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Community Research Cagrilintide with GLP1s Semaglutide Tirzepatide Retatrutide

Threads marked with the 'Community Research' prefix involve ongoing research, high-quality logs, or in-depth community discussions backed by experience, data, or expert input.
LevButlerov

LevButlerov

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Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!

Feedback from @JimmyO187
JimmyO187 said:
I recently introduced Cagrilintide to assist and more so trial along side with Retatrutide. Wasn’t really getting appetite suppression from it and popped in 1mg of Cag and said goodbye to the desire to eat which wasn’t the intended goal so I’ll be dialling that back a smidge. Currently sitting @ 2mg of Reta a week on a Sunday
Click to expand...
I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:
Wookie said:
Cravings have really died off that i have dropped Cagrilintide amd lowered Retatrutide. Its almost at the point in could drop reta but it has so many other benefits than just appetite suppression.
Click to expand...

Wookie said:
Cagrilintide is another GIP/GLP1 I guess, it works on a different pathways being an Amylin analogue which when stacked with Reta gives a 4th agonist.
I was having bad appetite control especially in the afternoon/evening mainly for carbs amd i couldn't work out why. I even increased reta dosage up to 8/10mg and still had the issues. This was extremely frustrating considering my cut I didn't go over 2.5mg and had no food noise.
After looking into it a bit i worked out it was 2 medicines perscribed by my Dr that was causing this.
- These two together = one of the strongest appetite-increasing combos in medicine.
- They are used clinically for patients who need to gain weight.
- The appetite pathways these meds hit are different from the ones Retatrutide suppresses.
Introduction of Cagrilintide took, id say a good 90% of the afternoon cravings away.
I have since dropped one of the meds and dont need the cag anymore but it definitely worked.
Click to expand...
I also found @G-Merc 80 was using Cagrilintide as well, he talks about it in his log and discusses side effects as well:
G-Merc 80 said:
Day 2 on Cagrilintide, 1mg weeky: food noise has all but shut down, you feel hungry but not like normal, just a stomach grumble with the brain not chasing a food hit, food feels like you could take it or leave it very easily and find myself needing to ensure i stick to the plan, another thing I am experincing is my normal meal size has me feeling so full that I hit a wall like a food coma and just want to sleep.

Digestion hasn't been effected in anyway and with adjusting the Reta dose down has improved it, so far it is yeilding results, better than I had anticipated (I am always a sceptic and always expect minimal results at best), I think this could be a great adjunct for those who are running high doses of a GLP1's to make food noise quieter whilst being able to lower their GLP1 dose.

Blood glucose is also a lot more predictable on a lower dose of Reta which I will also take as a win, the only issue I could see is that it WOULD be so EASY to just not eat, that is my Caution to those looking at trying, start 1mg MAX, anything more I think would screw you trying to eat. @LevButlerov Updated brother
Click to expand...
G-Merc 80 said:
Quick update on Cag, still going strong and working far better than I thought it would, has pretty much killed all hunger and hunger drive, making it a breeze to stick to my diet plan, I would strong recommend anyone who is finding it hard to stick to a diet even on GLP1's give this a go, the other benefit is being able to reduce the GLP1's which has improved bowl movements.
Click to expand...

G-Merc 80 said:
@LevButlerov Zero sides, in saying that it has only been a week but no sides to report, HUGE hunger suppression to the point I could simply not eat and not be bothered by it (I did start at 1mg, maybe had I started lower it may not have had as big of a suppression), It will remain a staple of my protocol until I finally get into the push phase as it has made running the deficit a walk in the park, I think the biggest bonus here is also diggestion is working far better after reducing the Reta down.

Again I am always sceptical but this one for me has proven to be worth its weight in gold in a very short window.
Click to expand...

I'll do a short write up on this for our community research thread, and let's add to it.

What is Cagrilintide?
For those of you just hearing about Cagrilintide (Cag); basically, it's a long acting "amylin mimic", usually it's used in a combo with a GLP1 to hit appetite from multiple angles.
Cagrilintide is an engineered amylin analogue that sticks around much longer, so it can be dosed less frequently, easy to combo this way with GLP1.

What is Amylin?
Amylin is a hormone your pancreas releases with insulin after you eat. It basically tells your brain you're full, helps slow down how food leaves your stomach, and can dial down post meal glucagon. Seems after Cag blood sugar rises slower.

Cagrilintide and GLP1
The combo idea Cag+GLP1 is simple! GLP1 reduces appetite and cravings, and amylin adds extra satiety and brake pedal signals.
For long time GLP1 users, the main question is going to be about nausea and constipation with it. I found with limited use by clients, it seems to cause acid reflux if you eat too much, moreso than with retatrutide alone.


EVO family Cagrilintide logs:
Studies
Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial
Click to expand...
https://pubmed.ncbi.nlm.nih.gov/34798060/

Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial
Click to expand...
https://pubmed.ncbi.nlm.nih.gov/33894838/

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity
Click to expand...
https://pubmed.ncbi.nlm.nih.gov/40544433/



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Dreamer said:
Have been interested in Cag, when I was deep into my cut last time I was up to 1mg daily of reta and not getting any real appetite suppresion - well put together Lev, good work.
Click to expand...
Since you've been doing high retatrutide doses in your log, imo you're perfect to use cagrilintide and lower reta dose @Dreamer :D
 
LevButlerov said:
Since you've been doing high retatrutide doses in your log, imo you're perfect to use cagrilintide and lower reta dose @Dreamer :D
Click to expand...
Currently off all fat loss drugs while I push growth, but fully intend to use my cruise to tighten up, so will revisit
 
Dreamer said:
Have been interested in Cag, when I was deep into my cut last time I was up to 1mg daily of reta and not getting any real appetite suppresion - well put together Lev, good work.
Click to expand...
Reta appetite suppression does drop if you stay on it a while. So it’s a good trick to add cag when that happens
 
LevButlerov said:
Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!

Feedback from @JimmyO187

I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:



I also found @G-Merc 80 was using Cagrilintide as well, he talks about it in his log and discusses side effects as well:





I'll do a short write up on this for our community research thread, and let's add to it.

What is Cagrilintide?
For those of you just hearing about Cagrilintide (Cag); basically, it's a long acting "amylin mimic", usually it's used in a combo with a GLP1 to hit appetite from multiple angles.
Cagrilintide is an engineered amylin analogue that sticks around much longer, so it can be dosed less frequently, easy to combo this way with GLP1.

