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@fingers86 your dose has been updated to 20mg on the main page and first post. Thanks again for updating.
Community Research MOTS-C Peptide - Overview, Dosing, and Reviews
- Thread starter HarleyGuy
- Start date
Threads marked with the 'Community Research' prefix involve ongoing research, high-quality logs, or in-depth community discussions backed by experience, data, or expert input.
Currently on day 4 of the 4mg experement. A Small bit of a lethargic feeling this morning I feel it's due to the dosage adjustment but keeping it running for at least a week maybe the rest of the month as planned but just playing it by ear for now
This is great feedback thanks @Demon_throne! I'm currently running SS31 for 8 weeks and will reintroduce MOTS afterwards and depending on your feedback I'll go about 4mg myself.
I think I've hit 3 months on 2mg before I added this trial of 4mg.
Might be time to drop it out and bring it back in after a few weeks
I cut out all mito's to run SS31 and will reintroduce them all with a bang. I'm hoping to have a couple more of the mito for community research by then. I have 5-amino-1mq, MOTS, SLUPP, NAD+ all set to go once SS31 is done and I wanna increase SS31 to 5mg once my SS31 touchdown lands. Might be a good reason to drop an SS31 community research thread as well, it's super niche but is up and coming.
Well for most (I think all you'll end up tagging me
) as I'm running almost the whole Mito -ss31
haha you and me both I had almost all of them going until I threw in SS31 to run solo. You're definitely the MITO beast so far on EVO.Well for most (I think all you'll end up tagging me
@Jaxss added MOTS-c and a review to his log here 
https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/page-2#post-2038345
Feedback from @Jaxss on 1mg pre-workout:
https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/page-2#post-2038345Feedback from @Jaxss on 1mg pre-workout:
I’m about 10-11 days into Mots C, have purchased from a verified source from the Aus section.
Been dosing 1mg for the first week, first thing in the morning.
Dizziness was pretty bad for a few days, would get big post workout crashes - similar to feeling hypoglycemic.
10-11 days later, really liking the compound and using 1.3mg daily (10 units on insulin syringe, as it’s a 40mg vial with 3ml BAC).
I love the compound. As others have said, it’s no stimulant though the day-to-day fatigue or downshift in energy whilst cutting hasn’t been there.
Really shines with stamina and finding that extra gear for workouts, cardio and just life post workout (I train in the mornings).
I do find it feels a bit harder hitting / mildly dizzy if used fasted (even though I use 15g HBCD pre workout and another 30g HBCD intra with my EAA’s).
Did take it today alongside a small cream of rice pre workout meal and found it still shone with stamina regardless.
I honestly feel and look tighter around my waist and feel as if it is shuttling carbs in particular into the right areas.
One of my favourite peptides. Going to use Reta at 1mg/week alongside it.
I can’t see or feel the need to want to push the dosages of Mots C any higher as it’s working well and every day I am doing something - whether it be weight training or a cardio only day.
Been dosing 1mg for the first week, first thing in the morning.
Dizziness was pretty bad for a few days, would get big post workout crashes - similar to feeling hypoglycemic.
10-11 days later, really liking the compound and using 1.3mg daily (10 units on insulin syringe, as it’s a 40mg vial with 3ml BAC).
I love the compound. As others have said, it’s no stimulant though the day-to-day fatigue or downshift in energy whilst cutting hasn’t been there.
Really shines with stamina and finding that extra gear for workouts, cardio and just life post workout (I train in the mornings).
I do find it feels a bit harder hitting / mildly dizzy if used fasted (even though I use 15g HBCD pre workout and another 30g HBCD intra with my EAA’s).
Did take it today alongside a small cream of rice pre workout meal and found it still shone with stamina regardless.
I honestly feel and look tighter around my waist and feel as if it is shuttling carbs in particular into the right areas.
One of my favourite peptides. Going to use Reta at 1mg/week alongside it.
I can’t see or feel the need to want to push the dosages of Mots C any higher as it’s working well and every day I am doing something - whether it be weight training or a cardio only day.
Thanks for the feedback @Scrut123.
Be sure and let us know how it's going around the 3-4 week mark as well.
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@Jaxss reported in Log he uses 1mg pre workout mots-c sub q injection and feels more energy for training 
https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/post-2040791
https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/post-2040791
@theJimJim added MOTS-c to his peptide stack at 2mg here https://www.evolutionary.org/forums...y-recomp-cycle-log.109409/page-5#post-2038158
@theJimJim any feedback so far I noticed you started it on 10Apr?
https://www.evolutionary.org/forums...y-recomp-cycle-log.109409/page-5#post-2038158@theJimJim any feedback so far I noticed you started it on 10Apr?
can you please post pics of your mots-C thank you
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what brand is this?
Regenex - they’re in the Aus approved supplier section.
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Looks good
Hey brother,
Hit us up on threema again and we will send you a free bottle of MOTs 40mg for your review
Much love
What a guyHey brother,
Hit us up on threema again and we will send you a free bottle of MOTs 40mg for your review
Much love
@gar71 updated his MOTS-c dose to 2mg in his log here https://www.evolutionary.org/forums...quipoise-cycle-log.108091/page-5#post-2044566
https://www.evolutionary.org/forums...quipoise-cycle-log.108091/page-5#post-2044566
@Jaxss updated his MOTS-c dose to 1.5mg in his log here https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/page-3#post-2043400
He also provided a great review of MOTS-c as it behaves with him as seen below:
https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/page-3#post-2043400He also provided a great review of MOTS-c as it behaves with him as seen below:
@OwEv751 posted in his log about having unwanted skin reactions to MOTS-c here https://www.evolutionary.org/forums/threads/pct-and-peptides-log.110181/page-2#post-2048518
https://www.evolutionary.org/forums/threads/pct-and-peptides-log.110181/page-2#post-2048518
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This might be very unique case@OwEv751 posted in his log about having unwanted skin reactions to MOTS-c here
This is the second member to have a skin reaction to MOTS-c of this nature.
View attachment 218373
@HarleyGuy havent seen this before
It is the only that became an issue for sure.This might be very unique case
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yes issues seem rare
I haven't read anyone having this issue, very interesting; wondering if there is HPLC testing on purity and contaminates you can review from this batch? do you think KPV could help with this @HarleyGuy , I know it has helped me with histamine response.
