Accutane for acne

[wolfpackalpha]

A lot of bodybuilders have problems with acne, but what are the remedies? have you guys heard of accutane? read more:

Accutane: http://www.evolutionary.org/accutane-isotretinoin

 

[gearhead]

bro i did accutane...really helps with acne but def dries the skin pretty badly....

 

[stretch512]

Great article - I have never had an acne problem but I have known multiple people to use accutane. Yes it does work the sides can vary and can be many - one that commonly came up was stomach issues. At the end though I see the drug do its job.

 

[Hesnobradpitt]

i have found it effective and easy to use at 20mg ed with minimal sides.

Brad.

 

[Mission2]

I don't have any issues with acne, but I know a few bros that say Accutane works wonders.

 

[RickRock]

Accutane most definitely works to fight acne very well, but it comes with a price. Some of the side effects of Accutane can be pretty bad

 

[stevesmi]

its all about the risk v rewards with any drug. important to read the article and make a smart decision.. doctors should not be the ones making final decisions on this sort of stuff

 

[stretch512]

Totally agree with that last statement - sooo many times I see people taking Dr.'s word as final authority when it comes to all types of medications and ultimately it's your body so you should be conscious about it and determine how you need to proceed.

 

[stevesmi]

Totally agree with that last statement - sooo many times I see people taking Dr.'s word as final authority when it comes to all types of medications and ultimately it's your body so you should be conscious about it and determine how you need to proceed.

exactly that's why there are 30 year olds on 7 different medications in this country.

each medication covers up another side of the other. you from taking 1 to 3 to 5 to 7 and so on. its never ending

I would rather die than be put on pills the rest of my life sorry.

 

[mr.buffman]

What about 10mg eod for battling cycle acne or pct acne

 

[rcorchid]

I took 40 mg/day for about 2 months (script from dermatologist). I also tried 20 mg every other day as i had facial acne real bad. I just couldn't stand taking it anymore I felt like shit all the time and it made my liver enzymes skyrocket.

 

[JackSteel]

I used it as a child but not til a few years ago did I start hearing about all the lawsuits. Bad stuff. Rids the acne but so would gas and a match. Possibilities of brain issues etc.


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[Casca]

With bloods consistently done every month, u can reap the rewards and watch out for any signs of risk.

U run risk with ALL the self medicating/adminstering, that we do.

Plus stop eating like shit, drinking heavily and all the other vices.

Just cause u look good on the outside, shit can be real serious on the inside, BLOODS BABY, BLOODS!!!!!


Casca

The Green Machine

 

[injfuel]

With bloods consistently done every month, u can reap the rewards and watch out for any signs of risk.

U run risk with ALL the self medicating/adminstering, that we do.

Plus stop eating like shit, drinking heavily and all the other vices.

Just cause u look good on the outside, shit can be real serious on the inside, BLOODS BABY, BLOODS!!!!!


Casca

The Green Machine

Agree completely ! I know many guys on cycle with high BP and don't even try to correct the issue , also know many guys been cycling for years and NEVER got blood work once , I'm on 20mg ED of accutane and it reduced 80% of my acne and I have experienced no side effects

 

[Kobe8jf1234]

I need get some got acne that won't go away

 

[Druboutin]

I'm on 20 mg a day to help clear up the mess that was left from my last cycle.. That decision was made after I exhausted all other resources (doxycycline, retin-a, all the natural remedies, ketoconazol, etc).

Plan on dropping it during the oral kickstart on my next cycle, and then starting back up on a preventative dose of 10mg per day.

It's been 3 weeks and I'm really starting to clear up. Eyes feel a little dry, but not enough to warrant eye drops, and I've had to put on chapstick a few times, but outside of that nothing major.

Great article with background info.

 

[Druboutin]

With bloods consistently done every month, u can reap the rewards and watch out for any signs of risk.

U run risk with ALL the self medicating/adminstering, that we do.

Plus stop eating like shit, drinking heavily and all the other vices.

