HIGH CRP

[R&Dpharma]

POSTING ON BEHALF OF A CUSTOMER

Just want to get a few opinions on the following for a customer

Hey lads,

I don’t usually post on Evo but I’m on here a fair bit reading threads, so figured I’d throw this up and get some opinions.

I got bloods done last week and a few things stood out that I want to check with you guys.

Bloods:
• Oestradiol: 236 (high).
Over the last few weeks my nips went puffy and I could feel small lumps behind them. No pain or sensitivity though.
• CK: 797 U/L
• CRP: 17 mg/L
I train hard and push most sets to failure, which is my preferred training style, but even with that, CK and CRP seem way higher than I’d expect.

• Total test: 43 nmol/L
• Free test: 1244 pmol/L
Everything else was in range.

What I’ve been running:
• Test E 100–150mg/week (I inject almost daily)
• Mast E 100–150mg/week (kept 1:1 with test)
• Motts C 500mcg, mainly on training days (4x5/week)
• SLU 200–300mcg, mainly on training days (4–5x/week)
• GLOW 3–5mg/week (been great for skin)
• HGH 2IU every night
• Reta 1mg Mon & Thurs

My whole approach is low doses, minimal sides. Nothing here looks crazy to me, which is why a CRP of 17 has me concerned.

When the gyno started, I ran 60mg ralox for ~2 weeks. It reduced the gyno by about 50%. I stopped ralox ~2 weeks before the blood test, but wondering if that could still be impacting CRP?

I barely drink. Maybe every 2–3 months I’ll go out and have a night, but nothing regular.

I dropped Mast completely ~2 weeks ago. Gyno is basically gone now. Nips still a little puffy but the hard lumps are gone.

For context, I ran 150-200mg test most of the year before adding Mast and peptides. On 150-200mg I had no sides and felt great. Had very good sleep, motivation and discipline were on point and mentally was feeling strong. When I added Mast, I dropped test to 100–150mg with the idea of slowly titrating up. I’m very reactive to compounds and start getting sides once test goes past ~300–350mg.

Main concern:
Why the hell is my CRP so high?

This is the highest it’s ever been. The only other time it was elevated was Dec 2024 when I ran some trash NPP from an Evo source (never again). Max dosage of NPP at the time was no more than 200mg.

I eat clean (can post diet if needed), work 6 days a week running my own business (stress is high but that’s life), and usually sleep 7–8 hours. Last month sleep has been pretty shit though.

Supps I’m currently on:
• Vitamin C
• Magnesium
• Citrus bergamot
• NAC
• DIM
• Fish oil
• Krill oil
• Nattokinase
• Vitamin K2
• P5P
• Moringa
• Turmeric
• Copper chelate
• Pantothenic acid

I’m not here to sugarcoat anything or get defensive. Just want honest feedback. What could be driving CRP this high, and what would you change or pull? How do I bring CRP down within range?

Not sure if naming sources is appropriate besides test. R&D is posting this for me since I can’t post yet. I messaged him first because the test is his and I’ve run it before with zero issues. He’s a gentleman and always answers queries promptly even when he doesn’t need to.

Appreciate any insight. Let me know if I’ve missed anything.

 

[R&Dpharma]

@Karza16

 

[alian23]

I think you are on too many supplements. Drop the supplements for one or two weeks and then see how you go.

If your diet is on point you will be fine without those supplements.

 

[bacwater]

Could be some sort of infection hard to say

 

[Eveflorence]

POSTING ON BEHALF OF A CUSTOMER

Just want to get a few opinions on the following for a customer

Hey lads,

I don’t usually post on Evo but I’m on here a fair bit reading threads, so figured I’d throw this up and get some opinions.

I got bloods done last week and a few things stood out that I want to check with you guys.

Bloods:
• Oestradiol: 236 (high).
Over the last few weeks my nips went puffy and I could feel small lumps behind them. No pain or sensitivity though.
• CK: 797 U/L
• CRP: 17 mg/L
I train hard and push most sets to failure, which is my preferred training style, but even with that, CK and CRP seem way higher than I’d expect.