Yes for sure KPV will help after the fact but not preventing the onset of a reaction.
I should have clarified I actually don't believe it has anything to do with the fact that it's MOTS-c and it has more to do with his own immune system reacting to what could be a wide variety of possibilities like pH, type of Bac water, volume injected, concentration, or buffers that need to be included and even the different lengths of amino acids in the peptide. HGH for example is 191 amino acids and I've never seen a reaction to the longer chains.
Big shout out to @RegenexPharma for more quality Mots-C. Arrived today.
Still dosing 10 units on my insulin syringe, after mixing 3ml BAC (8 units gives a 1mg dose, so just slightly above 1mg).
Strangely enough, my last week or so I’ve been getting small red rashes at the injection site and what looks to be a little welt/bug bite looking thing with some localised swelling on my abdomen where I go sub-q. Have been feeling quite a sting on injection too.
Seems to improve at the injection site after 2-3 days.
Will rotate injection sites more. I think I’ve over cooked my abdomen for sub q especially with Mots-C.
Otherwise, everything has stabilised and feel fantastic.
Still dosing 10 units on my insulin syringe, after mixing 3ml BAC (8 units gives a 1mg dose, so just slightly above 1mg).
Strangely enough, my last week or so I’ve been getting small red rashes at the injection site and what looks to be a little welt/bug bite looking thing with some localised swelling on my abdomen where I go sub-q. Have been feeling quite a sting on injection too.
Seems to improve at the injection site after 2-3 days.
Will rotate injection sites more. I think I’ve over cooked my abdomen for sub q especially with Mots-C.
Otherwise, everything has stabilised and feel fantastic.
Attachments
Glad you got it bro
we appreciated your write up and experience for the community so it was our pleasure to shoot another one out.Regarding the small red marks or mild irritation at injection sites with MOTS-c, so here’s a clear breakdown for anyone running it:
What most people are seeing is a localized histamine response, not a bad batch or anything “wrong” with the peptide.
When you inject subQ, especially with peptides, you can trigger mast cells in the skin - this releases histamine and can cause:
• small red marks or dots
• slight swelling (like a tiny welt)
• mild itch or warmth
This is fairly common with MOTS-c and a few other peptides, especially with frequent injections.
Some people who are more sensitive to histamine also find relief using an antihistamine or spacing injections out.
Personally, we need to take an antihistamines before injections of Mots otherwise we get an itchy stomach for hours
antihistamines stopped/minimized it.Thanks again bro
Makes perfect sense!Glad you got it bro
Regarding the small red marks or mild irritation at injection sites with MOTS-c, so here’s a clear breakdown for anyone running it:
What most people are seeing is a localized histamine response, not a bad batch or anything “wrong” with the peptide.
When you inject subQ, especially with peptides, you can trigger mast cells in the skin - this releases histamine and can cause:
• small red marks or dots
• slight swelling (like a tiny welt)
• mild itch or warmth
This is fairly common with MOTS-c and a few other peptides, especially with frequent injections.
Some people who are more sensitive to histamine also find relief using an antihistamine or spacing injections out.
Personally, we need to take an antihistamines before injections of Mots otherwise we get an itchy stomach for hours
Thanks again bro
I had a feeling it may have been due to that, if anything I was hanging out for some kind of a skin response as heaps of others had it - now I see it for myself
Thanks again and for the write up just now too. Much appreciated!
Thanks for clarifying this @RegenexPharma and for chimin in, much appreciated.Glad you got it bro
Regarding the small red marks or mild irritation at injection sites with MOTS-c, so here’s a clear breakdown for anyone running it:
What most people are seeing is a localized histamine response, not a bad batch or anything “wrong” with the peptide.
When you inject subQ, especially with peptides, you can trigger mast cells in the skin - this releases histamine and can cause:
• small red marks or dots
• slight swelling (like a tiny welt)
• mild itch or warmth
This is fairly common with MOTS-c and a few other peptides, especially with frequent injections.
Some people who are more sensitive to histamine also find relief using an antihistamine or spacing injections out.
Personally, we need to take an antihistamines before injections of Mots otherwise we get an itchy stomach for hours
Thanks again bro
We have a pic and another review on this issue here
https://www.evolutionary.org/forums...dosing-and-reviews.110114/page-3#post-2048612It's all very common in certain individuals @Scrut123 and like most allergies it will get better in time after prolonged exposure as was the case with myself.
man the PIP from NAD+... everybody complains about GHK-cu online, why the fuck didn't anyone warn me about NAD+ fucking injecting lava into my stomach this shit is ridiculous
What MG/ML did you reconstitute your NAD+ at brother?
NAD is known for its sting or painful injections but not having your concentration so high can help with the sting.
Just depends what size MG bottle you have and how Much solution you added to the vial
1000mg bottle from ironclad mixed with 4ml bacWhat MG/ML did you reconstitute your NAD+ at brother?
NAD is known for its sting or painful injections but not having your concentration so high can help with the sting.
Just depends what size MG bottle you have and how Much solution you added to the vial
NAD+ stings for me too bro. Its one of those things I put up with though because along with MOTs I feel great on it
Hahahaha yes brother!!!! I love the NAD+ PIP, bring it on! It's my favourite PIP. Makes GHK-Cu be a little b*tch
What’s the top end so far you’ve seen dosage wise @HarleyGuy
On the original post I keep the dosing ranges updated of all our brothers by editing the first post with updates as applicable. Believe it or not @fingers86 has the record at the moment with 20mg.
Here's the updated range if you check the original post which was updated on 23Apr here
https://www.evolutionary.org/forums...rview-dosing-and-reviews.110114/#post-2025166 or you can just check it out quoted belowEVO members' MOTS-c daily dosing ranges: 1mg - 20mg
<<updated 23Apr2026>>
Thanks mate 20mg is hectic lol. I only just ended up doing 5mg pre workout by pure accident and was insane tbh sitting top of zone 4 my HR felt like it was only just in zone 2 though effort wiseOn the original post I keep the dosing ranges updated of all our brothers by editing the first post with updates as applicable. Believe it or not @fingers86 has the record at the moment with 20mg.