What is Amylin?
Amylin is a hormone your pancreas releases with insulin after you eat. It basically tells your brain you're full, helps slow down how food leaves your stomach, and can dial down post meal glucagon. Seems after Cag blood sugar rises slower.

Cagrilintide and GLP1
The combo idea Cag+GLP1 is simple! GLP1 reduces appetite and cravings, and amylin adds extra satiety and brake pedal signals.
For long time GLP1 users, the main question is going to be about nausea and constipation with it. I found with limited use by clients, it seems to cause acid reflux if you eat too much, moreso than with retatrutide alone.


EVO family Cagrilintide logs:
Studies

https://pubmed.ncbi.nlm.nih.gov/34798060/


https://pubmed.ncbi.nlm.nih.gov/33894838/


https://pubmed.ncbi.nlm.nih.gov/40544433/



@BeMe @HarleyGuy @s.gentz
@Allupfromhere @Pigsy @Dreamer @Freki @R.AP
@waggat @Coolguy @Trenhead3cc @Kopite67 @codezz @Yuri @Shakey
@rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell
Click to expand...
Great write up brother, I will add to this in the coming weeks 💪🏼
 
Dreamer said:
Currently off all fat loss drugs while I push growth, but fully intend to use my cruise to tighten up, so will revisit
Click to expand...
sorry :D I have so many logs in my head sometimes I get a bit lost, but you were on a high doses of retatrutide correct? @Dreamer this was the use for cagrilintide i was thinking about.
 
LevButlerov said:
sorry :D I have so many logs in my head sometimes I get a bit lost, but you were on a high doses of retatrutide correct? @Dreamer this was the use for cagrilintide i was thinking about.
Click to expand...
I was at one point yes, I believe in my last log, I also tried at the start of my bulk, but my food volume was too high.

I intend to use cagri in my upcoming cruise
 
Dreamer said:
I was at one point yes, I believe in my last log, I also tried at the start of my bulk, but my food volume was too high.

I intend to use cagri in my upcoming cruise
Click to expand...
Retatrutide and cagrilintide would love to see you combo it for research in this thread :D @Dreamer
 
LevButlerov said:
Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!

Feedback from @JimmyO187

I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:



I also found @G-Merc 80 was using Cagrilintide as well, he talks about it in his log and discusses side effects as well:





I'll do a short write up on this for our community research thread, and let's add to it.

What is Cagrilintide?
For those of you just hearing about Cagrilintide (Cag); basically, it's a long acting "amylin mimic", usually it's used in a combo with a GLP1 to hit appetite from multiple angles.
Cagrilintide is an engineered amylin analogue that sticks around much longer, so it can be dosed less frequently, easy to combo this way with GLP1.

What is Amylin?
Amylin is a hormone your pancreas releases with insulin after you eat. It basically tells your brain you're full, helps slow down how food leaves your stomach, and can dial down post meal glucagon. Seems after Cag blood sugar rises slower.

Cagrilintide and GLP1
The combo idea Cag+GLP1 is simple! GLP1 reduces appetite and cravings, and amylin adds extra satiety and brake pedal signals.
For long time GLP1 users, the main question is going to be about nausea and constipation with it. I found with limited use by clients, it seems to cause acid reflux if you eat too much, moreso than with retatrutide alone.


EVO family Cagrilintide logs:
Studies

https://pubmed.ncbi.nlm.nih.gov/34798060/


https://pubmed.ncbi.nlm.nih.gov/33894838/


https://pubmed.ncbi.nlm.nih.gov/40544433/



@BeMe @HarleyGuy @s.gentz
@Allupfromhere @Pigsy @Dreamer @Freki @R.AP
@waggat @Coolguy @Trenhead3cc @Kopite67 @codezz @Yuri @Shakey
@rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell
Click to expand...
Perfectly summarized info that all can absorb and very detailed in pointing us to what matters... that one study with a 68-week human trial of n=3417 is outstanding clinical data. I had no idea Cag was so well researched!

I think Cag could be added to Reta and be the new 4th generation GLP-1.

@JimmyO187 looks like you're taking the lead as our live EVO guinea pig on this one with @JimmyO187 and @Wookie being the trailblazers.

Great community research thread to get us started on this one and I think Cag has staying power as a peptide in our space.
 
LevButlerov said:
Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!
Click to expand...
Pretty compelling anecdotal results here!
 
HarleyGuy said:
Perfectly summarized info that all can absorb and very detailed in pointing us to what matters... that one study with a 68-week human trial of n=3417 is outstanding clinical data. I had no idea Cag was so well researched!

I think Cag could be added to Reta and be the new 4th generation GLP-1.

@JimmyO187 looks like you're taking the lead as our live EVO guinea pig on this one with @JimmyO187 and @Wookie being the trailblazers.

Great community research thread to get us started on this one and I think Cag has staying power as a peptide in our space.
Click to expand...
When you finish your move :D we should have you stack ratatrutide with cagrilintide @HarleyGuy
 
LevButlerov said:
When you finish your move :D we should have you stack ratatrutide with cagrilintide @HarleyGuy
Click to expand...
I literally was just sourcing it as I clicked over to this to reply haha. That's the plan brother!
 
LevButlerov said:
I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:
Click to expand...
I realize this may be off topic in this thread, but I was even more intrigued by the mention of the 2 hunger increasing drugs. Unfortunately it doesn't sound like either would be suitable for my case lol.
 
not_an_astronaut said:
I realize this may be off topic in this thread, but I was even more intrigued by the mention of the 2 hunger increasing drugs. Unfortunately it doesn't sound like either would be suitable for my case lol.
Click to expand...
These two definitely not. You're thinking more along the lines of GHRP's.
 
not_an_astronaut said:
Yes, those would be a better option. The only concern with those is possible insulin sensitivity issues.
Click to expand...
Keep diet in check and pack in the clean foods and you'll be fine. You'll have to do that with any ghrelin agonist anyway.
 
This could be a really good hack right here on keeping your appetite down while also shredding at the same time and off-setting the metabolism changes on reta.
 
LevButlerov said:
Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!

Feedback from @JimmyO187

I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:



I also found @G-Merc 80 was using Cagrilintide as well, he talks about it in his log and discusses side effects as well:





I'll do a short write up on this for our community research thread, and let's add to it.