• Total test: 43 nmol/L
• Free test: 1244 pmol/L
Everything else was in range.

What I’ve been running:
• Test E 100–150mg/week (I inject almost daily)
• Mast E 100–150mg/week (kept 1:1 with test)
• Motts C 500mcg, mainly on training days (4x5/week)
• SLU 200–300mcg, mainly on training days (4–5x/week)
• GLOW 3–5mg/week (been great for skin)
• HGH 2IU every night
• Reta 1mg Mon & Thurs

My whole approach is low doses, minimal sides. Nothing here looks crazy to me, which is why a CRP of 17 has me concerned.

When the gyno started, I ran 60mg ralox for ~2 weeks. It reduced the gyno by about 50%. I stopped ralox ~2 weeks before the blood test, but wondering if that could still be impacting CRP?

I barely drink. Maybe every 2–3 months I’ll go out and have a night, but nothing regular.

I dropped Mast completely ~2 weeks ago. Gyno is basically gone now. Nips still a little puffy but the hard lumps are gone.

For context, I ran 150-200mg test most of the year before adding Mast and peptides. On 150-200mg I had no sides and felt great. Had very good sleep, motivation and discipline were on point and mentally was feeling strong. When I added Mast, I dropped test to 100–150mg with the idea of slowly titrating up. I’m very reactive to compounds and start getting sides once test goes past ~300–350mg.

Main concern:
Why the hell is my CRP so high?

This is the highest it’s ever been. The only other time it was elevated was Dec 2024 when I ran some trash NPP from an Evo source (never again). Max dosage of NPP at the time was no more than 200mg.

I eat clean (can post diet if needed), work 6 days a week running my own business (stress is high but that’s life), and usually sleep 7–8 hours. Last month sleep has been pretty shit though.

Supps I’m currently on:
• Vitamin C
• Magnesium
• Citrus bergamot
• NAC
• DIM
• Fish oil
• Krill oil
• Nattokinase
• Vitamin K2
• P5P
• Moringa
• Turmeric
• Copper chelate
• Pantothenic acid

I’m not here to sugarcoat anything or get defensive. Just want honest feedback. What could be driving CRP this high, and what would you change or pull? How do I bring CRP down within range?

Not sure if naming sources is appropriate besides test. R&D is posting this for me since I can’t post yet. I messaged him first because the test is his and I’ve run it before with zero issues. He’s a gentleman and always answers queries promptly even when he doesn’t need to.

Appreciate any insight. Let me know if I’ve missed anything.

Haven't been sick recently by any chance? What has your previous readings been?

It's either general inflammation which is obviously common to all of us or your body might have been fighting some sort of infection you might not even been aware of.

How's heart rate and blood pressure been?
I wouldn't freak out just yet.

 

[deltaforce]

Probably check your white blood cell count, if you did a full blood count test, should have the readings. If WBC is elevated, could be a some sort of an infection or an inflammation. I had a similar reading a while back due to an inflammation. It was okay after 2 weeks.

 

[Freki]

POSTING ON BEHALF OF A CUSTOMER

Just want to get a few opinions on the following for a customer

Hey lads,

I don’t usually post on Evo but I’m on here a fair bit reading threads, so figured I’d throw this up and get some opinions.

I got bloods done last week and a few things stood out that I want to check with you guys.

Bloods:
• Oestradiol: 236 (high).
Over the last few weeks my nips went puffy and I could feel small lumps behind them. No pain or sensitivity though.
• CK: 797 U/L
• CRP: 17 mg/L
I train hard and push most sets to failure, which is my preferred training style, but even with that, CK and CRP seem way higher than I’d expect.

• Total test: 43 nmol/L
• Free test: 1244 pmol/L
Everything else was in range.