Here's the updated range if you check the original post which was updated on 23Apr here
Glad you got it bro
Regarding the small red marks or mild irritation at injection sites with MOTS-c, so here’s a clear breakdown for anyone running it:
What most people are seeing is a localized histamine response, not a bad batch or anything “wrong” with the peptide.
When you inject subQ, especially with peptides, you can trigger mast cells in the skin - this releases histamine and can cause:
• small red marks or dots
• slight swelling (like a tiny welt)
• mild itch or warmth
This is fairly common with MOTS-c and a few other peptides, especially with frequent injections.
Some people who are more sensitive to histamine also find relief using an antihistamine or spacing injections out.
Personally, we need to take an antihistamines before injections of Mots otherwise we get an itchy stomach for hours
Thanks again bro
There is nothing wrong with the actual Mots-c. As a test, I gave 1mg of the exact same reconstituted Mots-c (that caused me issues), to the missus 3 times now and she had no issues.
Certain individual have Mast Cell Activation Syndrome (MCAS) which is a unique disorder where the mast cells responds inappropriately. Further reading here.
I have tried everything under the sun and unfortunately you cannot beat the disorder. This includes:
-vitamin C
-Curcumin
-Quercetin
-TA1
-KPV
-timing anti allergy to Mots-c shot (i.e. zyrtac / claratyne
-Zinc Oxide powder
What I have been able to do is drastically reduce the INITIAL histamine response within the first 24hrs of the injection. From day 2 onwards, it is 100% guaranteed that the injection site will have hives and is intensely itchy. Dropping a bandaid onto the spot helps prevent scratching a bit.
It also interrupts deep sleep. The entire night my heartrate would be elevated due to the Mots-c reactions.
I think that's what this is for you for sure. Not much you can do about it but mitigate accordingly which you're doing well.
This was some great feedback for those looking for anecdotes on 5mg+ doses. Thanks @Yeahnah!
@Warthog61 added 1.5mg of MOTS-c. You can follow along in his log here https://www.evolutionary.org/forums...team-us-pharmacies.109845/page-5#post-2058843
https://www.evolutionary.org/forums...team-us-pharmacies.109845/page-5#post-2058843
@Jaxss finished running MOTS-c and posted a review in his log on finishing it here https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/page-4#post-2059704
https://www.evolutionary.org/forums/threads/recomp-phase-cycle-log.109665/page-4#post-2059704
@kcates added 1mg MOTS-c ED in his log here https://www.evolutionary.org/forums...my-first-cut-ever.106162/page-20#post-2063262
https://www.evolutionary.org/forums...my-first-cut-ever.106162/page-20#post-2063262
lol, i would say its not that bad when half of marriages end in divorce. Not saying u should do it but i dont think society cares that much about marriage like we use to.
@8enni8lanko added 1mg MOTS-c ED in his log here https://www.evolutionary.org/forums/threads/41-y-o-trt-retatrutide-training-recomp-log.110773/
https://www.evolutionary.org/forums/threads/41-y-o-trt-retatrutide-training-recomp-log.110773/
G'day Evo Fam
Sorry I'm a bit late to this one @HarleyGuy I wasn't able to run Mots-c for a while there with sponsor changeover and world supply issues but I'm back on now and hope to contribute something useful. My Brother you've put alot of incredible work into this one.
Previous doses were 1-2mg PWO but I found myself experiencing lethargy from midmorning onward, much better responses from 500mcg for sustained clarity and energy.
Now that I'm back on I tried a little experiment of night time pinning at 500mcg, still very early days but I have woken up leaner and feeling amazing on these two pins. Energy and clarity of thought were very good and sustained through the entire day. Fasted BG has been very good and exactly the same both mornings at 5.1 on the dot.
I'm going to continue this approach and see where it takes me.
Sorry I'm a bit late to this one @HarleyGuy I wasn't able to run Mots-c for a while there with sponsor changeover and world supply issues but I'm back on now and hope to contribute something useful. My Brother you've put alot of incredible work into this one.
Previous doses were 1-2mg PWO but I found myself experiencing lethargy from midmorning onward, much better responses from 500mcg for sustained clarity and energy.
Now that I'm back on I tried a little experiment of night time pinning at 500mcg, still very early days but I have woken up leaner and feeling amazing on these two pins. Energy and clarity of thought were very good and sustained through the entire day. Fasted BG has been very good and exactly the same both mornings at 5.1 on the dot.
I'm going to continue this approach and see where it takes me.
Welcome to our little corner of EVO where MOTS-c is the convo of the day @Doctakay! Thanks so much for this amazing review this was insightful.G'day Evo Fam
Sorry I'm a bit late to this one @HarleyGuy I wasn't able to run Mots-c for a while there with sponsor changeover and world supply issues but I'm back on now and hope to contribute something useful. My Brother you've put alot of incredible work into this one.
Previous doses were 1-2mg PWO but I found myself experiencing lethargy from midmorning onward, much better responses from 500mcg for sustained clarity and energy.
Now that I'm back on I tried a little experiment of night time pinning at 500mcg, still very early days but I have woken up leaner and feeling amazing on these two pins. Energy and clarity of thought were very good and sustained through the entire day. Fasted BG has been very good and exactly the same both mornings at 5.1 on the dot.
I'm going to continue this approach and see where it takes me.
Interesting that at a lower dose you're noticing better effects. I like feedback like this.
Please keep us posted on the night time approach you have going, super interesting and unorthodox I like it!
I've updated your dosing range on our main page here
https://www.evolutionary.org/forums...rview-dosing-and-reviews.110114/#post-2025166
Id get rid of my dick before getting rid of my family!
On the MOTS-c front, the performance benefits are real. Theres a lag from start to seeing result - another thing that makes it more likely a true increase in the number of mitochondria. My VO2max estimates are close to where i was when putting in 10hrs a week of hard cycling training and im only doing 4-5hrs and theyre not focused efforts.
Rating: 1-11
Endurance: 10
Strength: 0
Fat burning: 3
Focus: 0
Immediate endurance boost: 0
Making up for being a lazy fuck who doesn't do cardio: 11
Compared to cardarine,
I do think its signaling is strong and amplified by cardio. Compared to cardarine, id say its close after 2 months of use. Cardarine is way better if you want results within an hour of taking it.