What is Cagrilintide?
For those of you just hearing about Cagrilintide (Cag); basically, it's a long acting "amylin mimic", usually it's used in a combo with a GLP1 to hit appetite from multiple angles.
Cagrilintide is an engineered amylin analogue that sticks around much longer, so it can be dosed less frequently, easy to combo this way with GLP1.

What is Amylin?
Amylin is a hormone your pancreas releases with insulin after you eat. It basically tells your brain you're full, helps slow down how food leaves your stomach, and can dial down post meal glucagon. Seems after Cag blood sugar rises slower.

Cagrilintide and GLP1
The combo idea Cag+GLP1 is simple! GLP1 reduces appetite and cravings, and amylin adds extra satiety and brake pedal signals.
For long time GLP1 users, the main question is going to be about nausea and constipation with it. I found with limited use by clients, it seems to cause acid reflux if you eat too much, moreso than with retatrutide alone.


EVO family Cagrilintide logs:
Studies

https://pubmed.ncbi.nlm.nih.gov/34798060/


https://pubmed.ncbi.nlm.nih.gov/33894838/


https://pubmed.ncbi.nlm.nih.gov/40544433/



@BeMe @HarleyGuy @s.gentz
@Allupfromhere @Pigsy @Dreamer @Freki @R.AP
@waggat @Coolguy @Trenhead3cc @Kopite67 @codezz @Yuri @Shakey
@rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell
Click to expand...
Great write up. I don't really have much interest in GLP-1 stuff but this is interesting none the less. Sux for tirzepatide cuz this combo basically makes that useless now.
 
Im on GW and Trizepitide and its been working great for me i could literally not eat if i felt like not doing so, different compounds work for different people, i got zero out of reta and way more out of Trizepitide
 
@G-Merc 80 posted about his Cagrilintide use, he uses 1mg of Cag per week and it really helped his blood sugar and lowered cravings.

https://www.evolutionary.org/forums...comp-log-changing-my-life.106206/post-1999892
G-Merc 80 said:
Cagrilintide

This has been a really good adjunct with Reta, I lowered my dose of Reta and added 1mg of Cag, this squashed my hunger and stopped me being backed up, i also noticed smoother blood sugar levels across the day with adding this in, highly recommend this.

I have found throughout this journey I prefer short acting esters, they just seem to agree with me over longer acting esters, I also prefer pinning daily to stop peaks happening as I tend to be more sensitive to them.
Mast P
Test P
NPP
Tren A
Click to expand...
 
LevButlerov said:
Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!

Feedback from @JimmyO187

I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:



I also found @G-Merc 80 was using Cagrilintide as well, he talks about it in his log and discusses side effects as well:





I'll do a short write up on this for our community research thread, and let's add to it.

What is Cagrilintide?
For those of you just hearing about Cagrilintide (Cag); basically, it's a long acting "amylin mimic", usually it's used in a combo with a GLP1 to hit appetite from multiple angles.
Cagrilintide is an engineered amylin analogue that sticks around much longer, so it can be dosed less frequently, easy to combo this way with GLP1.

What is Amylin?
Amylin is a hormone your pancreas releases with insulin after you eat. It basically tells your brain you're full, helps slow down how food leaves your stomach, and can dial down post meal glucagon. Seems after Cag blood sugar rises slower.

Cagrilintide and GLP1
The combo idea Cag+GLP1 is simple! GLP1 reduces appetite and cravings, and amylin adds extra satiety and brake pedal signals.
For long time GLP1 users, the main question is going to be about nausea and constipation with it. I found with limited use by clients, it seems to cause acid reflux if you eat too much, moreso than with retatrutide alone.


EVO family Cagrilintide logs:
Studies

https://pubmed.ncbi.nlm.nih.gov/34798060/


https://pubmed.ncbi.nlm.nih.gov/33894838/


https://pubmed.ncbi.nlm.nih.gov/40544433/



@BeMe @HarleyGuy @s.gentz
@Allupfromhere @Pigsy @Dreamer @Freki @R.AP
@waggat @Coolguy @Trenhead3cc @Kopite67 @codezz @Yuri @Shakey
@rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell
Click to expand...
Awesome write up and summary mate. Some solid feedback in those logs.
 
2Thick said:
you can add it without needing it as part of a blend so it would be a good option. I think six months into using RETA would be a good time to start it.
Click to expand...
Gotta follow the money. See my post earlier this week re the oral GLP product in development. It'll sell better than the injectable.
 
Mobster said:
Gotta follow the money. See my post earlier this week re the oral GLP product in development. It'll sell better than the injectable.
Click to expand...
Ive been seeing tv ads for that version for a few months now in the states
 
ROIDDERS said:
i'd rather inject once a week, then take an oral daily but i know other people are the opposite
Click to expand...
Im so used to injections at this point i would feel like something designed originally to be injected would not be as effective in a pill, i could be completely wrong with my thinking on that though.
 
I may have to give this stuff a go. Sounds good to me
 
ROIDDERS said:
i'd rather inject once a week, then take an oral daily but i know other people are the opposite
Click to expand...

Noah Wixx said:
Im so used to injections at this point i would feel like something designed originally to be injected would not be as effective in a pill, i could be completely wrong with my thinking on that though.
Click to expand...

2Thick said:
I'm sure it will sell well. People hate injecting.
Click to expand...

ROIDDERS said:
I think an insulin needle is super easy.
Click to expand...

Agree with you all. Big Pharma made orals for the masses and it's put a stigma on injections when in reality I'd subQ anything vs. oral any day. I think Big Pharma doesn't have a take on the slin pin industry or they'd be properly making most drugs subQ.
 
HarleyGuy said:
Agree with you all. Big Pharma made orals for the masses and it's put a stigma on injections when in reality I'd subQ anything vs. oral any day. I think Big Pharma doesn't have a take on the slin pin industry or they'd be properly making most drugs subQ.
Click to expand...
You are onto something with that way of thinking they make certain dissolving tabs taste like a sweat tart
 
LevButlerov said:
Recently I've been having discussions with EVO brother @JimmyO187 in his log about Cagrilintide use. I've also started to have some of my clients use it who were not responding to lower doses of retatrutide. Example, when a client couldn't get the results with 8mgs of retatrutide (tested!) adding Cagrilintide allowed us to lower the reta dose to 2mgs and get more results!

Feedback from @JimmyO187

I also spoke to @Wookie about his use of Cagrilintide in his log, and this is his view:



I also found @G-Merc 80 was using Cagrilintide as well, he talks about it in his log and discusses side effects as well:





I'll do a short write up on this for our community research thread, and let's add to it.

