pH should drift closer to the bac pH when heavily diluted, and more to the peptide and buffers if heavily concentrated. So high concentrated multi-loading should have wider pH swings as well. So high con multi loading might have shortened windows, but thats still plenty of time.
I doubt many are running concentrations like mine, so most probably wont run into precipitation unless im misjudging community recon protocols lol.
Did the vid mention if those 3 have the same Ph?
@HarleyGuy, what about pH testing for your next experiment? Might have to outsource to the community for peptides you dont have/are niche. Would have to to standardize the solution concentration across the board as reconsititution ratio would effect pH.
Things like nad and gluta might need to be diluted again in syringe or sterile vial to get the concentration needed for pH testing.
Also @HarleyGuy i meant outsource to the community as in get other members to test their peps (ones you dont have), not send you theirs. Lol
Oh no I like the latter idea, everyone send me your peps!!
So the video did mention they were different. 2 of then were slightly different and really in range of each other. Which would have worked fine. Then I think it was NAD+ that was like 2 points below the other 2. I tried to find the video but can't find it to watch it again and get the ranges for you. So I looked up the ph myself. Motsc is approximate 5.0-7.0, ss-31 5.5-7, and NAD is 3.0-4.5 more acidic. All based on bastericstatic water.
This makes sense because NAD+ definitely acts and feels different right from loading it into the pin (separately) to it's PIP etc. All of this eventually goes away for me over time and I have zero issues.
@Demon_throne increased his MOTS-c dose to 4mg ED
https://www.evolutionary.org/forums/threads/mots-c-effects-sides.110263/#post-2033843Bumped to 4mg for the month to test it out will let you know if I notice anything different
That would explain the IM nad pip. Sub q is fine, but IM is fun.
I guess because it's more acidic
I’ve noticed, taking mots-c pre trainer instead of with the other mito stack gives me abit more energy training. When I was taking all the mito stack together, I seemed to feel really sleepy about 30 minutes afterwards.
Mito stack is:
Mots-c 4mg pre workout
5 amino-1mq 2mg daily
SS31 2mg daily
I’ve also experimented with slu-pp-332
I’ve taking all ranges of doses from 5mg 4 times daily to 20mg 4 times daily.
Last time I was playing around with the slu-pp-332 I took 100mg pre trainer. I felt like an absolute beast, focused, full of energy, cardio was easy.
I only ran these for short periods of time because there isn’t much research just yet. We don’t wanna be too silly with our body
Mito stack is:
Mots-c 4mg pre workout
5 amino-1mq 2mg daily
SS31 2mg daily
I’ve also experimented with slu-pp-332
I’ve taking all ranges of doses from 5mg 4 times daily to 20mg 4 times daily.
Last time I was playing around with the slu-pp-332 I took 100mg pre trainer. I felt like an absolute beast, focused, full of energy, cardio was easy.
I only ran these for short periods of time because there isn’t much research just yet. We don’t wanna be too silly with our body
As requested, i have been using 10mg mots morning and afternoon. Lfts are just in the guidelines even though i did a massive weights session the afternoon prior and fasted cardio 1hour before bloods drawn at 8. Cholesterol heading somewhat better using the ratio. Hdl has hit 1 but ldl is going wrong way. Would love to push mots further to test but getting expensive. Willing to go to 20mg am and pm if anyone would like to contribute to this experiment lol. Otherwise i do have 2 kits direct from china on way but need to get it tested before i use for experiment as want to know mots is doing or not doing things. Ps energy levels have never been higher than now at this dose.
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Thanks for your feedback @Nelsonhaha this is really helpful. What do you figure the sleepiness could be?
Thanks for the feedback on SLUPP as well I've added your review to the SLUPP megathread Community Research article here
SLU-PP-332 Peptide - Administration Routes, Dosing, and Reviews. I also added you to the list of EVO brothers who are or have run SLUPP on the main 1st post.
This is a great comprehensive review @fingers86 you've been a great contributor to this Community Research!
Your bloods are a relief seeing your CRP come way down like that. Cholesterol isn't that bad considering you're on cycle, both are only slightly out of range as expected but with a decent ratio that's improved from last time, and your BG is great. Your thyroid is definitely humming along well too.
Your experiment at 10mg twice a day (20mg total) is really appreciated and it appear (like many peptides as seen in clinical trials) that results are dose dependent with the long term effects still yet unknown. When I start including cario a lot more in June I will run MOTS-c much higher myself as well. Thanks again!
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