Compared to SLU
Id say slu is more of an energy boost, and better for fat loss. I didnt see anything that made me feel like there was a performance boost. If anything the extra heat is a sign your less efficient (i suspect its a weak mitochondrial etc uncoupler, think weak dnp). It did seem to make me feel more energized. Need to try again b/c could have been placebo. Will be trying USP's soon.
Great feedback for us @Flash_is_Fast this is really detailed I love it!Id get rid of my dick before getting rid of my family!
On the MOTS-c front, the performance benefits are real. Theres a lag from start to seeing result - another thing that makes it more likely a true increase in the number of mitochondria. My VO2max estimates are close to where i was when putting in 10hrs a week of hard cycling training and im only doing 4-5hrs and theyre not focused efforts.
Rating: 1-11
Endurance: 10
Strength: 0
Fat burning: 3
Focus: 0
Immediate endurance boost: 0
Making up for being a lazy fuck who doesn't do cardio: 11
Compared to cardarine,
I do think its signaling is strong and amplified by cardio. Compared to cardarine, id say its close after 2 months of use. Cardarine is way better if you want results within an hour of taking it.
Compared to SLU
Id say slu is more of an energy boost, and better for fat loss. I didnt see anything that made me feel like there was a performance boost. If anything the extra heat is a sign your less efficient (i suspect its a weak mitochondrial etc uncoupler, think weak dnp). It did seem to make me feel more energized. Need to try again b/c could have been placebo. Will be trying USP's soon.
I'm really impressed you compared it to Cardarine and love your feedback on the comparison.
We actually just discussed this comparison of SLUPP and MOTS-c to Cardarine in my guest appearance on the podcast that dropped today, you can listen here https://www.evolutionary.org/evolutionary-org-688-interview-with-evo-brother-harleyguy/
@Yeahnah has added MOTS-c to his log at 2mg EOD pwo with reviews here https://www.evolutionary.org/forums...peptides-cycle-log.109625/page-6#post-2066477
https://www.evolutionary.org/forums...peptides-cycle-log.109625/page-6#post-2066477
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@fitlittlelady posted mots-C feedback in her Log
https://www.evolutionary.org/forums/threads/training-fitness-cycle-log.110061/post-2066423
https://www.evolutionary.org/forums/threads/training-fitness-cycle-log.110061/post-2066423
I definitely feel like the Mots-C is helping give me more energy at the gym. I turned up at the gym feeling really pumped. Just ask @FromFat2Fit, I was dancing on the treadmill during my warm-up, and nearly slipped off the end
Lol, yeah I agree in a sense not sure if I will start chopping body parts off but I love my family. I committed to my wife and kids for life. She would have to do something really stupid to get me to divorce her like infidelity. If that is happening there is a deeper problem then just cheating going on.Id get rid of my dick before getting rid of my family!
On the MOTS-c front, the performance benefits are real. Theres a lag from start to seeing result - another thing that makes it more likely a true increase in the number of mitochondria. My VO2max estimates are close to where i was when putting in 10hrs a week of hard cycling training and im only doing 4-5hrs and theyre not focused efforts.
Rating: 1-11
Endurance: 10
Strength: 0
Fat burning: 3
Focus: 0
Immediate endurance boost: 0
Making up for being a lazy fuck who doesn't do cardio: 11
Compared to cardarine,
I do think its signaling is strong and amplified by cardio. Compared to cardarine, id say its close after 2 months of use. Cardarine is way better if you want results within an hour of taking it.
Compared to SLU
Id say slu is more of an energy boost, and better for fat loss. I didnt see anything that made me feel like there was a performance boost. If anything the extra heat is a sign your less efficient (i suspect its a weak mitochondrial etc uncoupler, think weak dnp). It did seem to make me feel more energized. Need to try again b/c could have been placebo. Will be trying USP's soon.
A couple of interesting additions I'd like to point out. After working with a lot of people and a large review of anecdotal reporting. A 3x a week with a total of 10mg per week for 4 to 12 weeks seems to be the sweet spot for most users.
Also good to note, that MOTS-c is not for everyone. For many users it makes them feel exhausted. The reason for this is that MOTS-c acting as a mitochondrial optimizer and pushing more energy out of the mitochondrial. For some this means red lining their engine because they have poorly performing mitochondria, or damaged mitochondria. In those cases you can use a combination of FOX04 to clear out senescent cells, and SS-31 to do some mitochondria repair and then circle back to MOTS-c
Also good to note, that MOTS-c is not for everyone. For many users it makes them feel exhausted. The reason for this is that MOTS-c acting as a mitochondrial optimizer and pushing more energy out of the mitochondrial. For some this means red lining their engine because they have poorly performing mitochondria, or damaged mitochondria. In those cases you can use a combination of FOX04 to clear out senescent cells, and SS-31 to do some mitochondria repair and then circle back to MOTS-c
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I'm not sure about FOX04 but as for SS31 what dosing are you thinking? I've seen 1-5mg ED for 4 weeks for example. SS31 is one that may work if you're older and want to do a deep clean before starting any mito peps.
I have heard online an 8 week regiment for repair of the ss-31 from different sources is a cycle they recommend. I don't recall the dose they suggested. Then afterwards try the motsc and you should have improvement. I have been feeling exhausted on motsc but I have heard in some folks you may feel exhausted your first week then it kicks in better. Others I heard nothing but exhausted and never worked good for them. I am going keep using mine for a couple of weeks before I decide anything. I have felt better today but I didn't really work that hard today but I did get a lot of things done.
FOX04 clears out all the dead cells in your system. It's an intense protocol, of only 3 shots. The shot are pretty painful, and you feel whipped out for a day or two, to after that, you system reboots and you feel great.
The most standard protocol most people use for SS-31 is 1 to 2mg daily, for a 4 to 8 week run
I’m just about to get started and will trial 1mg daily as seems very common among community members.
However, have been learning that higher individual doses provide better mitochondrial signal for adaptation. Daily may not matter as much. Total weekly dosage may not matter as much as individual dosage. Mots has a short half life but adaptation effects can last up to 48 hours. Adaptation is stimulated by the training.