What is Cagrilintide?
For those of you just hearing about Cagrilintide (Cag); basically, it's a long acting "amylin mimic", usually it's used in a combo with a GLP1 to hit appetite from multiple angles.
Cagrilintide is an engineered amylin analogue that sticks around much longer, so it can be dosed less frequently, easy to combo this way with GLP1.

What is Amylin?
Amylin is a hormone your pancreas releases with insulin after you eat. It basically tells your brain you're full, helps slow down how food leaves your stomach, and can dial down post meal glucagon. Seems after Cag blood sugar rises slower.

Cagrilintide and GLP1
The combo idea Cag+GLP1 is simple! GLP1 reduces appetite and cravings, and amylin adds extra satiety and brake pedal signals.
For long time GLP1 users, the main question is going to be about nausea and constipation with it. I found with limited use by clients, it seems to cause acid reflux if you eat too much, moreso than with retatrutide alone.


EVO family Cagrilintide logs:
Studies

https://pubmed.ncbi.nlm.nih.gov/34798060/


https://pubmed.ncbi.nlm.nih.gov/33894838/


https://pubmed.ncbi.nlm.nih.gov/40544433/



@BeMe @HarleyGuy @s.gentz
@Allupfromhere @Pigsy @Dreamer @Freki @R.AP
@waggat @Coolguy @Trenhead3cc @Kopite67 @codezz @Yuri @Shakey
@rizzlekdizzle @MarkNV @floridaman1984 @kcates @MarshMonsta @Wheels85 @TAGII @Jigglybuff @Pat7x @SPOONMAN366 @RoySimpson @PrinceDaddy @stevesmi @Coolguy @liftedlivingwithlegacy @3xCharm @waggat @Kopite67 @madcap71 @Ohdamn @Swcc @Mr.liftz @waggat @Iron_rose1 @BigVelvetG @Demon_throne @codezz @Farmboy @Bigdan85 @Kopite67 @Nasser1997o2 @b1ak @Corn Gromwell
Click to expand...
@methodical.force review this for your tirzepatide mix please.
 
HarleyGuy said:
Agree with you all. Big Pharma made orals for the masses and it's put a stigma on injections when in reality I'd subQ anything vs. oral any day. I think Big Pharma doesn't have a take on the slin pin industry or they'd be properly making most drugs subQ.
Click to expand...
A lot of people don't like injecting and a lot of people don't like needles around the house. You can't fault that.
 
HarleyGuy said:
Agree with you all. Big Pharma made orals for the masses and it's put a stigma on injections when in reality I'd subQ anything vs. oral any day. I think Big Pharma doesn't have a take on the slin pin industry or they'd be properly making most drugs subQ.
Click to expand...
I don't know much about it to be honest but yeah it is kind of crazy that a salesman right out of high school can make six figures selling drugs to doctors.
 
kcates said:
Great write up Lev, I am going to order some and try it. I am at 15mg a week right now with no where to go prescribed. I am at the highest dose I can get prescribed and I can eat right threw it if I wanted to. I will let you know how it goes once I start.
Click to expand...
Cagrilintide would be perfect for you @kcates you need to get tirzepatide dose dose its way too high 15mgs!
 
Quick one for those who are interested

I started my mum on Sunday with .5 Reta twice a week and cag .5 once a week, a few days in and she has noticed better overall gut health, better food suppression, with steadier blood levels without any big glucose spike; she had been on Tirz before this switch and agrees that this combination is working better for her.

She is 64 5'7 and pretty overweight, the only problem she is finding right now is that her hunger at the start of the day is almost non-existent and difficult to eat.

I will be tracking her closley, my dad is on Tirz and has been for the last 4 weeks and has only managed to drop 1 kg, so will be a good case to see how they both track on the different combinations
 
G-Merc 80 said:
Quick one for those who are interested

I started my mum on Sunday with .5 Reta twice a week and cag .5 once a week, a few days in and she has noticed better overall gut health, better food suppression, with steadier blood levels without any big glucose spike; she had been on Tirz before this switch and agrees that this combination is working better for her.

She is 64 5'7 and pretty overweight, the only problem she is finding right now is that her hunger at the start of the day is almost non-existent and difficult to eat.

I will be tracking her closley, my dad is on Tirz and has been for the last 4 weeks and has only managed to drop 1 kg, so will be a good case to see how they both track on the different combinations
Click to expand...
Very interesting case study :D thank you for sharing @G-Merc 80 I want to see how this progresses.
I'd love to see the tirzepatide part with your dad as well please!

@HarleyGuy @Allupfromhere @Pigsy @Dreamer @Freki @rizzlekdizzle @waggat @Trenhead3cc @Kopite67 @codezz @Yuri @MarkNV
 
G-Merc 80 said:
Quick one for those who are interested

I started my mum on Sunday with .5 Reta twice a week and cag .5 once a week, a few days in and she has noticed better overall gut health, better food suppression, with steadier blood levels without any big glucose spike; she had been on Tirz before this switch and agrees that this combination is working better for her.

She is 64 5'7 and pretty overweight, the only problem she is finding right now is that her hunger at the start of the day is almost non-existent and difficult to eat.

I will be tracking her closley, my dad is on Tirz and has been for the last 4 weeks and has only managed to drop 1 kg, so will be a good case to see how they both track on the different combinations
Click to expand...
Probably the closest thing we have to miracle drugs especially with the epidemic of obesity and unhealthy eating habits in the western world
 
kcates said:
Great write up Lev, I am going to order some and try it. I am at 15mg a week right now with no where to go prescribed. I am at the highest dose I can get prescribed and I can eat right threw it if I wanted to. I will let you know how it goes once I start.
Click to expand...
Definitely add Cag and drop your Tirz dose that's the absolute max. Clinical trials stopped there pretty much and in trials they always push it beyond the limits.
 
G-Merc 80 said:
Quick one for those who are interested

I started my mum on Sunday with .5 Reta twice a week and cag .5 once a week, a few days in and she has noticed better overall gut health, better food suppression, with steadier blood levels without any big glucose spike; she had been on Tirz before this switch and agrees that this combination is working better for her.

She is 64 5'7 and pretty overweight, the only problem she is finding right now is that her hunger at the start of the day is almost non-existent and difficult to eat.