What I’ve been running:
• Test E 100–150mg/week (I inject almost daily)
• Mast E 100–150mg/week (kept 1:1 with test)
• Motts C 500mcg, mainly on training days (4x5/week)
• SLU 200–300mcg, mainly on training days (4–5x/week)
• GLOW 3–5mg/week (been great for skin)
• HGH 2IU every night
• Reta 1mg Mon & Thurs

My whole approach is low doses, minimal sides. Nothing here looks crazy to me, which is why a CRP of 17 has me concerned.

When the gyno started, I ran 60mg ralox for ~2 weeks. It reduced the gyno by about 50%. I stopped ralox ~2 weeks before the blood test, but wondering if that could still be impacting CRP?

I barely drink. Maybe every 2–3 months I’ll go out and have a night, but nothing regular.

I dropped Mast completely ~2 weeks ago. Gyno is basically gone now. Nips still a little puffy but the hard lumps are gone.

For context, I ran 150-200mg test most of the year before adding Mast and peptides. On 150-200mg I had no sides and felt great. Had very good sleep, motivation and discipline were on point and mentally was feeling strong. When I added Mast, I dropped test to 100–150mg with the idea of slowly titrating up. I’m very reactive to compounds and start getting sides once test goes past ~300–350mg.

Main concern:
Why the hell is my CRP so high?

This is the highest it’s ever been. The only other time it was elevated was Dec 2024 when I ran some trash NPP from an Evo source (never again). Max dosage of NPP at the time was no more than 200mg.

I eat clean (can post diet if needed), work 6 days a week running my own business (stress is high but that’s life), and usually sleep 7–8 hours. Last month sleep has been pretty shit though.

Supps I’m currently on:
• Vitamin C
• Magnesium
• Citrus bergamot
• NAC
• DIM
• Fish oil
• Krill oil
• Nattokinase
• Vitamin K2
• P5P
• Moringa
• Turmeric
• Copper chelate
• Pantothenic acid

I’m not here to sugarcoat anything or get defensive. Just want honest feedback. What could be driving CRP this high, and what would you change or pull? How do I bring CRP down within range?

Not sure if naming sources is appropriate besides test. R&D is posting this for me since I can’t post yet. I messaged him first because the test is his and I’ve run it before with zero issues. He’s a gentleman and always answers queries promptly even when he doesn’t need to.

Appreciate any insight. Let me know if I’ve missed anything.

Rest the entire weekend , make sure properly hydrated and retest on monday.

How soon after training was the test taken?
Can we see the rest of the results?

 

[Ratatata]

Post clearly says he is posting in behalf of customer.
Also i was told p5p is toxic supplement Only to be used when nandrolone or tren is in used.
@R.AP could chime in more.

 

[R.AP]

POSTING ON BEHALF OF A CUSTOMER

Just want to get a few opinions on the following for a customer

Hey lads,

I don’t usually post on Evo but I’m on here a fair bit reading threads, so figured I’d throw this up and get some opinions.

I got bloods done last week and a few things stood out that I want to check with you guys.

Bloods:
• Oestradiol: 236 (high).
Over the last few weeks my nips went puffy and I could feel small lumps behind them. No pain or sensitivity though.
• CK: 797 U/L
• CRP: 17 mg/L
I train hard and push most sets to failure, which is my preferred training style, but even with that, CK and CRP seem way higher than I’d expect.

• Total test: 43 nmol/L
• Free test: 1244 pmol/L
Everything else was in range.

What I’ve been running:
• Test E 100–150mg/week (I inject almost daily)
• Mast E 100–150mg/week (kept 1:1 with test)
• Motts C 500mcg, mainly on training days (4x5/week)
• SLU 200–300mcg, mainly on training days (4–5x/week)
• GLOW 3–5mg/week (been great for skin)
• HGH 2IU every night
• Reta 1mg Mon & Thurs

My whole approach is low doses, minimal sides. Nothing here looks crazy to me, which is why a CRP of 17 has me concerned.

When the gyno started, I ran 60mg ralox for ~2 weeks. It reduced the gyno by about 50%. I stopped ralox ~2 weeks before the blood test, but wondering if that could still be impacting CRP?