Just cause u look good on the outside, shit can be real serious on the inside, BLOODS BABY, BLOODS!!!!!


Casca

The Green Machine

Yup, bloods are key. You should have no problem getting a dermatologist to give you a prescription and monthly bloods if you really need accutane. For guys without insurance, I'd still want to figure out a way to get bloods done more frequently than the typically mid/post cycle.

Fortunately for me, my liver enzymes didn't really move from baseline. Even as a child when I was on the crazy mega doses, my bloods were still ok. It's really individual.

 

[gymrat827]

great stuff, but the risks of the liver are bad. like real bad.

 

[kai1432]

Nothing works better than Accutane on Acnes.

 

[Druboutin]

Nothing works better than Accutane on Acnes.

Can also confirm that Kai provides quality stuff. 20 mg/day started to dry me out after about 2 weeks. Really clearing up going into the 3rd week.

 

[25homes]

Accutane works great but very toxic be careful

 

[Druboutin]

Abstract
Background: Isotretinoin, an oral retinoid, has been utilized to achieve long term remissions in cases of recalcitrant acne. In the
conventional dosage schedule, the use of oral isotretinoin has been limited by the occurrence of biochemical abnormalities such
as hypertriglyceridaemia and impaired liver function tests and radiological changes consistent with diffuse idiopathic skeletal
hyperostosis. Low-dose intermittent regimen of oral isotretinoin has been evolved as a cost effective alternative to the conventional
dosage regimen in cases of acne. This study addresses the issue of adverse effects of low-dose intermittent isotretinoin and the
safety of this regimen.
Methods: A total of 60 cases of recalcitrant acne were included in the study. Baseline haematological, biochemical and radiological
investigations were carried out. Low-dose intermittent isotretinoin was instituted in a dose of 0.5 mg/kg/day for one week in every
four weeks for six months. The investigations were repeated at the end of six months therapy.
Result: High triglyceride levels occurred in 5% of cases whereas impaired liver function tests and skeletal hyperostosis of the
spine were not observed in any case after low-dose intermittent isotretinoin.
Conclusion: The low-dose intermittent regimen in cases of acne may be utilized to limit the systemic toxicity of oral isotretinoin.


Keep it in the 10-20 mg range if possible

 

[Druboutin]

Investigators in Israel conducted a prospective, observational, open-label study of isotretinoin in 638 patients with moderate acne. Patients were divided into two groups. Group 1 contained 495 patients aged 12 to 20 years with a 2:1 female:male ratio. Group 2 contained 122 patients aged 21 to 35 years with a 3.5:1 female:male ratio. All patients received 20 mg/day of isotretinoin for 6 months. Patients were evaluated every 2 months through unblinded clinical examinations and laboratory tests. Pregnancy tests were done at baseline for women with childbearing potential. Follow-up was not explicitly reported but took place over a period of up to 4 years.

A total of 617 patients completed the study. In group 1, 95% of patients achieved considerable improvement or complete remission of their acne; 26 patients (5%) did not respond and either their isotretinoin dose was increased to 30–40 mg/day, oral erythromycin was added, or the low-dose isotretinoin was continued for 8 months until remission occurred. The mean cumulative dose in group 1 was 70 mg/kg. In the follow-up period, 20 patients (4%) relapsed. Polycystic ovary syndrome was subsequently diagnosed in 7 of the patients who relapsed.

In group 2, 93% achieved significant improvement or remission, and 7% did not respond. In these nonresponders, the isotretinoin dose was either increased or continued at the low-dose level for 9 months until remission was achieved. The mean total dose was 67 mg/kg. Seven patients (6%) relapsed; of these, polycystic ovary syndrome was diagnosed in two.

The most common side effects were mild cheilitis (91%) and mild xerosis (43%). Epistaxis was reported in 2.5%. There were no pregnancies and no reported depression or other psychological side effects. A slight and transient elevation of liver enzymes (5%) and serum lipids (4%) was seen. One patient discontinued the medication due to a marked increase in triglycerides.