I will be tracking her closley, my dad is on Tirz and has been for the last 4 weeks and has only managed to drop 1 kg, so will be a good case to see how they both track on the different combinations
Click to expand...
Thanks for this anecdotal data @G-Merc 80! You're helping someone way over here in Canada now because after reading this it just dawned on me that my Dad (78 yrs old) is saying he's stalled and is at 10mg Tirz. I'm going to source some Cag and do what you did with your Mom and report it here.
 
HarleyGuy said:
Definitely add Cag and drop your Tirz dose that's the absolute max. Clinical trials stopped there pretty much and in trials they always push it beyond the limits.
Click to expand...
Yeah 15mg is max dose I can get prescribed. When I get the cagrilitide in I am going to cut again. What do y'all think about adding slupp-332 to the mix for an afternoon energy boost? I order some and going to try it. I have heard doctors that prescribe slupp-322 say this has worked for there patients. This is my biggest problem with cutting is the energy loss in the afternoons which effects my work performance which effects my bank account since the faster I get work done the faster and more money I make.
 
kcates said:
I have heard doctors that prescribe slupp-322 say this has worked for there patients.
Click to expand...
No way man, really? This is super niche and not prescribe-able yet I thought. No clinical human data that's made it to trials yet. Lots of anecdotal data though. It's one of the few peptides that has to be taken orally until we figure out how to have it homogeneously reconstitute and be soluble in a carrier because it's hydrophobic and hates water.

In my log you'll see I'm about to reconstitute SLU-PP-332 with C8 MCT oil as it's been anecdotally shown to reconstitute well in oil. It has to be filtered etc., but I'm going to try it because then at least we know what dose is actually going in SubQ vs. the guesswork of how bioavailable it is on the pass through the stomach.

To answer your question: the preliminary data on this looks incredible. I'm currently running 2mg oral and even at 1mg I got a face flush for the first couple weeks so it's doing something in terms of metabolism and the whole exercise mimetic idea.

There's a bunch of other members that can pipe in here that are running it to help you out with feedback


Here's some members with their doses:

@liftedlivingwithlegacy 1mg
@LH5515 20mg preworkout
@justapotato 50mg
@Allupfromhere 50mg (but went as high as 100mg)
@roguepineapple 20mg
@fingers86 140mg
 
kcates said:
Yeah 15mg is max dose I can get prescribed. When I get the cagrilitide in I am going to cut again. What do y'all think about adding slupp-332 to the mix for an afternoon energy boost? I order some and going to try it. I have heard doctors that prescribe slupp-322 say this has worked for there patients. This is my biggest problem with cutting is the energy loss in the afternoons which effects my work performance which effects my bank account since the faster I get work done the faster and more money I make.
Click to expand...
have you considering adding 10mgs cardarine ed? @kcates
 
HarleyGuy said:
No way man, really? This is super niche and not prescribe-able yet I thought. No clinical human data that's made it to trials yet. Lots of anecdotal data though. It's one of the few peptides that has to be taken orally until we figure out how to have it homogeneously reconstitute and be soluble in a carrier because it's hydrophobic and hates water.

In my log you'll see I'm about to reconstitute SLU-PP-332 with C8 MCT oil as it's been anecdotally shown to reconstitute well in oil. It has to be filtered etc., but I'm going to try it because then at least we know what dose is actually going in SubQ vs. the guesswork of how bioavailable it is on the pass through the stomach.

To answer your question: the preliminary data on this looks incredible. I'm currently running 2mg oral and even at 1mg I got a face flush for the first couple weeks so it's doing something in terms of metabolism and the whole exercise mimetic idea.

There's a bunch of other members that can pipe in here that are running it to help you out with feedback


Here's some members with their doses:

@liftedlivingwithlegacy 1mg
@LH5515 20mg preworkout
@justapotato 50mg
@Allupfromhere 50mg (but went as high as 100mg)
@roguepineapple 20mg
@fingers86 140mg
Click to expand...
this is awesome :D @HarleyGuy we should get an SLUPP community research thread up :D
 
HarleyGuy said:
No way man, really? This is super niche and not prescribe-able yet I thought. No clinical human data that's made it to trials yet. Lots of anecdotal data though. It's one of the few peptides that has to be taken orally until we figure out how to have it homogeneously reconstitute and be soluble in a carrier because it's hydrophobic and hates water.

In my log you'll see I'm about to reconstitute SLU-PP-332 with C8 MCT oil as it's been anecdotally shown to reconstitute well in oil. It has to be filtered etc., but I'm going to try it because then at least we know what dose is actually going in SubQ vs. the guesswork of how bioavailable it is on the pass through the stomach.

To answer your question: the preliminary data on this looks incredible. I'm currently running 2mg oral and even at 1mg I got a face flush for the first couple weeks so it's doing something in terms of metabolism and the whole exercise mimetic idea.

There's a bunch of other members that can pipe in here that are running it to help you out with feedback


Here's some members with their doses:

@liftedlivingwithlegacy 1mg
@LH5515 20mg preworkout
@justapotato 50mg
@Allupfromhere 50mg (but went as high as 100mg)
@roguepineapple 20mg
@fingers86 140mg
Click to expand...
Who wants to sponsor this guy to do 1g a day lol
 
fingers86 said:
Who wants to sponsor this guy to do 1g a day lol
Click to expand...
what do you mean 1gram per day? @fingers86 I think @HarleyGuy is talking about 1-2 mg (milligrams) not grams where did you get gram?
140mgs you doing? :D not sure what you mean
HarleyGuy said:
No way man, really? This is super niche and not prescribe-able yet I thought. No clinical human data that's made it to trials yet. Lots of anecdotal data though. It's one of the few peptides that has to be taken orally until we figure out how to have it homogeneously reconstitute and be soluble in a carrier because it's hydrophobic and hates water.

In my log you'll see I'm about to reconstitute SLU-PP-332 with C8 MCT oil as it's been anecdotally shown to reconstitute well in oil. It has to be filtered etc., but I'm going to try it because then at least we know what dose is actually going in SubQ vs. the guesswork of how bioavailable it is on the pass through the stomach.

To answer your question: the preliminary data on this looks incredible. I'm currently running 2mg oral and even at 1mg I got a face flush for the first couple weeks so it's doing something in terms of metabolism and the whole exercise mimetic idea.

There's a bunch of other members that can pipe in here that are running it to help you out with feedback


Here's some members with their doses:

@liftedlivingwithlegacy 1mg
@LH5515 20mg preworkout
@justapotato 50mg
@Allupfromhere 50mg (but went as high as 100mg)
@roguepineapple 20mg
@fingers86 140mg
Click to expand...
 