Great thread on the pep, lots of great info in here
I’ll consider a log.
But as Robarock said above. Something like 3mg 3x a week or 5mg 2x a week around intense training sessions.
I’ll start 1mg daily to get a baseline “feel” then try something like this
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Make sure and report back here on this thread how you feel on the 1mg for your baseline.
You can also start a MOTS-c log for us too.
I just started a peptide-only log; you can check it out here
My GLOW and Reta Log powered by OxygenPharm
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@Doctakay posted in LOG updates on MOTS-C
Main quote: "Night before dosing has been 500mcg light days, and 1mg for high days. So tomorrow night will be 1mg. Feeling the slight rise in body temp and minor increase in heart rate. Tomorrow night I'll try to remember to do some before and after BP tests."
https://www.evolutionary.org/forums...atrutide-mots-c-cycle-log.108892/post-2076297
Main quote: "Night before dosing has been 500mcg light days, and 1mg for high days. So tomorrow night will be 1mg. Feeling the slight rise in body temp and minor increase in heart rate. Tomorrow night I'll try to remember to do some before and after BP tests."
https://www.evolutionary.org/forums...atrutide-mots-c-cycle-log.108892/post-2076297
Great review @Doctakay I'd be really interested in the BP and also the difference in 500mcg BP vs. 1mg BP as well
What are you thinking in terms of when to take your BP after the dose? 1 hour after?
I just wanted to echo and emphasize something @Doctakay added to his log regarding MOTS-c here https://www.evolutionary.org/forums...-mots-c-cycle-log.108892/page-13#post-2076297
This is regarding the histamine response we've seen in a member who posted pics as well and is regarding MOTS-c reactions:
"While we're touching on Mots-C, an observation I have made is the histamine type responses can be minimised by diluting the dose. Instead of 1ml BAC for 10mg vial, reconstituting at 2ml for 10mg leaves me with no irritation or rash at the pin site. @HarleyGuy"
https://www.evolutionary.org/forums...-mots-c-cycle-log.108892/page-13#post-2076297This is regarding the histamine response we've seen in a member who posted pics as well and is regarding MOTS-c reactions:
"While we're touching on Mots-C, an observation I have made is the histamine type responses can be minimised by diluting the dose. Instead of 1ml BAC for 10mg vial, reconstituting at 2ml for 10mg leaves me with no irritation or rash at the pin site. @HarleyGuy"
@HarleyGuy great article man, and I found it cause I was listening to the most recent podcast you were on this morning and your talking about this. I’d love to try it and see the insulin sensitivity effects it has. As a type 1 I notice that kind of shit instantly obviously. When I started trizepitide my daily insulin needs fell by about 33% for the exact same macros. TRT had about a 10-15% on daily insulin also when I started that.
Very cool feedback bro. A type 1 diabetic would be able to give us the coolest anecdotal evidence for the insulin sensitivity that MOTS-c is best known for.
The best way to test the histamine reaction to Mots-c is to take an anti-histamine with an injection an gauge the difference in response. If you don't have a reaction, the you know its histamine, if you still do, it could be something else going on.I just wanted to echo and emphasize something @Doctakay added to his log regarding MOTS-c here
This is regarding the histamine response we've seen in a member who posted pics as well and is regarding MOTS-c reactions:
"While we're touching on Mots-C, an observation I have made is the histamine type responses can be minimised by diluting the dose. Instead of 1ml BAC for 10mg vial, reconstituting at 2ml for 10mg leaves me with no irritation or rash at the pin site. @HarleyGuy"
I was thinking about an hour. Grab a few baseline measurements, and then an hour later see whats happening. And measure 30 mins later again. I'm sure I'm noticing a a slight increase in resting heart rate and body temperature somewhere around 45 mins after pinning.
Yeah maybe a control of the exact same food and exercise for 1 week and then 1 week on Mot to see the sensitivity effects in total daily insulin delivery…
This sounds perfect! Looking forward to hearing about it. Great experiment and feedback for the community.
Quite right exactly. A control week with variable being MOTS-c would tell us a ton!Yeah maybe a control of the exact same food and exercise for 1 week and then 1 week on Mot to see the sensitivity effects in total daily insulin delivery…
Appreciate the write up and all the comments. I’m curious if anyone has come off MOTS-c and felt they kept their cardio gains long term?
I’m training BJJ and competing in about 3 months, so I’m looking to maximise training output.
Current schedule:
Would adding it in now be better, or waiting until 8 weeks out from comp?
I’m training BJJ and competing in about 3 months, so I’m looking to maximise training output.
Current schedule:
- Weights every morning except Wednesday and Sunday
- Pool or mobility work at lunch, alternating days except Sunday
- BJJ Monday, Wednesday, Friday, and Saturday
Would adding it in now be better, or waiting until 8 weeks out from comp?
LevButlerov
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welcome to the EVO family
@Bubblebee It's a bit hard to say what you should do without knowing your log, have you gotten it ready to post?
Hi brother, welcome to the site. The mechanism of MOTS-c is mostly focused on mitochondrial optimization, this usually means, more energy while cycling it, there are some other benefits as well that are a downstream effect of higher energy availability. All that being said, the cardio gain you may feel is mostly a byproduct of this energy boost. It wouldn't be maintained after you stop.
@Warthog61 reintroduced MOTS-c in his log here https://www.evolutionary.org/forums...team-us-pharmacies.109845/page-7#post-2075764
He will be advising on it's effects on his RHR
https://www.evolutionary.org/forums...team-us-pharmacies.109845/page-7#post-2075764He will be advising on it's effects on his RHR
Thank you could what I need as I step up my cardio.i might actually do some vo2 max testing as well. Before halfway and after.
Just to have some data
This sounds awesome I say go for it and report back here with your data! Would be great data!
Is there instructions on how to start a log? Does the log have to be with Evo supplied gear?A log would really change things and help you dial in with the EVO family without guessing
LevButlerov
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you dont need a sponsor to start a log
@CJM it takes about 15min to start one easy and you get VIP and EVO family support! see below.HOW-TO LOG?
Why is a Log Journal important?
