Following to see how this goes for you. My wife just started Ret and just took her 3rd shot. She started at 2mg and then bumped to 4mg this shot. She hasn't felt anything until now. She thought maybe after being on the Sema and switching and being overweight a lot she needed more to get rid of the food noise. She feels it now and likes it because it doesn't come with the sides like Sema did with the digestion issues.