LevButlerov said:
what do you mean 1gram per day? @fingers86 I think @HarleyGuy is talking about 1-2 mg (milligrams) not grams where did you get gram?
140mgs you doing? :D not sure what you mean
Click to expand...
Im not currently doing any lol. But was trying different things and got to 70mg twice a day 1 fasted in morning 1 with lunch seemed to prevent the mid arvo crash. Bit pricey. Even thought of trying 1 smaller dose with lunch but only made same size caps.
 
HarleyGuy said:
No way man, really? This is super niche and not prescribe-able yet I thought. No clinical human data that's made it to trials yet. Lots of anecdotal data though. It's one of the few peptides that has to be taken orally until we figure out how to have it homogeneously reconstitute and be soluble in a carrier because it's hydrophobic and hates water.

In my log you'll see I'm about to reconstitute SLU-PP-332 with C8 MCT oil as it's been anecdotally shown to reconstitute well in oil. It has to be filtered etc., but I'm going to try it because then at least we know what dose is actually going in SubQ vs. the guesswork of how bioavailable it is on the pass through the stomach.

To answer your question: the preliminary data on this looks incredible. I'm currently running 2mg oral and even at 1mg I got a face flush for the first couple weeks so it's doing something in terms of metabolism and the whole exercise mimetic idea.

There's a bunch of other members that can pipe in here that are running it to help you out with feedback


Here's some members with their doses:

@liftedlivingwithlegacy 1mg
@LH5515 20mg preworkout
@justapotato 50mg
@Allupfromhere 50mg (but went as high as 100mg)
@roguepineapple 20mg
@fingers86 140mg
Click to expand...
I learned the best way to mix the 5mg slup-332 with .5 ml DMSO. Then take a new sterile vial and put 2ml of basteric water in the new vial. Then add the .5 ml solution as slow as humanly possible like barely let drops hit the side and go down into the water and swirl every couple of drops with the needle still in the vial.Once it is all in there then draw out the needle. Then inject 10ml of that solution to get 200mcg or 25ml to get 500mcg. This is what I was planning to try.
 
kcates said:
I learned the best way to mix the 5mg slup-332 with .5 ml DMSO. Then take a new sterile vial and put 2ml of basteric water in the new vial. Then add the .5 ml solution as slow as humanly possible like barely let drops hit the side and go down into the water and swirl every couple of drops with the needle still in the vial.Once it is all in there then draw out the needle. Then inject 10ml of that solution to get 200mcg or 25ml to get 500mcg. This is what I was planning to try.
Click to expand...
I can't in good conscious recommend using DMSO in any quantity for injection. I have a more tried method with human anecdotal data using MCT oil that I will get a move on faster and post in my log and tag you.

My recommendation: never inject DMSO
 
fingers86 said:
And not planning on 1g per day either
Click to expand...
:ROFLMAO: LOL did you read Lev's reply to you? https://www.evolutionary.org/forums...-tirzepatide-retatrutide.109649/#post-2006958

Nowhere did anyone mention doing 1g of SLUPP. Not sure where you read this. I started with 1mg and am now at 2mg of oral.
For subQ I will likely start at 500mcg and not use any type of water nor DMSO.

I just posted a community research thread on this in fact: https://www.evolutionary.org/forums...inistration-routes-dosing-and-reviews.109779/
 
kcates said:
I learned the best way to mix the 5mg slup-332 with .5 ml DMSO.
Click to expand...
I know who suggested this and after some research on it I can't recommend it. I was considering it but now it's entirely out of the question.

This is from the Health Canada website and is a link to Canadian Forces regarding using DMSO even for topical treatment: https://www.canada.ca/content/dam/dnd-mdn/documents/health/nutrition/supplement-fact-sheet-dmso.pdf

"The companies that produce industrial grade DMSO often use the same equipment to produce toxic substances such as pesticides and so contamination is inevitable. Unfortunately, much of the DMSO sold on the black market is industrial grade and could cause serious short and long-term problems in its users."

This is only in regards to topical let alone injecting it into yourself. There are only 2-3 known medical reasons to use medical grade DMSO for injection and otherwise it's super high risk as it is a very potent solvent.
 
HarleyGuy said:
:ROFLMAO: LOL did you read Lev's reply to you? https://www.evolutionary.org/forums...-tirzepatide-retatrutide.109649/#post-2006958

Nowhere did anyone mention doing 1g of SLUPP. Not sure where you read this. I started with 1mg and am now at 2mg of oral.
For subQ I will likely start at 500mcg and not use any type of water nor DMSO.

I just posted a community research thread on this in fact: https://www.evolutionary.org/forums...inistration-routes-dosing-and-reviews.109779/
Click to expand...
same! i’ve gotten great results as well so never had the need to push anymore! @HarleyGuy
 
Firm believer in Reta and what it can do! I started taking last year and my gut issues that i had in past bad gas, reflux and all that has been almost non existent! I have been able to take on more and more carbs and stayed lean through it! i have tried daily,2x, no just do a boils dose of 2.5mg a week! have no food noise really doesn’t suppress and im able to use the benefits during the bulk! We all know the benefits during the cut but being able to have it running in the background during this push has def made a difference!
 
kcates said:
Never mind I didn't see or u posted it while I posted my question. I am reading the article now u posted
Click to expand...
I'm thinking full 100% EO now given the argument you raised on polarity, very convincing and well articulated bro. See the research thread for my reply.
 
liftedlivingwithlegacy said:
Firm believer in Reta and what it can do! I started taking last year and my gut issues that i had in past bad gas, reflux and all that has been almost non existent! I have been able to take on more and more carbs and stayed lean through it! i have tried daily,2x, no just do a boils dose of 2.5mg a week! have no food noise really doesn’t suppress and im able to use the benefits during the bulk! We all know the benefits during the cut but being able to have it running in the background during this push has def made a difference!
Click to expand...
Retatrutide works its amazing :D @liftedlivingwithlegacy
 
HarleyGuy said:
I'm thinking full 100% EO now given the argument you raised on polarity, very convincing and well articulated bro. See the research thread for my reply.
Click to expand...
It's actually kind of scary it may look like it mixed well with MCT but then your first shot you could get 90%of it slupp and 10% MCT because it dissolved and looked fine but didn't disperse evenly then u apparently feel bad from that dose. I guess the first easy work around was put it in a pill but what I am learning is the stomach can destroy it before u absorb it all.
 
kcates said:
It's actually kind of scary it may look like it mixed well with MCT but then your first shot you could get 90%of it slupp and 10% MCT because it dissolved and looked fine but didn't disperse evenly then u apparently feel bad from that dose. I guess the first easy work around was put it in a pill but what I am learning is the stomach can destroy it before u absorb it all.
Click to expand...
The science behind the benefits of this when we figure out how to make it injectable without dsmo is awesome looking.
 