- Doing a log will actually help you way more than just dropping random updates. When you lay it all out week by week you start to see patterns in your body that you won’t catch otherwise.
- Other guys here run logs all the time and there’s no privacy issue, nobody is asking for your name or anything personal, it is just training, diet, and how the compound feels.
- The feedback you get is also way better because people can follow along and spot things you might miss. It also helps the next guy who is thinking about running the same compound so you are giving back while you learn.
- Even if you think you might not stick with it, just starting the log makes it easier to come back and add quick notes. That way you get more out of what you are running instead of keeping it all in your head.
To really guide you we need more info from you:
- Please share your diet, training, cardio, sleep, supplements etc log with us in a NEW thread, full log journal so our guidance is based on facts you provide.
- It will take 15-20 minutes max.
- We have 100s of years of experience between us, so you need to post a LOG Journal with your stats (weight,height,age, years training, cycle history) diet, training, cardio, supplement, sleep details. If you don't log what you eat or train now, open NOTES on phone and start recording it there and paste here. Very easy.
- Please post a Log Journal asap for us
Please click the anabolic forum
https://www.evolutionary.org/forums/forums/anabolic-steroids-and-peds.2/
top RIGHT, you see: +POST THREAD
click that
in Title: write your cycle name, like> My _____ Cycle Log
___ = the name of your log
example: My testosterone cycle Log
in body: write your planned cycle or cycle you doing now, your diet, training and we will help you along on your cycle
here are examples of LOG Journals
https://www.evolutionary.org/forums/threads/first-testosterone-cycle-log.104133/
https://www.evolutionary.org/forums/threads/sustanon-trenomast-deca-dbol-cycle-journal.105881/
https://www.evolutionary.org/forums/threads/s-gentz-2025-26-growth-phase-log-with-psl.106514/
https://www.evolutionary.org/forums...var-bpc157-beligas-pharmaqo-cycle-log.104843/
https://www.evolutionary.org/forums...g-log-sponsored-by-purity-source-labs.103669/
https://www.evolutionary.org/forums...erone-cycle-and-beginner-training-log.106310/
https://www.evolutionary.org/forums/threads/average-trt-back-to-savage-cycle-journal.106252
https://www.evolutionary.org/forums...-testosterone-masteron-primobolan-deca.105348
https://www.evolutionary.org/forums...odybuilding-log-masters-55-competitor.102611/
https://www.evolutionary.org/forums...ron-npp-tren-anadrol-log-to-stage-2025.102590
P.S. are you listening to our podcast? if not, you should; this podcast is about steroids, sarms, peptides, and bodybuilding:
https://www.evolutionary.org/podcasts/
https://podcasts.apple.com/us/podcast/evolutionary-bodybuilding-radio/id1798623410
https://open.spotify.com/show/53q1RFTgG4h6TQHsJ4xY6Z
@leolkn added 5mg of MOTS-c EOD in his log here https://www.evolutionary.org/forums/threads/training-and-recomp-cycle-log-with-us-pharmacies.111228/
https://www.evolutionary.org/forums/threads/training-and-recomp-cycle-log-with-us-pharmacies.111228/
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@Davie_Rich19 reported his mots-c dose at 2mgs ED 1 hour preworkout
https://www.evolutionary.org/forums...-labs-and-retatrutide-log.110229/post-2083424
https://www.evolutionary.org/forums...-labs-and-retatrutide-log.110229/post-2083424
MOTS-c PEPTIDE (a.k.a.: "MOTS")
A readable layman's overview
<<updated 25May2026>>
View attachment 205576
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References:
https://pubmed.ncbi.nlm.nih.gov/31293078/
https://www.nature.com/articles/s41467-020-20790-0
https://doi.org/10.1016/j.cmet.2015.02.009
Journal of Alzheimer's Drug Discovery Foundation
Human Trial 1b of MOTS-c Analogue Results
EVO - Members' Dosing and Anecdotal Reports
What Is MOTS-c Peptide? (And Why We Are Paying Attention)
MOTS-c is a 16 amino acid peptide that is coded by the mitochondrial genome. The mitochondria are the “power generators” in cells that convert chemical energy from food into a form that cells can use. MOTS-c is a mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA and involved in regulating metabolism and energy balance. It plays a key role in helping the body adapt to metabolic stress, such as exercise and caloric restriction. MOTS-c has shown to protect against insulin resistance and obesity in older test subjects, muscle catabolism in the aging, and even supports memory function in aging subjects.
Unlike most peptides, MOTS-c can travel to the nucleus and influence gene expression related to metabolism and cellular function.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome
- MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway
- MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis
- MOTS-c protects against age- and diet-dependent insulin resistance and obesity even in the environment of a high fat diet
- MOTS-c efficacy may only be clinically significant in older human subjects where it is observed to be in decline as subjects age
Important Reality Check!
- MOTS-c is not approved by regulatory agencies like Health Canada or the FDA
- Most evidence is preclinical (animal-based)
- Long-term safety and optimal dosing in humans are unknown (EVO members' anecdotal experiences and dosing seen below)
- MOTS-c has had clinically significant results in aging animal-based and human subjects and may not be efficacious to younger subjects
- Not everyone may need this and this is not a promotion for you to use MOTS-c, however clinical data in rodents (and minimal human studies) shows it is very promising!
Why MOTS-C Matters For Us?
MOTS-c activates AMP-activated protein kinase (AMPK), a central regulator of cellular energy often referred to as the body’s “metabolic master switch.”
This pathway is also activated by:
- Exercise
- Fasting
- Caloric restriction in general
Our Potential Fitness Benefits of MOTS-C
MOTS-c has been shown to improve metabolic flexibility and prevent fat accumulation even under high-fat diet conditions in animal models.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Demonstrated reduced weight gain and improved glucose metabolism in mice
2. Improved Endurance & Physical Performance
Study Evidence (see references):
- Research shows MOTS-c can enhance physical performance and mimic some adaptations typically seen with exercise.
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
- Improved running capacity and muscle function in older mice
3. Better Muscle Energy Utilization
MOTS-c improves how skeletal muscle uses glucose, making workouts more efficient at the cellular level.