I barely drink. Maybe every 2–3 months I’ll go out and have a night, but nothing regular.

I dropped Mast completely ~2 weeks ago. Gyno is basically gone now. Nips still a little puffy but the hard lumps are gone.

For context, I ran 150-200mg test most of the year before adding Mast and peptides. On 150-200mg I had no sides and felt great. Had very good sleep, motivation and discipline were on point and mentally was feeling strong. When I added Mast, I dropped test to 100–150mg with the idea of slowly titrating up. I’m very reactive to compounds and start getting sides once test goes past ~300–350mg.

Main concern:
Why the hell is my CRP so high?

This is the highest it’s ever been. The only other time it was elevated was Dec 2024 when I ran some trash NPP from an Evo source (never again). Max dosage of NPP at the time was no more than 200mg.

I eat clean (can post diet if needed), work 6 days a week running my own business (stress is high but that’s life), and usually sleep 7–8 hours. Last month sleep has been pretty shit though.

Supps I’m currently on:
• Vitamin C
• Magnesium
• Citrus bergamot
• NAC
• DIM
• Fish oil
• Krill oil
• Nattokinase
• Vitamin K2
• P5P
• Moringa
• Turmeric
• Copper chelate
• Pantothenic acid

I’m not here to sugarcoat anything or get defensive. Just want honest feedback. What could be driving CRP this high, and what would you change or pull? How do I bring CRP down within range?

Not sure if naming sources is appropriate besides test. R&D is posting this for me since I can’t post yet. I messaged him first because the test is his and I’ve run it before with zero issues. He’s a gentleman and always answers queries promptly even when he doesn’t need to.

Appreciate any insight. Let me know if I’ve missed anything.

Hey bro! Thanks for submitting. e2 is elevated but not too concerning in and of itself. Based on what they've said your client likely just needs to lower their test dose a smidge, increase injection frequency or lower their body fat percentage.

Was your client hydrated the morning of their test?

CK of 700 is pretty typical for someone training hard, but a CRP of that high is telling us there there may be something going on.

Was your client ill at the time the bloods were drawn? Had they recently suffered an injury? Did they have a known infection?

Thanks for the tag @Ratatata

@LevButlerov

 

[R&Dpharma]

Thanks for the input everyone I'm sure he is reading the comments but unable to comment because his account is new or something I will ask him these questions

 

[R&Dpharma]

Really helpful boys thanks with all the evidence I think it was illness he was a little sick 2 weeks prior (something from Bali) and a day after the test

 

[willipede]

Really helpful boys thanks with all the evidence I think it was illness he was a little sick 2 weeks prior (something from Bali) and a day after the test

I think this is the likely source, would be good to see the rest of the testing results, full blood count etc.

Also if I was him, id be retesting in a few weeks to make sure CRP is trending down

 

[ltdevo]

I'm going to go with the high CRP caused by MOTS-C and SLU-PP.

I'm swinging in the dark here, but those two compounds together have an incredibly high potential for oxidative stress, which if left unchecked is causing the inflammatory responses needed to drive high CRP. MOTS-C will increase mitochondrial biogenesis, leading to higher levels of mitochondria, and the SLU-PP-332 will aim to shuttle more electrons through the mitochondrial electron transport chain complex's. Together you've got a synergistic effect on potential for oxidative stress by increasing the potential for ATP output. Long story short, there's a bunch of molecules floating around with high levels of reactivity (unpaired electrons) that look for donors to oxidise, and that could be any other molecule that is part of another cell or biological tissue.

Yes I understand they're low dose, and the supplement list does have some antioxidants in there, but there is also no B vitamin complex, essential for the health of the inner mitochondrial membranes, and without those you have a leak of electron leakage to form reactive oxygen species (ROS).

All other exogenous sources of compounds are incredibly low-inflammation risk (test, mast, glow, HGH, reta).

Drop those two and re-test in 3-4 weeks.