@G-Merc 80 added his updates on Cagrilintide use with Retatrutide
https://www.evolutionary.org/forums...-changing-my-life.106206/page-11#post-2010744
G-Merc 80 said:
Quick little update on Reta/Cag combo

Sponsored by @shadow labs , loving their Reta, thanks legends!
Coached by @R.AP

3rd week into the Reta and Cag combo, since starting this combo i have been able to keep Reta dose lower, keep good hunger suppression and smooth out blood levels; this is now 100% how I will run my Reta.

Will update the main subject once my mum hits the end of her 2nd week, but as we are able to run reta low she has gone from split dose to single dose without any negative side affects, as we paired it with Cag hunger suppression is on point, she is really happy to see the weight coming down without feeling like she was starving herself.
Click to expand...
 
G-Merc 80 said:
Quick one for those who are interested

I started my mum on Sunday with .5 Reta twice a week and cag .5 once a week, a few days in and she has noticed better overall gut health, better food suppression, with steadier blood levels without any big glucose spike; she had been on Tirz before this switch and agrees that this combination is working better for her.

She is 64 5'7 and pretty overweight, the only problem she is finding right now is that her hunger at the start of the day is almost non-existent and difficult to eat.

I will be tracking her closley, my dad is on Tirz and has been for the last 4 weeks and has only managed to drop 1 kg, so will be a good case to see how they both track on the different combinations
Click to expand...
Just checking with you @G-Merc 80 on how your Mom and Dad are doing on the Reta and Tirz? Any updates how are they feeling? Still at 0.5mg of Reta/Cag for Mom and Dad is on how much Tirz now?

My Dad had to ask me to lower it from 12.5mg so we went to 7.5mg then back to 10mg and staying at 10mg now. He's on week 17 and has lost 40lbs down from 310lbs to 269lbs.
 
I have added Cagrilintide to my GLP1 stack along with Reta.

You can check this in my log here ➡️ HarleyGuy's Log - Cag 1mg added to 3mg Reta

1mg Cag per week has been added to 3mg Reta with a noticeable reduction in appetite!
 
HarleyGuy said:
Just checking with you @G-Merc 80 on how your Mom and Dad are doing on the Reta and Tirz? Any updates how are they feeling? Still at 0.5mg of Reta/Cag for Mom and Dad is on how much Tirz now?

My Dad had to ask me to lower it from 12.5mg so we went to 7.5mg then back to 10mg and staying at 10mg now. He's on week 17 and has lost 40lbs down from 310lbs to 269lbs.
Click to expand...
Quick update:

Mum is on 2mg Reta and 1.5mg Cag, her hunger is under control and slowly losing weight, the problem is she refuses to track her intake and isnt happy with the slow progress, I put a lot of the slow progress down to the love of Vino.

Dad is on 5mg Tirz and is seeing more weight loss, but he has reduced his Vino which has helped with this, I also note I have my Mother in-law on 5mg Tirz as she tries to shed a bunch of weight before her knee surgery, she has dropped over 10kg in 4 weeks, again by stopping the drinking; Both have a reduced desire to drink when speaking to them about it, then doing a little research Tirz has been shown to suppress the desire to drink alcohol which in both dad and mother in-law has been shown and helped with their weight loss goals.
 
G-Merc 80 said:
Quick update:

Mum is on 2mg Reta and 1.5mg Cag, her hunger is under control and slowly losing weight, the problem is she refuses to track her intake and isnt happy with the slow progress, I put a lot of the slow progress down to the love of Vino.

Dad is on 5mg Tirz and is seeing more weight loss, but he has reduced his Vino which has helped with this, I also note I have my Mother in-law on 5mg Tirz as she tries to shed a bunch of weight before her knee surgery, she has dropped over 10kg in 4 weeks, again by stopping the drinking; Both have a reduced desire to drink when speaking to them about it, then doing a little research Tirz has been shown to suppress the desire to drink alcohol which in both dad and mother in-law has been shown and helped with their weight loss goals.
Click to expand...
Thanks for this great update @G-Merc 80 this is some good feedback for the Community Research.

I replied to this more extensively in your log but I've noticed too my Dad isn't having as many beers per night (according to Mum) as he used to. It's that reward system I suppose.

I'll be staying on the 1mg Cag with 3mg Reta so far I'm loving it, let's Reta do it's work and the Cag takes the edge off appetite that Reta lacks.
 
Feedback on both 1mg and 2mg of Cagrilintide from my log

HarleyGuy said:
  • Cagrilintide was noticeable from Week # 1. It had a noticeable effect on appetite suppression
  • Increasing Cagrilintide to 2mg along with 3mg Reta has an amazing effect on appetite suppression. Nighttime cravings are gone and no appetite to worry about. I eat when I want to eat and for function only.
Click to expand...
 
kcates said:
No I haven't. I haven't learned much about that one yet.
Click to expand...
cardarine easy to add and not too expensive :D Us-pharmacies.to has clean cardarine @kcates
you can see @HarleyGuy just posted TD pics for Team USP @US-pharmacies has a nice Cardarine bottle in it they are already 10mgs from their ebiom line i think
https://www.evolutionary.org/forums...-and-us-domestic-shipping.109549/post-2056266
HarleyGuy said:
❤️‍🔥TOUCHDOWN❤️‍🔥

I'll be pinning some Sust500 tonight!!


View attachment 222607​

Team USP Champions:

@US-pharmacies @BlackSheep00 @catdadironman @HarleyGuy @LevButlerov @MarkNV @Neuro @Noah Wixx @Nood @RawCutlery @satxbber @trenAMP @eazy_ @Mobster
Click to expand...
28apr-us-pharmacies-touchdown-td-sust500-webp.222607
 
kcates said:
No I haven't. I haven't learned much about that one yet.
Click to expand...
Oh bro, check @LevButlerov's pic of my touchdown. I plan on running @US-pharmacies cardarine when I amp up the cardio come June, it is very noticeable for endurance and you really get your sweat on hard!
 