Study Evidence (see references):
- MOTS-c enhances insulin sensitivity in skeletal muscle
4. Improved Insulin Sensitivity
One of the strongest areas of evidence: MOTS-c enhances insulin sensitivity and glucose uptake.
Study Evidence (see references):
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- Showed improved insulin response and reduced insulin resistance
5. Longevity & Recovery Potential
MOTS-c levels decline with age, and supplementation in animal models has been linked to improved physical function and metabolic health in older subjects.
Study Evidence (see references):
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
Human Research (Early but Emerging)
While most data comes from animal studies, early human research suggests MOTS-c is relevant to fitness and metabolic health. A MOTS-c analogue was shown to significantly decrease glucose levels, body weight, and ALT/AST levels at a dose of 25mg ED subQ over 4 weeks.
Human Study (ref: MOTS-c Human Study Extrapolation):
- Found correlations between MOTS-c levels and insulin sensitivity in humans
- "MOTS-c is hypothesized to be involved in the longevity of the Japanese" (ref: MOTS-c Human Study Extrapolation)
- "The findings supported a role for MOTS-c as an endocrine-like peptide influencing insulin signaling pathways. The authors proposed that mitochondrial-derived peptides could serve as metabolic regulators and potential therapeutic targets for conditions such as obesity, insulin resistance, and type 2 diabetes. This study helped establish MOTS-c’s relevance in human metabolic physiology and inspired further investigations into its mechanisms and clinical applications."
- "In the older cohort, higher MOTS-c levels were associated with improved muscle quality, based on maximal leg-press load relative to thigh cross-sectional area."
- "The Phase 1b study was a randomized, double-blind, placebo-controlled evaluation of a 25 mg dose of CB4211 (MOTS-c analogue) given once daily by subcutaneous injection for four weeks in 20 obese subjects with nonalcoholic fatty liver disease (NAFLD)." (ref: Human Trial 1b of MOTS-c analogue results)
- "Evaluation of the exploratory pharmacodynamic endpoints from the Phase 1b stage of the study comparing CB4211 to placebo demonstrated robust and significant reductions in key biomarkers of liver damage, ALT and AST, a significant decrease in glucose levels, and a trend towards lower body weight after four weeks of treatment." (ref: Human Trial 1b of MOTS-c analogue results)
Bottom Line for Fitness (Backed by Science)
MOTS-c is one of the most promising emerging peptides for:
- Fat loss support
- Endurance and performance
- Metabolic efficiency
- Healthy aging
- Liver and organ support
- Alzheimer's treatment
But right now, the science while exciting, is still early-stage and human clinical validation is limited. (ref: MOTS-c Human Study Extrapolation)
EVO members MOTS-c doses, anecdotal feedback and further research requests:
- Quick cruise around EVO led me to these members and their doses with some anecdotal feedback
- Please provide any reviews you wish to contribute include timing and reconstitution method that works best (ie: 2ml in 40mg vial, etc)
- Please update your current dose of MOTS-c including your own quote on your thoughts about this peptide
- MOTS-c is a bit of a niche peptide and those that run it usually know another member that does; I'd ask that you please tag as many EVO brothers or sisters you know that are running MOTS-c so that they can contribute to this research
- If you have or are currently running MOTS-c and were not tagged below please add yourself to this community research thread by replying and I will add you to the list
- Please add any additional research on MOTS-c to add to this research article including anecdotal experieces
EVO members' MOTS-c daily dosing ranges: 500mcg - 20mg
@Allupfromhere 2mg ED “Mots c is one of my favs” "Mots c is like and endless fuel tank, i couldnt believe the stability in energy it has given me. Top 3 in my ranks for sure" You can follow his log here
@San Andreas 2mg ED You can follow his log here
@Darth_Vader 5mg e3d You can follow his log here
@Demon_throne 4mg ED "The bread and butter of my mito stack." You can follow his log here
@jwright1275 4mg e3d You can follow his log here
@G-Merc 80 1mg ED “I love MOTS-C and have found that SS31 pairs perfectly with it, just clean feelilng energy boost.” You can follow his log here
@Shakey 1mg ED You can follow his log here
@HarleyGuy 1mg ED You can follow his log here
@Dreamer 5mg Pre-Bed “I have shared around the place how I use MOTS C, I take mine in the evening with my large intake of carbs, I have seen a massive improvement in fasting BGL in the morning and in turn insulin sensititivty by doing this.
I think peptides can be used in numerous different ways and applications once you understand what they do to YOUR body because they do seem to be highly individual, play around with them and monitor with data, they are incredibly useful for alot of things” You can follow his log here
@RogueCherry 1mg ED You can follow her log here
@Freakfitness 1mg ED You can follow his log here
@Eveflorence 2mg ED “Found this worked amazingly well. Noticeable increases in energy, motivation, endurance and overall feeling of well-being. I want to have another run of it soon.” You can follow his log here
@Doctakay 500mcg-2mg pwo/ED You can follow his log here
@jenkemj 2mg ED You can follow his log here
@willipede 1mg ED You can follow his log here
@Made_Man 2mg ED You can follow his log here
@TheOne1 10mg ED “So far my experience has been positive and i like the extra efficiency it has brought into my workouts. Also I have noticed a bit extra pump too. I'm looking forward to week 2 on this and seeing what else it can unlock as I use it more.” You can follow his log here
@madcap71 2mg pwo You can follow his log here
@Flash_is_Fast 1mg pwo You can follow his log here
@fatboy999 1mg ED You can follow his log here
@OwEv751 2mg EOD You can follow his log here
@gar71 1-2mg ED You can follow his log here
@Thoranosaurus_flex 1mg ED You can follow his log here
@treebeard 3.5mg E3D You can follow his log here
@fingers862mg ED*updated to 20mg ED 07Apr* You can follow his log here
@Nelsonhaha 4mg pwo You can follow his log here
@Jaxss 1-1.5mg pwo You can follow his log here
@theJimJim 2mg ED You can follow his log here
@PrinceDaddy 1mg ED You can follow his log here
@Warthog61 1-1.5mg ED You can follow his log here
@kcates 1mg ED You can follow his log here
@8enni8lanko 1mg ED You can follow his log here
@Yeahnah 2mg EOD pwo You can follow his log here
@leolkn 5mg EOD You can follow his log here
Thanks for reading,
HarleyGuy
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Interested Participants:
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This is awesome bro, @HarleyGuy.