Anyway, disclaimer... I am not a doctor. Thanks for listening.

 

[willipede]

I'm going to go with the high CRP caused by MOTS-C and SLU-PP.

Id be shocked if they were to be the cause, unless contaminated.

I've ran both mots-c as well as slu, never had a CRP above 3 with any cycles, there is something seriously wrong if you've got unexplain highly elevated CRP

Although I do think there could be more to the story

 

[Allupfromhere]

Acute illness at the time of testing?

I believe the original post has had discussions with another extremely valuable member here in private with @Cg20

Feel free to post the discussion for community benifit also brother if you like.

 

[Cg20]

I'm going to go with the high CRP caused by MOTS-C and SLU-PP.

I'm swinging in the dark here, but those two compounds together have an incredibly high potential for oxidative stress, which if left unchecked is causing the inflammatory responses needed to drive high CRP. MOTS-C will increase mitochondrial biogenesis, leading to higher levels of mitochondria, and the SLU-PP-332 will aim to shuttle more electrons through the mitochondrial electron transport chain complex's. Together you've got a synergistic effect on potential for oxidative stress by increasing the potential for ATP output. Long story short, there's a bunch of molecules floating around with high levels of reactivity (unpaired electrons) that look for donors to oxidise, and that could be any other molecule that is part of another cell or biological tissue.

Yes I understand they're low dose, and the supplement list does have some antioxidants in there, but there is also no B vitamin complex, essential for the health of the inner mitochondrial membranes, and without those you have a leak of electron leakage to form reactive oxygen species (ROS).

All other exogenous sources of compounds are incredibly low-inflammation risk (test, mast, glow, HGH, reta).

Drop those two and re-test in 3-4 weeks.

Anyway, disclaimer... I am not a doctor. Thanks for listening.

Nah not the case, acute viral/ bacterial infections will massively raise crp, I called it before he even got in contact with me but the causation was a bacterial infection, and the ck/ast/alt elevations were from training close to time of bloodtest.

He is getting follow up bloods in 1-2 weeks after the sickness has had enough time to properly clear, and I guarantee the crp number looks drastically different

 

[Eddie Haskell]

Thanks for the input everyone I'm sure he is reading the comments but unable to comment because his account is new or something I will ask him these questions

@Karza16 is active now, account out of spam que. please ask him to login.

 

[Cg20]

Nah not the case, acute viral/ bacterial infections will massively raise crp, I called it before he even got in contact with me but the causation was a bacterial infection, and the ck/ast/alt elevations were from training close to time of bloodtest.

He is getting follow up bloods in 1-2 weeks after the sickness has had enough time to properly clear, and I guarantee the crp number looks drastically different

Crp number looks drastically different as does ck/AST/alt, I’ve told him to take a few days off training before testing again

 

[Made_Man]

@Iron_rose1 did you want to have a look at this, right up your alley

 

[AUwomenizer]

Retest after week rest and good sleep. Better be dropping all the peptides too

 

[Iron_rose1]

Hello,
What is your client's body fat %?

Sometimes excess fat and even high level of testestrone can convert into estrogen ( which is reflected in the blood report as well)

Higher Oestradiol= Higher CRP

Also, multiple supplements can put liver under added stress resulting in higher CRP.
Perhaps recalibrate Reta dosage for BF% reduction if its elevated as well as Test dosage.


If your client wants to support liver and reduce CRP and inflammation, consider
IV or IM Glutathione - One of the strongest anti-oxidanants and liver detox compound. Oral form isn't as effective. I know your client is on NAC, which is converted into Glutathione but its additional work and step for already tired and over-worked liver.

Calcium D glucoronate 500mg - Liver support, prevent re-absorption of estrogen back in the body.

 

[ltdevo]

Nah not the case, acute viral/ bacterial infections will massively raise crp, I called it before he even got in contact with me but the causation was a bacterial infection, and the ck/ast/alt elevations were from training close to time of bloodtest.