I stated 1mg of cagrilitide with 12.5mg terzepatide yesterday. The plan is to use the cag while decreasing my terzepatide to a goal of 2.5mg a week. At that point I have to continue to use the terzepatide for my prescription but I am going to add 1mg a week of Retatrutide. At that point I will decide if I will continue a maintenance dose of cag or just discontinue. Hopefully by that point I have figured out a good recovery dose of test. Then I will run a bulk and a cycle. Let's GO Cag!
 
kcates said:
I stated 1mg of cagrilitide with 12.5mg terzepatide yesterday. The plan is to use the cag while decreasing my terzepatide to a goal of 2.5mg a week. At that point I have to continue to use the terzepatide for my prescription but I am going to add 1mg a week of Retatrutide. At that point I will decide if I will continue a maintenance dose of cag or just discontinue. Hopefully by that point I have figured out a good recovery dose of test. Then I will run a bulk and a cycle. Let's GO Cag!
Click to expand...
Cool bro keep us posted on the Cag!!
 
@kcates posted a Cagrilintide thread experimenting with 1mg of Cag to reduce his Tirzepatide dose here ➡️
https://www.evolutionary.org/forums/threads/cagrilintide-my-experiment-and-my-experience.110787/

kcates said:
Cagrilintide: The experiment is for myself to try a new peptide and also see if it can be used while i reduce my dosage on Terzepatide. I started Terzepatide September of 2023. I was put on it for diabetes. It did wonders for curing my diabetes at the starting does and when i went to 5 mg. After that i started chasing having the medicine get rid of the food noise at first and I ended up at 7mg. Then at that point i learned i needed to eat protein to grow muscle and get stronger. During this time iset a powerlifting goal I wanted to reach before I turned 50 years old. If you want to learn more about that you can read my first log, https://www.evolutionary.org/forums...irzepatide-to-testosterone-anavar-log.103301/. During this time I wanted to eat and I taught myself to eat right through the medication so I could reached my powerlifting goal Aug. 9th 2025. I wanted to take a break from the bulk and try and cut. The plan was to cut and raise my medication up to start getting rid of the food noise again. I then went to 10mg, 12.5mg and 15mg and it did nothing for me. So at that point I didn't know what to do. I had been hearing from others that there is this other peptide called Cagrilintide that stops food noise through a different pathway. Then I decided I wanted to try it and while trying it I would reduce my terzepatide back down to a goal dose of 2.5mg which is the lowest dose that I can go on with my prescription of Mounjaro. This is where this experiment for myself and maybe it will help other people who end up on the max dose of GLP-1 drug and it is not working for them any longer and they want to reduce back down or get off but don't want all the food noise to come rushing back and they just get fatter then when they started the drug. I am just going to talk about my experience going through this. My concern with just cutting my glp-1 back down with out adding in a helper was that maybe the terzepatide is curbing a lot of food noise that I don't even realize and if I go down with out it the food noise all comes roaring back.

My Information:
Age: 50 years young
Height: 5' 10"
Weight: as of 5/1/26: 235 lbs
body fat%: from last inbody scan as of 4/23/26 20.6
Training experience: 2 years 6+ months

Training: I run a push, pull, legs work out 6 days a week. If you want to follow along with my training you can check out my other current log that I am updating with all my training stuff. https://www.evolutionary.org/forums...d-to-200lbs-or-less-my-first-cut-ever.106162/

Diet: It is pretty much the same thing day in and day out. Meal after training 6 eggs, 12 ounces of ground beef 90/10 and 9 ounces of white rice. Dinner is a pound of meat and some veggies if i can get them in. You will see in this log diet has changed to less food.

Supplements:
Preworkout:
10 grams of creatine mono
2.5 grams of HMB
liquid IV packet
15 grams of psyllium husk

Supplements after eating my meal after training:

Thorn Basic nutrients 2/daily
CoQ10 200mg daily
3600mg fish oil daily
Pre and probiotic 20 billion cells and 12 strains
vitamin D with k2 Mk-7 10,000 Iu/ 200mcg
Lutein and Zeaxanthin
Telemisartan-hctz 80-12.5 mg

Supplements on the way to work:
10 grams of creatine mono
2.5 grams of HMB
liquid IV packet
15 grams of psyllium husk

Supplements before bed:
Magnesium Glycinate 360 mg

PEDS and Peptides:
Testosterone Cypionate 140 mg divided into 3 shots per week
Nandrolone Decanoate 50mg divided into 3 shots per week
Mounjaro (terzepatide) 12.5 mg per week
Cagrilintide 1mg per week
GH 4iu 30 minutes before bed

Cycle Plans: I have no plans of a cycle at this time. I am currently working to find a good TRT level where my blood work is within good levels. I have high hematocrit and red blood cells as of my last blood work. You can read my current training log to find out more about that there.

Goals of this experiment: To reduce my terzepatide back down to the lowest does. While using the least amount of cagrilintide. Then once i reach the the minimum dose I plan to add 1 mg of retatrutide to the mix. If I lose weight while i go through this process that is an added benefit but not the primary goal here.
Click to expand...
 
Robarock said:
Late to this conversation, but Cagr, can be a great addition to any GLP to assist with food noise. What I've found with clients I work with is that tesofensine works even better.
Click to expand...
Sounds like a separate research thread for Teso is in the works then. I don't know if any are running it on EVO however.
 
Robarock said:
It's one of those peptides that seems to run under the radar. It's a amazing tool for weight loss and improved dopamine signalling.
Click to expand...
Lots of data on Cag including anecdotal. 2mg of Cag worked better for me than Semaglutide.
 
Robarock said:
Late to this conversation, but Cagr, can be a great addition to any GLP to assist with food noise. What I've found with clients I work with is that tesofensine works even better.
Click to expand...
Tesofensine is on my list but i'm happy for you to start a new thread on it :D
 
LevButlerov said:
Tesofensine is on my list but i'm happy for you to start a new thread on it :D
Click to expand...
Sounds good. I've personally not used it on its own, and all the clients I've worked with, it's always been stacked with Reta to crank the weight loss up to 11. One type of person it works for is someone really affected by loss of interest. The Gaba side of Teso addresses that.
 
Robarock said:
Sounds good. I've personally not used it on its own, and all the clients I've worked with, it's always been stacked with Reta to crank the weight loss up to 11. One type of person it works for is someone really affected by loss of interest. The Gaba side of Teso addresses that.
Click to expand...
You can talk about the stack in that case :D
 
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