I’ve been researching MOTS-c for over a year now. My first run was about 8 weeks at 2 mg daily. It worked incredibly well up until around week 8, when I started noticing significant fatigue, my gym pumps disappeared, and overall training performance wasn’t feeling the same.
I took about two weeks off, then ran SS-31 at 5 mg daily for 3 weeks. During that period, I saw major improvements in both HRV and resting heart rate, my energy levels remained stable throughout the day, and my sleep quality was excellent. At the time, I was also running 150 mg/week of Test E during both peptide protocols.
My understanding is that MOTS-c is an excellent tool to have available, but because it activates AMPK, it can potentially interfere with mTOR signaling if timing isn’t considered. For that reason, I personally prefer running it every other day (EOD) and try to keep at least 2–3 hours between my MOTS-c injection and weight training session. My goal is to minimize any potential impact on mTOR signaling during resistance training and muscle growth. That said, if I’m doing an endurance-focused workout—such as conditioning work, longer cardio sessions, or something with a strong aerobic component. I actually prefer taking the MOTS-c shot before training because the energy, endurance, and work capacity benefits are very noticeable for me.
I should’ve mentioned that I was running 5mg daily and since I did the switch to EOD I haven’t noticed ANY difference in energy/mood.
This was a very detailed and comprehensive review brother. A novel review at 5mg as well!This is awesome bro, @HarleyGuy.
I’ve been researching MOTS-c for over a year now. My first run was about 8 weeks at 2 mg daily. It worked incredibly well up until around week 8, when I started noticing significant fatigue, my gym pumps disappeared, and overall training performance wasn’t feeling the same.
I took about two weeks off, then ran SS-31 at 5 mg daily for 3 weeks. During that period, I saw major improvements in both HRV and resting heart rate, my energy levels remained stable throughout the day, and my sleep quality was excellent. At the time, I was also running 150 mg/week of Test E during both peptide protocols.
My understanding is that MOTS-c is an excellent tool to have available, but because it activates AMPK, it can potentially interfere with mTOR signaling if timing isn’t considered. For that reason, I personally prefer running it every other day (EOD) and try to keep at least 2–3 hours between my MOTS-c injection and weight training session. My goal is to minimize any potential impact on mTOR signaling during resistance training and muscle growth. That said, if I’m doing an endurance-focused workout—such as conditioning work, longer cardio sessions, or something with a strong aerobic component. I actually prefer taking the MOTS-c shot before training because the energy, endurance, and work capacity benefits are very noticeable for me.
I should’ve mentioned that I was running 5mg daily and since I did the switch to EOD I haven’t noticed ANY difference in energy/mood.
Thanks for sharing @Leozin. I think when I start it again I’ll be trying 4-5mg myself as well. Same with SS31
I generally only run it 3x a week at 3.5mg. I've found for me that's the best balance for me.This is awesome bro, @HarleyGuy.
I’ve been researching MOTS-c for over a year now. My first run was about 8 weeks at 2 mg daily. It worked incredibly well up until around week 8, when I started noticing significant fatigue, my gym pumps disappeared, and overall training performance wasn’t feeling the same.
I took about two weeks off, then ran SS-31 at 5 mg daily for 3 weeks. During that period, I saw major improvements in both HRV and resting heart rate, my energy levels remained stable throughout the day, and my sleep quality was excellent. At the time, I was also running 150 mg/week of Test E during both peptide protocols.
My understanding is that MOTS-c is an excellent tool to have available, but because it activates AMPK, it can potentially interfere with mTOR signaling if timing isn’t considered. For that reason, I personally prefer running it every other day (EOD) and try to keep at least 2–3 hours between my MOTS-c injection and weight training session. My goal is to minimize any potential impact on mTOR signaling during resistance training and muscle growth. That said, if I’m doing an endurance-focused workout—such as conditioning work, longer cardio sessions, or something with a strong aerobic component. I actually prefer taking the MOTS-c shot before training because the energy, endurance, and work capacity benefits are very noticeable for me.
I should’ve mentioned that I was running 5mg daily and since I did the switch to EOD I haven’t noticed ANY difference in energy/mood.
Yeah I am thinking to go only on my off days to try it out. Pre fasted cardio
@Dumptruck added 5mg MOTS-c on rest days in the morning. You can see this in his log here https://www.evolutionary.org/forums/threads/2026-bodybuilding-prep-cycle-log.111278/
https://www.evolutionary.org/forums/threads/2026-bodybuilding-prep-cycle-log.111278/
@Nickh27 is running 2mg of MOTS-c every AM and it's helping him through feeling under the weather. You can see this in his log here https://www.evolutionary.org/forums...tosterone-raptor-labs-retatrutide-log.110247/
"Mots-c definitely helping with the energy levels throughout the day while being so sick along with the 3ius of growth at night time assisting with the sleep"
https://www.evolutionary.org/forums...tosterone-raptor-labs-retatrutide-log.110247/"Mots-c definitely helping with the energy levels throughout the day while being so sick along with the 3ius of growth at night time assisting with the sleep"
Mots-C has be one of the better compounds I have experienced. As a Husband and father with a full time job aswell as running a business fatigue is something I was battling daily and was effecting my progress dramatically. 3:30am Wake up every day for my gym sessions have become so much easier with consistent energy levels through out the day.@Nickh27 is running 2mg of MOTS-c every AM and it's helping him through feeling under the weather. You can see this in his log here
"Mots-c definitely helping with the energy levels throughout the day while being so sick along with the 3ius of growth at night time assisting with the sleep"
Current protocol is 2mg daily in the AM before leaving home for the gym
Excellent feedback on 2mg of MOTS-c in the morning @Nickh27! Many have reported the avoidance of that afternoon crash.
@Katsumi added 1mg of MOTS-c to her Mito pep protocol in her log here https://www.evolutionary.org/forums...ponsored-by-ugl-oz.107073/page-2#post-2038479
https://www.evolutionary.org/forums...ponsored-by-ugl-oz.107073/page-2#post-2038479Similar threads