He is getting follow up bloods in 1-2 weeks after the sickness has had enough time to properly clear, and I guarantee the crp number looks drastically different

I hope this is the case haha. Will keep an eye out for this, please update when results are in

 

[Karza16]

Hey lads,

Firstly I want to thank all of you for your input. Its awesome to see such a strong community helping each other out.

About 2 weeks before the test I had a family member come back from Bali and he got me sick. At the time of the blood test I felt as if I was no longer ill which is why I decided to get tested. Although the following day after the test I was sick again with a minor sore throat and a slight headache. I woke up today with a minor headache again and won't be training today.

After reading all of the responses I will do the following;

Will do daily test injections
Drop the Motts-C and SLU for the time being
Start taking Glutathione (which I have on hand) and B vitamin complex
Get re-tested in two/three weeks and post the results

I took bp and hr yesterday between 5-6pm and it was 93/69 and 70.
Retested now and its 109/72 and 85. HR is slightly elevated at the moment.

Happy to post all of the results if you lads want to see them.

 

[Cg20]

Hello,
What is your client's body fat %?

Sometimes excess fat and even high level of testestrone can convert into estrogen ( which is reflected in the blood report as well)

Higher Oestradiol= Higher CRP

Also, multiple supplements can put liver under added stress resulting in higher CRP.
Perhaps recalibrate Reta dosage for BF% reduction if its elevated as well as Test dosage.


If your client wants to support liver and reduce CRP and inflammation, consider
IV or IM Glutathione - One of the strongest anti-oxidanants and liver detox compound. Oral form isn't as effective. I know your client is on NAC, which is converted into Glutathione but its additional work and step for already tired and over-worked liver.

Calcium D glucoronate 500mg - Liver support, prevent re-absorption of estrogen back in the body.

Higher e2 = higher crp is a dumb blanket statement when you have no idea what his e2 is, and statements like that can lead to people tanking their e2 when it isn’t necessary.

I saw his bloods, his liver is fine, so instead of assuming random things that bloodwork will tell you, make accurate judgement calls on what you actually see in front of you.

 

[Iron_rose1]

Higher e2 = higher crp is a dumb blanket statement when you have no idea what his e2 is, and statements like that can lead to people tanking their e2 when it isn’t necessary.

I saw his bloods, his liver is fine, so instead of assuming random things that bloodwork will tell you, make accurate judgement calls on what you actually see in front of you.

Bloods:
• Oestradiol: 236 (high).

Higher Oestradiol= Higher CRP

Higher e2 = higher crp is a dumb blanket statement when you have no idea what his e2 is

I used the term Oestradiol and his is 236

 

[Woodiee]

Most likely a sickness or some sort of infection(viral) perhaps. Retest in 4-6 weeks. His test levels are very high considering only 150mg/Week. Assuming this is a cruise, drop the dose to control your e2. Your body will thank you later.

 

[neoraven]

What about the mast he dropped and said his gyno went away? 100% sure it was mast

 

[RRRaus]

Hey mate!

What is the link between elevated e2 and elevated crp?

Thank you

I used the term Oestradiol and his is 236

e

 

[willipede]

What about the mast he dropped and said his gyno went away? 100% sure it was mast

If the mast was actually test i would expect testosterone to be higher than 42nmol/L

Looks like the raloxifene and mast were dropped at the same time which could explain the elevated e2

 

[Iron_rose1]

Hey mate!

What is the link between elevated e2 and elevated crp?

Thank you


e

Oestradiol in males is pro-inflammatory and CRP is an inflammatory marker.
So more Oestradiol means higher potential inflammation hence higher CRP value

 

[Wheelhouse87]

Ive had CRP higher then that with bloods.. was after a "bad injection" due to the inflammatory etc.
Im no pro at all but have even had other mates that have had high CRP and always came down to some kind of injury or potential sickness they had at the time of test.
I just re-test in like 4 weeks time and if its bacm to normal ranges then sweet.
Thats just my personal opinions from my bloods and some mates