Here's one with a bigger sample size.. Again, these are doses of 2-4x what I'd recommend starting at. Most people can see great improvement in the 10-20 mg range.

 

[JackSteel]

Investigators in Israel conducted a prospective, observational, open-label study of isotretinoin in 638 patients with moderate acne. Patients were divided into two groups. Group 1 contained 495 patients aged 12 to 20 years with a 2:1 female:male ratio. Group 2 contained 122 patients aged 21 to 35 years with a 3.5:1 female:male ratio. All patients received 20 mg/day of isotretinoin for 6 months. Patients were evaluated every 2 months through unblinded clinical examinations and laboratory tests. Pregnancy tests were done at baseline for women with childbearing potential. Follow-up was not explicitly reported but took place over a period of up to 4 years.

A total of 617 patients completed the study. In group 1, 95% of patients achieved considerable improvement or complete remission of their acne; 26 patients (5%) did not respond and either their isotretinoin dose was increased to 30–40 mg/day, oral erythromycin was added, or the low-dose isotretinoin was continued for 8 months until remission occurred. The mean cumulative dose in group 1 was 70 mg/kg. In the follow-up period, 20 patients (4%) relapsed. Polycystic ovary syndrome was subsequently diagnosed in 7 of the patients who relapsed.

In group 2, 93% achieved significant improvement or remission, and 7% did not respond. In these nonresponders, the isotretinoin dose was either increased or continued at the low-dose level for 9 months until remission was achieved. The mean total dose was 67 mg/kg. Seven patients (6%) relapsed; of these, polycystic ovary syndrome was diagnosed in two.

The most common side effects were mild cheilitis (91%) and mild xerosis (43%). Epistaxis was reported in 2.5%. There were no pregnancies and no reported depression or other psychological side effects. A slight and transient elevation of liver enzymes (5%) and serum lipids (4%) was seen. One patient discontinued the medication due to a marked increase in triglycerides.


Here's one with a bigger sample size.. Again, these are doses of 2-4x what I'd recommend starting at. Most people can see great improvement in the 10-20 mg range.

It definitely has effects on the brain too. I wonder what those studies say. The fold out had a picture of a new born baby that had a gigantic head and other birth defects. Even was said to possibly cause things like depression and ADD. Id rather have acne personally. At least it's temporary. My lips would get so chapped on that stuff as a kid.



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[Casca]

With a dermo and bloodwork it is not like the days of old Jack, their r guidlines that must know be followed. Seems as though ur throwing everything in this thread in a negative manner except the kitchen sink. We here ya, ur no fan.

There r others here if used legitimately, could really benefit from it greatly.


Casca

The Green Machine

 

[Druboutin]

The issue is it's historically never been used in low doses. Dr.'s originally thought mega dosing the medicine to get permanent results was the answer. It wasn't until the last decade, and really even more recent than that that studies have been done on low dose therapy.

With lower doses, chapped lips, dry skin and a few nose bleeds are the sides that most will experience. Less than 5% will experience liver issues. Of course you will always have outliers (as with any drug) who may suffer something worse, and potentially permanent.

Using while pregnant is a different story, and depression was also linked to higher dosages.

It's relatively safe in the 10-20 (even up to 40) range. I'd say keep it in the 10-20 range just to be safe, and of course get bloodwork as a precaution.

 

[Shrine]

exactly that's why there are 30 year olds on 7 different medications in this country.

each medication covers up another side of the other. you from taking 1 to 3 to 5 to 7 and so on. its never ending

I would rather die than be put on pills the rest of my life sorry.

Its all about the money my friend. End of story

 

[Casca]

Its all about the money my friend. End of story

How ironic u say that.


Casca

The Green Machine

 

[hurricane]

Use this as a last resort guys. The sides can be down right wicked on it!

 

[trnj1988]

Yes, Agreed

exactly that's why there are 30 year olds on 7 different medications in this country.

each medication covers up another side of the other. you from taking 1 to 3 to 5 to 7 and so on. its never ending

I would rather die than be put on pills the rest of my life sorry.