There have been a few recent studies done on novaldex (tamoxifen) for gyno. Basically showed a dose of 20mg per day for an extended period was able to reverse gyno - even gyno that has been around a while. One of the studies used a period of 3 months and showed complete gyno removal, but the write up suggested treatment of up to 6 months. If you're friend goes on Letro, he should expect to have his sex drive shrink to nothing if he uses the kind of doses in most of the gyno nuking cycles. We guys need a little estrogen in order to have a normal libido.